Published in Ann Hum Genet on November 01, 1963
Strategies for studying heterogeneous genetic traits in humans by using a linkage map of restriction fragment length polymorphisms. Proc Natl Acad Sci U S A (1986) 9.51
Estimating the power of a proposed linkage study for a complex genetic trait. Am J Hum Genet (1989) 4.42
Two-trait-locus linkage analysis: a powerful strategy for mapping complex genetic traits. Am J Hum Genet (1993) 3.76
A genomewide scan for age-related macular degeneration provides evidence for linkage to several chromosomal regions. Am J Hum Genet (2003) 3.23
The search for heterogeneity in insulin-dependent diabetes mellitus (IDDM): linkage studies, two-locus models, and genetic heterogeneity. Am J Hum Genet (1983) 3.23
Detecting linkage for genetically heterogeneous diseases and detecting heterogeneity with linkage data. Am J Hum Genet (1986) 3.16
Parametric and nonparametric multipoint linkage analysis with imprinting and two-locus-trait models: application to mite sensitization. Am J Hum Genet (2000) 2.70
Meta-analysis of 13 genome scans reveals multiple cleft lip/palate genes with novel loci on 9q21 and 2q32-35. Am J Hum Genet (2004) 2.65
Evidence for a susceptibility gene for autism on chromosome 2 and for genetic heterogeneity. Am J Hum Genet (2001) 2.51
Replication of linkage studies of complex traits: an examination of variation in location estimates. Am J Hum Genet (1999) 2.50
Joint linkage of multiple loci for a complex disorder. Am J Hum Genet (1993) 2.20
Linkage analysis of neurofibromatosis (von Recklinghausen disease). J Med Genet (1983) 2.13
Linkage analysis in the presence of errors I: complex-valued recombination fractions and complex phenotypes. Am J Hum Genet (2000) 2.05
Waardenburg syndrome (WS) type I is caused by defects at multiple loci, one of which is near ALPP on chromosome 2: first report of the WS consortium. Am J Hum Genet (1992) 1.94
Inter- and intrafamilial heterogeneity: effective sampling strategies and comparison of analysis methods. Am J Hum Genet (1992) 1.91
Identification of a schizophrenia-associated functional noncoding variant in NOS1AP. Am J Psychiatry (2009) 1.85
Linkage of familial breast cancer to chromosome 17q21 may not be restricted to early-onset disease. Am J Hum Genet (1992) 1.71
Genome scan, fine-mapping, and candidate gene analysis of non-syndromic cleft lip with or without cleft palate reveals phenotype-specific differences in linkage and association results. Hum Hered (2009) 1.71
Genomewide scan for linkage reveals evidence of several susceptibility loci for alopecia areata. Am J Hum Genet (2007) 1.55
Linkage of an autosomal dominant clefting syndrome (Van der Woude) to loci on chromosome Iq. Am J Hum Genet (1990) 1.48
HLA and the inheritance of multiple sclerosis: linkage analysis of 72 pedigrees. Am J Hum Genet (1980) 1.46
Genome scan for loci involved in cleft lip with or without cleft palate, in Chinese multiplex families. Am J Hum Genet (2002) 1.44
Localization of the autosomal dominant HLA-linked spinocerebellar ataxia (SCA1) locus, in two kindreds, within an 8-cM subregion of chromosome 6p. Am J Hum Genet (1991) 1.43
Cutaneous malignant melanoma and familial dysplastic nevi: evidence for autosomal dominance and pleiotropy. Am J Hum Genet (1986) 1.39
Examination of potential overlap in autism and language loci on chromosomes 2, 7, and 13 in two independent samples ascertained for specific language impairment. Hum Hered (2004) 1.38
Logarithm of odds (lods) for linkage in complex inheritance. Proc Natl Acad Sci U S A (1996) 1.36
Heterogeneity analysis of breast cancer families by using age at onset as a covariate. Am J Hum Genet (1992) 1.33
Confirmation of genetic linkage between atopic IgE responses and chromosome 11q13. J Med Genet (1992) 1.32
The PARK8 locus in autosomal dominant parkinsonism: confirmation of linkage and further delineation of the disease-containing interval. Am J Hum Genet (2003) 1.30
Use of molecular haplotypes specific for the human pro alpha 2(I) collagen gene in linkage analysis of the mild autosomal dominant forms of osteogenesis imperfecta. Am J Hum Genet (1986) 1.29
Localization of a gene for familial hemophagocytic lymphohistiocytosis at chromosome 9q21.3-22 by homozygosity mapping. Am J Hum Genet (1999) 1.27
A new statistical test for linkage heterogeneity. Am J Hum Genet (1988) 1.26
KELVIN: a software package for rigorous measurement of statistical evidence in human genetics. Hum Hered (2011) 1.23
The detection of linkage and heterogeneity in nuclear families for complex disorders: one versus two marker loci. Am J Hum Genet (1989) 1.18
Genetic linkage between a locus for 6-PGD and the Rh locus: evaluation of possible heterogeneity in the recombination fraction between sexes and among families. Am J Hum Genet (1971) 1.18
Problems in the definition, interpretation, and evaluation of genetic heterogeneity. Am J Hum Genet (2001) 1.17
Evidence for a susceptibility gene for anorexia nervosa on chromosome 1. Am J Hum Genet (2002) 1.17
Contributions of PTCH gene variants to isolated cleft lip and palate. Cleft Palate Craniofac J (2006) 1.16
A major susceptibility locus for systemic lupus erythemathosus maps to chromosome 1q31. Am J Hum Genet (2002) 1.10
Genetic linkage of human height is confirmed to 9q22 and Xq24. Hum Genet (2006) 1.10
Linkage relationship of X-linked juvenile retinoschisis with Xp22.1-p22.3 probes. Am J Hum Genet (1990) 1.08
Locus heterogeneity for Waardenburg syndrome is predictive of clinical subtypes. Am J Hum Genet (1994) 1.06
A multilocus model of the genetic architecture of autoimmune thyroid disorder, with clinical implications. Am J Hum Genet (2008) 1.03
Linkage heterogeneity between X-linked retinitis pigmentosa and a map of 10 RFLP loci. Am J Hum Genet (1989) 1.02
A genome-wide linkage and association study of musical aptitude identifies loci containing genes related to inner ear development and neurocognitive functions. Mol Psychiatry (2014) 1.01
Role of genetic heterogeneity and epistasis in bladder cancer susceptibility and outcome: a learning classifier system approach. J Am Med Inform Assoc (2013) 1.00
A genome-wide linkage scan for bone mineral density in an extended sample: evidence for linkage on 11q23 and Xq27. J Med Genet (2004) 1.00
A genome wide linkage scan for cleft lip and palate and dental anomalies. Am J Med Genet A (2008) 0.99
Effects of updating linkage evidence across subsets of data: reanalysis of the autism genetic resource exchange data set. Am J Hum Genet (2005) 0.98
The trimmed-haplotype test for linkage disequilibrium. Am J Hum Genet (2000) 0.95
Genetic heterogeneity among kindreds with Alport syndrome. Am J Hum Genet (1986) 0.95
Exploiting gene x gene interaction in linkage analysis. BMC Proc (2007) 0.95
Linkage methods in human genetics before the computer. Hum Genet (2005) 0.95
A population-based study of familial Alzheimer disease: linkage to chromosomes 14, 19, and 21. Am J Hum Genet (1994) 0.94
Two novel quantitative trait linkage analysis statistics based on the posterior probability of linkage: application to the COGA families. BMC Genet (2005) 0.94
A genome-wide linkage scan for cleft lip and cleft palate identifies a novel locus on 8p11-23. Am J Med Genet A (2007) 0.94
A review of the 'Statistical Analysis for Genetic Epidemiology' (S.A.G.E.) software package. Hum Genomics (2004) 0.94
A second-generation genomic screen for multiple sclerosis. Am J Hum Genet (2004) 0.94
Novel method for combined linkage and genome-wide association analysis finds evidence of distinct genetic architecture for two subtypes of autism. J Neurodev Disord (2011) 0.93
Exclusion of a schizophrenia susceptibility gene from the chromosome 5q11-q13 region: new data and a reanalysis of previous reports. Am J Hum Genet (1990) 0.93
TDT-HET: a new transmission disequilibrium test that incorporates locus heterogeneity into the analysis of family-based association data. BMC Bioinformatics (2012) 0.92
Dissecting trait heterogeneity: a comparison of three clustering methods applied to genotypic data. BMC Bioinformatics (2006) 0.92
Genetic homogeneity in Sjögren-Larsson syndrome: linkage to chromosome 17p in families of different non-Swedish ethnic origins. Am J Hum Genet (1995) 0.91
Localization and replication of the systemic lupus erythematosus linkage signal at 4p16: interaction with 2p11, 12q24 and 19q13 in European Americans. Hum Genet (2006) 0.91
Binomial mixture model-based association tests under genetic heterogeneity. Ann Hum Genet (2009) 0.91
Detection of linkage for heterogeneous disorders by using multipoint linkage analysis. Am J Hum Genet (1991) 0.89
Linkage of low-density lipoprotein size to the lipoprotein lipase gene in heterozygous lipoprotein lipase deficiency. Am J Hum Genet (1999) 0.89
Sampling strategies for linkage studies. Eur Arch Psychiatry Clin Neurosci (1991) 0.88
Confronting complexity in late-onset Alzheimer disease: application of two-stage analysis approach addressing heterogeneity and epistasis. Genet Epidemiol (2008) 0.86
Employing MCMC under the PPL framework to analyze sequence data in large pedigrees. Front Genet (2013) 0.85
Linkage of cutaneous malignant melanoma/dysplastic nevi to chromosome 9p, and evidence for genetic heterogeneity. Am J Hum Genet (1994) 0.84
Computer simulation of linkage and heterogeneity in tuberous sclerosis: a critical evaluation of the collaborative family data. J Med Genet (1992) 0.84
Ordered subset analysis for case-control studies. Genet Epidemiol (2010) 0.83
A molecular genetic study of autism and related phenotypes in extended pedigrees. J Neurodev Disord (2013) 0.82
Practical considerations for dividing data into subsets prior to PPL analysis. Hum Hered (2008) 0.82
Evidence for asthma susceptibility genes on chromosome 11 in an African-American population. Hum Genet (2003) 0.82
Combined linkage and linkage disequilibrium analysis of a motor speech phenotype within families ascertained for autism risk loci. J Neurodev Disord (2010) 0.81
Interpreting nonsignificant outcomes of heterogeneity tests in gene mapping. Am J Hum Genet (1991) 0.80
Revisiting schizophrenia linkage data in the NIMH Repository: reanalysis of regularized data across multiple studies. Am J Psychiatry (2014) 0.80
Association mapping of complex trait loci with context-dependent effects and unknown context variable. Genetics (2006) 0.80
Posterior probability of linkage analysis of autism dataset identifies linkage to chromosome 16. Psychiatr Genet (2008) 0.79
A likelihood ratio test for genome-wide association under genetic heterogeneity. Ann Hum Genet (2013) 0.77
A combined test of linkage heterogeneity. Am J Hum Genet (1994) 0.76
Distribution of model-based multipoint heterogeneity lod scores. Genet Epidemiol (2010) 0.76
Genome-wide linkage analysis of blood pressure under locus heterogeneity. BMC Genet (2003) 0.76
Is schizophrenia linked to chromosome 1q? Science (2002) 0.75
An application of the latent p value method to assess linkage in asthma pedigrees. Hum Hered (2010) 0.75
On modeling locus heterogeneity using mixture distributions. BMC Genet (2004) 0.75
Likelihood ratio testing for admixture models with application to genetic linkage analysis. Biometrics (2011) 0.75
Detection of genetic heterogeneity between families of insulin-dependent diabetes mellitus patients using linkage analysis. Am J Hum Genet (1985) 0.75
A model-integrated multipoint Bayesian analysis of hypertension in the Framingham Heart Study data finds little evidence of linkage. BMC Genet (2003) 0.75
Rapid plasma reagin test for syphilis. Public Health Rep (1957) 9.75
Some comments on the statistical methods used in linkage investigations. Am J Hum Genet (1959) 4.66
The estimation of gene frequencies in a random-mating population. Ann Hum Genet (1955) 4.06
Quantitative studies on the mechanism of gastric secretion in health and disease. Ann Surg (1950) 3.61
Preliminary evaluation of N, N'-dibenzylethylenediamine dipenicillin G in acute gonorrhea in the male. Am J Syph Gonorrhea Vener Dis (1952) 3.15
Untreated syphilis in the male Negro. X. Twenty years of clinical observation of untreated syphilitic and presumably nonsyphilitic groups. J Chronic Dis (1956) 2.75
Treatment of early infectious syphilis with N,N'dibenzylethylenediamine dipenicillin G. Am J Syph Gonorrhea Vener Dis (1954) 2.62
Studies on the circulation in the neonatal period. The circulation in the respiratory distress syndrome. Pediatrics (1961) 2.48
Studies of respiratory physiology in the newborn infant. III. Measurements of mechanics of respiration. J Clin Invest (1957) 2.43
Benzathine penicillin G in the treatment of syphilis. Bull World Health Organ (1956) 2.43
The electrolytes of the labyrinthine fluids. Laryngoscope (1954) 2.34
Counting methods in genetical statistics. Ann Hum Genet (1957) 2.13
Experimental hyperfunction of the gastric antrum with ulcer formation. Ann Surg (1951) 2.12
Non-random distribution of certain homologous pairs of normal human chromosomes in metaphase. Nature (1962) 2.03
Respiration of full term and of premature infants. AMA Am J Dis Child (1950) 1.94
Electron microscopy of the organ of Corti. Am J Anat (1957) 1.91
A test for segregation ratios in family data. Ann Hum Genet (1956) 1.87
Effects of withholding fluid in the immediate postnatal period. Pediatrics (1953) 1.81
Structure of the nerve endings on the external hair cells of the guinea pig cochlea as studied by serial sections. J Ultrastruct Res (1961) 1.67
Estimates of the sex ratio of mutation rates in sex-linked conditions by the method of maximum likelihood. Ann Hum Genet (1958) 1.58
The sex ratio of mutation rates of sex-linked recessive genes in man with particular reference to Duchenne type muscular dystrophy. Ann Hum Genet (1958) 1.53
Dental extraction in haemophilia. Lancet (1957) 1.51
Studies of respiratory physiology in the newborn infant. II. Observations during and after respiratory distress. Acta Paediatr Suppl (1954) 1.47
Studies of respiratory physiology in the newborn infant. I. Observations on normal premature and full-term infants. J Clin Invest (1955) 1.46
Pulmonary hyaline membranes in newborn infants; statistical, morpho logic and experimental study of their nature, occurrence and significance. Pediatrics (1951) 1.45
Structure of the stria vascularis and the spiral prominence. Ann Otol Rhinol Laryngol (1957) 1.43
A note on the treatment of diaper rash with alkyl-dimethyl-benzyl-ammonium chlorides (roccal). J Pediatr (1950) 1.42
Colour blindness and the Duchenne-type muscular dystrophy. Ann Hum Genet (1956) 1.42
The oxygen equilibrium of fetal and adult human hemoglobin. J Biol Chem (1953) 1.40
Modification of cochlear potentials produced by streptomycin poisoning and by extensive venous obstruction. Laryngoscope (1958) 1.36
Effect of supersaturated atmospheres on insensible water loss in the newborn infant. Pediatrics (1954) 1.35
Treatment of early infectious syphilis with N,N'-dibenzylethylenediamine dipenicillin G; a second report. Bull World Health Organ (1954) 1.32
Metabolic aspects of idiopathic respiratory distress (hyaline membrane syndrome) in newborn infants. Pediatrics (1961) 1.29
Microscopic structure of the utricle. Ann Otol Rhinol Laryngol (1956) 1.27
Pulmonary function in the newborn infant. II. Perfusion--estimation by analysis of the arterial-alveolar carbon dioxide difference. Pediatrics (1962) 1.23
ADJUSTMENT OF VENTILATION, INTRAPULMONARY GAS EXCHANGE, AND ACID-BASE BALANCE DURING THE FIRST DAY OF LIFE. INFANTS WITH EARLY RESPIRATORY DISTRESS. Pediatrics (1965) 1.22
Measurement of thoracic gas volume in the newborn infant. J Clin Invest (1963) 1.21
The effect of banthine on gastric secretion in man and experimental animals. Gastroenterology (1950) 1.17
"Early" versus "late" feeding of infants of diabetic mothers. N Engl J Med (1961) 1.16
Overuse of milk in the diets of infants and children. J Am Med Assoc (1960) 1.12
Cardiac surgery with hypothermia and acetylcholine arrest. J Thorac Surg (1956) 1.11
Effect of transplantation of antrum of stomach on gastric secretion in experimental animals. Am J Physiol (1951) 1.11
Physiologic background of fetal anoxia at birth and cyanosis in the newborn. Am J Dis Child (1950) 1.08
Untreated syphilis in the male negro; background and current status of patients in the Tuskegee study. J Chronic Dis (1955) 1.07
The newborn patient. Pediatrics (1955) 1.06
Capillary areas of the cochlea in the guinea pig. Laryngoscope (1951) 1.05
Prenatal and neonatal nutrition. Pediatrics (1962) 1.05
Pulmonary function in the newborn infant. I. Methods: ventilation and gaseous metabolism. Pediatrics (1962) 1.03
Recent observations on the olivo-cochlear bundle. Ann Otol Rhinol Laryngol (1963) 1.03
ADJUSTMENT OF VENTILATION, INTRAPULMONARY GAS EXCHANGE, AND ACID-BASE BALANCE DURING THE FIRST DAY OF LIFE. NORMAL VALUES IN WELL INFANTS OF DIABETIC MOTHERS. Pediatrics (1964) 1.01
DC potentials of the membranous labyrinth. Am J Physiol (1958) 1.01
A note on the effects of method of ascertainment on segregation ratios. Ann Hum Genet (1959) 1.01
Effect of the Exalto-Mann-Williamson procedure on gastric secretion. AMA Arch Surg (1952) 1.01
Neonatal pulmonary disorders. Pediatr Clin North Am (1962) 0.98
Capillary areas of the membranous labyrinth. Ann Otol Rhinol Laryngol (1954) 0.98
The effect of wartime starvation in Holland upon pregnancy and its product. Am J Obstet Gynecol (1947) 0.98
Effect of sympathectomy on gastric secretion in total pouch dogs. Am J Physiol (1951) 0.98
Effects of maternal under nutrition upon the newborn infant in Holland (1944-1945). J Pediatr (1947) 0.97
The influence of polymorphonuclear leukocytes and macrophages on antibody production. J Immunol (1951) 0.97
International population movements as aids to communicable disease control. Public Health Rep (1958) 0.97
Ophthalmia neonatorum. Public Health Rep (1955) 0.96
The blood pressure of newborn infants in asphyxial states and in hyaline membrane disease. Pediatrics (1960) 0.95
Cardiovascular syphilis; a clinical study of 578 cases. Br J Vener Dis (1955) 0.95
THE EFFECT OF A DISTAL ARTERIOVENOUS FISTULA UPON AN AUTOGENOUS VEIN GRAFT IN THE VENOUS SYSTEM. J Surg Res (1963) 0.94
A CLINICAL TRIAL OF HIGH OXYGEN PRESSURE FOR THE RESPIRATORY-DISTRESS SYNDROME. N Engl J Med (1965) 0.93
On the estimation of intra-class correlation. Ann Hum Genet (1957) 0.92
The separation of the sexes of parents in the detection of linkage in man. Ann Eugen (1954) 0.90
Summating potentials of the cochlea. Am J Physiol (1958) 0.88
Inter relation between the cephalic and gastric phases of gastric secretion. Am J Physiol (1952) 0.87
Responsiveness and resuscitation of the newborn. The use of the Apgar score. Am J Dis Child (1961) 0.87
Reasons for delaying the feeding of premature infants. Ann Paediatr Fenn (1957) 0.85
Current trends in the feeding of infants and children. J Am Med Assoc (1956) 0.85
Leg volume changes observed in hyaline membrane disease. AMA J Dis Child (1959) 0.85
Effects and fate of human serum albumin administered intravenously and orally to premature infants. J Clin Invest (1950) 0.85
Persistence and utilization of maternal iron for blood formation during infancy. J Clin Invest (1955) 0.84
Experimental gastrojejunal ulcers due to antrum hyperfunction. AMA Arch Surg (1951) 0.83
Water and electrolyte economy in newborn infants of diabetic mothers. Acta Paediatr (1960) 0.82
The capillaries of the vestibular membranous labyrinth in the guinea pig. Laryngoscope (1953) 0.81
PULMONARY FUNCTION IN THE NEWBORN INFANT. V. TRAPPED GAS IN THE NORMAL INFANT'S LUNG. J Clin Invest (1963) 0.81
Effects of withholding fluid intake in the immediately postnatal period. AMA Am J Dis Child (1952) 0.79
Nutrition in the neonatal period. Proc Nutr Soc (1958) 0.79
Special problems of the newborn; summary of round table discussion. Pediatrics (1955) 0.78
Innervation pattern of the cochlea. The internal hair cell. Trans Am Otol Soc (1961) 0.77
Effect of weight reduction in obese pregnant women on pregnancy, labor, and delivery, and on the condition of the infant at birth. Am J Obstet Gynecol (1962) 0.77
Circulatory factors in relation to idiopathic respiratory distress (hyaline membrane disease) in the newborn. J Pediatr (1960) 0.77
DIAGNOSIS AND TREATMENT: USE AND MISUSE OF OXYGEN IN TREATMENT OF PREMATURES. Pediatrics (1964) 0.76
Effects of maternal malnutrition on fetal development. Am J Dis Child (1947) 0.76
Transplacental iron: its persistence during infancy as studied isotopically. AMA Am J Dis Child (1950) 0.76
Therapy of early syphilis with artificial fever in combination with mapharsen, bismuth, and penicillin. Am J Syph Gonorrhea Vener Dis (1952) 0.75
Appraising the nutritional status of mothers and infants. Am J Public Health Nations Health (1948) 0.75
A FURTHER EXTENSION OF THE IN VIVO OXYGEN-DISSOCIATION CURVE FOR THE BLOOD OF THE NEWBORN INFANT. J Clin Invest (1964) 0.75
Gastric ulcer following esophagogastric anastomosis for carcinoma of the esophagus or gastric cardia. Ann Surg (1957) 0.75
Studies on lymphedema of the extremities. Ann Surg (1962) 0.75
Oral penicillin and fever in the treatment of early syphilis. Am J Syph Gonorrhea Vener Dis (1952) 0.75
Diseases of the newborn; asphyxia, atelectasis, erythroblastosis. Bull Vanc Med Assoc (1947) 0.75
RESPIRATORY PHYSIOLOGY AND RESPIRATORY DISTRESS IN THE NEWBORN INFANT. Int Anesthesiol Clin (1965) 0.75
Diseases of the newborn; diarrhea, prematurity. Bull Vanc Med Assoc (1947) 0.75
Physiological peculiarities of newborn infants. Bull Vanc Med Assoc (1947) 0.75
The causes of abdominal pain in infants and children. Bull Vanc Med Assoc (1947) 0.75
The incidence of placenta praevia and antepartum haemorrhage according to maternal age and parity. Ann Eugen (1947) 0.75