Published in J Mol Biol on October 20, 1992
Prediction of water and metal binding sites and their affinities by using the Fold-X force field. Proc Natl Acad Sci U S A (2005) 2.31
Carbonic anhydrase as a model for biophysical and physical-organic studies of proteins and protein-ligand binding. Chem Rev (2008) 2.27
Escherichia coli glutamate- and arginine-dependent acid resistance systems increase internal pH and reverse transmembrane potential. J Bacteriol (2004) 2.14
Entrapment of carbon dioxide in the active site of carbonic anhydrase II. J Biol Chem (2008) 1.98
A left-hand beta-helix revealed by the crystal structure of a carbonic anhydrase from the archaeon Methanosarcina thermophila. EMBO J (1996) 1.64
Proton solvation and transport in aqueous and biomolecular systems: insights from computer simulations. J Phys Chem B (2007) 1.59
The active site architecture of Pisum sativum beta-carbonic anhydrase is a mirror image of that of alpha-carbonic anhydrases. EMBO J (2000) 1.45
Crystal structure of the dimeric extracellular domain of human carbonic anhydrase XII, a bitopic membrane protein overexpressed in certain cancer tumor cells. Proc Natl Acad Sci U S A (2001) 1.39
Elucidation of the proton transport mechanism in human carbonic anhydrase II. J Am Chem Soc (2009) 1.37
Neutron structure of human carbonic anhydrase II: implications for proton transfer. Biochemistry (2010) 1.26
Docking validation resources: protein family and ligand flexibility experiments. J Chem Inf Model (2010) 1.25
A plant-type (beta-class) carbonic anhydrase in the thermophilic methanoarchaeon Methanobacterium thermoautotrophicum. J Bacteriol (1999) 1.20
Cryptophane xenon-129 nuclear magnetic resonance biosensors targeting human carbonic anhydrase. J Am Chem Soc (2009) 1.17
Protein design: toward functional metalloenzymes. Chem Rev (2014) 1.17
Comparison of electron paramagnetic resonance methods to determine distances between spin labels on human carbonic anhydrase II. Biophys J (2001) 1.17
Crystal structure of the secretory form of membrane-associated human carbonic anhydrase IV at 2.8-A resolution. Proc Natl Acad Sci U S A (1996) 1.16
Structural analysis of inhibitor binding to human carbonic anhydrase II. Protein Sci (1998) 1.16
Structural study of X-ray induced activation of carbonic anhydrase. Proc Natl Acad Sci U S A (2009) 1.14
Preferred orientations of His64 in human carbonic anhydrase II. Biochemistry (2007) 1.13
Structure determination of murine mitochondrial carbonic anhydrase V at 2.45-A resolution: implications for catalytic proton transfer and inhibitor design. Proc Natl Acad Sci U S A (1995) 1.11
Role of hydrophilic residues in proton transfer during catalysis by human carbonic anhydrase II. Biochemistry (2008) 1.09
"Proton holes" in long-range proton transfer reactions in solution and enzymes: A theoretical analysis. J Am Chem Soc (2006) 1.09
Structures of murine carbonic anhydrase IV and human carbonic anhydrase II complexed with brinzolamide: molecular basis of isozyme-drug discrimination. Protein Sci (1998) 1.08
Characterization of heterologously produced carbonic anhydrase from Methanosarcina thermophila. J Bacteriol (1996) 1.05
Novel disulfide engineering in human carbonic anhydrase II using the PAIRWISE side-chain geometry database. Protein Sci (2000) 1.03
Insights towards sulfonamide drug specificity in α-carbonic anhydrases. Bioorg Med Chem (2012) 1.02
Origins of enhanced proton transport in the Y7F mutant of human carbonic anhydrase II. J Am Chem Soc (2008) 1.00
Ultrahigh resolution crystal structures of human carbonic anhydrases I and II complexed with "two-prong" inhibitors reveal the molecular basis of high affinity. J Am Chem Soc (2006) 1.00
Apo-human carbonic anhydrase II revisited: implications of the loss of a metal in protein structure, stability, and solvent network. Biochemistry (2009) 0.98
Structural analysis of charge discrimination in the binding of inhibitors to human carbonic anhydrases I and II. J Am Chem Soc (2007) 0.96
Carbonic anhydrase in Acetobacterium woodii and other acetogenic bacteria. J Bacteriol (1997) 0.94
The extent of pyrene excimer fluorescence emission is a reflector of distance and flexibility: analysis of the segment linking the LDL receptor-binding and tetramerization domains of apolipoprotein E3. Biochemistry (2012) 0.92
Designing hydrolytic zinc metalloenzymes. Biochemistry (2014) 0.91
Carbonic anhydrase II-based metal ion sensing: Advances and new perspectives. Biochim Biophys Acta (2009) 0.90
Structure of a 129Xe-cryptophane biosensor complexed with human carbonic anhydrase II. J Am Chem Soc (2008) 0.90
Mechanism of ADP-ribosylation removal revealed by the structure and ligand complexes of the dimanganese mono-ADP-ribosylhydrolase DraG. Proc Natl Acad Sci U S A (2009) 0.88
Increasing the net charge and decreasing the hydrophobicity of bovine carbonic anhydrase decreases the rate of denaturation with sodium dodecyl sulfate. Biophys J (2006) 0.88
Origin of mechanical strength of bovine carbonic anhydrase studied by molecular dynamics simulation. Biophys J (2004) 0.87
New protein footprinting: fast photochemical iodination combined with top-down and bottom-up mass spectrometry. J Am Soc Mass Spectrom (2012) 0.86
Optimal bundling of transmembrane helices using sparse distance constraints. Protein Sci (2004) 0.86
Properties of intramolecular proton transfer in carbonic anhydrase III. Biophys J (1998) 0.85
Atomic resolution studies of carbonic anhydrase II. Acta Crystallogr D Biol Crystallogr (2010) 0.85
Secondary interactions involving zinc-bound ligands: roles in structural stabilization and macromolecular interactions. J Inorg Biochem (2011) 0.85
Structure-assisted redesign of a protein-zinc-binding site with femtomolar affinity. Proc Natl Acad Sci U S A (1995) 0.84
Structural features that govern enzymatic activity in carbonic anhydrase from a low-temperature adapted fish, Chionodraco hamatus. Biophys J (2007) 0.84
Proton transport in carbonic anhydrase: Insights from molecular simulation. Biochim Biophys Acta (2009) 0.84
Exploring local flexibility/rigidity in psychrophilic and mesophilic carbonic anhydrases. Biophys J (2009) 0.83
Probing the surface of human carbonic anhydrase for clues towards the design of isoform specific inhibitors. Biomed Res Int (2015) 0.83
Location of binding sites in small molecule rescue of human carbonic anhydrase II. Biophys J (2006) 0.82
Effect of active-site mutation at Asn67 on the proton transfer mechanism of human carbonic anhydrase II. Biochemistry (2009) 0.82
Estimating kinetic and thermodynamic parameters from single molecule enzyme-inhibitor interactions. Langmuir (2008) 0.82
Pretransition and progressive softening of bovine carbonic anhydrase II as probed by single molecule atomic force microscopy. Protein Sci (2005) 0.82
Crystal structure of human carbonic anhydrase II complexed with an anti-convulsant sugar sulphamate. Biochem J (2002) 0.81
Protein adsorption orientation in the light of fluorescent probes: mapping of the interaction between site-directly labeled human carbonic anhydrase II and silica nanoparticles. Biophys J (2005) 0.81
Characterization of the Copper(II) Binding Sites in Human Carbonic Anhydrase II. Inorg Chem (2015) 0.80
Probing the energetics of dissociation of carbonic anhydrase-ligand complexes in the gas phase. Biophys J (1999) 0.80
Coordination contributions to protein stability in metal-substituted carbonic anhydrase. J Biol Inorg Chem (2016) 0.80
A nonessential role for Arg 55 in cyclophilin18 for catalysis of proline isomerization during protein folding. Protein Sci (2009) 0.79
Modification of carbonic anhydrase II with acetaldehyde, the first metabolite of ethanol, leads to decreased enzyme activity. BMC Biochem (2008) 0.79
Transient conformational remodeling of folding proteins by GroES-individually and in concert with GroEL. J Chem Biol (2013) 0.78
Thermodynamic parameters for the association of fluorinated benzenesulfonamides with bovine carbonic anhydrase II. Chem Asian J (2007) 0.78
Conformational effects on the circular dichroism of Human Carbonic Anhydrase II: a multilevel computational study. PLoS One (2013) 0.77
A novel acetate-bound complex of human carbonic anhydrase II. Acta Crystallogr Sect F Struct Biol Cryst Commun (2008) 0.77
Role of zinc in catalytic activity of carbonic anhydrase IX. Arch Biochem Biophys (2012) 0.77
A Crystallographic Examination of Predisposition versus Preorganization in de Novo Designed Metalloproteins. J Am Chem Soc (2016) 0.77
Plant Carbonic Anhydrases: Structures, Locations, Evolution, and Physiological Roles. Mol Plant (2016) 0.77
A comparative CD study of carbonic anhydrase isoenzymes with different number of tryptophans: impact on calculation of secondary structure content. Protein Sci (1996) 0.76
Recognition and binding of a helix-loop-helix peptide to carbonic anhydrase occurs via partly folded intermediate structures. Biophys J (2010) 0.76
GroEL-induced topological dislocation of a substrate protein β-sheet core: a solution EPR spin-spin distance study. J Chem Biol (2010) 0.76
Comparison of solution and crystal properties of Co(II)-substituted human carbonic anhydrase II. Arch Biochem Biophys (2010) 0.75
Human carbonic anhydrase II-cyanate inhibitor complex: putting the debate to rest. Acta Crystallogr F Struct Biol Commun (2014) 0.75
Tracking solvent and protein movement during CO2 release in carbonic anhydrase II crystals. Proc Natl Acad Sci U S A (2016) 0.75
Coupling Protein Dynamics with Proton Transport in Human Carbonic Anhydrase II. J Phys Chem B (2016) 0.75
Comparison and analysis of zinc and cobalt-based systems as catalytic entities for the hydration of carbon dioxide. PLoS One (2013) 0.75
Coordination complexes of 4-methylimidazole with Zn(II) and Cu(II) in gas phase and in water: a DFT study. J Mol Model (2016) 0.75
Modeling the structure and proton transfer pathways of the mutant His-107-Tyr of human carbonic anhydrase II. J Mol Model (2012) 0.75
Familial thrombophilia due to a previously unrecognized mechanism characterized by poor anticoagulant response to activated protein C: prediction of a cofactor to activated protein C. Proc Natl Acad Sci U S A (1993) 4.57
Refined structure of human carbonic anhydrase II at 2.0 A resolution. Proteins (1988) 4.32
Crystal structure of human carbonic anhydrase C. Nat New Biol (1972) 4.10
Chromospheric alfvenic waves strong enough to power the solar wind. Science (2007) 3.58
The origins of hot plasma in the solar corona. Science (2011) 2.83
An epidemiologic study of Lyme disease in southern Sweden. N Engl J Med (1995) 2.82
Three-dimensional structure of the ribosomal translocase: elongation factor G from Thermus thermophilus. EMBO J (1994) 2.78
Crystallographic studies of inhibitor binding sites in human carbonic anhydrase II: a pentacoordinated binding of the SCN- ion to the zinc at high pH. Proteins (1988) 2.73
Structure of phosphate-free ribonuclease A refined at 1.26 A. Biochemistry (1988) 2.53
Crystal structure of catechol O-methyltransferase. Nature (1994) 2.49
Letter: Recognition of structural domains in globular proteins. J Mol Biol (1974) 2.42
Crystal structure of the superantigen staphylococcal enterotoxin type A. EMBO J (1995) 1.99
Characterization of the binding sites of protein L11 and the L10.(L12)4 pentameric complex in the GTPase domain of 23 S ribosomal RNA from Escherichia coli. J Mol Biol (1990) 1.97
Insulin secretion and insulin sensitivity in relation to glucose tolerance: lessons from the Botnia Study. Diabetes (2000) 1.90
Structure-function relationships in lactate dehydrogenase. Proc Natl Acad Sci U S A (1973) 1.87
Crystal structure of Thermotoga maritima ribosome recycling factor: a tRNA mimic. Science (1999) 1.82
Structure of a mutant EF-G reveals domain III and possibly the fusidic acid binding site. J Mol Biol (2000) 1.78
Viral dynamics in primary HIV-1 infection. Karolinska Institutet Primary HIV Infection Study Group. AIDS (2000) 1.75
The ribosomal protein L8 is a complex L7/L12 and L10. FEBS Lett (1976) 1.68
Structure of the C-terminal domain of the ribosomal protein L7/L12 from Escherichia coli at 1.7 A. J Mol Biol (1987) 1.68
Acute stroke management and patient outcome: the value of Neurovascular Care Units (NCU). Stroke (1974) 1.59
Crystal structure of the haloalkane dehalogenase from Sphingomonas paucimobilis UT26. Biochemistry (2000) 1.48
Crystal structure of the ribosomal protein S6 from Thermus thermophilus. EMBO J (1994) 1.47
The structure of elongation factor G in complex with GDP: conformational flexibility and nucleotide exchange. Structure (1996) 1.43
Long-term safety, tolerability and efficacy of fesoterodine treatment in subjects with overactive bladder symptoms. Int J Clin Pract (2010) 1.41
The expression of CCAAT/enhancer binding protein (C/EBP) in the human ovary in vivo: specific increase in C/EBPbeta during epithelial tumour progression. Br J Cancer (1999) 1.25
Determination of terbutaline in plasma by gas chromatography chemical ionization mass spectrometry. Biomed Mass Spectrom (1980) 1.22
Crystal structure of a superantigen bound to MHC class II displays zinc and peptide dependence. EMBO J (2001) 1.21
Structural studies of ribosomes. Prog Biophys Mol Biol (1982) 1.20
Structural basis for the negative allostery between Ca(2+)- and Mg(2+)-binding in the intracellular Ca(2+)-receptor calbindin D9k. Protein Sci (1997) 1.19
Letter: Molecular symmetry axes and subunit interfaces in certain dehydrogenases. J Mol Biol (1973) 1.18
Purification and identification of the violaxanthin deepoxidase as a 43 kDa protein. Photosynth Res (1996) 1.17
Refined structure of bovine carbonic anhydrase III at 2.0 A resolution. Proteins (1993) 1.16
The crystal structure of ribosomal protein L22 from Thermus thermophilus: insights into the mechanism of erythromycin resistance. Structure (1998) 1.16
Crystal structure of the Escherichia coli dUTPase in complex with a substrate analogue (dUDP). Nat Struct Biol (1996) 1.14
The stoichiometry and reconstitution of a stable protein complex from Escherichia coli ribosomes. FEBS Lett (1979) 1.14
Asymmetric dimethylarginine (ADMA) as a risk marker for stroke and TIA in a Swedish population. Atherosclerosis (2005) 1.13
A gene conferring susceptibility to type 2 diabetes in conjunction with obesity is located on chromosome 18p11. Diabetes (2001) 1.13
Epstein-Barr virus (EBV) can immortalize B-cll cells activated by cytokines. Leukemia (1994) 1.11
Growth- and differentiation-associated expression of bcl-2 in B-chronic lymphocytic leukemia cells. Blood (1992) 1.11
Regulation of violaxanthin de-epoxidase activity by pH and ascorbate concentration. Photosynth Res (1995) 1.10
Cloning and nucleotide sequence of the cyclic AMP receptor protein-regulated Salmonella typhimurium pepE gene and crystallization of its product, an alpha-aspartyl dipeptidase. J Bacteriol (1994) 1.08
Structural comparison of the prokaryotic ribosomal proteins L7/L12 and L30. Proteins (1988) 1.08
The dynamic structure of EF-G studied by fusidic acid resistance and internal revertants. J Mol Biol (1996) 1.07
The crystallography beamline I711 at MAX II. J Synchrotron Radiat (2000) 1.07
Symptom distress and life situation in adolescents with cancer. Cancer Nurs (1997) 1.06
Archaeal ribosomal protein L1: the structure provides new insights into RNA binding of the L1 protein family. Structure (2000) 1.06
Crystallographic analysis of Thr-200-->His human carbonic anhydrase II and its complex with the substrate, HCO3-. Proteins (1993) 1.06
Crystal structure of human erythrocyte carbonic anhydrase C. 3. Molecular structure of the enzyme and of one enzyme-inhibitor complex at 5-5 A resolution. J Mol Biol (1967) 1.05
Crystallization of and preliminary X-ray data for an intracellular vitamin A-binding protein from rat liver. J Biol Chem (1981) 1.04
Crystal structure of phospholipase C from Bacillus cereus complexed with a substrate analog. J Mol Biol (1993) 1.04
X-ray analysis of metal-substituted human carbonic anhydrase II derivatives. Acta Crystallogr D Biol Crystallogr (1994) 1.03
The flexible region of protein L12 from bacterial ribosomes studied by proton nuclear magnetic resonance. J Biol Chem (1989) 1.03
Bambuterol, a carbamate ester prodrug of terbutaline, as inhibitor of cholinesterases in human blood. Drug Metab Dispos (1989) 1.03
Clinical significance of chronic biologic false positive Wassermann reaction and "antinuclear factors". Acta Med Scand (1966) 1.02
Serum levels of lymphokines and soluble cellular receptors in primary Epstein-Barr virus infection and in patients with chronic fatigue syndrome. J Infect Dis (1992) 1.02
Relation between cardiac dimensions and peak oxygen uptake. J Cardiovasc Magn Reson (2010) 1.01
Crystal structure of the RNA binding ribosomal protein L1 from Thermus thermophilus. EMBO J (1996) 1.01
Novel mutations and a mutational hotspot in the MODY3 gene. Diabetes (1997) 1.01
Depressive illness in Parkinson's disease--indication of a more advanced and widespread neurodegenerative process? Acta Neurol Scand (2008) 1.00
Surgical-site infections within 60 days of coronary artery by-pass graft surgery. J Hosp Infect (2004) 1.00
The crystal structure of staphylococcal enterotoxin H: implications for binding properties to MHC class II and TcR molecules. J Mol Biol (2000) 1.00
Prevalence of cdtABC genes encoding cytolethal distending toxin among Haemophilus ducreyi and Actinobacillus actinomycetemcomitans strains. J Med Microbiol (2001) 1.00
Structural analysis of the zinc hydroxide-Thr-199-Glu-106 hydrogen-bond network in human carbonic anhydrase II. Proteins (1993) 0.99
Crystallization of and preliminary X-ray data for the plasma retinol-binding protein. J Biol Chem (1984) 0.99
Active suppression in orally tolerized rats coincides with in situ transforming growth factor-beta (TGF-beta) expression in the draining lymph nodes. Clin Exp Immunol (1999) 0.99
Drug latentiation of terbutaline. In vitro serum esterase catalyzed hydrolysis of a series of acyl-substituted mono- and diesters of terbutaline. Acta Pharm Suec (1974) 0.98
Crystal structure of a ribosomal component at 2.6 A resolution. Nature (1980) 0.98
Phylogeography and Pleistocene refugia of the adder (Vipera berus) as inferred from mitochondrial DNA sequence data. Mol Ecol (2006) 0.98
Tolterodine extended release improves patient-reported outcomes in overactive bladder: results from the IMPACT trial. Int J Clin Pract (2006) 0.96
[A simple water-deprivation test and its reliability]. Nord Med (1965) 0.96
Functional anion binding sites in dogfish M4 lactate dehydrogenase. J Mol Biol (1973) 0.96
BCR/ABL-negative chronic myeloid leukemia with ETV6/ABL fusion. Genes Chromosomes Cancer (1997) 0.95
Symptom-specific efficacy of tolterodine extended release in patients with overactive bladder: the IMPACT trial. Int J Clin Pract (2006) 0.95
Atomic co-ordinates for dogfish M4 apo-lactate dehydrogenase. Biochem Biophys Res Commun (1973) 0.93
An intact conformation at the tip of elongation factor G domain IV is functionally important. FEBS Lett (1998) 0.93
Incidence of myelodysplastic syndromes in a Swedish population. Eur J Haematol (1995) 0.93
X-ray structure of a ribonuclease A-uridine vanadate complex at 1.3 A resolution. Acta Crystallogr D Biol Crystallogr (1997) 0.93
The structure of human carbonic anhydrase II in complex with bromide and azide. FEBS Lett (1993) 0.93
A CD4+ T cell line-secreted factor, growth promoting for normal and leukemic B cells, identified as thioredoxin. Int Immunol (1995) 0.92
Glyoxylic acid condensation: a new fluorescence method for the histochemical demonstration of biogenic monoamines. Acta Physiol Scand (1973) 0.92
Orientational order and dynamics of hydration water in a single crystal of bovine pancreatic trypsin inhibitor. Biophys J (1999) 0.92
Life situation and problems as reported by children with cancer and their parents. J Pediatr Oncol Nurs (1997) 0.91
Crystal structure of human erythrocyte carbonic anhydrase C. VI. The three-dimensional structure at high resolution in relation to other mammalian carbonic anhydrases. Cold Spring Harb Symp Quant Biol (1972) 0.91
Hydrolysis of 3H-bambuterol, a carbamate prodrug of terbutaline, in blood from humans and laboratory animals in vitro. Biochem Pharmacol (1988) 0.91
Mutations in the G-domain of elongation factor G from Thermus thermophilus affect both its interaction with GTP and fusidic acid. J Biol Chem (2001) 0.91
Coping strategies and health-related quality of life among spouses of continuous ambulatory peritoneal dialysis, haemodialysis, and transplant patients. J Adv Nurs (2000) 0.91
Protein biosynthesis: structural studies of the elongation cycle. FEBS Lett (1998) 0.90
A design for a World Wide Web decision-support system using a controlled medical terminology. Proc AMIA Annu Fall Symp (1996) 0.90
Parental reports of changes and challenges that result from parenting a child with cancer. J Pediatr Oncol Nurs (1997) 0.90
Refined structure of the acetazolamide complex of human carbonic anhydrase II at 1.9 A. Int J Biol Macromol (1990) 0.90
Crystal structure of ribosomal protein S8 from Thermus thermophilus reveals a high degree of structural conservation of a specific RNA binding site. J Mol Biol (1998) 0.90