Published in J Struct Biol on September 01, 2003
TNF-α and IL-1β promote a disintegrin-like and metalloprotease with thrombospondin type I motif-5-mediated aggrecan degradation through syndecan-4 in intervertebral disc. J Biol Chem (2011) 1.39
Inflammatory cytokines associated with degenerative disc disease control aggrecanase-1 (ADAMTS-4) expression in nucleus pulposus cells through MAPK and NF-κB. Am J Pathol (2013) 1.36
Micro- and nanomechanical analysis of articular cartilage by indentation-type atomic force microscopy: validation with a gel-microfiber composite. Biophys J (2010) 1.26
Regulation of CCN2/connective tissue growth factor expression in the nucleus pulposus of the intervertebral disc: role of Smad and activator protein 1 signaling. Arthritis Rheum (2010) 1.11
Lateral nanomechanics of cartilage aggrecan macromolecules. Biophys J (2006) 1.08
BMP-2 and TGF-beta stimulate expression of beta1,3-glucuronosyl transferase 1 (GlcAT-1) in nucleus pulposus cells through AP1, TonEBP, and Sp1: role of MAPKs. J Bone Miner Res (2010) 1.08
Time-dependent nanomechanics of cartilage. Biophys J (2011) 1.07
High-bandwidth AFM-based rheology reveals that cartilage is most sensitive to high loading rates at early stages of impairment. Biophys J (2013) 1.03
A coarse-grained molecular model for glycosaminoglycans: application to chondroitin, chondroitin sulfate, and hyaluronic acid. Biophys J (2005) 1.02
Gel-like behavior in aggrecan assemblies. J Chem Phys (2008) 0.98
Self-assembling peptide hydrogels modulate in vitro chondrogenesis of bovine bone marrow stromal cells. Tissue Eng Part A (2010) 0.97
Spatial organization and mechanical properties of the pericellular matrix on chondrocytes. Biophys J (2013) 0.96
Nanomechanics of the Cartilage Extracellular Matrix. Annu Rev Mater Res (2011) 0.93
Cartilage aggrecan can undergo self-adhesion. Biophys J (2008) 0.92
Tension amplification in molecular brushes in solutions and on substrates. J Phys Chem B (2009) 0.92
Activation of TonEBP by calcium controls {beta}1,3-glucuronosyltransferase-I expression, a key regulator of glycosaminoglycan synthesis in cells of the intervertebral disc. J Biol Chem (2009) 0.92
Controlled delivery of transforming growth factor β1 by self-assembling peptide hydrogels induces chondrogenesis of bone marrow stromal cells and modulates Smad2/3 signaling. Tissue Eng Part A (2010) 0.92
Avidin as a model for charge driven transport into cartilage and drug delivery for treating early stage post-traumatic osteoarthritis. Biomaterials (2013) 0.91
Adult equine bone marrow stromal cells produce a cartilage-like ECM mechanically superior to animal-matched adult chondrocytes. Matrix Biol (2010) 0.91
Molecular Biomechanics: The Molecular Basis of How Forces Regulate Cellular Function. Mol Cell Biomech (2010) 0.91
Structure and interactions of aggrecans: statistical thermodynamic approach. Biophys J (2008) 0.90
Single-molecule force spectroscopy of cartilage aggrecan self-adhesion. Biophys J (2010) 0.90
Stochastic nanoroughness modulates neuron-astrocyte interactions and function via mechanosensing cation channels. Proc Natl Acad Sci U S A (2014) 0.88
Insensitivity to salt of assembly of a rigid biopolymer aggrecan. Phys Rev Lett (2008) 0.88
Hypoxic regulation of β-1,3-glucuronyltransferase 1 expression in nucleus pulposus cells of the rat intervertebral disc: role of hypoxia-inducible factor proteins. Arthritis Rheum (2011) 0.87
Nanotechnology biomimetic cartilage regenerative scaffolds. Arch Plast Surg (2014) 0.86
Osmotic pressure of aqueous chondroitin sulfate solution: a molecular modeling investigation. Biophys J (2005) 0.85
Age-related nanostructural and nanomechanical changes of individual human cartilage aggrecan monomers and their glycosaminoglycan side chains. J Struct Biol (2012) 0.82
The influence of sub-micron inhibitory clusters on growth cone substratum attachments and CD44 expression. Biomaterials (2008) 0.82
Aggrecan, an unusual polyelectrolyte: review of solution behavior and physiological implications. Acta Biomater (2011) 0.80
Composition-function relationships during IL-1-induced cartilage degradation and recovery. Osteoarthritis Cartilage (2009) 0.80
Transforming growth factor β controls CCN3 expression in nucleus pulposus cells of the intervertebral disc. Arthritis Rheum (2011) 0.80
Smad3 controls β-1,3-glucuronosyltransferase 1 expression in rat nucleus pulposus cells: implications of dysregulated expression in disc disease. Arthritis Rheum (2012) 0.80
Adult bone marrow stromal cell-based tissue-engineered aggrecan exhibits ultrastructure and nanomechanical properties superior to native cartilage. Osteoarthritis Cartilage (2010) 0.79
Molecular adhesion between cartilage extracellular matrix macromolecules. Biomacromolecules (2014) 0.79
Order within disorder: aggrecan chondroitin sulphate-attachment region provides new structural insights into protein sequences classified as disordered. Proteins (2010) 0.78
Normal and shear interactions between hyaluronan-aggrecan complexes mimicking possible boundary lubricants in articular cartilage in synovial joints. Biomacromolecules (2012) 0.78
Computational model for the analysis of cartilage and cartilage tissue constructs. J Tissue Eng Regen Med (2013) 0.77
Characterization of collagenous matrix assembly in a chondrocyte model system. J Biomed Mater Res A (2009) 0.77
Probing Interactions between Aggrecan and Mica Surface by the Atomic Force Microscopy. J Polym Sci B Polym Phys (2010) 0.76
TGFβ regulates Galectin-3 expression through canonical Smad3 signaling pathway in nucleus pulposus cells: implications in intervertebral disc degeneration. Matrix Biol (2015) 0.76
Ionic strength dependence of polyelectrolyte brush thickness. Soft Matter (2012) 0.75
Cell Surface Access Is Modulated by Tethered Bottlebrush Proteoglycans. Biophys J (2016) 0.75
Tension Amplification in Tethered Layers of Bottle-Brush Polymers. Macromolecules (2016) 0.75
Hierarchical organization of cartilage proteoglycans. Macromol Symp (2011) 0.75
Cartilage-targeting drug delivery: can electrostatic interactions help? Nat Rev Rheumatol (2017) 0.75
The Good the Bad and the Ugly of Glycosaminoglycans in Tissue Engineering Applications. Pharmaceuticals (Basel) (2017) 0.75
Local myocardial insulin-like growth factor 1 (IGF-1) delivery with biotinylated peptide nanofibers improves cell therapy for myocardial infarction. Proc Natl Acad Sci U S A (2006) 2.75
Articular cartilage and osteoarthritis. Instr Course Lect (2005) 2.39
Materials design principles of ancient fish armour. Nat Mater (2008) 2.30
Mechanical injury of cartilage explants causes specific time-dependent changes in chondrocyte gene expression. Arthritis Rheum (2005) 1.94
Nanoscale heterogeneity promotes energy dissipation in bone. Nat Mater (2007) 1.92
Thioredoxin-interacting protein (Txnip) is a critical regulator of hepatic glucose production. J Biol Chem (2007) 1.78
Innate immune system activation in osteoarthritis: is osteoarthritis a chronic wound? Curr Opin Rheumatol (2008) 1.64
Custom design of the cardiac microenvironment with biomaterials. Circ Res (2005) 1.63
Pervasive nanoscale deformation twinning as a catalyst for efficient energy dissipation in a bioceramic armour. Nat Mater (2014) 1.62
Proteoglycan degradation after injurious compression of bovine and human articular cartilage in vitro: interaction with exogenous cytokines. Arthritis Rheum (2003) 1.59
The effects of glucosamine hydrochloride on subchondral bone changes in an animal model of osteoarthritis. Arthritis Rheum (2007) 1.58
Mechanical compression of cartilage explants induces multiple time-dependent gene expression patterns and involves intracellular calcium and cyclic AMP. J Biol Chem (2004) 1.56
FGF21 and the late adaptive response to starvation in humans. J Clin Invest (2015) 1.55
Evaluation of adult equine bone marrow- and adipose-derived progenitor cell chondrogenesis in hydrogel cultures. J Orthop Res (2008) 1.43
Onset of preclinical osteoarthritis: the angular spatial organization permits early diagnosis. Arthritis Rheum (2011) 1.43
Compressive nanomechanics of opposing aggrecan macromolecules. J Biomech (2005) 1.41
Influence of tissue maturation and antioxidants on the apoptotic response of articular cartilage after injurious compression. Arthritis Rheum (2004) 1.38
Effects of dynamic compressive loading on chondrocyte biosynthesis in self-assembling peptide scaffolds. J Biomech (2004) 1.37
Gene expression profiles of human chondrocytes during passaged monolayer cultivation. J Orthop Res (2008) 1.36
Deletion of the alpha-arrestin protein Txnip in mice promotes adiposity and adipogenesis while preserving insulin sensitivity. Diabetes (2010) 1.36
Protection mechanisms of the iron-plated armor of a deep-sea hydrothermal vent gastropod. Proc Natl Acad Sci U S A (2010) 1.35
Recent progress in understanding molecular mechanisms of cartilage degeneration during osteoarthritis. Ann N Y Acad Sci (2011) 1.34
Pathomechanisms of cartilage destruction by mechanical injury. Ann Anat (2005) 1.31
Mechanical injury potentiates proteoglycan catabolism induced by interleukin-6 with soluble interleukin-6 receptor and tumor necrosis factor alpha in immature bovine and adult human articular cartilage. Arthritis Rheum (2009) 1.27
Three-dimensional head model simulation of transcranial magnetic stimulation. IEEE Trans Biomed Eng (2004) 1.23
Unrecognized misplacement of endotracheal tubes by ground prehospital providers. Prehosp Emerg Care (2007) 1.23
Shear and compression differentially regulate clusters of functionally related temporal transcription patterns in cartilage tissue. J Biol Chem (2006) 1.21
Mechanical regulation of mitogen-activated protein kinase signaling in articular cartilage. J Biol Chem (2003) 1.19
Effects of short-term glucocorticoid treatment on changes in cartilage matrix degradation and chondrocyte gene expression induced by mechanical injury and inflammatory cytokines. Arthritis Res Ther (2011) 1.19
Mechanical injury and cytokines cause loss of cartilage integrity and upregulate proteins associated with catabolism, immunity, inflammation, and repair. Mol Cell Proteomics (2009) 1.19
Mechanical overload induces VEGF in cartilage discs via hypoxia-inducible factor. Am J Pathol (2004) 1.18
Shear- and compression-induced chondrocyte transcription requires MAPK activation in cartilage explants. J Biol Chem (2007) 1.15
Poroelasticity of cartilage at the nanoscale. Biophys J (2011) 1.11
Identification and characterization of CPS1 as a hyaluronic acid synthase contributing to the pathogenesis of Cryptococcus neoformans infection. Eukaryot Cell (2007) 1.11
Nanobiomechanics of repair bone regenerated by genetically modified mesenchymal stem cells. Tissue Eng Part A (2008) 1.11
Mechanisms and kinetics of glycosaminoglycan release following in vitro cartilage injury. Arthritis Rheum (2004) 1.11
Nanomechanical properties of individual chondrocytes and their developing growth factor-stimulated pericellular matrix. J Biomech (2006) 1.10
Nanogranular origins of the strength of bone. Nano Lett (2006) 1.10
Transport and binding of insulin-like growth factor I through articular cartilage. Arch Biochem Biophys (2003) 1.09
Lateral nanomechanics of cartilage aggrecan macromolecules. Biophys J (2006) 1.08
Evaluation of medium supplemented with insulin-transferrin-selenium for culture of primary bovine calf chondrocytes in three-dimensional hydrogel scaffolds. Tissue Eng (2005) 1.08
Effect of mineral content on the nanoindentation properties and nanoscale deformation mechanisms of bovine tibial cortical bone. J Mater Sci Mater Med (2005) 1.08
Modulation of lubricin biosynthesis and tissue surface properties following cartilage mechanical injury. Arthritis Rheum (2009) 1.08
Chondrocyte mechanotransduction: effects of compression on deformation of intracellular organelles and relevance to cellular biosynthesis. Osteoarthritis Cartilage (2004) 1.08
Time-dependent nanomechanics of cartilage. Biophys J (2011) 1.07
Nanoscale variation in surface charge of synthetic hydroxyapatite detected by chemically and spatially specific high-resolution force spectroscopy. Biomaterials (2005) 1.05
Dynamic compression stimulates proteoglycan synthesis by mesenchymal stem cells in the absence of chondrogenic cytokines. Tissue Eng Part A (2009) 1.05
Serum free light chains as biomarkers for systemic lupus erythematosus disease activity. Arthritis Care Res (Hoboken) (2011) 1.04
High-bandwidth AFM-based rheology reveals that cartilage is most sensitive to high loading rates at early stages of impairment. Biophys J (2013) 1.03
TSG-6 regulates bone remodeling through inhibition of osteoblastogenesis and osteoclast activation. J Biol Chem (2008) 1.02
A coarse-grained molecular model for glycosaminoglycans: application to chondroitin, chondroitin sulfate, and hyaluronic acid. Biophys J (2005) 1.02
Knockout of ADAMTS5 does not eliminate cartilage aggrecanase activity but abrogates joint fibrosis and promotes cartilage aggrecan deposition in murine osteoarthritis models. J Orthop Res (2010) 1.01
Adamts5 deletion blocks murine dermal repair through CD44-mediated aggrecan accumulation and modulation of transforming growth factor β1 (TGFβ1) signaling. J Biol Chem (2011) 1.01
Relevance of collagen piezoelectricity to "Wolff's Law": a critical review. Med Eng Phys (2009) 1.00
Quantitative microstructural studies of the armor of the marine threespine stickleback (Gasterosteus aculeatus). J Struct Biol (2010) 1.00
Bio-inspired interfacial strengthening strategy through geometrically interlocking designs. J Mech Behav Biomed Mater (2012) 1.00
Structural and nanoindentation studies of stem cell-based tissue-engineered bone. J Biomech (2006) 0.98
Self-assembling peptide hydrogels modulate in vitro chondrogenesis of bovine bone marrow stromal cells. Tissue Eng Part A (2010) 0.97
Mechanical motion promotes expression of Prg4 in articular cartilage via multiple CREB-dependent, fluid flow shear stress-induced signaling pathways. Genes Dev (2014) 0.97
Vulnerability of the superficial zone of immature articular cartilage to compressive injury. Arthritis Rheum (2010) 0.97
Intraarticular injection of heparin-binding insulin-like growth factor 1 sustains delivery of insulin-like growth factor 1 to cartilage through binding to chondroitin sulfate. Arthritis Rheum (2010) 0.96
Preservation and analysis of nonequilibrium solute concentration distributions within mechanically compressed cartilage explants. J Biochem Biophys Methods (2002) 0.95
Nanomechanics of opposing glycosaminoglycan macromolecules. J Biomech (2005) 0.94
Electrochemically controlled swelling and mechanical properties of a polymer nanocomposite. ACS Nano (2009) 0.93
Nanomechanics of the Cartilage Extracellular Matrix. Annu Rev Mater Res (2011) 0.93
Cartilage aggrecan can undergo self-adhesion. Biophys J (2008) 0.92
Controlled delivery of transforming growth factor β1 by self-assembling peptide hydrogels induces chondrogenesis of bone marrow stromal cells and modulates Smad2/3 signaling. Tissue Eng Part A (2010) 0.92
Engineering insulin-like growth factor-1 for local delivery. FASEB J (2008) 0.92
Impact of brain tissue filtering on neurostimulation fields: a modeling study. Neuroimage (2013) 0.92
Avidin as a model for charge driven transport into cartilage and drug delivery for treating early stage post-traumatic osteoarthritis. Biomaterials (2013) 0.91
Molecular Biomechanics: The Molecular Basis of How Forces Regulate Cellular Function. Mol Cell Biomech (2010) 0.91
In vitro gene transfer to chondrocytes and synovial fibroblasts by adenoviral vectors. Methods Mol Med (2004) 0.91
Three-dimensional structure of the shell plate assembly of the chiton Tonicella marmorea and its biomechanical consequences. J Struct Biol (2012) 0.91
Murine tendon function is adversely affected by aggrecan accumulation due to the knockout of ADAMTS5. J Orthop Res (2011) 0.91
Modulation of hyaluronan production by CD44 positive glioma cells. Int J Cancer (2010) 0.90
Nanoscale shear deformation mechanisms of opposing cartilage aggrecan macromolecules. Biophys J (2007) 0.90
Transport and equilibrium uptake of a peptide inhibitor of PACE4 into articular cartilage is dominated by electrostatic interactions. Arch Biochem Biophys (2010) 0.90
Catabolic responses of chondrocyte-seeded peptide hydrogel to dynamic compression. Ann Biomed Eng (2009) 0.88
Role of aggrecanase 1 in Lyme arthritis. Arthritis Rheum (2006) 0.88
Mechanics of composite elasmoid fish scale assemblies and their bioinspired analogues. J Mech Behav Biomed Mater (2012) 0.88
Distinct horizontal patterns in the spatial organization of superficial zone chondrocytes of human joints. J Struct Biol (2008) 0.88
Hyaluronan injection in murine osteoarthritis prevents TGFbeta 1-induced synovial neovascularization and fibrosis and maintains articular cartilage integrity by a CD44-dependent mechanism. Arthritis Res Ther (2012) 0.87
Stiffness and strength of suture joints in nature. Phys Rev E Stat Nonlin Soft Matter Phys (2011) 0.87
Proliferative remodeling of the spatial organization of human superficial chondrocytes distant from focal early osteoarthritis. Arthritis Rheum (2010) 0.86
Interleukin-1alpha treatment of meniscal explants stimulates the production and release of aggrecanase-generated, GAG-substituted aggrecan products and also the release of pre-formed, aggrecanase-generated G1 and m-calpain-generated G1-G2. Cell Tissue Res (2010) 0.85
Dynamic mechanical properties of the tissue-engineered matrix associated with individual chondrocytes. J Biomech (2009) 0.85
Osmotic pressure of aqueous chondroitin sulfate solution: a molecular modeling investigation. Biophys J (2005) 0.85