Published in Diabetes on November 01, 2003
CTLs are targeted to kill beta cells in patients with type 1 diabetes through recognition of a glucose-regulated preproinsulin epitope. J Clin Invest (2008) 3.11
Demonstration of islet-autoreactive CD8 T cells in insulitic lesions from recent onset and long-term type 1 diabetes patients. J Exp Med (2012) 2.86
Autoreactive CD8 T cells associated with beta cell destruction in type 1 diabetes. Proc Natl Acad Sci U S A (2005) 2.70
Translational mini-review series on type 1 diabetes: Systematic analysis of T cell epitopes in autoimmune diabetes. Clin Exp Immunol (2007) 2.28
Simultaneous detection of circulating autoreactive CD8+ T-cells specific for different islet cell-associated epitopes using combinatorial MHC multimers. Diabetes (2010) 1.91
Identification of novel IGRP epitopes targeted in type 1 diabetes patients. Clin Immunol (2008) 1.38
Recognition of a subregion of human proinsulin by class I-restricted T cells in type 1 diabetic patients. Proc Natl Acad Sci U S A (2005) 1.35
An update on the use of NOD mice to study autoimmune (Type 1) diabetes. Expert Rev Clin Immunol (2010) 1.13
Islet amyloid polypeptide is a target antigen for diabetogenic CD4+ T cells. Diabetes (2011) 1.04
Killer artificial antigen-presenting cells: a novel strategy to delete specific T cells. Blood (2007) 1.01
Recognition of human proinsulin leader sequence by class I-restricted T-cells in HLA-A*0201 transgenic mice and in human type 1 diabetes. Diabetes (2008) 0.98
Polyunsaturated fatty acids and membrane organization: elucidating mechanisms to balance immunotherapy and susceptibility to infection. Chem Phys Lipids (2008) 0.92
T cell recognition of autoantigens in human type 1 diabetes: clinical perspectives. Clin Dev Immunol (2011) 0.89
Prevention of "Humanized" diabetogenic CD8 T-cell responses in HLA-transgenic NOD mice by a multipeptide coupled-cell approach. Diabetes (2011) 0.88
Human CD8 responses to a complete epitope set from preproinsulin: implications for approaches to epitope discovery. J Clin Immunol (2008) 0.87
Killer artificial antigen-presenting cells: the synthetic embodiment of a 'guided missile'. Immunotherapy (2010) 0.85
Pre-existing autoimmunity determines type 1 diabetes outcome after Flt3-ligand treatment. J Autoimmun (2009) 0.84
Cutting edge: CD4 T cells reactive to an islet amyloid polypeptide peptide accumulate in the pancreas and contribute to disease pathogenesis in nonobese diabetic mice. J Immunol (2013) 0.82
The role of HLA class I gene variation in autoimmune diabetes. Rev Diabet Stud (2005) 0.81
Detection of GAD65 autoreactive T-cells by HLA class I tetramers in type 1 diabetic patients. J Biomed Biotechnol (2009) 0.80
Incidental CD8 T cell reactivity against caspase-cleaved apoptotic self-antigens from ubiquitously expressed proteins in islets from prediabetic human leucocyte antigen-A2 transgenic non-obese diabetic mice. Clin Exp Immunol (2011) 0.80
The Development and Application of HLA Tetramers in the Detection, Characterization and Therapy of Type 1 Diabetes Mellitus. Rev Diabet Stud (2007) 0.78
Glucagon-reactive islet-infiltrating CD8 T cells in NOD mice. Immunology (2015) 0.78
Novel autoantigens in type 1 diabetes. Am J Transl Res (2013) 0.76
Ratite oils promote keratinocyte cell growth and inhibit leukocyte activation. Poult Sci (2015) 0.75
Autoimmune diabetes: ongoing development of immunological intervention strategies targeted directly against autoreactive T cells. Rev Diabet Stud (2004) 0.75
Beta-cell ABCA1 influences insulin secretion, glucose homeostasis and response to thiazolidinedione treatment. Nat Med (2007) 3.53
Prediction of spontaneous autoimmune diabetes in NOD mice by quantification of autoreactive T cells in peripheral blood. J Clin Invest (2003) 2.37
Signaling lymphocytic activation molecule-associated protein controls NKT cell functions. J Immunol (2005) 1.98
Locus co-occupancy, nucleosome positioning, and H3K4me1 regulate the functionality of FOXA2-, HNF4A-, and PDX1-bound loci in islets and liver. Genome Res (2010) 1.90
The Ca(v)1.4 calcium channel is a critical regulator of T cell receptor signaling and naive T cell homeostasis. Immunity (2011) 1.73
The flavanol (-)-epigallocatechin 3-gallate inhibits amyloid formation by islet amyloid polypeptide, disaggregates amyloid fibrils, and protects cultured cells against IAPP-induced toxicity. Biochemistry (2010) 1.63
Different effects of FK506, rapamycin, and mycophenolate mofetil on glucose-stimulated insulin release and apoptosis in human islets. Cell Transplant (2009) 1.60
Increased dietary fat promotes islet amyloid formation and beta-cell secretory dysfunction in a transgenic mouse model of islet amyloid. Diabetes (2003) 1.49
Cutting edge: Increased IL-17-secreting T cells in children with new-onset type 1 diabetes. J Immunol (2010) 1.40
Molecular dissection of 2B4 signaling: implications for signal transduction by SLAM-related receptors. Mol Cell Biol (2004) 1.38
Islet amyloid polypeptide and type 2 diabetes. Exp Gerontol (2003) 1.33
Cholesterol in islet dysfunction and type 2 diabetes. J Clin Invest (2008) 1.32
Rifampicin does not prevent amyloid fibril formation by human islet amyloid polypeptide but does inhibit fibril thioflavin-T interactions: implications for mechanistic studies of beta-cell death. Biochemistry (2008) 1.32
In situ beta cell death promotes priming of diabetogenic CD8 T lymphocytes. J Immunol (2002) 1.30
HDL and LDL cholesterol significantly influence beta-cell function in type 2 diabetes mellitus. Curr Opin Lipidol (2010) 1.29
Loss of both ABCA1 and ABCG1 results in increased disturbances in islet sterol homeostasis, inflammation, and impaired β-cell function. Diabetes (2012) 1.26
Carriers of loss-of-function mutations in ABCA1 display pancreatic beta-cell dysfunction. Diabetes Care (2010) 1.26
Rapid and fatal meningococcal disease due to a strain of Neisseria meningitidis containing the capsule null locus. Clin Infect Dis (2005) 1.25
Identification of Novel HLA-A*0201-restricted epitopes in recent-onset type 1 diabetic subjects and antibody-positive relatives. Diabetes (2006) 1.21
IL-1 blockade attenuates islet amyloid polypeptide-induced proinflammatory cytokine release and pancreatic islet graft dysfunction. J Immunol (2011) 1.20
Recognition of HLA class I-restricted beta-cell epitopes in type 1 diabetes. Diabetes (2006) 1.20
Optimization of epicutaneous immunization for the induction of CTL. Vaccine (2003) 1.19
A multi-year analysis of islet transplantation compared with intensive medical therapy on progression of complications in type 1 diabetes. Transplantation (2008) 1.18
Detection and genotyping of varicella-zoster virus by TaqMan allelic discrimination real-time PCR. J Clin Microbiol (2004) 1.17
Decidual NK cells alter in vitro first trimester extravillous cytotrophoblast migration: a role for IFN-gamma. J Immunol (2006) 1.17
miR-33a modulates ABCA1 expression, cholesterol accumulation, and insulin secretion in pancreatic islets. Diabetes (2012) 1.16
Islet cholesterol accumulation due to loss of ABCA1 leads to impaired exocytosis of insulin granules. Diabetes (2011) 1.12
Impaired NH2-terminal processing of human proislet amyloid polypeptide by the prohormone convertase PC2 leads to amyloid formation and cell death. Diabetes (2006) 1.12
Local expression of B7-H4 by recombinant adenovirus transduction in mouse islets prolongs allograft survival. Transplantation (2009) 1.10
Prevention of murine autoimmune diabetes by CCL22-mediated Treg recruitment to the pancreatic islets. J Clin Invest (2011) 1.10
Improved human pancreatic islet isolation for a prospective cohort study of islet transplantation vs best medical therapy in type 1 diabetes mellitus. Arch Surg (2005) 1.09
Regulation of autoimmune diabetes by complete Freund's adjuvant is mediated by NK cells. J Immunol (2004) 1.08
Resident macrophages mediate islet amyloid polypeptide-induced islet IL-1β production and β-cell dysfunction. Diabetes (2013) 1.08
Improving function and survival of pancreatic islets by endogenous production of glucagon-like peptide 1 (GLP-1). Proc Natl Acad Sci U S A (2006) 1.02
Application of in situ ductal perfusion to facilitate isolation of high-quality RNA from mouse pancreas. Biotechniques (2006) 1.02
B7-H4 Treatment of T Cells Inhibits ERK, JNK, p38, and AKT Activation. PLoS One (2012) 1.00
The sulfated triphenyl methane derivative acid fuchsin is a potent inhibitor of amyloid formation by human islet amyloid polypeptide and protects against the toxic effects of amyloid formation. J Mol Biol (2010) 1.00
Innate immune control of EBV-infected B cells by invariant natural killer T cells. Blood (2013) 0.99
Murine CD160, Ig-like receptor on NK cells and NKT cells, recognizes classical and nonclassical MHC class I and regulates NK cell activation. J Immunol (2005) 0.98
Role of beta-cell prohormone convertase (PC)1/3 in processing of pro-islet amyloid polypeptide. Diabetes (2004) 0.97
Apolipoprotein-mediated lipid antigen presentation in B cells provides a pathway for innate help by NKT cells. Blood (2009) 0.96
Early treatment of NOD mice with B7-H4 reduces the incidence of autoimmune diabetes. Diabetes (2011) 0.96
Death and dysfunction of transplanted β-cells: lessons learned from type 2 diabetes? Diabetes (2014) 0.96
Amyloid inhibitors enhance survival of cultured human islets. Biochim Biophys Acta (2009) 0.94
Association of the X-linked lymphoproliferative disease gene product SAP/SH2D1A with 2B4, a natural killer cell-activating molecule, is dependent on phosphoinositide 3-kinase. J Biol Chem (2002) 0.94
Thioredoxin-interacting protein promotes islet amyloid polypeptide expression through miR-124a and FoxA2. J Biol Chem (2014) 0.93
Small interfering RNA-mediated suppression of proislet amyloid polypeptide expression inhibits islet amyloid formation and enhances survival of human islets in culture. Diabetes (2008) 0.93
Activating the NLRP3 inflammasome using the amyloidogenic peptide IAPP. Methods Mol Biol (2013) 0.92
The central repeat domain 1 of Kaposi's sarcoma-associated herpesvirus (KSHV) latency associated-nuclear antigen 1 (LANA1) prevents cis MHC class I peptide presentation. Virology (2011) 0.92
The X-linked inhibitor of apoptosis protein enhances survival of murine islet allografts. Diabetes (2005) 0.90
Kinetics and genomic profiling of adult human and mouse β-cell maturation. Islets (2011) 0.90
Cholesterol in beta-cell dysfunction: the emerging connection between HDL cholesterol and type 2 diabetes. Curr Diab Rep (2010) 0.90
Role for glycogen synthase kinase-3 in NK cell cytotoxicity and X-linked lymphoproliferative disease. J Immunol (2005) 0.90
RasGRP1 regulates antigen-induced developmental programming by naive CD8 T cells. J Immunol (2009) 0.90
Advances and challenges in islet transplantation: islet procurement rates and lessons learned from suboptimal islet transplantation. J Transplant (2011) 0.90
Role of carboxypeptidase E in processing of pro-islet amyloid polypeptide in {beta}-cells. Endocrinology (2004) 0.88
The complement C5b-9 complexes induced injury of glomerular mesangial cells in rats with Thy-1 nephritis by increasing nitric oxide synthesis. Life Sci (2006) 0.88
CD1d and CD1c expression in human B cells is regulated by activation and retinoic acid receptor signaling. J Immunol (2011) 0.87
Processing of pro-islet amyloid polypeptide in the constitutive and regulated secretory pathways of beta cells. Mol Endocrinol (2005) 0.86
Islet allograft rejection is independent of toll-like receptor signaling in mice. Transplantation (2009) 0.85
The effect of apolipoprotein E deficiency on islet amyloid deposition in human islet amyloid polypeptide transgenic mice. Diabetologia (2003) 0.85
B7-H4 induces donor-specific tolerance in mouse islet allografts. Cell Transplant (2011) 0.85
Short-term stability of pathogen-specific nucleic acid targets in clinical samples. J Clin Microbiol (2012) 0.85
Chronic active Epstein-Barr virus infection associated with low expression of leukocyte-associated immunoglobulin-like receptor-1 (LAIR-1) on natural killer cells. J Clin Immunol (2003) 0.84
Critical role for IFN-gamma in natural killer cell-mediated protection from diabetes. Eur J Immunol (2008) 0.84
Evaluation of a diagnostic polymerase chain reaction assay for Neisseria meningitidis in North America and field experience during an outbreak. Arch Pathol Lab Med (2002) 0.84
IFN-gamma-mediated extravillous trophoblast outgrowth inhibition in first trimester explant culture: a role for insulin-like growth factors. Mol Hum Reprod (2008) 0.83
XIAP inhibition of β-cell apoptosis reduces the number of islets required to restore euglycemia in a syngeneic islet transplantation model. Islets (2010) 0.83
Translational control of glucose-induced islet amyloid polypeptide production in pancreatic islets. Endocrinology (2012) 0.83
Natural killer cells from children with type 1 diabetes have defects in NKG2D-dependent function and signaling. Diabetes (2011) 0.83
Adult stem or progenitor cells in treatment for type 1 diabetes: current progress. Can J Surg (2007) 0.82
Differentiation of mouse embryonic stem cells into endoderm without embryoid body formation. PLoS One (2010) 0.82
Role of the TLR signaling molecule TRIF in β-cell function and glucose homeostasis. Islets (2010) 0.82
IL-1 mediates amyloid-associated islet dysfunction and inflammation in human islet amyloid polypeptide transgenic mice. Diabetologia (2014) 0.82
T-cell epitopes in type 1 diabetes. Curr Diab Rep (2004) 0.81
Synergistic inhibition of tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis in human pancreatic beta cells by Bcl-2 and X-linked inhibitor of apoptosis. Hum Immunol (2005) 0.81
NKT cells are required for complete Freund's adjuvant-mediated protection from autoimmune diabetes. J Immunol (2011) 0.81
Effects of "moxibustion serum" on proliferation and phenotypes of tumor infiltrating lymphocytes. J Tradit Chin Med (2003) 0.80
Progression of spontaneous autoimmune diabetes is associated with a switch in the killing mechanism used by autoreactive CTL. Int Immunol (2004) 0.80
Endogenous expression of B7-H4 improves long-term murine islet allograft survival. Transplantation (2013) 0.79
The X-linked lymphoproliferative syndrome gene product SAP regulates B cell function through the FcgammaRIIB receptor. Cell Signal (2008) 0.79
Optimizing outcomes of hematopoietic stem cell transplantation for severe combined immunodeficiency. Clin Immunol (2009) 0.79
Altered glutathione homeostasis in heart augments cardiac lipotoxicity associated with diet-induced obesity in mice. J Biol Chem (2011) 0.78
B7-H4 Pathway in Islet Transplantation and β-Cell Replacement Therapies. J Transplant (2011) 0.78
CCL22 Prevents Rejection of Mouse Islet Allografts and Induces Donor-Specific Tolerance. Cell Transplant (2015) 0.78
Improving islet engraftment by gene therapy. J Transplant (2011) 0.78
Decidual NK cell-derived conditioned medium (dNK-CM) mediates VEGF-C secretion in extravillous cytotrophoblasts. Am J Reprod Immunol (2011) 0.77
Extended life span is associated with insulin resistance in a transgenic mouse model of insulinoma secreting human islet amyloid polypeptide. Am J Physiol Endocrinol Metab (2003) 0.77