Published in Nat Med on January 01, 1995
Redesigning an FKBP-ligand interface to generate chemical dimerizers with novel specificity. Proc Natl Acad Sci U S A (1998) 3.88
The immunophilin FK506-binding protein modulates Ca2+ release channel closure in rat heart. J Physiol (1997) 2.01
Inhibition of human immunodeficiency virus type 1 replication in human cells by Debio-025, a novel cyclophilin binding agent. Antimicrob Agents Chemother (2008) 1.46
Hair growth modulation by topical immunophilin ligands: induction of anagen, inhibition of massive catagen development, and relative protection from chemotherapy-induced alopecia. Am J Pathol (1997) 1.17
Rectification of skeletal muscle ryanodine receptor mediated by FK506 binding protein. Biophys J (1995) 1.10
A role for FKBP52 in Tau protein function. Proc Natl Acad Sci U S A (2010) 1.07
FKBP12 is a critical regulator of the heart rhythm and the cardiac voltage-gated sodium current in mice. Circ Res (2011) 0.99
From nature to the laboratory and into the clinic. Bioorg Med Chem (2008) 0.95
Dissociation of FKBP12.6 from ryanodine receptor type 2 is regulated by cyclic ADP-ribose but not beta-adrenergic stimulation in mouse cardiomyocytes. Cardiovasc Res (2009) 0.92
Regulation of ATP-induced calcium release in COS-7 cells by calcineurin. Biochem J (2000) 0.84
Constructing molecular complexity and diversity: total synthesis of natural products of biological and medicinal importance. Chem Soc Rev (2012) 0.84
Immunosuppressant FK506 induces interleukin-6 production through the activation of transcription factor nuclear factor (NF)-kappa(B). Implications for FK506 nephropathy. J Clin Invest (1996) 0.83
Correlation of naturally occurring HIV-1 resistance to DEB025 with capsid amino acid polymorphisms. Viruses (2013) 0.81
Analysis of FK506, timcodar (VX-853) and FKBP51 and FKBP52 chaperones in control of glucocorticoid receptor activity and phosphorylation. Pharmacol Res Perspect (2014) 0.80
Timcodar (VX-853) Is a Non-FKBP12 Binding Macrolide Derivative That Inhibits PPARγ and Suppresses Adipogenesis. PPAR Res (2016) 0.78
Uncoupling of Ca2+ transport ATPase in muscle and blood platelets by diacylglycerol analogues and cyclosporin A antagonism. Biochem J (1997) 0.78
FK506 inhibition of gliostatin/thymidine phosphorylase production induced by tumor necrosis factor-α in rheumatoid fibroblast-like synoviocytes. Rheumatol Int (2010) 0.78
Transgenic analysis of the role of FKBP12.6 in cardiac function and intracellular calcium release. Assay Drug Dev Technol (2011) 0.78
The role of FK506-binding proteins 12 and 12.6 in regulating cardiac function. Pediatr Cardiol (2012) 0.76
PEP-1-FK506BP inhibits alkali burn-induced corneal inflammation on the rat model of corneal alkali injury. BMB Rep (2015) 0.76
Intra-CA1 administration of FK-506 (tacrolimus) in rat impairs learning and memory in an inhibitory avoidance paradigm. Iran J Basic Med Sci (2015) 0.75
The immunophilin FKBP4 (FKBP52/FKBP59) maps to the distal short arm of human chromosome 12. Mamm Genome (1998) 0.75
RAFT1 phosphorylation of the translational regulators p70 S6 kinase and 4E-BP1. Proc Natl Acad Sci U S A (1998) 8.03
Microarrays of cells expressing defined cDNAs. Nature (2001) 5.05
Stress and mTORture signaling. Oncogene (2006) 3.84
Lymphocyte apoptosis: mediation by increased type 3 inositol 1,4,5-trisphosphate receptor. Science (1996) 1.92
Raptor and mTOR: subunits of a nutrient-sensitive complex. Curr Top Microbiol Immunol (2004) 1.75
Immunophilin FK506 binding protein associated with inositol 1,4,5-trisphosphate receptor modulates calcium flux. Proc Natl Acad Sci U S A (1995) 1.64
Colony stimulating factor-1 (CSF-1) stimulates temperature dependent phosphorylation and activation of the RAF-1 proto-oncogene product. EMBO J (1990) 1.55
Neurabin is a synaptic protein linking p70 S6 kinase and the neuronal cytoskeleton. Proc Natl Acad Sci U S A (1998) 1.38
High-sensitivity sequencing of large proteins: partial structure of the rapamycin-FKBP12 target. Protein Sci (1994) 1.24
Neural actions of immunophilin ligands. Trends Pharmacol Sci (1998) 1.18
The 12 kD FK 506 binding protein FKBP12 is released in the male reproductive tract and stimulates sperm motility. Mol Med (1998) 0.78