Published in Proc Natl Acad Sci U S A on October 15, 2003
The mitochondrial-derived peptide MOTS-c promotes metabolic homeostasis and reduces obesity and insulin resistance. Cell Metab (2015) 1.89
Unraveling insulin-like growth factor binding protein-3 actions in human disease. Endocr Rev (2009) 1.76
Humanin: a novel central regulator of peripheral insulin action. PLoS One (2009) 1.55
Antiapoptotic factor humanin is expressed in normal and tumoral pituitary cells and protects them from TNF-α-induced apoptosis. PLoS One (2014) 1.43
The neurosurvival factor Humanin inhibits beta-cell apoptosis via signal transducer and activator of transcription 3 activation and delays and ameliorates diabetes in nonobese diabetic mice. Metabolism (2009) 1.31
Humanin inhibits neuronal cell death by interacting with a cytokine receptor complex or complexes involving CNTF receptor alpha/WSX-1/gp130. Mol Biol Cell (2009) 1.27
Identification of a novel cell death receptor mediating IGFBP-3-induced anti-tumor effects in breast and prostate cancer. J Biol Chem (2010) 1.20
Humanin is expressed in human vascular walls and has a cytoprotective effect against oxidized LDL-induced oxidative stress. Cardiovasc Res (2010) 1.15
Humanin: a harbinger of mitochondrial-derived peptides? Trends Endocrinol Metab (2013) 1.13
The emerging role of the mitochondrial-derived peptide humanin in stress resistance. J Mol Endocrinol (2013) 1.12
Humanin preserves endothelial function and prevents atherosclerotic plaque progression in hypercholesterolemic ApoE deficient mice. Atherosclerosis (2011) 1.05
Starvation, detoxification, and multidrug resistance in cancer therapy. Drug Resist Updat (2012) 1.01
IGFBP-3, a marker of cellular senescence, is overexpressed in human papillomavirus-immortalized cervical cells and enhances IGF-1-induced mitogenesis. J Virol (2004) 1.00
What's new in the IGF-binding proteins? Growth Horm IGF Res (2004) 0.99
Potent humanin analog increases glucose-stimulated insulin secretion through enhanced metabolism in the β cell. FASEB J (2013) 0.96
Humanin, a cytoprotective peptide, is expressed in carotid atherosclerotic [corrected] plaques in humans. PLoS One (2012) 0.96
Antiangiogenic antitumor activities of IGFBP-3 are mediated by IGF-independent suppression of Erk1/2 activation and Egr-1-mediated transcriptional events. Blood (2011) 0.96
Vitiligo: a possible model of degenerative diseases. PLoS One (2013) 0.94
Mitochondrial stress signaling in longevity: a new role for mitochondrial function in aging. Redox Biol (2014) 0.93
A humanin derivative reduces amyloid beta accumulation and ameliorates memory deficit in triple transgenic mice. PLoS One (2011) 0.92
The cytoprotective peptide humanin is induced and neutralizes Bax after pro-apoptotic stress in the rat testis. Andrology (2013) 0.92
The Mitochondrial-Derived Peptide Humanin Protects RPE Cells From Oxidative Stress, Senescence, and Mitochondrial Dysfunction. Invest Ophthalmol Vis Sci (2016) 0.91
Protection of blood retinal barrier and systemic vasculature by insulin-like growth factor binding protein-3. PLoS One (2012) 0.91
Interaction of insulin-like growth factor-binding protein-3 and BAX in mitochondria promotes male germ cell apoptosis. J Biol Chem (2009) 0.90
Circulating humanin levels are associated with preserved coronary endothelial function. Am J Physiol Heart Circ Physiol (2012) 0.90
Naturally occurring mitochondrial-derived peptides are age-dependent regulators of apoptosis, insulin sensitivity, and inflammatory markers. Aging (Albany NY) (2016) 0.89
Silencing neuroglobin enhances neuronal vulnerability to oxidative injury by down-regulating 14-3-3gamma. Acta Pharmacol Sin (2009) 0.88
Insulin-like growth factor binding protein-3 suppresses vascular endothelial growth factor expression and tumor angiogenesis in head and neck squamous cell carcinoma. Cancer Sci (2012) 0.88
Mechanisms by which different functional states of mitochondria define yeast longevity. Int J Mol Sci (2015) 0.87
Humanin prevents intra-renal microvascular remodeling and inflammation in hypercholesterolemic ApoE deficient mice. Life Sci (2012) 0.87
New role for the mitochondrial peptide humanin: protective agent against chemotherapy-induced side effects. J Natl Cancer Inst (2014) 0.86
Pharmacokinetics and tissue distribution of humanin and its analogues in male rodents. Endocrinology (2013) 0.86
The trans-Golgi proteins SCLIP and SCG10 interact with chromogranin A to regulate neuroendocrine secretion. Biochemistry (2008) 0.86
Humanin and age-related diseases: a new link? Front Endocrinol (Lausanne) (2014) 0.84
Diminished mTOR signaling: a common mode of action for endocrine longevity factors. Springerplus (2014) 0.84
Assessing the clinical utility of measuring Insulin-like Growth Factor Binding Proteins in tissues and sera of melanoma patients. J Transl Med (2008) 0.83
Protective Effects of Rosa damascena and Its Active Constituent on Aβ(25-35)-Induced Neuritic Atrophy. Evid Based Complement Alternat Med (2011) 0.83
The emergence of the mitochondrial genome as a partial regulator of nuclear function is providing new insights into the genetic mechanisms underlying age-related complex disease. Hum Genet (2013) 0.83
The participation of insulin-like growth factor-binding protein 3 released by astrocytes in the pathology of Alzheimer's disease. Mol Brain (2015) 0.79
The mitochondrial-derived peptide humanin activates the ERK1/2, AKT, and STAT3 signaling pathways and has age-dependent signaling differences in the hippocampus. Oncotarget (2016) 0.79
Secreted calmodulin-like skin protein inhibits neuronal death in cell-based Alzheimer's disease models via the heterotrimeric Humanin receptor. Cell Death Dis (2013) 0.78
Amyloid beta-mediated epigenetic alteration of insulin-like growth factor binding protein 3 controls cell survival in Alzheimer's disease. PLoS One (2014) 0.78
The effects of humanin and its analogues on male germ cell apoptosis induced by chemotherapeutic drugs. Apoptosis (2015) 0.78
Humanin protects against chemotherapy-induced stage-specific male germ cell apoptosis in rats. Andrology (2015) 0.77
MOTS-c: A novel mitochondrial-derived peptide regulating muscle and fat metabolism. Free Radic Biol Med (2016) 0.77
Humanin: Functional Interfaces with IGF-I. Growth Horm IGF Res (2016) 0.76
The Potent Humanin Analogue (HNG) Protects Germ Cells and Leucocytes While Enhancing Chemotherapy-Induced Suppression of Cancer Metastases in Male Mice. Endocrinology (2015) 0.76
A Fleeting Glimpse Inside microRNA, Epigenetics, and Micropeptidomics. Adv Exp Med Biol (2015) 0.76
The insulin-like growth factor system in chronic kidney disease: Pathophysiology and therapeutic opportunities. Kidney Res Clin Pract (2012) 0.76
Genetic Interactions Explain Variance in Cingulate Amyloid Burden: An AV-45 PET Genome-Wide Association and Interaction Study in the ADNI Cohort. Biomed Res Int (2015) 0.75
Humanin rescues cultured rat cortical neurons from NMDA-induced toxicity through the alleviation of mitochondrial dysfunction. Drug Des Devel Ther (2017) 0.75
Humanin G (HNG) protects age-related macular degeneration (AMD) transmitochondrial ARPE-19 cybrids from mitochondrial and cellular damage. Cell Death Dis (2017) 0.75
Numtogenesis as a Mechanism for Development of Cancer. Semin Cancer Biol (2017) 0.75
Protective Mechanisms of the Mitochondrial-Derived Peptide Humanin in Oxidative and Endoplasmic Reticulum Stress in RPE Cells. Oxid Med Cell Longev (2017) 0.75
Induction of the growth inhibitor IGF-binding protein 3 by p53. Nature (1995) 3.55
Humanin peptide suppresses apoptosis by interfering with Bax activation. Nature (2003) 2.66
Role of insulin-like growth factors and their binding proteins in growth control and carcinogenesis. J Cell Physiol (2000) 2.47
Insulin-like growth factor (IGF)-binding protein-3 induces apoptosis and mediates the effects of transforming growth factor-beta1 on programmed cell death through a p53- and IGF-independent mechanism. J Biol Chem (1997) 2.44
A rescue factor abolishing neuronal cell death by a wide spectrum of familial Alzheimer's disease genes and Abeta. Proc Natl Acad Sci U S A (2001) 2.39
Serum insulin-like growth factor I regulates brain amyloid-beta levels. Nat Med (2002) 2.13
Direct functional interactions between insulin-like growth factor-binding protein-3 and retinoid X receptor-alpha regulate transcriptional signaling and apoptosis. J Biol Chem (2000) 1.67
Control of cell survival by IGF signaling pathways. Growth Horm IGF Res (2002) 1.56
A tripartite motif protein TRIM11 binds and destabilizes Humanin, a neuroprotective peptide against Alzheimer's disease-relevant insults. Eur J Neurosci (2003) 1.52
Neural apoptosis. Ann Neurol (1995) 1.49
Evidence for in vivo production of Humanin peptide, a neuroprotective factor against Alzheimer's disease-related insults. Neurosci Lett (2002) 1.39
Characterization of insulin-like growth factor binding protein-3 (IGFBP-3) binding to human breast cancer cells: kinetics of IGFBP-3 binding and identification of receptor binding domain on the IGFBP-3 molecule. Endocrinology (1999) 1.16
Transferrin is an insulin-like growth factor-binding protein-3 binding protein. J Clin Endocrinol Metab (2001) 1.12
Humanin rescues human cerebrovascular smooth muscle cells from Abeta-induced toxicity. J Neurochem (2003) 1.05
Two serine residues distinctly regulate the rescue function of Humanin, an inhibiting factor of Alzheimer's disease-related neurotoxicity: functional potentiation by isomerization and dimerization. J Neurochem (2003) 1.05
Humanin inhibits cell death of serum-deprived PC12h cells. Neuroreport (2002) 1.03
Death and survival of neuronal cells exposed to Alzheimer's insults. J Neurosci Res (2002) 1.02
Identification of essential amino acids in Humanin, a neuroprotective factor against Alzheimer's disease-relevant insults. Peptides (2003) 1.00
Expression of the cytokine leukemia inhibitory factor and pro-apoptotic insulin-like growth factor binding protein-3 in Alzheimer's disease. Acta Neuropathol (2002) 0.96
Insulin-like growth factor I (IGF-I) protects cells from apoptosis by Alzheimer's V642I mutant amyloid precursor protein through IGF-I receptor in an IGF-binding protein-sensitive manner. J Neurosci (2001) 0.96
Involvement of c-Jun N-terminal kinase in amyloid precursor protein-mediated neuronal cell death. J Neurochem (2003) 0.96
A novel rat gene encoding a Humanin-like peptide endowed with broad neuroprotective activity. FASEB J (2002) 0.95
Differential expression of insulin-like growth factor binding proteins (IGFBP) 4 and 5 mRNA in the rat brain after transient hypoxic-ischemic injury. Brain Res Mol Brain Res (1993) 0.91
Emerging beta-amyloid therapies for the treatment of Alzheimer's disease. Curr Pharm Des (2003) 0.89
Induction of p53-dependent, insulin-like growth factor-binding protein-3-mediated apoptosis in glioblastoma multiforme cells by a protein kinase Calpha antisense oligonucleotide. Mol Pharmacol (1999) 0.88
Insulin-like growth factor binding protein 5 and type-1 insulin-like growth factor receptor are differentially regulated during apoptosis in cerebellar granule cells. J Neurochem (2001) 0.87
Plasminogen binds the heparin-binding domain of insulin-like growth factor-binding protein-3. Am J Physiol (1998) 0.81
Functionally significant insulin-like growth factor I receptor mutations in centenarians. Proc Natl Acad Sci U S A (2008) 5.14
Growth hormone receptor deficiency is associated with a major reduction in pro-aging signaling, cancer, and diabetes in humans. Sci Transl Med (2011) 3.84
EWS/FLI-1 silencing and gene profiling of Ewing cells reveal downstream oncogenic pathways and a crucial role for repression of insulin-like growth factor binding protein 3. Mol Cell Biol (2004) 3.33
Phenotypic effects of leptin replacement on morbid obesity, diabetes mellitus, hypogonadism, and behavior in leptin-deficient adults. Proc Natl Acad Sci U S A (2004) 2.41
SnoRNA Snord116 (Pwcr1/MBII-85) deletion causes growth deficiency and hyperphagia in mice. PLoS One (2008) 2.27
Activation of TRPV1 by dietary capsaicin improves endothelium-dependent vasorelaxation and prevents hypertension. Cell Metab (2010) 2.11
Growth inhibitory effect of low fat diet on prostate cancer cells: results of a prospective, randomized dietary intervention trial in men with prostate cancer. J Urol (2010) 1.94
IGFBP-3 is a metastasis suppression gene in prostate cancer. Cancer Res (2011) 1.87
The peroxisome proliferator-activated receptor gamma/retinoid X receptor alpha heterodimer targets the histone modification enzyme PR-Set7/Setd8 gene and regulates adipogenesis through a positive feedback loop. Mol Cell Biol (2009) 1.78
Fasting and cancer treatment in humans: A case series report. Aging (Albany NY) (2009) 1.71
Reduced levels of IGF-I mediate differential protection of normal and cancer cells in response to fasting and improve chemotherapeutic index. Cancer Res (2010) 1.69
Liver-specific deletion of the growth hormone receptor reveals essential role of growth hormone signaling in hepatic lipid metabolism. J Biol Chem (2009) 1.69
Long-term surveillance of growth hormone therapy. J Clin Endocrinol Metab (2011) 1.64
Uncoupling protein 2 ablation exacerbates high-salt intake-induced vascular dysfunction. Am J Hypertens (2010) 1.62
Humanin: a novel central regulator of peripheral insulin action. PLoS One (2009) 1.55
Novel non-steroidal/non-anilide type androgen antagonists with an isoxazolone moiety. Bioorg Med Chem (2002) 1.53
A tripartite motif protein TRIM11 binds and destabilizes Humanin, a neuroprotective peptide against Alzheimer's disease-relevant insults. Eur J Neurosci (2003) 1.52
Females exhibit more extensive amyloid, but not tau, pathology in an Alzheimer transgenic model. Brain Res (2008) 1.51
Carbohydrate restriction, prostate cancer growth, and the insulin-like growth factor axis. Prostate (2008) 1.50
Effect of altering dietary omega-6/omega-3 fatty acid ratios on prostate cancer membrane composition, cyclooxygenase-2, and prostaglandin E2. Clin Cancer Res (2006) 1.50
Rapid apoptosis induction by IGFBP-3 involves an insulin-like growth factor-independent nucleomitochondrial translocation of RXRalpha/Nur77. J Biol Chem (2005) 1.49
Discovery of oxysterol-derived pharmacological chaperones for NPC1: implication for the existence of second sterol-binding site. Chem Biol (2013) 1.49
TWIK-1 and TREK-1 are potassium channels contributing significantly to astrocyte passive conductance in rat hippocampal slices. J Neurosci (2009) 1.48
High-sensitivity C-reactive protein predicts target organ damage in Chinese patients with metabolic syndrome. Metabolism (2007) 1.45
Improvement in aqueous solubility in small molecule drug discovery programs by disruption of molecular planarity and symmetry. J Med Chem (2011) 1.45
Perspectives in mammalian IGFBP-3 biology: local vs. systemic action. Am J Physiol Cell Physiol (2009) 1.44
The role of the insulin-like growth factor system in prenatal growth. Mol Genet Metab (2005) 1.40
Evidence for in vivo production of Humanin peptide, a neuroprotective factor against Alzheimer's disease-related insults. Neurosci Lett (2002) 1.39
The N-terminal domain of Slack determines the formation and trafficking of Slick/Slack heteromeric sodium-activated potassium channels. J Neurosci (2009) 1.38
The ternary IGF complex influences postnatal bone acquisition and the skeletal response to intermittent parathyroid hormone. J Endocrinol (2006) 1.37
Update of guidelines for the use of growth hormone in children: the Lawson Wilkins Pediatric Endocrinology Society Drug and Therapeutics Committee. J Pediatr (2003) 1.36
Insulin-like growth factor binding protein-3 inhibits the growth of non-small cell lung cancer. Cancer Res (2002) 1.34
The neurosurvival factor Humanin inhibits beta-cell apoptosis via signal transducer and activator of transcription 3 activation and delays and ameliorates diabetes in nonobese diabetic mice. Metabolism (2009) 1.31
Cellular internalization of insulin-like growth factor binding protein-3: distinct endocytic pathways facilitate re-uptake and nuclear localization. J Biol Chem (2003) 1.31
Crystal structure of Vigna radiata cytokinin-specific binding protein in complex with zeatin. Plant Cell (2006) 1.29
Humanin inhibits neuronal cell death by interacting with a cytokine receptor complex or complexes involving CNTF receptor alpha/WSX-1/gp130. Mol Biol Cell (2009) 1.27
A functional genomics approach for the identification of putative tumor suppressor genes: Dickkopf-1 as suppressor of HeLa cell transformation. Carcinogenesis (2003) 1.27
A Rac1/phosphatidylinositol 3-kinase/Akt3 anti-apoptotic pathway, triggered by AlsinLF, the product of the ALS2 gene, antagonizes Cu/Zn-superoxide dismutase (SOD1) mutant-induced motoneuronal cell death. J Biol Chem (2004) 1.26
D-serine is a key determinant of glutamate toxicity in amyotrophic lateral sclerosis. EMBO J (2007) 1.26
Characterization of amyotrophic lateral sclerosis-linked P56S mutation of vesicle-associated membrane protein-associated protein B (VAPB/ALS8). J Biol Chem (2006) 1.25
The somatomedin hypothesis 2007: 50 years later. J Clin Endocrinol Metab (2007) 1.24
Serum complexes of insulin-like growth factor-1 modulate skeletal integrity and carbohydrate metabolism. FASEB J (2008) 1.23
Phase II prospective randomized trial of a low-fat diet with fish oil supplementation in men undergoing radical prostatectomy. Cancer Prev Res (Phila) (2011) 1.23
Dietary feeding of silibinin inhibits prostate tumor growth and progression in transgenic adenocarcinoma of the mouse prostate model. Cancer Res (2007) 1.22
Effect of isocaloric low-fat diet on human LAPC-4 prostate cancer xenografts in severe combined immunodeficient mice and the insulin-like growth factor axis. Clin Cancer Res (2003) 1.22
Insulin-like growth factor I (IGF-I) and IGF binding protein-1 modulate prostate cancer cell growth and apoptosis: possible mediators for the effects of diet and exercise on cancer cell survival. Endocrinology (2003) 1.20
Effect of diet and exercise on serum insulin, IGF-I, and IGFBP-1 levels and growth of LNCaP cells in vitro (United States). Cancer Causes Control (2002) 1.20
Association between the insulin resistance of puberty and the insulin-like growth factor-I/growth hormone axis. J Clin Endocrinol Metab (2002) 1.18
Neuroprotection by baicalein in ischemic brain injury involves PTEN/AKT pathway. J Neurochem (2009) 1.17
Activation of the cold-sensing TRPM8 channel triggers UCP1-dependent thermogenesis and prevents obesity. J Mol Cell Biol (2012) 1.17
Involvement of tyrosine kinases and STAT3 in Humanin-mediated neuroprotection. Life Sci (2005) 1.17
Effect of low-fat diet on development of prostate cancer and Akt phosphorylation in the Hi-Myc transgenic mouse model. Cancer Res (2008) 1.16
Increased transient receptor potential canonical type 3 channels in vasculature from hypertensive rats. Hypertension (2008) 1.16
Novel stimulatory role for insulin-like growth factor binding protein-2 in prostate cancer cells. Int J Cancer (2003) 1.15
Humanin is expressed in human vascular walls and has a cytoprotective effect against oxidized LDL-induced oxidative stress. Cardiovasc Res (2010) 1.15
Control of aging and longevity by IGF-I signaling. Exp Gerontol (2005) 1.14
DNA repair gene polymorphisms and risk of pancreatic cancer. Clin Cancer Res (2009) 1.13
Mono- and dihydroxylated metabolites of thalidomide: synthesis and TNF-alpha production-inhibitory activity. Chem Pharm Bull (Tokyo) (2006) 1.13
Humanin: a harbinger of mitochondrial-derived peptides? Trends Endocrinol Metab (2013) 1.13
Direct ortho cupration: a new route to regioselectively functionalized aromatics. J Am Chem Soc (2007) 1.13
The effects of varying dietary carbohydrate and fat content on survival in a murine LNCaP prostate cancer xenograft model. Cancer Prev Res (Phila) (2009) 1.13
The emerging role of the mitochondrial-derived peptide humanin in stress resistance. J Mol Endocrinol (2013) 1.12
Insulin-like growth factor binding protein-3 mediates tumor necrosis factor-alpha-induced apoptosis: role of Bcl-2 phosphorylation. Cell Growth Differ (2002) 1.11
Rapid insulin-like growth factor (IGF)-independent effects of IGF binding protein-3 on endothelial cell survival. J Clin Endocrinol Metab (2003) 1.11
Quantitative ontogeny of murine insulin-like growth factor (IGF)-I, IGF-binding protein-3 and the IGF-related acid-labile subunit. Growth Horm IGF Res (2007) 1.11
S-nitrosothiol depletion in amyotrophic lateral sclerosis. Proc Natl Acad Sci U S A (2006) 1.11
Central and opposing effects of IGF-I and IGF-binding protein-3 on systemic insulin action. Diabetes (2006) 1.10
Separation of alpha-glucosidase-inhibitory and liver X receptor-antagonistic activities of phenethylphenyl phthalimide analogs and generation of LXRalpha-selective antagonists. Bioorg Med Chem (2009) 1.10
A novel Akt/PKB-interacting protein promotes cell adhesion and inhibits familial amyotrophic lateral sclerosis-linked mutant SOD1-induced neuronal death via inhibition of PP2A-mediated dephosphorylation of Akt/PKB. Cell Signal (2007) 1.09
The cytoplasmic domain of Alzheimer's amyloid-beta protein precursor causes sustained apoptosis signal-regulating kinase 1/c-Jun NH2-terminal kinase-mediated neurotoxic signal via dimerization. J Pharmacol Exp Ther (2003) 1.08
Low insulin-like growth factor-1 level predicts survival in humans with exceptional longevity. Aging Cell (2014) 1.08
Humanin preserves endothelial function and prevents atherosclerotic plaque progression in hypercholesterolemic ApoE deficient mice. Atherosclerosis (2011) 1.05
Two serine residues distinctly regulate the rescue function of Humanin, an inhibiting factor of Alzheimer's disease-related neurotoxicity: functional potentiation by isomerization and dimerization. J Neurochem (2003) 1.05
Protein knockdown using methyl bestatin-ligand hybrid molecules: design and synthesis of inducers of ubiquitination-mediated degradation of cellular retinoic acid-binding proteins. J Am Chem Soc (2010) 1.04
Death and survival of neuronal cells exposed to Alzheimer's insults. J Neurosci Res (2002) 1.02
NK4, an antagonist of hepatocyte growth factor (HGF), inhibits growth of multiple myeloma cells: molecular targeting of angiogenic growth factor. Blood (2007) 1.02
Opposing roles of insulin-like growth factor binding protein 3 and humanin in the regulation of testicular germ cell apoptosis. Endocrinology (2009) 1.01
p53-Dependent and p53-independent induction of insulin-like growth factor binding protein-3 by deoxyribonucleic acid damage and hypoxia. J Clin Endocrinol Metab (2005) 1.01
Total synthesis of batzelladine D. Org Lett (2002) 1.01
Wnt5a promotes adhesion of human dermal fibroblasts by triggering a phosphatidylinositol-3 kinase/Akt signal. Cell Signal (2007) 1.01