Published in Curr Top Microbiol Immunol on January 01, 2004
The coordinate regulation of the p53 and mTOR pathways in cells. Proc Natl Acad Sci U S A (2005) 7.38
Systematic investigation of genetic vulnerabilities across cancer cell lines reveals lineage-specific dependencies in ovarian cancer. Proc Natl Acad Sci U S A (2011) 4.15
Dysregulation of mTOR signaling in fragile X syndrome. J Neurosci (2010) 3.73
Disruption of the mouse mTOR gene leads to early postimplantation lethality and prohibits embryonic stem cell development. Mol Cell Biol (2004) 3.20
Rapamycin reverses hypertrophic cardiomyopathy in a mouse model of LEOPARD syndrome-associated PTPN11 mutation. J Clin Invest (2011) 1.84
Finding new components of the target of rapamycin (TOR) signaling network through chemical genetics and proteome chips. Proc Natl Acad Sci U S A (2004) 1.75
mTOR signaling: implications for cancer and anticancer therapy. Br J Cancer (2006) 1.72
Leucine stimulates protein synthesis in skeletal muscle of neonatal pigs by enhancing mTORC1 activation. Am J Physiol Endocrinol Metab (2008) 1.49
Negative regulation of mTOR activation by diacylglycerol kinases. Blood (2011) 1.46
Targeting TORC2 in multiple myeloma with a new mTOR kinase inhibitor. Blood (2010) 1.35
Targeting the phosphatidylinositol 3-kinase signaling pathway in breast cancer. Oncologist (2011) 1.32
The role of intracellular signaling in insulin-mediated regulation of drug metabolizing enzyme gene and protein expression. Pharmacol Ther (2006) 1.27
mTOR-dependent cell survival mechanisms. Cold Spring Harb Perspect Biol (2012) 1.24
Complex regulation of mammalian target of rapamycin complex 1 in the basomedial hypothalamus by leptin and nutritional status. Endocrinology (2009) 1.19
S6K1 plays a key role in glial transformation. Cancer Res (2008) 1.16
The mTORC2 complex regulates terminal differentiation of C2C12 myoblasts. Mol Cell Biol (2009) 1.11
The Arabidopsis-mei2-like genes play a role in meiosis and vegetative growth in Arabidopsis. Plant Cell (2006) 1.00
mTOR controls ovarian follicle growth by regulating granulosa cell proliferation. PLoS One (2011) 1.00
Liver regeneration. Transl Res (2014) 0.99
Receptor signaling in immune cell development and function. Immunol Res (2011) 0.98
Deptor knockdown enhances mTOR Activity and protein synthesis in myocytes and ameliorates disuse muscle atrophy. Mol Med (2011) 0.96
MicroRNA-21 is induced by rapamycin in a model of tuberous sclerosis (TSC) and lymphangioleiomyomatosis (LAM). PLoS One (2013) 0.96
A role for Raptor phosphorylation in the mechanical activation of mTOR signaling. Cell Signal (2013) 0.93
Nutrient withdrawal rescues growth factor-deprived cells from mTOR-dependent damage. Aging (Albany NY) (2010) 0.91
Regulation of mTORC1 complex assembly and signaling by GRp58/ERp57. Mol Cell Biol (2011) 0.90
The Arabidopsis Mei2 homologue AML1 binds AtRaptor1B, the plant homologue of a major regulator of eukaryotic cell growth. BMC Plant Biol (2005) 0.90
The role and regulation of mTOR in T-lymphocyte function. Arch Immunol Ther Exp (Warsz) (2012) 0.88
mTOR Pathway and mTOR Inhibitors in Head and Neck Cancer. ISRN Otolaryngol (2012) 0.85
Regulation of protein synthesis by amino acids in muscle of neonates. Front Biosci (Landmark Ed) (2011) 0.85
Evaluation of apoptosis induction by concomitant inhibition of MEK, mTOR, and Bcl-2 in human acute myelogenous leukemia cells. Mol Cancer Ther (2014) 0.83
The role of mechanistic target of rapamycin (mTOR) complexes signaling in the immune responses. Nutrients (2013) 0.82
Intestinal cell kinase (ICK) promotes activation of mTOR complex 1 (mTORC1) through phosphorylation of Raptor Thr-908. J Biol Chem (2012) 0.81
Metabolic regulation of manganese superoxide dismutase expression via essential amino acid deprivation. J Biol Chem (2008) 0.81
Inhibition of mycobacterial infection by the tumor suppressor PTEN. J Biol Chem (2012) 0.80
Parkin prevents cortical atrophy and Aβ-induced alterations of brain metabolism: ¹³C NMR and magnetic resonance imaging studies in AD models. Neuroscience (2012) 0.78
Integrating metabolism and longevity through insulin and IGF1 signaling. Endocrinol Metab Clin North Am (2012) 0.78
Role of ischaemic preconditioning in liver regeneration following major liver resection and transplantation. World J Gastroenterol (2007) 0.77
Caloric Restriction Normalizes Obesity-Induced Alterations on Regulators of Skeletal Muscle Growth Signaling. Lipids (2016) 0.76
Proteomic analysis of immediate-early response plasma proteins after 70% and 90% partial hepatectomy. Hepatol Res (2012) 0.75
RAFT1 phosphorylation of the translational regulators p70 S6 kinase and 4E-BP1. Proc Natl Acad Sci U S A (1998) 8.03
Microarrays of cells expressing defined cDNAs. Nature (2001) 5.05
Stress and mTORture signaling. Oncogene (2006) 3.84
Lymphocyte apoptosis: mediation by increased type 3 inositol 1,4,5-trisphosphate receptor. Science (1996) 1.92
Immunophilin FK506 binding protein associated with inositol 1,4,5-trisphosphate receptor modulates calcium flux. Proc Natl Acad Sci U S A (1995) 1.64
Colony stimulating factor-1 (CSF-1) stimulates temperature dependent phosphorylation and activation of the RAF-1 proto-oncogene product. EMBO J (1990) 1.55
Neurabin is a synaptic protein linking p70 S6 kinase and the neuronal cytoskeleton. Proc Natl Acad Sci U S A (1998) 1.38
Immunophilins and the nervous system. Nat Med (1995) 1.34
High-sensitivity sequencing of large proteins: partial structure of the rapamycin-FKBP12 target. Protein Sci (1994) 1.24
Neural actions of immunophilin ligands. Trends Pharmacol Sci (1998) 1.18
The 12 kD FK 506 binding protein FKBP12 is released in the male reproductive tract and stimulates sperm motility. Mol Med (1998) 0.78