PubRank

Paul D Robbins

Author PubWeight™ 134.83‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Interleukin-17 promotes angiogenesis and tumor growth. Blood 2002 4.90
2 Prevalence of neutralizing antibodies to adenoviral serotypes 5 and 35 in the adult populations of The Gambia, South Africa, and the United States. Clin Diagn Lab Immunol 2004 2.58
3 Synovial fibroblasts spread rheumatoid arthritis to unaffected joints. Nat Med 2009 2.55
4 Protection of mice and poultry from lethal H5N1 avian influenza virus through adenovirus-based immunization. J Virol 2006 2.47
5 Targeted inhibition of Stat3 with a decoy oligonucleotide abrogates head and neck cancer cell growth. Proc Natl Acad Sci U S A 2003 2.35
6 NF-κB inhibition delays DNA damage-induced senescence and aging in mice. J Clin Invest 2012 1.91
7 Exosomes as a short-range mechanism to spread alloantigen between dendritic cells during T cell allorecognition. J Immunol 2008 1.77
8 Exosomes derived from IL-10-treated dendritic cells can suppress inflammation and collagen-induced arthritis. J Immunol 2005 1.74
9 SIRT1 negatively regulates the mammalian target of rapamycin. PLoS One 2010 1.68
10 The roles of tumor-derived exosomes in cancer pathogenesis. Clin Dev Immunol 2011 1.67
11 UpGene: Application of a web-based DNA codon optimization algorithm. Biotechnol Prog 2004 1.67
12 Gene transfer to human joints: progress toward a gene therapy of arthritis. Proc Natl Acad Sci U S A 2005 1.57
13 Effects of a SARS-associated coronavirus vaccine in monkeys. Lancet 2003 1.49
14 Widespread and stable pancreatic gene transfer by adeno-associated virus vectors via different routes. Diabetes 2006 1.45
15 Exosomes derived from genetically modified DC expressing FasL are anti-inflammatory and immunosuppressive. Mol Ther 2005 1.38
16 Muscle-derived stem/progenitor cell dysfunction limits healthspan and lifespan in a murine progeria model. Nat Commun 2012 1.37
17 Marked prolongation of cardiac allograft survival by dendritic cells genetically engineered with NF-kappa B oligodeoxyribonucleotide decoys and adenoviral vectors encoding CTLA4-Ig. J Immunol 2002 1.32
18 DNA damage drives accelerated bone aging via an NF-κB-dependent mechanism. J Bone Miner Res 2013 1.31
19 Effective treatment of inflammatory disease models with exosomes derived from dendritic cells genetically modified to express IL-4. J Immunol 2007 1.30
20 The oxidative DNA lesions 8,5'-cyclopurines accumulate with aging in a tissue-specific manner. Aging Cell 2012 1.30
21 NF-κB in Aging and Disease. Aging Dis 2011 1.28
22 Indoleamine 2,3-dioxygenase expression in transplanted NOD Islets prolongs graft survival after adoptive transfer of diabetogenic splenocytes. Diabetes 2002 1.23
23 Amelioration of chronic murine colitis by peptide-mediated transduction of the IkappaB kinase inhibitor NEMO binding domain peptide. J Immunol 2007 1.22
24 Efficiency of protein transduction is cell type-dependent and is enhanced by dextran sulfate. J Biol Chem 2002 1.21
25 Sirt1 interacts with transducin-like enhancer of split-1 to inhibit nuclear factor kappaB-mediated transcription. Biochem J 2007 1.19
26 Arthritis gene therapy and its tortuous path into the clinic. Transl Res 2013 1.18
27 Intratumoral delivery of dendritic cells engineered to secrete both interleukin (IL)-12 and IL-18 effectively treats local and distant disease in association with broadly reactive Tc1-type immunity. Cancer Res 2003 1.18
28 Therapeutic effect of exosomes from indoleamine 2,3-dioxygenase-positive dendritic cells in collagen-induced arthritis and delayed-type hypersensitivity disease models. Arthritis Rheum 2009 1.18
29 Chaperone displacement from mutant cystic fibrosis transmembrane conductance regulator restores its function in human airway epithelia. FASEB J 2008 1.17
30 Imaging secretory vesicles by fluorescent protein insertion in propeptide rather than mature secreted peptide. Traffic 2002 1.17
31 Prevention of diabetes in NOD mice by administration of dendritic cells deficient in nuclear transcription factor-kappaB activity. Diabetes 2003 1.15
32 Dual transduction of insulin-like growth factor-I and interleukin-1 receptor antagonist protein controls cartilage degradation in an osteoarthritic culture model. J Orthop Res 2005 1.15
33 Mitochondrial-derived reactive oxygen species (ROS) play a causal role in aging-related intervertebral disc degeneration. J Orthop Res 2013 1.13
34 Protection of islets by in situ peptide-mediated transduction of the Ikappa B kinase inhibitor Nemo-binding domain peptide. J Biol Chem 2003 1.12
35 Targeting of XJB-5-131 to mitochondria suppresses oxidative DNA damage and motor decline in a mouse model of Huntington's disease. Cell Rep 2012 1.12
36 Tumor-derived exosomes confer antigen-specific immunosuppression in a murine delayed-type hypersensitivity model. PLoS One 2011 1.11
37 Adenoviral-mediated transfer of TGF-beta1 but not IGF-1 induces chondrogenic differentiation of human mesenchymal stem cells in pellet cultures. Exp Hematol 2005 1.11
38 MHC class II+ exosomes in plasma suppress inflammation in an antigen-specific and Fas ligand/Fas-dependent manner. J Immunol 2007 1.10
39 Dendritic cells transduced to express interleukin-4 prevent diabetes in nonobese diabetic mice with advanced insulitis. Hum Gene Ther 2003 1.10
40 Peptide-based inhibition of NF-κB rescues diaphragm muscle contractile dysfunction in a murine model of Duchenne muscular dystrophy. Mol Med 2011 1.09
41 Effective treatment of established mouse collagen-induced arthritis by systemic administration of dendritic cells genetically modified to express FasL. Mol Ther 2002 1.09
42 Accelerated aging of intervertebral discs in a mouse model of progeria. J Orthop Res 2010 1.08
43 Immunosuppressive effects of glucosamine. J Biol Chem 2002 1.08
44 Gene transfer of manganese superoxide dismutase extends islet graft function in a mouse model of autoimmune diabetes. Diabetes 2003 1.08
45 Adverse effects of adenovirus-mediated gene transfer of human transforming growth factor beta 1 into rabbit knees. Arthritis Res Ther 2003 1.07
46 The insulin secretory granule is the major site of K(ATP) channels of the endocrine pancreas. Diabetes 2003 1.04
47 Broad cellular immunity with robust memory responses to simian immunodeficiency virus following serial vaccination with adenovirus 5- and 35-based vectors. J Gen Virol 2006 1.03
48 Arthritis gene therapy's first death. Arthritis Res Ther 2008 1.03
49 The fate of mesenchymal stem cells transplanted into immunocompetent neonatal mice: implications for skeletal gene therapy via stem cells. Mol Ther 2004 1.01
50 IL-1ra/IGF-1 gene therapy modulates repair of microfractured chondral defects. Clin Orthop Relat Res 2007 1.00
51 PhiC31 integrase mediates integration in cultured synovial cells and enhances gene expression in rabbit joints. J Gene Med 2006 1.00
52 SIRT1 associates with eIF2-alpha and regulates the cellular stress response. Sci Rep 2011 0.99
53 Innate immunity mediated by the cytokine IL-1 homologue 4 (IL-1H4/IL-1F7) induces IL-12-dependent adaptive and profound antitumor immunity. J Immunol 2003 0.98
54 Orthopedic gene therapy in 2008. Mol Ther 2008 0.98
55 The 2003 Nicolas Andry Award. Orthopaedic gene therapy. Clin Orthop Relat Res 2004 0.98
56 Signaling mechanisms involved in the response to genotoxic stress and regulating lifespan. Int J Biochem Cell Biol 2007 0.97
57 Biologic response of human intervertebral disc cells to gene therapy cocktail. Spine (Phila Pa 1976) 2008 0.96
58 An overview of underlying causes and animal models for the study of age-related degenerative disorders of the spine and synovial joints. J Orthop Res 2013 0.95
59 Gene therapy for arthritis: what next? Arthritis Rheum 2006 0.95
60 Clinical responses to gene therapy in joints of two subjects with rheumatoid arthritis. Hum Gene Ther 2009 0.95
61 Intra-articular gene delivery and expression of interleukin-1Ra mediated by self-complementary adeno-associated virus. J Gene Med 2009 0.95
62 NF-κB negatively impacts the myogenic potential of muscle-derived stem cells. Mol Ther 2011 0.95
63 Identification of a synovial fibroblast-specific protein transduction domain for delivery of apoptotic agents to hyperplastic synovium. Mol Ther 2003 0.94
64 Premature aging-related peripheral neuropathy in a mouse model of progeria. Mech Ageing Dev 2011 0.94
65 Getting arthritis gene therapy into the clinic. Nat Rev Rheumatol 2010 0.94
66 ISSLS prize winner: inhibition of NF-κB activity ameliorates age-associated disc degeneration in a mouse model of accelerated aging. Spine (Phila Pa 1976) 2012 0.94
67 Modulation of the immune response using dendritic cell-derived exosomes. Methods Mol Biol 2007 0.94
68 Plasma-derived MHC class II+ exosomes from tumor-bearing mice suppress tumor antigen-specific immune responses. Eur J Immunol 2012 0.93
69 Gene therapy in musculoskeletal repair. Ann N Y Acad Sci 2007 0.93
70 B7-1/2, but not PD-L1/2 molecules, are required on IL-10-treated tolerogenic DC and DC-derived exosomes for in vivo function. Eur J Immunol 2009 0.93
71 AAV8-mediated gene transfer of interleukin-4 to endogenous beta-cells prevents the onset of diabetes in NOD mice. Mol Ther 2008 0.93
72 Systemic delivery of NEMO binding domain/IKKγ inhibitory peptide to young mdx mice improves dystrophic skeletal muscle histopathology. Neurobiol Dis 2011 0.92
73 Possible novel therapy for malignant gliomas with secretable trimeric TRAIL. PLoS One 2009 0.92
74 Stroma formation and angiogenesis by overexpression of growth factors, cytokines, and proteolytic enzymes in human skin grafted to SCID mice. J Invest Dermatol 2003 0.92
75 Expression and activity of the CDK inhibitor p57Kip2 in chondrocytes undergoing hypertrophic differentiation. J Bone Miner Res 2004 0.92
76 Safety assessment of intradiscal gene transfer: a pilot study. Spine J 2006 0.92
77 Hyperactive Himar1 transposase mediates transposition in cell culture and enhances gene expression in vivo. Hum Gene Ther 2006 0.91
78 Regenerating the injured kidney with human umbilical cord mesenchymal stem cell-derived exosomes. Stem Cell Res Ther 2013 0.91
79 Exosomes released from Mycoplasma infected tumor cells activate inhibitory B cells. PLoS One 2012 0.91
80 Increased function and survival of IL-15-transduced human dendritic cells are mediated by up-regulation of IL-15Ralpha and Bcl-2. J Leukoc Biol 2002 0.90
81 Induction of pregnancy during established EAE halts progression of CNS autoimmune injury via pregnancy-specific serum factors. J Neuroimmunol 2010 0.89
82 Gene combination transfer to block autoimmune damage in transplanted islets of Langerhans. Exp Diabesity Res 2004 0.89
83 The adeno associated viral vector as a strategy for intradiscal gene transfer in immune competent and pre-exposed rabbits. Spine (Phila Pa 1976) 2005 0.88
84 Isolation of muscle-derived stem/progenitor cells based on adhesion characteristics to collagen-coated surfaces. Methods Mol Biol 2013 0.88
85 Local administration of IL-12-transfected dendritic cells induces antitumor immune responses to colon adenocarcinoma in the liver in mice. J Exp Ther Oncol 2002 0.88
86 In vivo expression of HGF/NK1 and GLP-1 From dsAAV vectors enhances pancreatic ß-cell proliferation and improves pathology in the db/db mouse model of diabetes. Diabetes 2010 0.88
87 Gene therapy of the rheumatic diseases: 1998 to 2008. Arthritis Res Ther 2009 0.87
88 Gene therapy for the treatment of musculoskeletal diseases. J Am Acad Orthop Surg 2005 0.86
89 Human, viral or mutant human IL-10 expressed after local adenovirus-mediated gene transfer are equally effective in ameliorating disease pathology in a rabbit knee model of antigen-induced arthritis. Arthritis Res Ther 2006 0.86
90 Identification of a cardiac specific protein transduction domain by in vivo biopanning using a M13 phage peptide display library in mice. PLoS One 2010 0.85
91 Human periprosthetic tissues implanted in severe combined immunodeficient mice respond to gene transfer of a cytokine inhibitor. J Bone Joint Surg Am 2005 0.85
92 Intra-articular injection of recombinant TRAIL induces synovial apoptosis and reduces inflammation in a rabbit knee model of arthritis. Arthritis Res Ther 2006 0.85
93 Altered trafficking of Fas and subsequent resistance to Fas-mediated apoptosis occurs by a wild-type p53 independent mechanism in esophageal adenocarcinoma. J Surg Res 2005 0.84
94 Ex vivo gene delivery of IL-1Ra and soluble TNF receptor confers a distal synergistic therapeutic effect in antigen-induced arthritis. Mol Ther 2002 0.84
95 Expression of a soluble transforming growth factor-beta (TGFbeta) receptor reduces tumorigenicity by regulating natural killer (NK) cell activity against 9L gliosarcoma in vivo. J Neurooncol 2003 0.84
96 Safety assessment of intradiscal gene therapy II: effect of dosing and vector choice. Spine (Phila Pa 1976) 2008 0.83
97 Dendritic cells transduced to express interleukin 4 reduce diabetes onset in both normoglycemic and prediabetic nonobese diabetic mice. PLoS One 2010 0.83
98 Will arthritis gene therapy become a clinical reality? Nat Clin Pract Rheumatol 2006 0.82
99 Comparative analysis of antitumor activity of CD40L, RANKL, and 4-1BBL in vivo following intratumoral administration of viral vectors or transduced dendritic cells. J Gene Med 2006 0.82
100 Regulation of chronic inflammatory and immune processes by extracellular vesicles. J Clin Invest 2016 0.82
101 Differential effects of IL-12 on the generation of alloreactive CTL mediated by murine and human dendritic cells: a critical role for nitric oxide. J Leukoc Biol 2003 0.82
102 Immunosuppressive exosomes: a new approach for treating arthritis. Int J Rheumatol 2012 0.82
103 Perspectives on the use of gene therapy for chronic joint diseases. Curr Gene Ther 2008 0.82
104 Gene transfer to the tendon-bone insertion site. Knee Surg Sports Traumatol Arthrosc 2004 0.82
105 Approaches for skeletal gene therapy. Crit Rev Eukaryot Gene Expr 2002 0.81
106 Early transcriptional events during osteogenic differentiation of human bone marrow stromal cells induced by Lim mineralization protein 3. Gene Expr 2010 0.81
107 Immunomodulation by adenoviral-mediated SCD40-Ig gene therapy for mouse allogeneic islet transplantation. Transplantation 2007 0.81
108 Interleukin 18 gene transfer expands the repertoire of antitumor Th1-type immunity elicited by dendritic cell-based vaccines in association with enhanced therapeutic efficacy. Cancer Res 2002 0.79
109 NF-κB activation with aging: characterization and therapeutic inhibition. Methods Mol Biol 2015 0.79
110 Peroxidation and externalization of phosphatidylserine associated with release of cytochrome c from mitochondria. Free Radic Biol Med 2003 0.79
111 Natural killer, but not natural killer T, cells play a necessary role in the promotion of an innate antitumor response induced by IL-18. Int J Cancer 2003 0.79
112 Protein transduction domains: applications for molecular medicine. Curr Gene Ther 2012 0.79
113 Comparative analysis of dendritic cells transduced with different anti-apoptotic molecules: sensitivity to tumor-induced apoptosis. J Gene Med 2004 0.78
114 Preclinical studies for pharmacokinetics and biodistribution of Ad-stTRAIL, an adenovirus delivering secretable trimeric TRAIL for gene therapy. Exp Mol Med 2011 0.78
115 Genotoxic stress accelerates age-associated degenerative changes in intervertebral discs. Mech Ageing Dev 2012 0.78
116 Lim mineralization protein 3 induces the osteogenic differentiation of human amniotic fluid stromal cells through Kruppel-like factor-4 downregulation and further bone-specific gene expression. J Biomed Biotechnol 2012 0.78
117 Dedifferentiation rescues senescence of progeria cells but only while pluripotent. Stem Cell Res Ther 2011 0.78
118 Gene therapy strategies to prevent autoimmune disorders. Curr Gene Ther 2002 0.77
119 Development of gene-based therapies for cartilage repair. Crit Rev Eukaryot Gene Expr 2002 0.77
120 PTD-mediated loading of tumor-seeking lymphocytes with prodrug-activating enzymes. AAPS J 2008 0.77
121 Cationic and tissue-specific protein transduction domains identification, characterization, and therapeutic application. Adv Genet 2010 0.77
122 Evaluation of peptide-mediated transduction in human CD34+ cells. Hum Gene Ther 2004 0.77
123 The 3rd International Meeting on Gene Therapy in Rheumatology and Orthopaedics. Arthritis Res Ther 2005 0.76
124 Feasibility of percutaneous gene transfer to an atrophic nonunion in a rabbit. Clin Orthop Relat Res 2004 0.76
125 Current status of gene therapy for rheumatoid arthritis. Curr Rheumatol Rep 2008 0.76
126 Advantages and limitations of particle-mediated transfection (gene gun) in cancer immuno-gene therapy using IL-10, IL-12 or B7-1 in murine tumor models. J Gene Med 2003 0.75
127 Adamts5 Deficiency Protects Mice from Chronic Tobacco Smoking-induced Intervertebral Disc Degeneration. Spine (Phila Pa 1976) 2017 0.75
128 Identification and characterization of tissue-specific protein transduction domains using peptide phage display. Methods Mol Biol 2011 0.75
129 Gene and cell therapies for diabetes mellitus: strategies and clinical potential. BioDrugs 2002 0.75