Published in J Pharmacol Exp Ther on September 01, 1960
The search for endogenous activators of the aryl hydrocarbon receptor. Chem Res Toxicol (2007) 3.68
Phenobarbital-induced synthesis of the microsomal drug-metabolizing enzyme system and its relationship to the proliferation of endoplasmic membranes. A morphological and biochemical study. J Cell Biol (1965) 3.55
Correlated morphometric and biochemical studies on the liver cell. II. Effects of phenobarbital on rat hepatocytes. J Cell Biol (1969) 2.41
Determinants of serum antipyrine half-lives in patients with liver disease. Gut (1973) 2.19
Polychlorinated biphenyls: a new type of inducer of cytochrome P-448 in the liver. Proc Natl Acad Sci U S A (1973) 1.48
Enzyme-membrane relationship in phenobarbital induction of synthesis of drug-metabolizing enzyme system and proliferation of endoplasmic membranes. J Cell Biol (1966) 1.48
Drug induction of hepatic glutathione S-transferases in male and female rats*. Biochem J (1975) 1.34
Increased thyroxine turnover and thyroidal function after stimulation of hepatocellular binding of thyroxine by phenobarbital. J Clin Invest (1968) 1.22
Increase of pentobarbitone metabolism induced in rats pretreated with some centrally acting compounds. Br J Pharmacol Chemother (1962) 0.97
Effects of 3-methylcholanthrene pretreatment on microsomal hydroxylation of 2-acetamidofluorene by various rat hepatomas. Biochem J (1970) 0.93
METHYLCHOLANTHRENE-INDUCED CHANGES IN RAT LIVER NUCLEAR RNA. Proc Natl Acad Sci U S A (1964) 0.91
AROMATIC-INDUCED PREVENTION OF FETAL TOXICITY OF 7,12-DIMETHYLBENZ(ALPHA)ANTHRACENE. J Exp Med (1964) 0.89
Phospholipid asymmetry in rough- and smooth-endoplasmic-reticulum membranes of untreated and phenobarbital-treated rat liver. Biochem J (1980) 0.85
Interactions of orphenadrine and phenobarbitone with chlorpromazine: plasma concentrations and effects in man. Br J Clin Pharmacol (1975) 0.85
Studies on the biogenesis of smooth endoplasmic reticulum membranes in hepatocytes of phenobarbital-treated rats. II. The site of phospholipid synthesis in the initial phase of membrane proliferation. J Cell Biol (1974) 0.85
On the relationship of liver glucose-6-phosphatase to the proliferation of endoplasmic reticulum in phenobarbital induction. J Cell Biol (1966) 0.82
AN EFFECT OF PHENOBARBITONE ON GRISEOFULVIN METABOLISM IN THE RAT. Br J Pharmacol Chemother (1964) 0.82
Effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin on drug metabolism and hepatic microsomes of rats and mice. Environ Health Perspect (1973) 0.80
The effect of phenobarbitone on protein synthesis by liver polyribosomes in fed and starved rats. Biochem J (1975) 0.78
The induction of microsomal electron transport enzymes. Mol Cell Biochem (1983) 0.78
Carbon tetrachloride-induced hepatic fibrosis and cirrhosis in the developing rat: an experimental model of cirrhosis in childhood. Br J Exp Pathol (1983) 0.77
The role of microsomal hydroxylases in the modification of chloroform hepatotoxicity in rats. Br J Exp Pathol (1975) 0.76
STUDIES ON THE BIOGENESIS OF SMOOTH ENDOPLASMIC RETICULUM MEMBRANES IN LIVERS OF PHENOBARBITAL-TREATED RATS : I. The Site of Activity of Acyltransferases Involved in Synthesis of the Membrane Phospholipid. J Cell Biol (1972) 0.76
Recollection of the early years of the research on cytochrome P450. Proc Jpn Acad Ser B Phys Biol Sci (2011) 0.76
Vitamin D status in different subgroups of British Asians. Br Med J (1978) 0.75
The influence of barbiturates on coumarin plasma levels and prothrombin response. J Clin Invest (1961) 0.75
The physiological disposition of phenylbutazone (butazolidin) in man and a method for its estimation in biological material. J Pharmacol Exp Ther (1953) 3.60
Substrate-induced synthesis and other properties of benzpyrene hydroxylase in rat liver. J Biol Chem (1957) 3.05
The fate of pentobarbital in man and dog and a method for its estimation in biological material. J Pharmacol Exp Ther (1953) 2.38
A potent new uricosuric agent, the sulfoxide metabolite of the phenylbutazone analogue, G-25671. J Pharmacol Exp Ther (1957) 2.20
The metabolic fate of phenylbutazone (butazolidin) in man. J Pharmacol Exp Ther (1955) 1.76
The metabolism of methylated aminoazo dyes. V. Evidence for induction of enzyme synthesis in the rat by 3-methylcholanthrene. Cancer Res (1956) 1.64
Ascorbic acid synthesis in normal and drug-treated rats, studied with L-ascorbic-1-C14 acid. J Biol Chem (1954) 1.61
DRUG INTERACTIONS IN MAN. I. LOWERING EFFECT OF PHENOBARBITAL ON PLASMA LEVELS OF BISHYDROXYCOUMARIN (DICUMAROL) AND DIPHENYLHYDANTOIN (DILANTIN). Clin Pharmacol Ther (1965) 1.55
The synthesis of l-ascorbic acid by the albino rat. J Biol Chem (1950) 1.53
PUROMYCIN INHIBITION OF ENZYME INDUCTION BY 3-METHYLCHOLANTHRENE AND PHENOBARBITAL. J Biol Chem (1963) 1.44
Metabolism of drugs in subjects with Laennec's cirrhosis. Med Exp Int J Exp Med (1959) 1.38
Stimulatory effect of foreign compounds on ascorbic acid biosynthesis and on drug-metabolizing enzymes. Nature (1959) 1.26
Contrasting effects of thyroxin on zoxazolamine and hexobarbital metabolism. Biochem Pharmacol (1961) 1.22
Missing step in guinea pigs required for the biosynthesis of L-ascorbic acid. Science (1956) 1.22
Observations on the antirheumatic and physiologic effects of phenylbutazone (butazolidin) and some comparisons with cortisone. Am J Med (1954) 1.22
Glucose dissimilation by Rhizopus. Arch Biochem Biophys (1953) 1.20
Stimulatory effect of barbital on urinary excretion of L-ascorbic acid and nonconjugated D-glucuronic acid. J Biol Chem (1957) 1.20
DRUG-INDUCED CHANGES IN STEROID METABOLISM. Ann N Y Acad Sci (1965) 1.19
Results of a clinical trial of G-28315, a sulfoxide analog of phenylbutazone, as a uricosuric agent in gouty subjects. Arthritis Rheum (1958) 1.18
Metabolism of ascorbic acid and related uronic acids, aldonic acids, and pentoses. Ann N Y Acad Sci (1961) 1.15
Pallido-pyramidal disease. J Neuropathol Exp Neurol (1954) 1.13
Metabolic interactions between L-ascorbic acid and drugs. Ann N Y Acad Sci (1961) 1.12
The metabolism of methylated aminoazo dyes. VI. Intracellular distribution and properties of the demethylase system. Cancer Res (1957) 1.11
Induction of microsomal enzyme synthesis by polycyclic aromatic hydrocarbons of different molecular sizes. J Biol Chem (1961) 1.10
The metabolism of 1-C14-L-ascorbic acid in guinea pigs. J Biol Chem (1951) 1.10
The effect of podophyllotoxin on tissue metabolism and enzyme systems. J Exp Med (1949) 1.08
A study of the inverse relationship between pKa and rate of renal excretion of phenylbutazone analogs in man and dog. Am J Med (1960) 1.08
Biochemical pharmacological considerations of phenylbutazone and its analogues. Ann N Y Acad Sci (1960) 1.08
The biotransformation of ethyl biscoumacetate (tromexan) in man, rabbit and dog. J Pharmacol Exp Ther (1953) 1.08
Phenylbutazone metabolites: antirheumatic, sodium-retaining and uricosuric effects in man. J Pharmacol Exp Ther (1958) 1.07
The synthesis of L-ascorbic acid in the rat from D-glucuronolactone and L-gulonolactone. J Biol Chem (1956) 1.07
Metabolism of L-ascorbic acid-1-C14 in man. J Biol Chem (1958) 1.06
Studies on the glucuronic acid pathway of glucose metabolism. J Biol Chem (1959) 1.06
The binding of salicylic acid and related substances to purified proteins. J Pharmacol Exp Ther (1961) 1.06
Missing step in man, monkey and guinea pig required for the biosynthesis of L-ascorbic acid. Nature (1957) 1.05
Zoxazolamine: physiological disposition, uricosuric properties. Am J Med (1958) 1.04
Observations on the drug-induced synthesis of D-glucuronic, L-gulonic and L-ascorbic acids in rats. J Pharmacol Exp Ther (1960) 1.03
STIMULATORY EFFECT OF PHENOBARBITAL ON THE METABOLISM OF DIPHENYLHYDANTOIN. J Pharmacol Exp Ther (1963) 1.02
SIMILARITIES BETWEEN OXIDATIVE DRUG-METABOLIZING ENZYMES AND STEROID HYDROXYLASES IN LIVER MICROSOMES. J Pharmacol Exp Ther (1964) 1.02
Induced synthesis of liver microsomal enzymes which metabolize foreign compounds. Science (1959) 1.01
Increased activity of androgen hydroxylases in liver microsomes of rats pretreated with phenobarbital and other drugs. J Biol Chem (1963) 1.01
The physiological disposition and fate of meperidine (demerol) in man and a method for its estimation in plasma. J Pharmacol Exp Ther (1955) 1.01
Intravenous anesthetics; new concepts. I. Experimental aspects. Curr Res Anesth Analg (1952) 0.98
Observations on G-25671, a phenylbutazone analogue (4-phenylthioethyl)-1,2-diphenyl 3,5-pyrazolidinedione). Proc Soc Exp Biol Med (1955) 0.97
Metabolism of L-gulonolactone in rats via pentose formation. Biochim Biophys Acta (1957) 0.97
Further observations on the metabolism of L-ascorbic acid in guinea pigs. J Biol Chem (1956) 0.97
The appearance of procaine in the spinal fluid during peridural block in man. J Pharmacol Exp Ther (1953) 0.96
APPLICATION OF DRUG METABOLISM TO DRUG TOXICITY STUDIES. Ann N Y Acad Sci (1965) 0.95
Observations on vitamin C activity of D-ascorbic acid. Proc Soc Exp Biol Med (1959) 0.95
Relationship between pKa and uricosuric activity in phenylbutazone analogues. Nature (1958) 0.95
INDUCED SYNTHESIS OF OXIDATIVE ENZYMES IN LIVER MICROSOMES BY POLYCYCLIC HYDROCARBONS AND DRUGS. Adv Enzyme Regul (1963) 0.94
Effect of a phenylbutazone analog (4-[phenylthioethyl]-1, 2-diphenyl 3, 5-pyrazolidinedione) on urate clearance and other discrete renal functions in gouty subjects; evaluation as uricosuric agent. J Clin Invest (1956) 0.93
BLOCKADE OF SOME METABOLIC EFFECTS OF CATECHOLAMINES BY N-ISOPROPYL METHOXAMINE (B.W. 61-43). J Pharmacol Exp Ther (1964) 0.92
The passage of thiopental into brain. J Pharmacol Exp Ther (1957) 0.91
IMPLICATIONS ON ENZYME INDUCTION FOR DRUG THERAPY. Am J Med (1964) 0.91
Observations on the metabolic transformation and effects of phenylbutazone in subjects with hepatic disease. Am J Med Sci (1954) 0.91
The passage of thiobarbiturates and their oxygen analogs into brain. J Pharmacol Exp Ther (1958) 0.90
Metabolism of C14-labeled ascorbic, dehydroascorbic and diketoglulonic acids in guinea pigs. Arch Biochem Biophys (1959) 0.87
Fatal cryptogenic neuropathy. Arch Neurol Psychiatry (1947) 0.87
Conversion of myo-inositol to D-glucuronic acid and L-gulonic acid in the rat. Biochim Biophys Acta (1959) 0.87
Metabolism of sulfinpyrazone (Anturane) and other thio analogues of phenylbutazone in man. J Pharmacol Exp Ther (1961) 0.87
Fatalities resulting from exposure to simulated high altitudes in decompression chambers; a clinicopathologic study of five cases. J Neuropathol Exp Neurol (1950) 0.86
Distribution and fate of alkylating agents. Ann N Y Acad Sci (1958) 0.85
The control of prothrombin activity with tromexan therapy. Am J Med (1953) 0.85
The physiological disposition of ethyl biscoumacetate (tromexan) in man and a method for its estimation in biological material. J Pharmacol Exp Ther (1952) 0.84
Multiple sclerosis with late onset of symptoms. Arch Neurol Psychiatry (1946) 0.84
Effects of buffered and unbuffered acetylsalicylic acid upon the gastric acidity of normal human subjects. J Pharm Sci (1962) 0.84
INHIBITION OF LIPID MOBILIZATION BY N-ISOPROPYL METHOXAMINE (B.W. 61-43). J Pharmacol Exp Ther (1964) 0.83
Metabolism of bis-beta-chloroethyl sulfide (sulfur mustard gas). Biochem Pharmacol (1961) 0.83
On the metabolism of o-ethoxybenzamide. J Pharmacol Exp Ther (1962) 0.82
Observations on in vitro adrenal steroid synthesis in the rat. Endocrinology (1954) 0.82
Metabolism of D-galactose to D-glucuronic acid, L-gulonic acid and L-ascorbic acid in normal and barbital-treated rats. Biochim Biophys Acta (1960) 0.82
The distribution of certain non-narcotic analgetic agents in the CNS of several species. J Pharmacol Exp Ther (1961) 0.82
Metabolism of L-ascorbic acid in rat kidney. J Biol Chem (1958) 0.82
Further observations on the biosynthesis of L-ascorbic acid from D-glucose in the rat. J Biol Chem (1956) 0.82
Studies on the incorporation of C14 administered as L-sorbose into L-ascorbic acid and D-glucose in rats. J Biol Chem (1955) 0.81
Metabolism of radioactive para-aminobenzoic acid in an Escherichia coli mutant. Proc Soc Exp Biol Med (1956) 0.81
Biosynthesis of L-ascorbic acid; basic defect in scurvy. Am J Med (1959) 0.80
Studies of the mechanism of L-xylulose formation by kidney enzymes. J Biol Chem (1959) 0.80
DEFINITION AND CLASSIFICATION OF HUMAN MALFORMATIONS. Dev Med Child Neurol (1963) 0.79
Metabolism of cysteamine. J Pharmacol Exp Ther (1957) 0.79
The metabolic fate of zoxazolamine (flexin) in man. J Pharmacol Exp Ther (1960) 0.78
On the metabolism and toxicity of methyl salicylate. J Pharmacol Exp Ther (1961) 0.78
Physiological disposition and metabolic fate of chlorzoxazone (paraflex) in man. J Pharmacol Exp Ther (1960) 0.77
The transmission of meperidine across the human placenta. Am J Obstet Gynecol (1952) 0.77
ENHANCED ANDROGEN HYDROXYLASE ACTIVITY IN LIVER MICROSOMES OF RATS AND DOGS TREATED WITH PHENYLBUTAZONE. J Pharmacol Exp Ther (1964) 0.77
PHYSIOLOGICAL DISTRIBUTION AND METABOLIC INACTIVATION OF CHLORCYCLIZINE AND CYCLIZINE. J Pharmacol Exp Ther (1965) 0.77
Formation of L-lyxonic and L-xylonic acids from L-ascorbic acid in rat kidney. J Biol Chem (1960) 0.77
Disturbances in sleep mechanism; a clinicopathologic study; lesions at the diencephalic level (hypothalamus). Arch Neurol Psychiatry (1946) 0.76
The effect of podophyllotoxin, colchicine, urethane, and nitrogen mustard on the respiration of normal and suprarenalectomized rat lymphatic tissue. J Exp Med (1950) 0.75