| Rank |
Title |
Journal |
Year |
PubWeight™‹?› |
|
1
|
The physiological disposition of phenylbutazone (butazolidin) in man and a method for its estimation in biological material.
|
J Pharmacol Exp Ther
|
1953
|
3.60
|
|
2
|
The fate of pentobarbital in man and dog and a method for its estimation in biological material.
|
J Pharmacol Exp Ther
|
1953
|
2.38
|
|
3
|
A potent new uricosuric agent, the sulfoxide metabolite of the phenylbutazone analogue, G-25671.
|
J Pharmacol Exp Ther
|
1957
|
2.20
|
|
4
|
Adaptive increases in drug-metabolizing enzymes induced by phenobarbital and other drugs.
|
J Pharmacol Exp Ther
|
1960
|
2.04
|
|
5
|
The metabolic fate of phenylbutazone (butazolidin) in man.
|
J Pharmacol Exp Ther
|
1955
|
1.76
|
|
6
|
Ascorbic acid synthesis in normal and drug-treated rats, studied with L-ascorbic-1-C14 acid.
|
J Biol Chem
|
1954
|
1.61
|
|
7
|
DRUG INTERACTIONS IN MAN. I. LOWERING EFFECT OF PHENOBARBITAL ON PLASMA LEVELS OF BISHYDROXYCOUMARIN (DICUMAROL) AND DIPHENYLHYDANTOIN (DILANTIN).
|
Clin Pharmacol Ther
|
1965
|
1.55
|
|
8
|
The synthesis of l-ascorbic acid by the albino rat.
|
J Biol Chem
|
1950
|
1.53
|
|
9
|
Metabolism of drugs in subjects with Laennec's cirrhosis.
|
Med Exp Int J Exp Med
|
1959
|
1.38
|
|
10
|
Stimulatory effect of foreign compounds on ascorbic acid biosynthesis and on drug-metabolizing enzymes.
|
Nature
|
1959
|
1.26
|
|
11
|
Missing step in guinea pigs required for the biosynthesis of L-ascorbic acid.
|
Science
|
1956
|
1.22
|
|
12
|
Observations on the antirheumatic and physiologic effects of phenylbutazone (butazolidin) and some comparisons with cortisone.
|
Am J Med
|
1954
|
1.22
|
|
13
|
Stimulatory effect of barbital on urinary excretion of L-ascorbic acid and nonconjugated D-glucuronic acid.
|
J Biol Chem
|
1957
|
1.20
|
|
14
|
Results of a clinical trial of G-28315, a sulfoxide analog of phenylbutazone, as a uricosuric agent in gouty subjects.
|
Arthritis Rheum
|
1958
|
1.18
|
|
15
|
Metabolism of ascorbic acid and related uronic acids, aldonic acids, and pentoses.
|
Ann N Y Acad Sci
|
1961
|
1.15
|
|
16
|
Metabolic interactions between L-ascorbic acid and drugs.
|
Ann N Y Acad Sci
|
1961
|
1.12
|
|
17
|
The metabolism of 1-C14-L-ascorbic acid in guinea pigs.
|
J Biol Chem
|
1951
|
1.10
|
|
18
|
A study of the inverse relationship between pKa and rate of renal excretion of phenylbutazone analogs in man and dog.
|
Am J Med
|
1960
|
1.08
|
|
19
|
Biochemical pharmacological considerations of phenylbutazone and its analogues.
|
Ann N Y Acad Sci
|
1960
|
1.08
|
|
20
|
The biotransformation of ethyl biscoumacetate (tromexan) in man, rabbit and dog.
|
J Pharmacol Exp Ther
|
1953
|
1.08
|
|
21
|
Phenylbutazone metabolites: antirheumatic, sodium-retaining and uricosuric effects in man.
|
J Pharmacol Exp Ther
|
1958
|
1.07
|
|
22
|
The synthesis of L-ascorbic acid in the rat from D-glucuronolactone and L-gulonolactone.
|
J Biol Chem
|
1956
|
1.07
|
|
23
|
Metabolism of L-ascorbic acid-1-C14 in man.
|
J Biol Chem
|
1958
|
1.06
|
|
24
|
Studies on the glucuronic acid pathway of glucose metabolism.
|
J Biol Chem
|
1959
|
1.06
|
|
25
|
Missing step in man, monkey and guinea pig required for the biosynthesis of L-ascorbic acid.
|
Nature
|
1957
|
1.05
|
|
26
|
Zoxazolamine: physiological disposition, uricosuric properties.
|
Am J Med
|
1958
|
1.04
|
|
27
|
Observations on the drug-induced synthesis of D-glucuronic, L-gulonic and L-ascorbic acids in rats.
|
J Pharmacol Exp Ther
|
1960
|
1.03
|
|
28
|
STIMULATORY EFFECT OF PHENOBARBITAL ON THE METABOLISM OF DIPHENYLHYDANTOIN.
|
J Pharmacol Exp Ther
|
1963
|
1.02
|
|
29
|
The physiological disposition and fate of meperidine (demerol) in man and a method for its estimation in plasma.
|
J Pharmacol Exp Ther
|
1955
|
1.01
|
|
30
|
Intravenous anesthetics; new concepts. I. Experimental aspects.
|
Curr Res Anesth Analg
|
1952
|
0.98
|
|
31
|
Further observations on the metabolism of L-ascorbic acid in guinea pigs.
|
J Biol Chem
|
1956
|
0.97
|
|
32
|
Metabolism of L-gulonolactone in rats via pentose formation.
|
Biochim Biophys Acta
|
1957
|
0.97
|
|
33
|
Observations on G-25671, a phenylbutazone analogue (4-phenylthioethyl)-1,2-diphenyl 3,5-pyrazolidinedione).
|
Proc Soc Exp Biol Med
|
1955
|
0.97
|
|
34
|
The appearance of procaine in the spinal fluid during peridural block in man.
|
J Pharmacol Exp Ther
|
1953
|
0.96
|
|
35
|
APPLICATION OF DRUG METABOLISM TO DRUG TOXICITY STUDIES.
|
Ann N Y Acad Sci
|
1965
|
0.95
|
|
36
|
Observations on vitamin C activity of D-ascorbic acid.
|
Proc Soc Exp Biol Med
|
1959
|
0.95
|
|
37
|
Relationship between pKa and uricosuric activity in phenylbutazone analogues.
|
Nature
|
1958
|
0.95
|
|
38
|
INDUCED SYNTHESIS OF OXIDATIVE ENZYMES IN LIVER MICROSOMES BY POLYCYCLIC HYDROCARBONS AND DRUGS.
|
Adv Enzyme Regul
|
1963
|
0.94
|
|
39
|
Effect of a phenylbutazone analog (4-[phenylthioethyl]-1, 2-diphenyl 3, 5-pyrazolidinedione) on urate clearance and other discrete renal functions in gouty subjects; evaluation as uricosuric agent.
|
J Clin Invest
|
1956
|
0.93
|
|
40
|
BLOCKADE OF SOME METABOLIC EFFECTS OF CATECHOLAMINES BY N-ISOPROPYL METHOXAMINE (B.W. 61-43).
|
J Pharmacol Exp Ther
|
1964
|
0.92
|
|
41
|
The passage of thiopental into brain.
|
J Pharmacol Exp Ther
|
1957
|
0.91
|
|
42
|
IMPLICATIONS ON ENZYME INDUCTION FOR DRUG THERAPY.
|
Am J Med
|
1964
|
0.91
|
|
43
|
Observations on the metabolic transformation and effects of phenylbutazone in subjects with hepatic disease.
|
Am J Med Sci
|
1954
|
0.91
|
|
44
|
The passage of thiobarbiturates and their oxygen analogs into brain.
|
J Pharmacol Exp Ther
|
1958
|
0.90
|
|
45
|
Conversion of myo-inositol to D-glucuronic acid and L-gulonic acid in the rat.
|
Biochim Biophys Acta
|
1959
|
0.87
|
|
46
|
Metabolism of sulfinpyrazone (Anturane) and other thio analogues of phenylbutazone in man.
|
J Pharmacol Exp Ther
|
1961
|
0.87
|
|
47
|
Metabolism of C14-labeled ascorbic, dehydroascorbic and diketoglulonic acids in guinea pigs.
|
Arch Biochem Biophys
|
1959
|
0.87
|
|
48
|
The control of prothrombin activity with tromexan therapy.
|
Am J Med
|
1953
|
0.85
|
|
49
|
The physiological disposition of ethyl biscoumacetate (tromexan) in man and a method for its estimation in biological material.
|
J Pharmacol Exp Ther
|
1952
|
0.84
|
|
50
|
INHIBITION OF LIPID MOBILIZATION BY N-ISOPROPYL METHOXAMINE (B.W. 61-43).
|
J Pharmacol Exp Ther
|
1964
|
0.83
|
|
51
|
Metabolism of L-ascorbic acid in rat kidney.
|
J Biol Chem
|
1958
|
0.82
|
|
52
|
Metabolism of D-galactose to D-glucuronic acid, L-gulonic acid and L-ascorbic acid in normal and barbital-treated rats.
|
Biochim Biophys Acta
|
1960
|
0.82
|
|
53
|
Further observations on the biosynthesis of L-ascorbic acid from D-glucose in the rat.
|
J Biol Chem
|
1956
|
0.82
|
|
54
|
Studies on the incorporation of C14 administered as L-sorbose into L-ascorbic acid and D-glucose in rats.
|
J Biol Chem
|
1955
|
0.81
|
|
55
|
Biosynthesis of L-ascorbic acid; basic defect in scurvy.
|
Am J Med
|
1959
|
0.80
|
|
56
|
Studies of the mechanism of L-xylulose formation by kidney enzymes.
|
J Biol Chem
|
1959
|
0.80
|
|
57
|
The metabolic fate of zoxazolamine (flexin) in man.
|
J Pharmacol Exp Ther
|
1960
|
0.78
|
|
58
|
The transmission of meperidine across the human placenta.
|
Am J Obstet Gynecol
|
1952
|
0.77
|
|
59
|
PHYSIOLOGICAL DISTRIBUTION AND METABOLIC INACTIVATION OF CHLORCYCLIZINE AND CYCLIZINE.
|
J Pharmacol Exp Ther
|
1965
|
0.77
|
|
60
|
Formation of L-lyxonic and L-xylonic acids from L-ascorbic acid in rat kidney.
|
J Biol Chem
|
1960
|
0.77
|
|
61
|
Physiological disposition and metabolic fate of chlorzoxazone (paraflex) in man.
|
J Pharmacol Exp Ther
|
1960
|
0.77
|
|
62
|
Stimulatory effect of chlorcyclizine on barbiturate metabolism.
|
J Pharmacol Exp Ther
|
1961
|
0.75
|
|
63
|
Formation of L-xylulose from L-gulonic acid in rat kidney.
|
Biochim Biophys Acta
|
1959
|
0.75
|
|
64
|
Clinical application of studies of the physiologic disposition of thiopental.
|
N Y State J Med
|
1956
|
0.75
|
|
65
|
Biochemical pharmacological considerations of zoxazolamine and chlorzoxazone metabolism.
|
Ann N Y Acad Sci
|
1960
|
0.75
|
|
66
|
Water-soluble vitamins, Part I. (Ascorbic acid, nicotinic acid, vitamin B6, biotin, inositol).
|
Annu Rev Biochem
|
1960
|
0.75
|
|
67
|
Physiological disposition of certain N-alkyl thiobarbiturates.
|
Anesthesiology
|
1955
|
0.75
|
|
68
|
Effect of phenylbutazone (butazolidin) on experimentally induced ocular inflammation.
|
AMA Arch Ophthalmol
|
1955
|
0.75
|
|
69
|
Metabolism of D-ascorbic acid-1-C14 in guinea pigs and rats.
|
J Biol Chem
|
1958
|
0.75
|
|
70
|
A p-nitro analogue of phenylbutazone possessing potent antirheumatic, sodium retaining and uricosuric properties.
|
J Pharmacol Exp Ther
|
1959
|
0.75
|
|
71
|
Observations on bound ascorbic acid in guinea pig liver.
|
Proc Soc Exp Biol Med
|
1956
|
0.75
|
|
72
|
THERAPEUTIC IMPLICATIONS OF DRUG METABOLISM.
|
Semin Hematol
|
1964
|
0.75
|
|
73
|
Physiologic disposition and uricosuric effect of a keto analog of oxyphenbutazone (G-29701).
|
Arthritis Rheum
|
1960
|
0.75
|
|
74
|
Sites of sensory blockade during segmental spinal and segmental peridural anesthesia in man.
|
Anesthesiology
|
1953
|
0.75
|
|
75
|
LOWERING EFFECT OF NEOSTIGMINE ON PLASMA FREE FATTY ACIDS.
|
Nature
|
1964
|
0.75
|
|
76
|
Observations on effect of 3-methylcholanthrene in scorbutic guinea pigs.
|
Proc Soc Exp Biol Med
|
1961
|
0.75
|
|
77
|
Intravenous anesthesia; new concepts. II. Clinical aspects.
|
Curr Res Anesth Analg
|
1952
|
0.75
|
|
78
|
Role of ascorbic acid in the formation and maintenance of dental structures.
|
Ann N Y Acad Sci
|
1961
|
0.75
|