Mutagenic dissection of hemoglobin cooperativity: effects of amino acid alteration on subunit assembly of oxy and deoxy tetramers.

PubWeight™: 1.22‹?› | Rank: Top 10%

🔗 View Article (PMID 1438173)

Published in Proteins on November 01, 1992

Authors

G J Turner1, F Galacteros, M L Doyle, B Hedlund, D W Pettigrew, B W Turner, F R Smith, W Moo-Penn, D L Rucknagel, G K Ackers

Author Affiliations

1: Department of Biology, Johns Hopkins University, Baltimore, Maryland 21218.

Articles citing this

Thrombin. Mol Aspects Med (2008) 1.80

Structural basis of cooperative ligand binding by the glycine riboswitch. Chem Biol (2011) 1.43

Chemical basis of glycine riboswitch cooperativity. RNA (2007) 1.32

Substitutions in woolly mammoth hemoglobin confer biochemical properties adaptive for cold tolerance. Nat Genet (2010) 1.17

Subunit dissociations in natural and recombinant hemoglobins. Protein Sci (1996) 1.07

Kinetic and spectroscopic studies of hemin acquisition in the hemophore HasAp from Pseudomonas aeruginosa. Biochemistry (2010) 1.05

Identification of a tertiary interaction important for cooperative ligand binding by the glycine riboswitch. RNA (2010) 1.04

Detection of changes in pairwise interactions during allosteric transitions: coupling between local and global conformational changes in GroEL. Proc Natl Acad Sci U S A (1997) 0.99

Human embryonic, fetal, and adult hemoglobins have different subunit interface strengths. Correlation with lifespan in the red cell. Protein Sci (2007) 0.97

Tetramer-dimer equilibrium of oxyhemoglobin mutants determined from auto-oxidation rates. Protein Sci (1998) 0.96

De novo characterization of the spleen transcriptome of the large yellow croaker (Pseudosciaena crocea) and analysis of the immune relevant genes and pathways involved in the antiviral response. PLoS One (2014) 0.88

Very empirical treatment of solvation and entropy: a force field derived from log Po/w. J Comput Aided Mol Des (2001) 0.85

Energetic differences at the subunit interfaces of normal human hemoglobins correlate with their developmental profile. Biochemistry (2009) 0.85

Properties of a recombinant human hemoglobin with aspartic acid 99(beta), an important intersubunit contact site, substituted by lysine. Protein Sci (1994) 0.84

The oxygen-binding intermediates of human hemoglobin: evaluation of their contributions to cooperativity using zinc-containing hybrids. Biophys J (1996) 0.83

Functional consequences of mutations at the allosteric interface in hetero- and homo-hemoglobin tetramers. Protein Sci (1993) 0.82

Single residue modification of only one dimer within the hemoglobin tetramer reveals autonomous dimer function. Proc Natl Acad Sci U S A (2002) 0.80

A recombinant human hemoglobin with asparagine-102(beta) substituted by alanine has a limiting low oxygen affinity, reduced marginally by chloride. Protein Sci (1995) 0.79

Intrinsic regulation of hemoglobin expression by variable subunit interface strengths. FEBS J (2011) 0.79

Heterometallic hybrids of homometallic human hemoglobins. Proc Natl Acad Sci U S A (1996) 0.78

Articles by these authors

The OR control system of bacteriophage lambda. A physical-chemical model for gene regulation. J Mol Biol (1985) 5.79

Quantitative model for gene regulation by lambda phage repressor. Proc Natl Acad Sci U S A (1982) 4.93

lambda Repressor and cro--components of an efficient molecular switch. Nature (1981) 4.52

Energetics of the HIV gp120-CD4 binding reaction. Proc Natl Acad Sci U S A (2000) 4.44

Quantitative DNase footprint titration: a method for studying protein-DNA interactions. Methods Enzymol (1986) 3.36

Analytical gel chromatography of proteins. Adv Protein Chem (1970) 2.42

"Footprint" titrations yield valid thermodynamic isotherms. Proc Natl Acad Sci U S A (1986) 2.35

Vitamin A transport in human vitamin A toxicity. N Engl J Med (1976) 2.29

Pyridinyl imidazole inhibitors of p38 mitogen-activated protein kinase bind in the ATP site. J Biol Chem (1997) 2.28

Identification and initial characterization of four novel members of the interleukin-1 family. J Biol Chem (2000) 2.24

Molecular code for cooperativity in hemoglobin. Science (1992) 2.06

Decreased incidence of urinary tract infections in circumcised male infants. Pediatrics (1985) 1.96

Structure of the regulatory complex of Escherichia coli IIIGlc with glycerol kinase. Science (1993) 1.96

Oxygenation-linked subunit interactions in human hemoglobin: analysis of linkage functions for constituent energy terms. Biochemistry (1976) 1.94

Incentive spirometry to prevent acute pulmonary complications in sickle cell diseases. N Engl J Med (1995) 1.80

Energetics of cooperative protein-DNA interactions: comparison between quantitative deoxyribonuclease footprint titration and filter binding. Biochemistry (1986) 1.69

Temperature-sensitive differential affinity of TRAIL for its receptors. DR5 is the highest affinity receptor. J Biol Chem (2000) 1.68

The effects of diseases of the liver, thyroid, and kidneys on the transport of vitamin A in human plasma. J Clin Invest (1971) 1.67

Relation of Action of Chlorine to Bacterial Death. Am J Public Health Nations Health (1935) 1.63

Kinetics of deoxyhemoglobin subunit dissociation determined by haptoglobin binding: estimation of the equilibrium constant from forward and reverse rates. Biochemistry (1976) 1.62

Molecular sieve studies of interacting protein systems. I. Equations for transport of associating systems. J Biol Chem (1967) 1.62

Hydrogen exchange measurement of the free energy of structural and allosteric change in hemoglobin. Science (1992) 1.60

Oxygenation-linked subunit interactions in human hemoglobin: experimental studies on the concentration dependence of oxygenation curves. Biochemistry (1976) 1.59

The natural history of asymptomatic osteonecrosis of the femoral head in adults with sickle cell disease. J Bone Joint Surg Am (2006) 1.58

[Extensive bone marrow necrosis and major sickle cell syndromes]. Rev Med Interne (1994) 1.56

Free energy coupling within macromolecules. The chemical work of ligand binding at the individual sites in co-operative systems. J Mol Biol (1983) 1.55

Determination of the monomer-dimer equilibrium of interleukin-8 reveals it is a monomer at physiological concentrations. Biochemistry (1994) 1.53

Priapism following splenectomy in an unstable hemoglobin: hemoglobin Olmsted beta 141 (H19) Leu-->Arg. Am J Hematol (1996) 1.52

New twists on an old story: hemoglobin. Trends Biochem Sci (1988) 1.52

The linkage between oxygenation and subunit dissociation in human hemoglobin. Proc Natl Acad Sci U S A (1974) 1.51

Endothelial dysfunction in patients with sickle cell disease is related to selective impairment of shear stress-mediated vasodilation. Blood (2001) 1.51

Coupled energetics of lambda cro repressor self-assembly and site-specific DNA operator binding II: cooperative interactions of cro dimers. J Mol Biol (2000) 1.47

Thermodynamic studies on subunit assembly in human hemoglobin. Temperature dependence of the dimer-tetramer association constants for oxygenated and unliganded hemoglobins. J Biol Chem (1977) 1.47

Self-assembly of bacteriophage lambda cI repressor: effects of single-site mutations on the monomer-dimer equilibrium. Biochemistry (1994) 1.43

Vitamin-A reversal of abnormal dark adaptation in cirrhosis. Study of effects on the plasma retinol transport system. Ann Intern Med (1978) 1.43

Effects of site-specific amino acid modification on protein interactions and biological function. Annu Rev Biochem (1985) 1.42

Long-range, small magnitude nonadditivity of mutational effects in proteins. Biochemistry (1995) 1.41

Experimental resolution of cooperative free energies for the ten ligation states of human hemoglobin. Proc Natl Acad Sci U S A (1985) 1.34

Stabilization and transport of severely ill infants. Pediatr Clin North Am (1973) 1.33

Kinetic analysis of a protein antigen-antibody interaction limited by mass transport on an optical biosensor. Biophys Chem (1997) 1.32

Clinical characteristics and biotransformation of sevoflurane in healthy human volunteers. Anesthesiology (1981) 1.32

Energetics of subunit dimerization in bacteriophage lambda cI repressor: linkage to protons, temperature, and KCl. Biochemistry (1991) 1.31

Dissection of the nucleotide and metal-phosphate binding sites in cAMP-dependent protein kinase. Biochemistry (1999) 1.29

The ABRF-MIRG'02 study: assembly state, thermodynamic, and kinetic analysis of an enzyme/inhibitor interaction. J Biomol Tech (2003) 1.29

Probing the energetics of proteins through structural perturbation: sites of regulatory energy in human hemoglobin. Proc Natl Acad Sci U S A (1982) 1.28

Genetic linkage between structural loci for albumin and group specific component (Gc). Am J Hum Genet (1966) 1.28

Amino acid substitution in two identical inherited human serum albumin variants: albumin Oliphant and albumin Ann Arbor. Biochemistry (1972) 1.27

Thermodynamic studies on subunit assembly in human hemoglobin. Self-association of oxygenated chains (alphaSH and betaSH): determination of stoichiometries and equilibrium constants as a function of temperature. J Biol Chem (1977) 1.27

Acute chest syndrome in adults with sickle cell disease. Chest (2000) 1.27

Mutual effects of protons, NaCl, and oxygen on the dimer-tetramer assembly of human hemoglobin. The dimer Bohr effect. J Biol Chem (1981) 1.27

Site-specific enthalpic regulation of DNA transcription at bacteriophage lambda OR. Biochemistry (1992) 1.27

The natural history of symptomatic osteonecrosis in adults with sickle-cell disease. J Bone Joint Surg Am (2003) 1.27

The linkage between oxygenation and subunit dissociation in human hemoglobin. Consequences for the analysis of oxygenation curves. Biochemistry (1975) 1.25

Lipids of Acanthamoeba castellanii. Composition and effects of phagocytosis on incorporation of radioactive precursors. J Cell Biol (1969) 1.25

Duplication of structural genes for hemoglobin alpha and beta chains in man. Ann N Y Acad Sci (1974) 1.24

Effects of lipoproteins on plasma viscosity. Atherosclerosis (1981) 1.24

Radioimmunoassay of human plasma retinol-binding protein. J Clin Invest (1970) 1.24

A direct comparison of the activities of two humanized respiratory syncytial virus monoclonal antibodies: MEDI-493 and RSHZl9. J Infect Dis (1999) 1.24

Elimination of Fc receptor-dependent effector functions of a modified IgG4 monoclonal antibody to human CD4. J Immunol (2000) 1.23

Hemoglobin S Antilles: a variant with lower solubility than hemoglobin S and producing sickle cell disease in heterozygotes. Proc Natl Acad Sci U S A (1986) 1.23

Characteristics and outcome of connective tissue diseases in patients with sickle-cell disease: report of 30 cases. Semin Arthritis Rheum (2008) 1.23

7-Dehydrostigmasterol and ergosterol: the major sterols of an amoeba. J Lipid Res (1968) 1.22

X-linked sideroblastic anemia: identification of the mutation in the erythroid-specific delta-aminolevulinate synthase gene (ALAS2) in the original family described by Cooley. Blood (1994) 1.22

Measurement and analysis of ligand-linked subunit dissociation equilibria in human hemoglobins. Methods Enzymol (1981) 1.21

Glycerol kinase from Escherichia coli and an Ala65-->Thr mutant: the crystal structures reveal conformational changes with implications for allosteric regulation. Structure (1998) 1.19

Homozygous Hb J Tongariki: evidence for only one alpha chain structural locus in Melanesians. Science (1970) 1.18

Isolation of lambda repressor mutants with defects in cooperative operator binding. Biochemistry (1993) 1.17

Coupled energetics of lambda cro repressor self-assembly and site-specific DNA operator binding I: analysis of cro dimerization from nanomolar to micromolar concentrations. Biochemistry (2000) 1.17

Crystal structures of Escherichia coli glycerol kinase variant S58-->W in complex with nonhydrolyzable ATP analogues reveal a putative active conformation of the enzyme as a result of domain motion. Biochemistry (1999) 1.17

Linked functions in allosteric proteins. Extension of the concerted (MWC) model for ligand-linked subunit assembly and its application to human hemoglobins. J Mol Biol (1981) 1.17

Alkaline Bohr effect of human hemoglobin Ao. J Mol Biol (1988) 1.16

Single-site mutations in the C-terminal domain of bacteriophage lambda cI repressor alter cooperative interactions between dimers adjacently bound to OR. Biochemistry (1994) 1.16

Determination of the equilibrium constants of associating protein systems. 3. Evaluation of the weight fraction of monomer from the weight-average partition coefficient (application to bovine liver glutamate dehydrogenase). Biochemistry (1969) 1.15

Defects of taste and smell in patients with hypothyroidism. Am J Med (1975) 1.15

Calorimetric analysis of lambda cI repressor binding to DNA operator sites. Biochemistry (1995) 1.15

Time-dependent changes in the density and hemoglobin F content of biotin-labeled sickle cells. J Clin Invest (1998) 1.14

Pulmonary function in sickle cell disease with or without acute chest syndrome. Eur Respir J (1998) 1.14

Beta-chain contact sites in the haemoglobin S polymer. Nature (1980) 1.13

Pasteurella multocida meningitis. Postgrad Med J (1980) 1.12

Therapeutic percutaneous aspiration of pancreatic pseudocysts. Dig Dis Sci (1981) 1.11

Escherichia coli glycerol kinase: role of a tetramer interface in regulation by fructose 1,6-bisphosphate and phosphotransferase system regulatory protein IIIglc. Biochemistry (1994) 1.09

Oxygen binding constants for human hemoglobin tetramers. Biochemistry (1987) 1.09

Carbon monoxide binding to human hemoglobin A0. Biochemistry (1987) 1.09

Serum vitamin A, retinol-binding protein, and prealbumin concentrations in protein-calorie malnutrition. I. A functional defect in hepatic retinol release. Am J Clin Nutr (1973) 1.09

Measurement of DNA-protein equilibria using gel chromatography: application to the HinfI restriction endonuclease. Biochemistry (1985) 1.07

Early glomerular dysfunction in patients with sickle cell anemia. Am J Kidney Dis (1998) 1.07

Prediction of the parameters of whole body cholesterol metabolism in humans. J Lipid Res (1980) 1.06

Reported measles in persons immunologically primed by prior vaccination. J Pediatr (1982) 1.06

Hb Belliard [alpha 56(E5)Lys----Asn] a new fast-moving alpha chain variant found in a subject of Spanish origin. Hemoglobin (1989) 1.06

Posture and lumbar puncture headache: a controlled trial in 50 patients. J R Soc Med (1982) 1.05

Cooperativity mutants of bacteriophage lambda cI repressor: temperature dependence of self-assembly. Biochemistry (1996) 1.05

Covalent binding of glutathione to hemoglobin. I. Inhibition of hemoglobin S polymerization. J Biol Chem (1986) 1.04

Thermodynamic analysis of human hemoglobins in terms of the Perutz mechanism: extensions of the Szabo--Karplus model to include subunit assembly. Biochemistry (1982) 1.03