Published in Methods Mol Med on January 01, 2004
Interleukin-1beta and tumor necrosis factor alpha inhibit chondrogenesis by human mesenchymal stem cells through NF-kappaB-dependent pathways. Arthritis Rheum (2009) 1.60
The proinflammatory cytokines IL-1beta and TNF-alpha induce the expression of Synoviolin, an E3 ubiquitin ligase, in mouse synovial fibroblasts via the Erk1/2-ETS1 pathway. Arthritis Res Ther (2006) 1.26
Use of genetically modified muscle and fat grafts to repair defects in bone and cartilage. Eur Cell Mater (2009) 1.15
Concepts in gene therapy for cartilage repair. Injury (2008) 1.08
Exogenous glucosamine globally protects chondrocytes from the arthritogenic effects of IL-1beta. Arthritis Res Ther (2006) 1.06
Evaluation of BMP-2 gene-activated muscle grafts for cranial defect repair. J Orthop Res (2011) 0.87
Rapid and reliable healing of critical size bone defects with genetically modified sheep muscle. Eur Cell Mater (2015) 0.82
Local myocardial insulin-like growth factor 1 (IGF-1) delivery with biotinylated peptide nanofibers improves cell therapy for myocardial infarction. Proc Natl Acad Sci U S A (2006) 2.75
Stem-like cells in bone sarcomas: implications for tumorigenesis. Neoplasia (2005) 2.62
Synovial fibroblasts spread rheumatoid arthritis to unaffected joints. Nat Med (2009) 2.55
Articular cartilage and osteoarthritis. Instr Course Lect (2005) 2.39
Mechanical injury of cartilage explants causes specific time-dependent changes in chondrocyte gene expression. Arthritis Rheum (2005) 1.94
Individual cartilage aggrecan macromolecules and their constituent glycosaminoglycans visualized via atomic force microscopy. J Struct Biol (2003) 1.92
Major biological obstacles for persistent cell-based regeneration of articular cartilage. Arthritis Res Ther (2007) 1.85
Custom design of the cardiac microenvironment with biomaterials. Circ Res (2005) 1.63
Proteoglycan degradation after injurious compression of bovine and human articular cartilage in vitro: interaction with exogenous cytokines. Arthritis Rheum (2003) 1.59
Gene transfer to human joints: progress toward a gene therapy of arthritis. Proc Natl Acad Sci U S A (2005) 1.57
Mechanical compression of cartilage explants induces multiple time-dependent gene expression patterns and involves intracellular calcium and cyclic AMP. J Biol Chem (2004) 1.56
Role of NF-kappaB transcription factors in antiinflammatory and proinflammatory actions of mechanical signals. Arthritis Rheum (2004) 1.52
Tissue engineering for articular cartilage repair--the state of the art. Eur Cell Mater (2013) 1.48
Expression of an exogenous human Oct-4 promoter identifies tumor-initiating cells in osteosarcoma. Cancer Res (2009) 1.46
Evaluation of adult equine bone marrow- and adipose-derived progenitor cell chondrogenesis in hydrogel cultures. J Orthop Res (2008) 1.43
Onset of preclinical osteoarthritis: the angular spatial organization permits early diagnosis. Arthritis Rheum (2011) 1.43
Compressive nanomechanics of opposing aggrecan macromolecules. J Biomech (2005) 1.41
Influence of tissue maturation and antioxidants on the apoptotic response of articular cartilage after injurious compression. Arthritis Rheum (2004) 1.38
Effects of dynamic compressive loading on chondrocyte biosynthesis in self-assembling peptide scaffolds. J Biomech (2004) 1.37
Gene expression profiles of human chondrocytes during passaged monolayer cultivation. J Orthop Res (2008) 1.36
Hypertrophy is induced during the in vitro chondrogenic differentiation of human mesenchymal stem cells by bone morphogenetic protein-2 and bone morphogenetic protein-4 gene transfer. Arthritis Res Ther (2009) 1.34
Direct percutaneous gene delivery to enhance healing of segmental bone defects. J Bone Joint Surg Am (2006) 1.32
Pathomechanisms of cartilage destruction by mechanical injury. Ann Anat (2005) 1.31
Mechanical injury potentiates proteoglycan catabolism induced by interleukin-6 with soluble interleukin-6 receptor and tumor necrosis factor alpha in immature bovine and adult human articular cartilage. Arthritis Rheum (2009) 1.27
Three-dimensional head model simulation of transcranial magnetic stimulation. IEEE Trans Biomed Eng (2004) 1.23
Osteogenesis by human mesenchymal stem cells cultured on silk biomaterials: comparison of adenovirus mediated gene transfer and protein delivery of BMP-2. Biomaterials (2006) 1.22
Facilitated endogenous repair: making tissue engineering simple, practical, and economical. Tissue Eng (2007) 1.21
Shear and compression differentially regulate clusters of functionally related temporal transcription patterns in cartilage tissue. J Biol Chem (2006) 1.21
Mechanical regulation of mitogen-activated protein kinase signaling in articular cartilage. J Biol Chem (2003) 1.19
Effects of short-term glucocorticoid treatment on changes in cartilage matrix degradation and chondrocyte gene expression induced by mechanical injury and inflammatory cytokines. Arthritis Res Ther (2011) 1.19
Mechanical injury and cytokines cause loss of cartilage integrity and upregulate proteins associated with catabolism, immunity, inflammation, and repair. Mol Cell Proteomics (2009) 1.19
Arthritis gene therapy and its tortuous path into the clinic. Transl Res (2013) 1.18
Mechanical overload induces VEGF in cartilage discs via hypoxia-inducible factor. Am J Pathol (2004) 1.18
Lentiviral-mediated gene delivery to synovium: potent intra-articular expression with amplification by inflammation. Mol Ther (2003) 1.15
Gene-induced chondrogenesis of primary mesenchymal stem cells in vitro. Mol Ther (2005) 1.15
Shear- and compression-induced chondrocyte transcription requires MAPK activation in cartilage explants. J Biol Chem (2007) 1.15
Osteogenic potential of reamer irrigator aspirator (RIA) aspirate collected from patients undergoing hip arthroplasty. J Orthop Res (2009) 1.15
Transgene persistence and cell turnover in the diarthrodial joint: implications for gene therapy of chronic joint diseases. Mol Ther (2007) 1.12
Concise review: Bone marrow-derived mesenchymal stem cells change phenotype following in vitro culture: implications for basic research and the clinic. Stem Cells (2014) 1.12
Mechanisms and kinetics of glycosaminoglycan release following in vitro cartilage injury. Arthritis Rheum (2004) 1.11
In vivo gene delivery to synovium by lentiviral vectors. Mol Ther (2002) 1.09
Transport and binding of insulin-like growth factor I through articular cartilage. Arch Biochem Biophys (2003) 1.09
Lateral nanomechanics of cartilage aggrecan macromolecules. Biophys J (2006) 1.08
Evaluation of medium supplemented with insulin-transferrin-selenium for culture of primary bovine calf chondrocytes in three-dimensional hydrogel scaffolds. Tissue Eng (2005) 1.08
Mesenchymal stem cell characteristics of human anterior cruciate ligament outgrowth cells. Tissue Eng Part A (2011) 1.08
Modulation of lubricin biosynthesis and tissue surface properties following cartilage mechanical injury. Arthritis Rheum (2009) 1.08
Chondrocyte mechanotransduction: effects of compression on deformation of intracellular organelles and relevance to cellular biosynthesis. Osteoarthritis Cartilage (2004) 1.08
Bone tissue engineering and repair by gene therapy. Front Biosci (2008) 1.07
Adverse effects of adenovirus-mediated gene transfer of human transforming growth factor beta 1 into rabbit knees. Arthritis Res Ther (2003) 1.07
Time-dependent nanomechanics of cartilage. Biophys J (2011) 1.07
Regenerative medicine and tissue engineering in orthopaedic surgery. Front Biosci (Elite Ed) (2011) 1.06
BMP12 and BMP13 gene transfer induce ligamentogenic differentiation in mesenchymal progenitor and anterior cruciate ligament cells. Cytotherapy (2010) 1.06
Exogenous glucosamine globally protects chondrocytes from the arthritogenic effects of IL-1beta. Arthritis Res Ther (2006) 1.06
Chordin knockdown enhances the osteogenic differentiation of human mesenchymal stem cells. Arthritis Res Ther (2008) 1.05
Dynamic compression stimulates proteoglycan synthesis by mesenchymal stem cells in the absence of chondrogenic cytokines. Tissue Eng Part A (2009) 1.05
Postnatal soluble FGFR3 therapy rescues achondroplasia symptoms and restores bone growth in mice. Sci Transl Med (2013) 1.04
Inflammatory cytokines induce a unique mineralizing phenotype in mesenchymal stem cells derived from human bone marrow. J Biol Chem (2013) 1.04
Arthritis gene therapy's first death. Arthritis Res Ther (2008) 1.03
Enhanced in vitro chondrogenesis of primary mesenchymal stem cells by combined gene transfer. Tissue Eng Part A (2009) 1.02
A coarse-grained molecular model for glycosaminoglycans: application to chondroitin, chondroitin sulfate, and hyaluronic acid. Biophys J (2005) 1.02
Relevance of collagen piezoelectricity to "Wolff's Law": a critical review. Med Eng Phys (2009) 1.00
Physical stimulation of chondrogenic cells in vitro: a review. Clin Orthop Relat Res (2011) 1.00
Gene transfer approaches to the healing of bone and cartilage. Mol Ther (2002) 1.00
Genetically enhanced engineering of meniscus tissue using ex vivo delivery of transforming growth factor-beta 1 complementary deoxyribonucleic acid. Tissue Eng (2007) 0.99
Gene transfer to articular chondrocytes with recombinant adenovirus. Methods Mol Biol (2003) 0.99
Improving chondrogenesis: potential and limitations of SOX9 gene transfer and mechanical stimulation for cartilage tissue engineering. Tissue Eng Part A (2010) 0.99
The 2003 Nicolas Andry Award. Orthopaedic gene therapy. Clin Orthop Relat Res (2004) 0.98
Gait and behavior in an IL1β-mediated model of rat knee arthritis and effects of an IL1 antagonist. J Orthop Res (2010) 0.98
Orthopedic gene therapy in 2008. Mol Ther (2008) 0.98
Self-assembling peptide hydrogels modulate in vitro chondrogenesis of bovine bone marrow stromal cells. Tissue Eng Part A (2010) 0.97
Mechanical motion promotes expression of Prg4 in articular cartilage via multiple CREB-dependent, fluid flow shear stress-induced signaling pathways. Genes Dev (2014) 0.97
Altered relative expression of BMPs and BMP inhibitors in cartilaginous areas of human fractures progressing towards nonunion. J Orthop Res (2009) 0.97
Vulnerability of the superficial zone of immature articular cartilage to compressive injury. Arthritis Rheum (2010) 0.97
Chondrogenesis of human bone marrow mesenchymal stem cells in fibrin-polyurethane composites. Tissue Eng Part A (2009) 0.96
Intraarticular injection of heparin-binding insulin-like growth factor 1 sustains delivery of insulin-like growth factor 1 to cartilage through binding to chondroitin sulfate. Arthritis Rheum (2010) 0.96
Mechanical load modulates chondrogenesis of human mesenchymal stem cells through the TGF-beta pathway. J Cell Mol Med (2009) 0.96