Published in Proc Natl Acad Sci U S A on October 15, 1962
REGULATORY MECHANISMS IN THE BIOSYNTHESIS OF ISOLEUCINE AND VALINE. I. GENETIC DEREPRESSION OF ENZYME FORMATION. J Bacteriol (1964) 4.23
ROLE OF VALYL-SRNA SYNTHETASE IN ENZYME REPRESSION. Proc Natl Acad Sci U S A (1965) 3.82
Isoleucine and valine metabolism of Escherichia coli. XV. Biochemical properties of mutants resistant to thiaisoleucine. J Bacteriol (1968) 3.70
Effect of different nutritional conditions on the synthesis of tricarboxylic acid cycle enzymes. J Bacteriol (1967) 3.64
Expression of the leucine operon. J Bacteriol (1966) 3.12
LINKAGE RELATIONSHIPS OF GENES CONTROLLING ISOLEUCINE, VALINE, AND LEUCINE BIOSYNTHESIS IN BACILLUS SUBTILIS. J Bacteriol (1965) 3.04
Regulation of branched-chain amino acid biosynthesis in Salmonella typhimurium: isolation of regulatory mutants. J Bacteriol (1969) 2.88
Symptosium on multiple forms of enzymes and control mechanisms. II. Enzyme multiplicity and function in the regulation of divergent metabolic pathways. Bacteriol Rev (1963) 2.41
Inhibition of isoleucyl-transfer ribonucleic acid synthetase in Escherichia coli by pseudomonic acid. Biochem J (1978) 2.41
Aromatic amino acid biosynthesis: regulation of shikimate kinase in Escherichia coli K-12. J Bacteriol (1979) 2.30
Role of transport systems in amino acid metabolism: leucine toxicity and the branched-chain amino acid transport systems. J Bacteriol (1977) 2.24
Isoleucine auxotrophy as a consequence of a mutationally altered isoleucyl-transfer ribonucleic acid synthetase. J Bacteriol (1971) 2.23
Mutants of Salmonella typhimurium with an altered leucyl-transfer ribonucleic acid synthetase. J Bacteriol (1971) 2.19
The complete nucleotide sequence of the ilvGMEDA operon of Escherichia coli K-12. Nucleic Acids Res (1987) 2.04
Regulation of synthesis of the aminoacyl-transfer ribonucleic acid synthetases for the branched-chain amino acids of Escherichia coli. J Bacteriol (1971) 1.96
Studies on L-serine deaminase in Escherichia coli K-12. J Bacteriol (1974) 1.90
Properties of threonine deaminase from a bacterium able to use threonine as sole source of carbon. J Bacteriol (1969) 1.89
Selection of temperature-sensitive activating enzyme mutants in Escherichia coli. J Bacteriol (1968) 1.75
Metabolic regulation in glucose-limited chemostat cultures of Escherichia coli. J Bacteriol (1970) 1.75
Regulation of branched-chain amino acid transport in Escherichia coli. J Bacteriol (1976) 1.67
The ILV5 gene of Saccharomyces cerevisiae is highly expressed. Nucleic Acids Res (1986) 1.60
Methionine-mediated repression in Saccharomyces cerevisiae: a pleiotropic regulatory system involving methionyl transfer ribonucleic acid and the product of gene eth2. J Bacteriol (1971) 1.60
New Map Location of ilvO in ESCHERICHIA COLI. Genetics (1976) 1.52
Isolation of transducing bacteriophages for the histidine and isoleucine-valine operons in Escherichia coli K-12. J Bacteriol (1972) 1.50
Isoleucine and valine metabolism in Escherichia coli. 18. Induction of acetohydroxy acid isomeroreductase. J Bacteriol (1972) 1.48
Multivalent repression of aspartic semialdehyde dehydrogenase in Escherichia coli K-12. J Bacteriol (1972) 1.47
Role of leucyl-tRNA synthetase in regulation of branched-chain amino-acid transport. Proc Natl Acad Sci U S A (1975) 1.44
Separate regulation of transport and biosynthesis of leucine, isoleucine, and valine in bacteria. J Bacteriol (1975) 1.41
An enzyme in yeast mitochondria that catalyzes a step in branched-chain amino acid biosynthesis also functions in mitochondrial DNA stability. EMBO J (1995) 1.37
Antipolarity in the ilv operon of Escherichia coli K-12. J Bacteriol (1969) 1.37
Effect of isoleucine, valine, or leucine starvation on the potential for formation of the branched-chain amino acid biosynthetic enzymes. J Bacteriol (1973) 1.33
Temperature-sensitive growth inhibition by valine in Salmonella typhimurium: alteration of one form of acetohydroxy acid synthetase. J Bacteriol (1973) 1.33
Metabolic basis for the isoleucine, pantothenate or methionine requirement of ilvG strains of Salmonella typhimurium. J Bacteriol (1982) 1.31
Isoleucine and valine metabolism in Escherichia coli K-12: detection and measurement of ilv-specific messenger ribonucleic acid. J Bacteriol (1974) 1.30
Autoregulation: a role for a biosynthetic enzyme in the control of gene expression. Proc Natl Acad Sci U S A (1973) 1.29
Derepressed levels of the isoleucine-valine and leucine enzymes in his T 1504, a strain of Salmonella typhimurium with altered leucine transfer ribonucleic acid. J Bacteriol (1974) 1.27
BIOSYNTHESIS OF VALINE AND ISOLEUCINE, VI. ENZYME REPRESSION IN SALMONELLA. Proc Natl Acad Sci U S A (1963) 1.23
Role for free isoleucine of glycyl-leucine in the repression of threonine deaminase in Escherichia coli. J Bacteriol (1974) 1.22
Involvement of threonine deaminase in multivalent repression of the isoleucine-valine pathway in Saccharomyces cerevisiae. Proc Natl Acad Sci U S A (1971) 1.21
Transcriptional activity of the transposable element Tn10 in the Salmonella typhimurium ilvGEDA operon. Proc Natl Acad Sci U S A (1982) 1.19
Biosynthesis of branched-chain amino acids in yeast: regulation of synthesis of the enzymes of isoleucine and valine biosynthesis. J Bacteriol (1969) 1.18
Regulation and mechanism of phosphoribosylpyrophosphate synthetase: repression by end products. J Bacteriol (1971) 1.18
Inhibition of growth of Salmonella typhimurium and of threonine deaminase and transaminase B by beta-chloroalanine. J Bacteriol (1971) 1.17
Salmonella typhimurium mutants with alternate requirements for vitamin B 6 or isoleucine. J Bacteriol (1971) 1.15
Mutations in genes cpxA and cpxB of Escherichia coli K-12 cause a defect in acetohydroxyacid synthase I function in vivo. J Bacteriol (1982) 1.14
Control of isoleucine, valine, and leucine biosynthesis. VI. Effect of 5',5',5'-trifluoroleucine on repression in Salmonella typhimurium. J Bacteriol (1969) 1.12
Serine transhydroxymethylase in methionine biosynthesis in Saccharomyces cerevisiae. J Bacteriol (1969) 1.11
Role of the leu-3 cistron in the regulation of the synthesis of isoleucine and valine biosynthetic enzymes of Neurospora. J Bacteriol (1974) 1.11
Multivalent repression and genetic depression of isoleucine-valine biosynthetic enzymes in Serratia marcescens. J Bacteriol (1971) 1.10
New amino acid regulatory locus having unusual properties in heterozygous merodiploids. J Bacteriol (1972) 1.09
Acetohydroxy acid synthetase with a pH optimum of 7.5 from Neurospora crassa mitochondria: characterization and partial purification. J Bacteriol (1972) 1.08
Multivalent repression of isoleucine- valine biosynthesis in Saccharomyces cerevisiae. J Bacteriol (1969) 1.07
Leucine biosynthesis in the blue-green bacterium Anacystis nidulans. J Bacteriol (1975) 1.07
Molecular cloning and expression of the ilvGEDAY genes from Salmonella typhimurium. J Bacteriol (1981) 1.07
Binding of integration host factor (IHF) to the ilvGp1 promoter of the ilvGMEDA operon of Escherichia coli K12. Nucleic Acids Res (1988) 1.03
Regulation of isoleucine-valine biosynthesis in Pseudomonas aeruginosa. II. Regulation of enzyme activity and synthesis. Genetics (1969) 1.01
Gene ilvY of Salmonella typhimurium. J Bacteriol (1980) 1.01
Evidence that the majority of leucine transfer ribonucleic acid is not involved in repression in Salmonella typhimurium. J Bacteriol (1971) 1.00
Mutations that convert the four leucine codons of the Salmonella typhimurium leu leader to four threonine codons. J Bacteriol (1985) 1.00
Suppressors of a genetic regulatory mutation affecting isoleucine-valine biosynthesis in Escherichia coli K-12. J Bacteriol (1978) 1.00
flrB, a regulatory locus controlling branched-chain amino acid biosynthesis in Salmonella typhimurium. J Bacteriol (1974) 0.99
Involvement of threonine deaminase in repression of the isoleucine-valine and leucine pathways in Saccharomyces cerevisiae. J Bacteriol (1973) 0.98
Derepression of synthesis of the aminoacyl-transfer ribonucleic acid synthetases for the branched-chain amino acids of Escherichia coli. J Bacteriol (1974) 0.98
Effect of cyclopentaneglycine on metabolism in Salmonella typhimurium. J Bacteriol (1972) 0.98
Branched-chain amino acid biosynthesis in Salmonella typhimurium: a quantitative analysis. J Bacteriol (1998) 0.98
Bacteriophage T4 virion dihydrofolate reductase: approaches to quantitation and assessment of function. J Virol (1977) 0.94
Repression by glucose of acetohydroxy acid synthetase in Escherichia coli B. Biochem J (1969) 0.93
Biodegradative L-threonine deaminase of Salmonella typhimurium. J Bacteriol (1974) 0.92
Isolation and characterization of ilvA, ilvBN, and ilvD mutants of Caulobacter crescentus. J Bacteriol (1991) 0.91
Evidence that repression mechanisms can exert control over the thr, leu, and ilv operons of Escherichia coli K-12. J Bacteriol (1983) 0.91
Regulation of the tryptophan synthetic enzymes in Clostridium butyricum. J Bacteriol (1972) 0.91
VALINE-ISOLEUCINE METABOLISM IN ACETOBACTER SUBOXYDANS AND THE INHIBITION OF GROWTH BY VALINE. J Bacteriol (1964) 0.90
ACETOLACTATE METABOLISM AND THE PRESENCE OF A DIHYDROXY ACID DEHYDRATASE IN MICRO-ORGANISMS. Biochem J (1965) 0.89
Enzymes of the isoleucine-valine pathway in Acinetobacter. J Bacteriol (1972) 0.88
Specificity of attenuation control in the ilvGMEDA operon of Escherichia coli K-12. J Bacteriol (1991) 0.88
Altered regulation of isoleucine-valine biosynthesis in a hisW mutant of Salmonella typhimurium. J Bacteriol (1982) 0.86
Bacterial catabolism of threonine. Threonine degradation initiated by l-threonine hydrolyase (deaminating) in a species of Corynebacterium. Biochem J (1977) 0.86
Regulation of Salmonella typhimurium ilvYC genes. J Bacteriol (1984) 0.84
Participation of branched-chain amino acid analogues in multivalent repression. J Bacteriol (1973) 0.84
Deoxyribonucleic acid-directed in vitro synthesis of ilv-specific messenger ribonucleic acid by extracts of Escherichia coli K-12. J Bacteriol (1974) 0.82
Improvement of an l-Leucine-Producing Mutant of Brevibacterium lactofermentum 2256 by Genetically Desensitizing It to alpha-Acetohydroxy Acid Synthetase. Appl Environ Microbiol (1986) 0.81
A structural gene for the DPN-specific glutamate dehydrogenase in Neurospora. Genetics (1967) 0.81
Analysis of regulation of the ilvGMEDA operon by using leader-attenuator-galK gene fusions. J Bacteriol (1990) 0.80
REPRESSION OF THE VALINE-ISOLEUCINE PATHWAY IN SALMONELLA. Proc Natl Acad Sci U S A (1963) 0.80
Biosynthesis of isoleucine and valine in Rhodopseudomonas spheroides: regulation of threonine deaminase activity. J Bacteriol (1971) 0.79
The absence of branched-chain amino acid and growth rate control at the internal ilvEp promoter of the ilvGMEDA operon. J Bacteriol (1991) 0.78
Reconstructed Ancestral Enzymes Impose a Fitness Cost upon Modern Bacteria Despite Exhibiting Favourable Biochemical Properties. J Mol Evol (2015) 0.78
Synthesis and activities of branched-chain aminoacyl-tRNA synthetases in threonine deaminase mutants of Escherichia coli. J Bacteriol (1978) 0.77
Cloning of the ilvA538 gene coding for feedback-hypersensitive threonine deaminase from Escherichia coli K-12. J Bacteriol (1982) 0.77
Point mutations in the regulatory region of the ilvGMEDA operon of Escherichia coli K-12. J Bacteriol (1989) 0.76
Complementation between different mutations in the ilvA gene of Escherichia coli K-12. J Bacteriol (1974) 0.75
Absence of acetohydroxy acid synthetase in a clinical isolate of Neisseria gonorrhoeae requiring isoleucine and valine. J Bacteriol (1980) 0.75
INSTABILITY OF ALPHA,BETA-DIHYDROXY ACID DEHYDRASE OF SALMONELLA. J Bacteriol (1963) 0.75
ISOLEUCINE AND VALINE METABOLISM IN ESCHERICHIA COLI. XII. CHARACTERIZATION OF A FACTOR INVOLVED IN ACETOLACTATE FORMATION. J Bacteriol (1964) 0.75
Effects of valine on protein synthesis and turnover in Pseudomonas saccharophila under "nongratuitous" inducing conditions. J Bacteriol (1967) 0.75
Prolonged antibiotic use induces intestinal injury in mice that is repaired after removing antibiotic pressure: implications for empiric antibiotic therapy. Metabolomics (2014) 0.75
CONTROL OF URACIL SYNTHESIS BY ARGININE IN ESCHERICHIA COLI. J Bacteriol (1964) 0.75
Description of the chemostat. Science (1950) 11.97
COORDINATE REPRESSION OF THE SYNTHESIS OF FOUR HISTIDINE BIOSYNTHETIC ENZYMES BY HISTIDINE. Proc Natl Acad Sci U S A (1959) 6.11
Threonine, Isoleucine, and Isoleucine-Valine Mutants of Salmonella Typhimurium. Genetics (1960) 5.65
Isoleucine and valine metabolism in Escherichia coli. XI. Valine inhibition of the growth of Escherichia coli strain K-12. J Bacteriol (1962) 4.82
Isoleucine and valine metabolism in Escherichia coli. X. The enzymatic formation of acetohydroxybutyrate. J Biol Chem (1961) 4.27
Isoleucine and valine metabolism in Escherichia coli. VII. A negative feedback mechanism controlling isoleucine biosynthesis. J Biol Chem (1958) 3.13
THE BIOSYNTHESIS OF ISOLEUCINE AND VALINE. I. ENZYMATIC TRANSFORMATION OF THE DIHYDROXY ACID PRECURSORS TO THE KETO ACID PRECURSORS. Proc Natl Acad Sci U S A (1954) 2.96
Another intermediate in leucine biosynthesis. Biochem Biophys Res Commun (1962) 2.43
Threonine deamination in Escherichia coli. II. Evidence for two L-threonine deaminases. J Bacteriol (1957) 5.39
Isoleucine and valine metabolism in Escherichia coli. V. alpha-Ketoisovaleric acid accumulation. J Biol Chem (1953) 4.98
Isoleucine and valine metabolism in Escherichia coli. XI. Valine inhibition of the growth of Escherichia coli strain K-12. J Bacteriol (1962) 4.82
Isoleucine and valine metabolism in Escherichia coli. V. Antagonism between isoleucine and valine. J Bacteriol (1955) 4.43
Evidence for a negative-feedback mechanism in the biosynthesis of isoleucine. Science (1956) 4.27
Isoleucine and valine metabolism in Escherichia coli. X. The enzymatic formation of acetohydroxybutyrate. J Biol Chem (1961) 4.27
BIOSYNTHESIS OF SERINE IN ESCHERICHIA COLI AND SALMONELLA TYPHIMURIUM. J Bacteriol (1963) 3.85
THE BIOSYNTHESIS OF LEUCINE. III. THE CONVERSION OF ALPHA-HYDROXY-BETA-CARBOXYISOCAPROATE TO ALPHA-KETOISOCAPROATE. Biochemistry (1964) 3.38
THE BIOSYNTHESIS OF LEUCINE. II. THE ENZYMIC ISOMERIZATION OF BETA-CARBOXY-BETA-HYDROXYISOCAPROATE AND ALPHA-HYDROXY-BETA-CARBOXYISOCAPROATE. Biochemistry (1964) 3.30
Isoleucine and valine metabolism in Escherichia coli. VIII. The formation of acetolactate. J Biol Chem (1958) 3.19
Isoleucine and valine metabolism in Escherichia coli. VII. A negative feedback mechanism controlling isoleucine biosynthesis. J Biol Chem (1958) 3.13
Conversion of ammonia to amino groups in Escherichia coli. J Bacteriol (1960) 2.96
Feedback control by endproduct inhibition. Cold Spring Harb Symp Quant Biol (1961) 2.71
CONTROL OF ISOLEUCINE, VALINE AND LEUCINE BIOSYNTHESIS. II. ENDPRODUCT INHIBITION BY VALINE OF ACETOHYDROXY ACID SYNTHETASE IN SALMONELLA TYPHIMURIUM. Biochim Biophys Acta (1964) 2.63
The rôle of alpha-keto- beta-ethylbutyric acid in the biosynthesis of isoleucine. J Biol Chem (1951) 2.52
Multivalent repression in the biosynthesis of threonine in Salmonella typhimurium and Escherichia coli. Biochem Biophys Res Commun (1963) 2.47
Evidence for two distinct enzyme systems forming acetolactate in Aerobacter aerogenes. J Biol Chem (1959) 2.31
The biosynthetic pathway of serine in salmonella typhimurium. Biochim Biophys Acta (1962) 2.25
Utilization of L-glutamic and 2-oxoglutaric acid as sole sources of carbon by Escherichia coli. J Gen Microbiol (1961) 2.15
Peritoneal dialysis. Clinical experience. N Engl J Med (1962) 2.05
Isoleucine and valine metabolism of Escherichia coli. I. Growth studies on amino acid-deficient mutants. J Biol Chem (1951) 1.98
Properties of tryptophanase from Escherichia coli. Biochim Biophys Acta (1962) 1.91
The biosynthesis of leucine. I. The accumulation of beta-carboxy-beta-hydroxyisocaproate by leucine auxotrophs of Salmonella typhimurium and Neurospora crassa. Biochemistry (1963) 1.79
Regulation of biosynthetic pathways. Physiol Rev (1962) 1.66
Threonine deamination in Escherichia coli. I. D- and L-threonine deaminase activities of cell-free extracts. J Bacteriol (1956) 1.54
The influence of the environment on acetate metabolism in Escherichia coli. J Bacteriol (1954) 1.51
Inhibitory effect of glucose on tryptophanase. J Bacteriol (1960) 1.37
Isoleucine and valine metabolism in Escherichia coli. IX. Utilization of acetolactate and acetohydroxybutyrate. J Biol Chem (1960) 1.31
The nutritional requirements of threonineless mutants of Escherichia coli. J Bacteriol (1953) 1.26
Tryptophanase-tryptophan synthetase systems in Escherichia coli. II. Effect of glucose. J Bacteriol (1962) 1.20
On the mechanism of development of resistance to streptomycin in Micrococcus pyogenes var. aureus. J Bacteriol (1955) 1.20
Influence of glucose on the growth factor requirement of a mutant of Escherichia coli. J Bacteriol (1953) 1.13
THE ABSOLUTE CONFIGURATION OF ALPHA-HYDROXY-BETA-CARBOXYISOCAPROIC ACID (3-ISOPROPYLMALIC ACID), AN INTERMEDIATE IN LEUCINE BIOSYNTHESIS. Biochemistry (1964) 1.06
Tryptophanase-tryptophan synthetase systems in Escherichia coli. I. Effect of tryptophan and related compounds. J Bacteriol (1962) 1.01
THE EFFECT OF L-VALINE ON ENZYME SYNTHESIS IN ESCHERICHIA COLI K-12. J Biol Chem (1965) 0.96
Isoleucine and valine metabolism of Escherichia coli. II. The accumulation of keto acids. J Biol Chem (1951) 0.93
Antimicrobial substances from seeds. J Am Pharm Assoc Am Pharm Assoc (1959) 0.85
Perforation of the interventicular septum following acute myocardial infarction: a report of four cases diagnosed ante mortem. Ann Intern Med (1956) 0.81
The syndrome of chronic pulmonary disease and gastroduodenal ulceration; a clinical study and literature review. AMA Arch Intern Med (1959) 0.78
Tryptophanase-tryptophan synthetase systems in Escherichia coli. III. Requirements for enzyne synthesis. J Bacteriol (1962) 0.75
Protection against hypertension, arteriolonecrosis and death by hog renal extracts in experimental malignant hypertension. Circ Res (1953) 0.75
Staphylococcal enterocolitis; case reports. W V Med J (1958) 0.75
Antimicrobial substances from resistant and non-resistant seeds. Nature (1959) 0.75
Atrial dominance: an electrocardiographic study with four representative case reports. W V Med J (1957) 0.75
Regulation mechanisms in the biosynthesis of alpha-acetolactic acid by Aerobacter aerogenes. Bull Res Counc Isr Sect E Exp Med (1959) 0.75
Complications of obstructive uropathy: acidosis, adrenal failure and water intoxication; case report. W V Med J (1958) 0.75
SERUM ELECTROLYTE AND OSMOLALITY CHANGES FOLLOWING TRANSURETHRAL RESECTION OF THE PROSTATE. J Urol (1965) 0.75
Clinical study of prevention of erythroblastosis with Rh hapten. J Am Med Assoc (1950) 0.75
Salicylate intoxication treated with artificial kidney. W V Med J (1958) 0.75
Treatment of experimental renal hypertension with renin and with antirenin. J Lab Clin Med (1950) 0.75
PYELO-ILEO-CYSTOSTOMY IN PITRESSIN-RESISTANT DIABETES INSIPIDUS. J Urol (1964) 0.75
Postoperative renal insufficiency treated by extracorporeal hemodialysis; case report. W V Med J (1958) 0.75