Published in J Biol Chem on March 30, 2010
The proliferating role of insulin and insulin-like growth factors in cancer. Trends Endocrinol Metab (2010) 1.67
The link between the metabolic syndrome and cancer. Int J Biol Sci (2011) 1.37
Novel protective properties of IGFBP-3 result in enhanced pericyte ensheathment, reduced microglial activation, increased microglial apoptosis, and neuronal protection after ischemic retinal injury. Am J Pathol (2011) 1.12
Homeobox D10 gene, a candidate tumor suppressor, is downregulated through promoter hypermethylation and associated with gastric carcinogenesis. Mol Med (2012) 1.03
Insulin-like growth factor: current concepts and new developments in cancer therapy. Recent Pat Anticancer Drug Discov (2012) 1.00
Regulation of retinal endothelial cell apoptosis through activation of the IGFBP-3 receptor. Apoptosis (2013) 0.98
Insulin-like growth factor-binding protein-3 (IGFBP-3) blocks the effects of asthma by negatively regulating NF-κB signaling through IGFBP-3R-mediated activation of caspases. J Biol Chem (2011) 0.98
Antiangiogenic antitumor activities of IGFBP-3 are mediated by IGF-independent suppression of Erk1/2 activation and Egr-1-mediated transcriptional events. Blood (2011) 0.96
Insulin-like growth factor binding protein-3 (IGFBP-3): Novel ligands mediate unexpected functions. J Cell Commun Signal (2013) 0.95
Insulin-like growth factor-binding protein-7 (IGFBP7): a promising gene therapeutic for hepatocellular carcinoma (HCC). Mol Ther (2013) 0.92
Insulin-like growth factor binding protein-3 inhibits monocyte adhesion to retinal endothelial cells in high glucose conditions. Mol Vis (2013) 0.91
Protection of blood retinal barrier and systemic vasculature by insulin-like growth factor binding protein-3. PLoS One (2012) 0.91
IGFBP-3 inhibits cytokine-induced insulin resistance and early manifestations of atherosclerosis. PLoS One (2013) 0.88
Role of insulin-like growth factor binding protein-3 in 1, 25-dihydroxyvitamin-d 3 -induced breast cancer cell apoptosis. Int J Cell Biol (2013) 0.84
Does milk intake promote prostate cancer initiation or progression via effects on insulin-like growth factors (IGFs)? A systematic review and meta-analysis. Cancer Causes Control (2017) 0.84
Activation of various downstream signaling molecules by IGFBP-3. J Cancer Ther (2014) 0.84
Inhibition of IGF1-R overcomes IGFBP7-induced chemotherapy resistance in T-ALL. BMC Cancer (2015) 0.83
IGFBP-3 nuclear localization predicts human prostate cancer recurrence. Horm Cancer (2012) 0.81
Intrinsic, Pro-Apoptotic Effects of IGFBP-3 on Breast Cancer Cells are Reversible: Involvement of PKA, Rho, and Ceramide. Front Endocrinol (Lausanne) (2011) 0.81
Prohibitin-2 binding modulates insulin-like growth factor-binding protein-6 (IGFBP-6)-induced rhabdomyosarcoma cell migration. J Biol Chem (2013) 0.80
The coordinate cellular response to insulin-like growth factor-I (IGF-I) and insulin-like growth factor-binding protein-2 (IGFBP-2) is regulated through vimentin binding to receptor tyrosine phosphatase β (RPTPβ). J Biol Chem (2015) 0.79
An ocular view of the IGF-IGFBP system. Growth Horm IGF Res (2013) 0.78
Insulin-like growth factor binding protein-3 links obesity and breast cancer progression. Oncotarget (2016) 0.76
The insulin-like growth factor system in chronic kidney disease: Pathophysiology and therapeutic opportunities. Kidney Res Clin Pract (2012) 0.76
Understanding the Key to Targeting the IGF Axis in Cancer: A Biomarker Assessment. Front Oncol (2015) 0.76
IL-13Rα2 uses TMEM219 in chitinase 3-like-1-induced signalling and effector responses. Nat Commun (2016) 0.76
Emerging role of insulin-like growth factor-binding protein 7 in hepatocellular carcinoma. J Hepatocell Carcinoma (2014) 0.76
Connecting myelin-related and synaptic dysfunction in schizophrenia with SNP-rich gene expression hubs. Sci Rep (2017) 0.75
Low expression levels of insulin-like growth factor binding protein-3 are correlated with poor prognosis for patients with hepatocellular carcinoma. Oncol Lett (2017) 0.75
Association between height and malignancy among children in the north of Iran. Iran J Ped Hematol Oncol (2015) 0.75
Suppression of IGF binding protein-3 by palmitate promotes hepatic inflammatory responses. FASEB J (2016) 0.75
Cellular actions of the insulin-like growth factor binding proteins. Endocr Rev (2002) 6.43
Caspase activation: the induced-proximity model. Proc Natl Acad Sci U S A (1999) 3.86
The insulin-like growth factor-binding protein (IGFBP) superfamily. Endocr Rev (1999) 3.54
Caspases in apoptosis and beyond. Oncogene (2008) 3.47
A license to kill. Cell (1996) 3.37
Insulin-like growth factor-binding proteins in serum and other biological fluids: regulation and functions. Endocr Rev (1997) 2.63
Insulin-like growth factor (IGF)-binding protein-3 induces apoptosis and mediates the effects of transforming growth factor-beta1 on programmed cell death through a p53- and IGF-independent mechanism. J Biol Chem (1997) 2.44
Potentiation of neuroblastoma metastasis by loss of caspase-8. Nature (2006) 2.12
IGFBP3 suppresses retinopathy through suppression of oxygen-induced vessel loss and promotion of vascular regrowth. Proc Natl Acad Sci U S A (2007) 1.88
IGFBP-4 is an inhibitor of canonical Wnt signalling required for cardiogenesis. Nature (2008) 1.77
IGF binding protein-3 regulates hematopoietic stem cell and endothelial precursor cell function during vascular development. Proc Natl Acad Sci U S A (2007) 1.77
Direct functional interactions between insulin-like growth factor-binding protein-3 and retinoid X receptor-alpha regulate transcriptional signaling and apoptosis. J Biol Chem (2000) 1.67
Interaction between the Alzheimer's survival peptide humanin and insulin-like growth factor-binding protein 3 regulates cell survival and apoptosis. Proc Natl Acad Sci U S A (2003) 1.61
Control of growth by the somatropic axis: growth hormone and the insulin-like growth factors have related and independent roles. Annu Rev Physiol (2001) 1.54
Insulin-like growth factor-binding protein-3 modulates expression of Bax and Bcl-2 and potentiates p53-independent radiation-induced apoptosis in human breast cancer cells. J Biol Chem (2000) 1.51
Rapid apoptosis induction by IGFBP-3 involves an insulin-like growth factor-independent nucleomitochondrial translocation of RXRalpha/Nur77. J Biol Chem (2005) 1.49
Insulin-like growth factor (IGF)-independent action of IGF-binding protein-3 in Hs578T human breast cancer cells. Cell surface binding and growth inhibition. J Biol Chem (1993) 1.49
Cellular growth inhibition by IGFBP-3 and TGF-beta1 requires LRP-1. FASEB J (2003) 1.41
Cellular internalization of insulin-like growth factor binding protein-3: distinct endocytic pathways facilitate re-uptake and nuclear localization. J Biol Chem (2003) 1.31
Epidermal growth factor receptor regulates aberrant expression of insulin-like growth factor-binding protein 3. Cancer Res (2004) 1.28
A transmembrane leucine zipper is required for activation of the dimeric receptor tyrosine kinase DDR1. J Biol Chem (2006) 1.27
Insulin-like growth factor binding protein 3 (IGFBP-3) potentiates TRAIL-induced apoptosis of human colorectal carcinoma cells through inhibition of NF-kappaB. Cell Death Differ (2006) 1.19
Nonsecreted insulin-like growth factor binding protein-3 (IGFBP-3) can induce apoptosis in human prostate cancer cells by IGF-independent mechanisms without being concentrated in the nucleus. J Biol Chem (2006) 1.17
Characterization of insulin-like growth factor binding protein-3 (IGFBP-3) binding to human breast cancer cells: kinetics of IGFBP-3 binding and identification of receptor binding domain on the IGFBP-3 molecule. Endocrinology (1999) 1.16
Demonstration of receptors for insulin-like growth factor binding protein-3 on Hs578T human breast cancer cells. J Biol Chem (1993) 1.13
Transferrin is an insulin-like growth factor-binding protein-3 binding protein. J Clin Endocrinol Metab (2001) 1.12
Unoccupied alpha(v)beta3 integrin regulates osteoclast apoptosis by transmitting a positive death signal. Mol Endocrinol (2004) 1.09
The interface between self-assembling erythropoietin receptor transmembrane segments corresponds to a membrane-spanning leucine zipper. J Biol Chem (2003) 1.08
Effect of insulin-like growth factor binding protein-1 on integrin signalling and the induction of apoptosis in human breast cancer cells. J Mol Endocrinol (1999) 1.08
Promotion of cancer cell migration: an insulin-like growth factor (IGF)-independent action of IGF-binding protein-6. J Biol Chem (2007) 1.07
Essential role for caspase-8 in transcription-independent apoptosis triggered by p53. J Biol Chem (2000) 1.07
Interactions of high affinity insulin-like growth factor-binding proteins with the type V transforming growth factor-beta receptor in mink lung epithelial cells. J Biol Chem (1999) 1.04
p53-Dependent and p53-independent induction of insulin-like growth factor binding protein-3 by deoxyribonucleic acid damage and hypoxia. J Clin Endocrinol Metab (2005) 1.01
Insulin-like growth factor-binding protein 3 induces caspase-dependent apoptosis through a death receptor-mediated pathway in MCF-7 human breast cancer cells. Cancer Res (2004) 1.00
Ribonucleic acid polymerase II binding subunit 3 (Rpb3), a potential nuclear target of insulin-like growth factor binding protein-3. Endocrinology (2006) 0.97
Insulin-like growth factor binding protein-3 prevents retinoid receptor heterodimerization: implications for retinoic acid-sensitivity in human breast cancer cells. Biochem Biophys Res Commun (2004) 0.95
Novel actions of IGFBP-3 on intracellular signaling pathways of insulin-secreting cells. Growth Horm IGF Res (2005) 0.88
Insulin-like growth factor binding protein-3 interacts with autocrine motility factor/phosphoglucose isomerase (AMF/PGI) and inhibits the AMF/PGI function. Cancer Res (2004) 0.86
Defined carboxy-terminal fragments of insulin-like growth factor (IGF) binding protein-2 exert similar mitogenic activity on cultured rat growth plate chondrocytes as IGF-I. Endocrinology (2008) 0.85
Induction of apoptosis in human prostate cancer cells by insulin-like growth factor binding protein-3 does not require binding to retinoid X receptor-alpha. Endocrinology (2007) 0.83
The effects of insulin-like growth factor binding protein-3 (IGFBP-3) on T47D breast cancer cells enriched for IGFBP-3 binding sites. Mol Cell Biochem (2004) 0.81
Characterization of the inhibition of DNA synthesis in proliferating mink lung epithelial cells by insulin-like growth factor binding protein-3. J Cell Biochem (2000) 0.79
The p110alpha isoform of PI3K is essential for proper growth factor signaling and oncogenic transformation. Proc Natl Acad Sci U S A (2006) 2.23
Genome-wide association study identifies a susceptibility locus for schizophrenia in Han Chinese at 11p11.2. Nat Genet (2011) 2.13
Genome-wide detection of LOH in prostate cancer using human SNP microarray technology. Genomics (2003) 1.80
Unraveling insulin-like growth factor binding protein-3 actions in human disease. Endocr Rev (2009) 1.76
Role of sphingosine kinase 2 in cell migration toward epidermal growth factor. J Biol Chem (2005) 1.67
Aldosterone mediates activation of the thiazide-sensitive Na-Cl cotransporter through an SGK1 and WNK4 signaling pathway. J Clin Invest (2009) 1.59
Human interventions to characterize novel relationships between the renin-angiotensin-aldosterone system and parathyroid hormone. Hypertension (2013) 1.55
A nationwide study of mass urine screening tests on Korean school children and implications for chronic kidney disease management. Clin Exp Nephrol (2012) 1.50
Diabetes mellitus, chronic hepatitis C, and hepatocellular carcinoma. Hepatology (2008) 1.41
Fulminant type 1 diabetes mellitus in Korean adolescents. J Pediatr Endocrinol Metab (2011) 1.39
Obesity and cardiovascular risk factors in Korean children and adolescents aged 10-18 years from the Korean National Health and Nutrition Examination Survey, 1998 and 2001. Am J Epidemiol (2006) 1.31
Prevalence of the metabolic syndrome in Korean adolescents aged 12-19 years from the Korean National Health and Nutrition Examination Survey 1998 and 2001. Diabetes Res Clin Pract (2006) 1.19
Hematuria and proteinuria in a mass school urine screening test. Pediatr Nephrol (2005) 1.17
Sexual dimorphism in innate immunity. Arthritis Rheum (2002) 1.14
Variants in ASB10 are associated with open-angle glaucoma. Hum Mol Genet (2011) 1.12
Inhibition of vimentin or beta1 integrin reverts morphology of prostate tumor cells grown in laminin-rich extracellular matrix gels and reduces tumor growth in vivo. Mol Cancer Ther (2009) 1.09
Effect of intense exercise on inflammatory cytokines and growth mediators in adolescent boys. Pediatrics (2002) 1.09
Connective tissue growth factor/IGF-binding protein-related protein-2 is a mediator in the induction of fibronectin by advanced glycosylation end-products in human dermal fibroblasts. Endocrinology (2002) 1.07
Sphingosine-1-phosphate phosphohydrolase regulates endoplasmic reticulum-to-golgi trafficking of ceramide. Mol Cell Biol (2006) 1.07
Role of sphingosine-1-phosphate phosphatase 1 in epidermal growth factor-induced chemotaxis. J Biol Chem (2004) 1.06
Insulin-like growth factor-binding protein 3 induces caspase-dependent apoptosis through a death receptor-mediated pathway in MCF-7 human breast cancer cells. Cancer Res (2004) 1.00
Serum kisspeptin levels in Korean girls with central precocious puberty. J Korean Med Sci (2011) 0.99
Amplification and overexpression of prosaposin in prostate cancer. Genes Chromosomes Cancer (2005) 0.99
Insulin-like growth factor-binding protein-3 suppresses tumor growth via activation of caspase-dependent apoptosis and cross-talk with NF-κB signaling. Cancer Lett (2011) 0.99
Genetic basis of Bartter syndrome in Korea. Nephrol Dial Transplant (2011) 0.98
Insulin-like growth factor-binding protein-3 (IGFBP-3) blocks the effects of asthma by negatively regulating NF-κB signaling through IGFBP-3R-mediated activation of caspases. J Biol Chem (2011) 0.98
MicroRNA-17-3p is a prostate tumor suppressor in vitro and in vivo, and is decreased in high grade prostate tumors analyzed by laser capture microdissection. Clin Exp Metastasis (2009) 0.97
An integrative review of factors associated with telomere length and implications for biobehavioral research. Nurs Res (2013) 0.97
Familial renal glucosuria: a clinicogenetic study of 23 additional cases. Pediatr Nephrol (2012) 0.95
Insulin-like growth factor binding protein 3 as an anticancer molecule in Ewing's sarcoma. Int J Cancer (2006) 0.95
Binding properties of insulin-like growth factor binding protein-3 (IGFBP-3), IGFBP-3 N- and C-terminal fragments, and structurally related proteins mac25 and connective tissue growth factor measured using a biosensor. Endocrinology (2002) 0.95
Dissociation of hyperglycemia from altered vascular contraction and relaxation mechanisms in caveolin-1 null mice. J Pharmacol Exp Ther (2013) 0.95
Engineering simulations for cancer systems biology. Curr Drug Targets (2012) 0.90
High allele frequency of the p.Q258X mutation and identification of a novel mis-splicing mutation in the STAR gene in Korean patients with congenital lipoid adrenal hyperplasia. Eur J Endocrinol (2011) 0.89
MDM2 controls the timely expression of cyclin A to regulate the cell cycle. Mol Cancer Res (2009) 0.89
Reference values for serum levels of insulin-like growth factor-I and insulin-like growth factor binding protein-3 in Korean children and adolescents. Clin Biochem (2011) 0.89
Targeting IGF-I, IGFBPs and IGF-I receptor system in cancer: the current and future in breast cancer therapy. Recent Pat Anticancer Drug Discov (2011) 0.89
Longitudinal standards for height and height velocity in Korean children and adolescents: the Kangwha study. [corrected]. J Korean Med Sci (2013) 0.89
IGFBP-3 inhibits cytokine-induced insulin resistance and early manifestations of atherosclerosis. PLoS One (2013) 0.88
Anibamine, a natural product CCR5 antagonist, as a novel lead for the development of anti-prostate cancer agents. Bioorg Med Chem Lett (2010) 0.87
Ankyrin repeat and suppressor of cytokine signaling box containing protein-10 is associated with ubiquitin-mediated degradation pathways in trabecular meshwork cells. Mol Vis (2013) 0.87
Lysine-specific demethylase 1: an epigenetic regulator of salt-sensitive hypertension. Am J Hypertens (2012) 0.87
Telomere length: a review of methods for measurement. Nurs Res (2014) 0.86
Insulin-like growth factor-binding protein-3 mediates high glucose-induced apoptosis by increasing oxidative stress in proximal tubular epithelial cells. Endocrinology (2011) 0.86
The effects of tenascin C knockdown on trabecular meshwork outflow resistance. Invest Ophthalmol Vis Sci (2013) 0.85
Atrial natriuretic peptide induces natriuretic peptide receptor-cGMP-dependent protein kinase interaction. J Biol Chem (2003) 0.84
Premenopausal sexual dimorphism in lipopolysaccharide-stimulated production and secretion of tumor necrosis factor. J Rheumatol (2004) 0.84
Enhanced expression of insulin-like growth factor binding protein-3 sensitizes the growth inhibitory effect of anticancer drugs in gastric cancer cells. Biochem Biophys Res Commun (2002) 0.84
Management of chronic hepatitis B in pregnancy. World J Gastroenterol (2012) 0.83
Immunophenotypic analysis of acute lymphocytic leukemia. Hematol Oncol Clin North Am (2002) 0.83
Analytical validation of a real-time reverse transcription-polymerase chain reaction quantitation of different transcripts of the Wilms' tumor suppressor gene (WT1). Anal Biochem (2002) 0.83
Human Oncoprotein MDM2 Up-regulates Expression of NF-κB2 Precursor p100 Conferring a Survival Advantage to Lung Cells. Genes Cancer (2011) 0.83
Direct renin inhibition modulates insulin resistance in caveolin-1-deficient mice. Metabolism (2012) 0.83
Proteomic analysis of the tumorigenic human prostate cell line M12 after microcell-mediated transfer of chromosome 19 demonstrates reduction of vimentin. Electrophoresis (2003) 0.83
cDNA microarray analysis identifies genes induced in common by peptide growth factors and androgen in human prostate epithelial cells. Mol Carcinog (2005) 0.82
Impact of PTEN on the expression of insulin-like growth factors (IGFs) and IGF-binding proteins in human gastric adenocarcinoma cells. Biochem Biophys Res Commun (2005) 0.82
A case of regression of atypical dense deposit disease without C3 deposition in a child. Korean J Pediatr (2010) 0.82
Effects of a structured exercise program on insulin resistance, inflammatory markers and physical fitness in obese Korean children. J Pediatr Endocrinol Metab (2010) 0.82
Perturbation of hyaluronan synthesis in the trabecular meshwork and the effects on outflow facility. Invest Ophthalmol Vis Sci (2012) 0.82
Amphibian pathogen Batrachochytrium dendrobatidis prevalence is correlated with season and not urbanization in central Virginia. Dis Aquat Organ (2010) 0.82
Isolation of erythroid cells from the mouse embryonic yolk sac by laser capture microdissection and subsequent microarray hybridization. Blood Cells Mol Dis (2006) 0.82
c-myb stimulates cell growth by regulation of insulin-like growth factor (IGF) and IGF-binding protein-3 in K562 leukemia cells. Biochem Biophys Res Commun (2009) 0.81
Wilms' tumor 1 silencing decreases the viability and chemoresistance of glioblastoma cells in vitro: a potential role for IGF-1R de-repression. J Neurooncol (2010) 0.81
Targeting insulin-like growth factor-I and insulin-like growth factor-binding protein-3 signaling pathways. A novel therapeutic approach for asthma. Am J Respir Cell Mol Biol (2014) 0.81
Preproghrelin Leu72Met polymorphism is not associated with type 2 diabetes mellitus. Metabolism (2006) 0.81
Spot urine albumin to creatinine ratio and serum cystatin C are effective for detection of diabetic nephropathy in childhood diabetic patients. J Korean Med Sci (2012) 0.80
Wilms tumor 1 expression in malignant gliomas and correlation of +KTS isoforms with p53 status. J Neurosurg (2007) 0.80
Preproghrelin Leu72Met polymorphism in obese Korean children. J Pediatr Endocrinol Metab (2005) 0.80
Factors Influencing Men's Interest in Gene Testing for Prostate Cancer Susceptibility. J Genet Couns (2002) 0.79
The common exon 3 polymorphism of the growth hormone receptor gene and the effect of growth hormone therapy on growth in Korean patients with Turner syndrome. Clin Endocrinol (Oxf) (2009) 0.79
Stevens-Johnson syndrome in a boy with nephrotic syndrome during prednisolone therapy. Pediatr Nephrol (2003) 0.79
IGFBP-3 sensitizes antiestrogen-resistant breast cancer cells through interaction with GRP78. Cancer Lett (2012) 0.79
Serum insulin-like growth factor-binding protein-3 level correlated with glycemic control and lipid profiles in children and adolescents with type 1 diabetes. J Pediatr Endocrinol Metab (2014) 0.79
A new class of mutations reveals a novel function for the original phosphatidylinositol 3-kinase binding site. Proc Natl Acad Sci U S A (2003) 0.78
Tobacco specific carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone suppresses a newly identified anti-tumor IGFBP-3/IGFBP-3R system in lung cancer cells. Lung Cancer (2013) 0.78
Adriamycin inhibits adipogenesis through the modulation of PPARγ and restoration of adriamycin-mediated inhibition of adipogenesis by PPARγ over-expression. Toxicol Mech Methods (2012) 0.78
The natural product CCR5 antagonist anibamine and its analogs as anti-prostate cancer agents. Bioorg Med Chem Lett (2011) 0.78
Efficacy and safety of LB03002, a once-weekly sustained-release human GH for 12-month treatment in Korean children with GH deficiency. Eur J Endocrinol (2013) 0.78
Potential of proteomics towards the investigation of the IGF-independent actions of IGFBP-3. Expert Rev Proteomics (2005) 0.77
A multi-institutional analysis of prehospital tourniquet use. J Trauma Acute Care Surg (2015) 0.77
The abnormalities of carbohydrate metabolism in Turner syndrome: analysis of risk factors associated with impaired glucose tolerance. Eur J Pediatr (2005) 0.77
Interleukin-20 receptor expression in the trabecular meshwork and its implication in glaucoma. J Ocul Pharmacol Ther (2014) 0.77
Computed tomographic scan: it's not just about the fracture. J Trauma Acute Care Surg (2014) 0.77
Final height and insulin-like growth factor-1 in children with medulloblastoma treated with growth hormone. Childs Nerv Syst (2013) 0.76
Effect of WT1 gene silencing on the tumorigenicity of human glioblastoma multiforme cells. J Neurosurg (2010) 0.76
Structure activity relationship studies of natural product chemokine receptor CCR5 antagonist anibamine toward the development of novel anti prostate cancer agents. Eur J Med Chem (2012) 0.76
Insulin-like growth factor binding protein-3 enhances etoposide-induced cell growth inhibition by suppressing the NF-κB activity in gastric cancer cells. Mol Cell Biochem (2015) 0.75
Hematologic aspects of myeloablative therapy and bone marrow transplantation. J Clin Lab Anal (2005) 0.75