THE MUTATION LOAD IN SMALL POPULATIONS.

The effect of deleterious mutations on neutral molecular variation. Genetics (1993) 20.07

The mutational load with epistatic gene interactions in fitness. Genetics (1966) 7.75

The frequency distribution of lethal chromosomes in finite populations. Proc Natl Acad Sci U S A (1968) 2.76

Fixation probability and time in subdivided populations. Genetics (2003) 2.59

Chikungunya virus emergence is constrained in Asia by lineage-specific adaptive landscapes. Proc Natl Acad Sci U S A (2011) 2.12

Muller's ratchet under epistatic selection. Genetics (1994) 2.01

Metapopulation extinction caused by mutation accumulation. Proc Natl Acad Sci U S A (2001) 1.66

Selection in finite populations with multiple alleles. II. Centripetal selection, mutation, and isoallelic variation. Genetics (1970) 1.60

Estimating the mutation load in human genomes. Nat Rev Genet (2015) 1.57

Estimation of deleterious-mutation parameters in natural populations. Genetics (1996) 1.54

Characteristics of neutral and deleterious protein-coding variation among individuals and populations. Am J Hum Genet (2014) 1.43

Heterosis increases the effective migration rate. Proc Biol Sci (2000) 1.43

Comparative RNA sequencing reveals substantial genetic variation in endangered primates. Genome Res (2011) 1.36

Reduced inbreeding depression after species range expansion. Proc Natl Acad Sci U S A (2009) 1.31

A threefold genetic allee effect: population size affects cross-compatibility, inbreeding depression and drift load in the self-incompatible Ranunculus reptans. Genetics (2005) 1.28

Inbreeding depression in small populations of self-incompatible plants. Genetics (2001) 1.27

Effects of restricted population size and increase in mutation rate on the genetic variation of quantitative characters. Genetics (1966) 1.26

The different sources of variation in inbreeding depression, heterosis and outbreeding depression in a metapopulation of Physa acuta. Genetics (2008) 1.22

Fitting background-selection predictions to levels of nucleotide variation and divergence along the human autosomes. Genome Res (2005) 1.22

Patterns of inbreeding depression and architecture of the load in subdivided populations. Genetics (2003) 1.19

The impact of population demography and selection on the genetic architecture of complex traits. PLoS Genet (2014) 1.19

Neighborhood Size in LITHOSPERMUM CAROLINIENSE. Genetics (1968) 1.11

Joint evolution of dispersal and inbreeding load. Genetics (2006) 1.11

Distance from sub-Saharan Africa predicts mutational load in diverse human genomes. Proc Natl Acad Sci U S A (2015) 1.06

An inbreeding model of associative overdominance during a population bottleneck. Genetics (2000) 1.05

Evolutionary layering and the limits to cellular perfection. Proc Natl Acad Sci U S A (2012) 1.04

On the origins of Mendelian disease genes in man: the impact of gene duplication. Mol Biol Evol (2011) 1.01

A population-based study of autosomal-recessive disease-causing mutations in a founder population. Am J Hum Genet (2012) 1.00

Genetic load in sexual and asexual diploids: segregation, dominance and genetic drift. Genetics (2007) 0.99

Surprising fitness consequences of GC-biased gene conversion: I. Mutation load and inbreeding depression. Genetics (2010) 0.94

Spatial heterogeneity in the strength of selection against deleterious alleles and the mutation load. Heredity (Edinb) (2012) 0.89

Characterization of deleterious mutations in outcrossing populations. Genetics (1998) 0.89

Inbreeding rate modifies the dynamics of genetic load in small populations. Ecol Evol (2012) 0.86

Effective population sizes for cytoplasmic and nuclear genes in a gynodioecious species. The role of the sex determination system. Genetics (2000) 0.84

A little bit of sex matters for genome evolution in asexual plants. Front Plant Sci (2015) 0.84

Purifying selection, drift, and reversible mutation with arbitrarily high mutation rates. Genetics (2014) 0.84

Effect of breeding structure on population genetic parameters in Drosophila. Genetics (2004) 0.83

The effect of overdominance on characterizing deleterious mutations in large natural populations. Genetics (1999) 0.81

When Is Selection Effective? Genetics (2016) 0.81

Inbreeding depression and low between-population heterosis in recently diverged experimental populations of a selfing species. Heredity (Edinb) (2010) 0.80

Conditions for positive and negative correlations between fitness and heterozygosity in equilibrium populations. Genetics (1998) 0.80

Surprising fitness consequences of GC-biased gene conversion. II. Heterosis. Genetics (2010) 0.80

Effects of Interference Between Selected Loci on the Mutation Load, Inbreeding Depression, and Heterosis. Genetics (2015) 0.79

The impact of recent population history on the deleterious mutation load in humans and close evolutionary relatives. Curr Opin Genet Dev (2016) 0.78

Understanding rare and common diseases in the context of human evolution. Genome Biol (2016) 0.78

Drift load in populations of small size and low density. Heredity (Edinb) (2012) 0.78

The Genetic Structure of Natural Populations of DROSOPHILA MELANOGASTER. Xviii. Clinal and Uniform Genetic Variation over Populations. Genetics (1984) 0.78

Heterosis and outbreeding depression in crosses between natural populations of Arabidopsis thaliana. Heredity (Edinb) (2015) 0.78

Drift Barriers to Quality Control when Genes Are Expressed at Different Levels. Genetics (2016) 0.77

The Role of Deleterious Substitutions in Crop Genomes. Mol Biol Evol (2016) 0.77

Interactions between evolutionary processes at high mutation rates. Evolution (2012) 0.76

Positive Selection and Centrality in the Yeast and Fly Protein-Protein Interaction Networks. Biomed Res Int (2016) 0.75

Increased heterosis in selfing populations of a perennial forb. AoB Plants (2015) 0.75

Limited dispersal, deleterious mutations and the evolution of sex. Genetics (1996) 0.75

The Effect of an Extreme and Prolonged Population Bottleneck on Patterns of Deleterious Variation: Insights from the Greenlandic Inuit. Genetics (2016) 0.75

An Evolving Genetic Architecture Interacts with Hill-Robertson Interference to Determine the Benefit of Sex. Genetics (2016) 0.75

Motoo Kimura and James Crow on the Infinitely Many Alleles Model. Genetics (2016) 0.75

Population size, center-periphery, and seed dispersers' effects on the genetic diversity and population structure of the Mediterranean relict shrub Cneorum tricoccon. Ecol Evol (2017) 0.75

Accumulation of Deleterious Mutations During Bacterial Range Expansions. Genetics (2017) 0.75

Effective purifying selection in ancient asexual oribatid mites. Nat Commun (2017) 0.75

Our load of mutations. Am J Hum Genet (1950) 24.01

AN ESTIMATE OF THE MUTATIONAL DAMAGE IN MAN FROM DATA ON CONSANGUINEOUS MARRIAGES. Proc Natl Acad Sci U S A (1956) 23.27

Some possibilities for measuring selection intensities in man. Hum Biol (1958) 17.45

The Distribution of Gene Frequencies in Populations. Proc Natl Acad Sci U S A (1937) 15.47

Selection for heterozygotes in small populations. Genetics (1962) 5.00

THE NUMBER OF ALLELES THAT CAN BE MAINTAINED IN A FINITE POPULATION. Genetics (1964) 45.28

On the probability of fixation of mutant genes in a population. Genetics (1962) 18.38

Some possibilities for measuring selection intensities in man. Hum Biol (1958) 17.45

Evidence that the segregation-distortion phenomenon in Drosophila involves chromosome breakage. Proc Natl Acad Sci U S A (1962) 3.87

Stochastic processes and distribution of gene frequencies under natural selection. Cold Spring Harb Symp Quant Biol (1955) 3.69

The maintenance of super-numerary chromosomes in wild populations of Lilium callosum by preferential segregation. Genetics (1961) 1.67

2. The concept of genetic load: a reply. Am J Hum Genet (1963) 1.49

Inbreeding and homozygosis in bees. Genetics (1950) 1.38

The resistance of DDT-resistant Drosophila to other insecticides. Science (1951) 1.11

FUNDAMENTAL STUDIES ON CLINICAL CHEMISTRY. VII. JANOVSKY REACTION OF POLYNITRODIPHENYL COMPOUNDS. Chem Pharm Bull (Tokyo) (1964) 0.90

General theory of population genetics: synthesis. Cold Spring Harb Symp Quant Biol (1955) 0.90

Inhibition of formation of actiomycin by D-isoleucine. J Antibiot (Tokyo) (1960) 0.89

N-Acetylvaline as the N-terminal group of chicken globin. J Biochem (1963) 0.88

Population genetics. Am J Hum Genet (1961) 0.87

Paper partition chromatography of alcohols using the potassium xanthogenates. Nature (1951) 0.86

A comparison of fetal and infant death rates in the progeny of radiologists and pathologists. Am J Roentgenol Radium Ther Nucl Med (1955) 0.85

Ionizing radiation and evolution. Sci Am (1959) 0.82

[ESTIMATION OF BONE MARROW FROM RADIOGRAPHY OF X-RAY EXAMINATION]. Nihon Igaku Hoshasen Gakkai Zasshi (1964) 0.80

Differences in susceptibility to ether in the virilis group of Drosophila. Genetics (1948) 0.76

Poisoning by organic phosphate insecticides. Calif Med (1955) 0.76

Influence of antidiuretic hormone on adrenal cortical activity in rats. Jpn J Physiol (1954) 0.76

A consequence of the dominance hypothesis of hybrid vigor. Genetics (1948) 0.75

Genetic considerations in establishing maximum radiation doses. Radiology (1957) 0.75

[Clinical serological studies on weak live measles virus vaccine]. Paediatr Jpn (1963) 0.75

[CLINICAL EFFECTIVENESS OF VERINA (NYLIDRIN HYDROCHLORIDE)]. Chiryo (1963) 0.75

The influence of 8-azaguanine on tumors and enhancement. Gan (1955) 0.75

Recovery of a chemical fraction from human nightsoil having an ovistatic effect upon Ascaris lumbricoides eggs. Exp Parasitol (1955) 0.75

[The constituents of Convallaria. II. The isolation of desglucocheirotoxin]. Yakugaku Zasshi (1962) 0.75

[CLINICAL OBSERVATIONS AND PATHOLOGICAL STUDY OF 2 CASES OF AMYLOIDOSIS]. Saishin Igaku (1965) 0.75

A possible metabolic pathway of gamma-guanido- and gamma-guanido-beta-oxy-butyric acid by heteroarginase. Jpn J Pharmacol (1961) 0.75

Induced abortions in Japan in 1953-1954: a demographic analysis of reports from designated physicians. Milbank Mem Fund Q (1959) 0.75

Experimental studies on ovicidal substances occurring in human nightsoil. Exp Parasitol (1955) 0.75

CLINICAL AND SEROLOGICAL OBSERVATIONS ON THE CHILDREN GIVEN ATTENUATED MEASLES VACCINE. Acta Paediatr Jpn (1963) 0.75

ON THE TREATMENT OF SPINAL CORD INJURY: REVIEW AND ANALYSIS OF 2300 CASES. Nihon Seikeigeka Gakkai Zasshi (1964) 0.75

[CONSTITUENTS OF CONVALLARIA. 3. ISOLATION OF CHELIDONIC ACID]. Yakugaku Zasshi (1964) 0.75

Molecular pharmacological studies on drug-receptor complexes system in drug action. II. The mode of action of parathion on an acetylcholine receptor. Chem Pharm Bull (Tokyo) (1963) 0.75

Adrenocortical function of the patients with hypertension and with coronary heart diseases. Endocrinol Jpn (1960) 0.75

[Myocardial infarct]. Naika (1962) 0.75

[STATISTICAL OBSERVATIONS ON THE DEGREE OF CURVATURE OF THE CERVICAL VERTEBRAE]. Nihon Seikeigeka Gakkai Zasshi (1964) 0.75

TECHNIQUE FOR ACQUIRING AND PREPARING THE HUMAN TEMPORAL BONE FOR THE STUDY OF MIDDLE AND INNER EAR PATHOLOGY. Trans Am Acad Ophthalmol Otolaryngol (1965) 0.75

Molecular pharmacological studies on drug-receptor complexes system in drug action. I. antagonism to acetylcholine of organophosphorous compounds. Chem Pharm Bull (Tokyo) (1963) 0.75

[Studies on electrocardiography in work load. I. Study of a standard for electrocardiography in work load. II. On the radioelectrocardiograph]. Showa Igakkai Zasshi (1963) 0.75

[Colorimetric determination of pentoses. I. Comparative studies and improvement of various methods]. Yakugaku Zasshi (1962) 0.75

[FUNDAMENTAL STUDIES ON CLINICAL CHEMISTRY. IV. OXIDATION PRODUCTS OF CHOLESTEROL IN ACETONE WITH KILIANI'S REAGENT AND THEIR DERIVATIVES]. Yakugaku Zasshi (1964) 0.75

[Some problems in regard to cesarean section]. Sanfujinka Chiryo (1963) 0.75

[THE EFFECTS OF HYPOTHERMIA ON THE ACTIVITY OF HEART AND OF ACTION OF THE CARDIAC AND DEPRESSOR NERVES IN URETHANE ANESTHETIZED RABBITS]. Fukuoka Igaku Zasshi (1963) 0.75

PEPTIDES FROM A TRYPTIC DIGEST OF BAKER'S YEAST CYTOCHROME C. Biochim Biophys Acta (1963) 0.75

Effect of injections of soluble antigen of the spleen size and antibody production in chickens. Anat Rec (1950) 0.75

Corticoid inhibition of adrenocortical stimulation due to surgical trauma of adrenal vein cannulation in dogs. Annu Rep Res Inst Environ Med Nagoya Univ (1962) 0.75

A test for increased resistance in a chronically poisoned mouse population. Am J Hyg (1951) 0.75

[STUDY ON A NEW DIFFERENTIAL-CONFIRMATORY MEDIUM FOR THE FAMILY ENTEROBACTERIACEAE]. Nihon Saikingaku Zasshi (1964) 0.75

[CHRONIC PERITONITIS AND PERITONEAL DISEASES]. Naika (1963) 0.75

FUNDAMENTAL STUDIES ON CLINICAL CHEMISTRY. X. A NEW MICRO METHOD FOR THE COLORIMETRIC DETERMINATION OF URINARY DEHYDROEPIANDROSTERONE. Chem Pharm Bull (Tokyo) (1965) 0.75

Reaction between polynitrobenzene and active methylene groups. V. Jaffé and Baljet reactions. Pharm Bull (1955) 0.75

The absence of a primary sex factor on the X-chromosome of Drosophila. Am Nat (1947) 0.75

Statistic observation of the isolation culture of tubercle bacilli in sputum. Kekkaku (1951) 0.75

MOLECULAR PHARMACOLOGICAL STUDIES ON DRUG-RECEPTOR COMPLEXES SYSTEM IN DRUG ACTION. III. THE SITE OF ACTION OF ORGANOPHOSPHATE GROUP ON THE ACETYLCHOLINE RECEPTOR SURFACE. Chem Pharm Bull (Tokyo) (1964) 0.75

Chemicopharmacological studies on antispasmodic action. VI. On statistical treatment of concentration-action relationship of acetylcholine on small intestines of mice. Pharm Bull (1956) 0.75

[Phytopharmacological studies on urine in urology. I]. Showa Igakkai Zasshi (1963) 0.75

[Application of chloramphenicol morpholine acetate in pediatrics]. J Antibiot B (1961) 0.75

[A cured case of obturator hernia]. Iryo (1961) 0.75

FUNDAMENTAL STUDIES ON CLINICAL CHEMISTRY. V. A SPECIFIC METHOD FOR THE DETERMINATION OF FREE CHOLESTEROL IN SERUM. Chem Pharm Bull (Tokyo) (1964) 0.75

Attenuative antidotal effects of guanidyl compounds on NH3 toxication. Jpn J Pharmacol (1961) 0.75

INACTIVATED MEASLES VIRUS VACCINE SUBSEQUENTLY CHALLENGED WITH LIVE ATTENUATED MEASLES VIRUS VACCINE. Jpn J Med Sci Biol (1965) 0.75

[New problems in traumatic neuroses]. Rinsho Geka (1962) 0.75

Reaction between polynitrobenzene and active methylene groups. IV. Reaction between 1-substituted 2,4,6-trinitrobenzene and acetone. Pharm Bull (1955) 0.75

FORMAL AND POPULATION GENETICS. Trans Am Acad Ophthalmol Otolaryngol (1965) 0.75

[COMPARATIVE STUDY OF THE RESULTS OF EARLY TREATMENT OF CONGENITAL HIP DISLOCATION]. Nihon Seikeigeka Gakkai Zasshi (1964) 0.75

MOLECULAR PHARMACOLOGICAL STUDIES ON DRUG-RECEPTOR COMPLEXES SYSTEM IN DRUG ACTION. IV. RELATIONSHIP BETWEEN ANTICHOLINERGIC AND ANTICHOLINESTERASE ACTIVITIES OF ORGANOPHOSPHORYL CHOLINE DERIVATIVES BASED ON THEIR CHEMICAL STRUCTURE. Chem Pharm Bull (Tokyo) (1964) 0.75

FRACTIONATION OF PEPTIDES OBTAINED BY TRYPTIC HYDROLYSIS OF BAKER'S YEAST CYTOCHROME C. J Biochem (1964) 0.75

Chemicopharmacological studies on antispasmodic action. V. Fundamental conditions of bioassay of acetylcholine and atropine on the isolated small intestines of mice. Pharm Bull (1956) 0.75

[APPEARANCE AND TERMINATION OF CARDIAC FIBRILLATION]. Nisshin Igaku Jpn J Med Prog (1963) 0.75

Some experimental data of biological action of anti-cancer agents. Acta Unio Int Contra Cancrum (1959) 0.75

Chromatography of arginine-containing peptides on a carboxylic acid resin. Biochim Biophys Acta (1959) 0.75

Occurrence of antidiuretic substance in human urine after heavy sweating. Jpn J Physiol (1953) 0.75

[A CASE OF ENCEPHALOPATHY INDUCED BY AMINOPYRINE HYPERSENSITIVITY]. Showa Igakkai Zasshi (1963) 0.75

[PULMONARY PARAGONIMIASIS]. Iryo (1964) 0.75

Studies on acylase activity and micro-organisms. XIX. Optical resolution of threonine. lvsine. trvptophan. and methionine by ucylase of soil bacteria. Chem Pharm Bull (Tokyo) (1962) 0.75

A CASE REPORT OF ATYPICAL MORQUIO-BRAILSFORD'S DISEASE, ACCOMPANIED BY CONGENITAL DISLOCATIONS OF THE HIPS AND THE KNEES. Yokohama Med Bull (1964) 0.75

[On a family with Marfan's syndrome]. Chiryo (1963) 0.75

Chemicopharmacological studies on antispasmodic action. VIII. On the antagonistic action of atropine and its methobromide to acetylcholine with the isolated small intestines of mice. Pharm Bull (1957) 0.75

[Enzymatic deamination of 8-azaguanine by ascites tumors in rats]. Gan (1954) 0.75

[Studies on the serum protein-bound polysaccharides in patients with cancer; especially on the possible site of their production]. Gan (1957) 0.75