Published in Clin Dev Immunol on July 19, 2011
Heparan sulfate and heparanase play key roles in mouse β cell survival and autoimmune diabetes. J Clin Invest (2011) 1.47
Immune therapy in type 1 diabetes mellitus. Nat Rev Endocrinol (2013) 1.02
On the perils of poor editing: regulation of peptide loading by HLA-DQ and H2-A molecules associated with celiac disease and type 1 diabetes. Expert Rev Mol Med (2012) 0.95
The role of MIF in type 1 and type 2 diabetes mellitus. J Diabetes Res (2014) 0.87
A peptide's perspective on antigen presentation to the immune system. Nat Chem Biol (2013) 0.84
Selective immunotargeting of diabetogenic CD4 T cells by genetically redirected T cells. Immunology (2014) 0.84
Structural Characteristics of HLA-DQ that May Impact DM Editing and Susceptibility to Type-1 Diabetes. Front Immunol (2013) 0.80
T cells recognizing a peptide contaminant undetectable by mass spectrometry. PLoS One (2011) 0.77
Making the most of major histocompatibility complex molecule multimers: applications in type 1 diabetes. Clin Dev Immunol (2012) 0.76
Novel autoantigens in type 1 diabetes. Am J Transl Res (2013) 0.76
Current and Future Clinical Applications of Zinc Transporter-8 in Type 1 Diabetes Mellitus. Chin Med J (Engl) (2015) 0.75
CD127 expression inversely correlates with FoxP3 and suppressive function of human CD4+ T reg cells. J Exp Med (2006) 14.33
Effects of insulin in relatives of patients with type 1 diabetes mellitus. N Engl J Med (2002) 7.00
The NOD mouse: a model of immune dysregulation. Annu Rev Immunol (2005) 6.71
Effect of intensive therapy on residual beta-cell function in patients with type 1 diabetes in the diabetes control and complications trial. A randomized, controlled trial. The Diabetes Control and Complications Trial Research Group. Ann Intern Med (1998) 6.13
GAD treatment and insulin secretion in recent-onset type 1 diabetes. N Engl J Med (2008) 5.74
Effects of oral insulin in relatives of patients with type 1 diabetes: The Diabetes Prevention Trial--Type 1. Diabetes Care (2005) 5.04
Multiple immuno-regulatory defects in type-1 diabetes. J Clin Invest (2002) 4.73
In situ characterization of autoimmune phenomena and expression of HLA molecules in the pancreas in diabetic insulitis. N Engl J Med (1985) 4.65
Early expression of antiinsulin autoantibodies of humans and the NOD mouse: evidence for early determination of subsequent diabetes. Proc Natl Acad Sci U S A (2000) 3.89
Development of type 1 diabetes despite severe hereditary B-lymphocyte deficiency. N Engl J Med (2001) 3.85
Identification of the beta cell antigen targeted by a prevalent population of pathogenic CD8+ T cells in autoimmune diabetes. Proc Natl Acad Sci U S A (2003) 3.75
Expanded T cells from pancreatic lymph nodes of type 1 diabetic subjects recognize an insulin epitope. Nature (2005) 3.62
Inverse relation between humoral and cellular immunity to glutamic acid decarboxylase in subjects at risk of insulin-dependent diabetes. Lancet (1993) 3.38
Etiology of type 1 diabetes. Immunity (2010) 3.28
Beta-cell function in new-onset type 1 diabetes and immunomodulation with a heat-shock protein peptide (DiaPep277): a randomised, double-blind, phase II trial. Lancet (2001) 3.26
Epitope specificity, cytokine production profile and diabetogenic activity of insulin-specific T cell clones isolated from NOD mice. Eur J Immunol (1995) 3.18
Acceleration of diabetes in young NOD mice with a CD4+ islet-specific T cell clone. Science (1990) 3.17
Autoreactive T cell responses show proinflammatory polarization in diabetes but a regulatory phenotype in health. J Clin Invest (2004) 3.17
CTLs are targeted to kill beta cells in patients with type 1 diabetes through recognition of a glucose-regulated preproinsulin epitope. J Clin Invest (2008) 3.11
Autoantibody appearance and risk for development of childhood diabetes in offspring of parents with type 1 diabetes: the 2-year analysis of the German BABYDIAB Study. Diabetes (1999) 3.00
Analysis of islet inflammation in human type 1 diabetes. Clin Exp Immunol (2009) 2.93
Chromogranin A is an autoantigen in type 1 diabetes. Nat Immunol (2010) 2.80
Autoreactive CD8 T cells associated with beta cell destruction in type 1 diabetes. Proc Natl Acad Sci U S A (2005) 2.70
Mononuclear cell infiltration and its relation to the expression of major histocompatibility complex antigens and adhesion molecules in pancreas biopsy specimens from newly diagnosed insulin-dependent diabetes mellitus patients. J Clin Invest (1993) 2.64
T cell-mediated inhibition of the transfer of autoimmune diabetes in NOD mice. J Exp Med (1989) 2.51
Recurrence of type 1 diabetes after simultaneous pancreas-kidney transplantation, despite immunosuppression, is associated with autoantibodies and pathogenic autoreactive CD4 T-cells. Diabetes (2010) 2.36
Structure of a human insulin peptide-HLA-DQ8 complex and susceptibility to type 1 diabetes. Nat Immunol (2001) 2.34
Autoreactive T cells in healthy individuals. J Immunol (2004) 2.29
Cellular immunity to a determinant common to glutamate decarboxylase and coxsackie virus in insulin-dependent diabetes. J Clin Invest (1994) 2.28
Translational mini-review series on type 1 diabetes: Systematic analysis of T cell epitopes in autoimmune diabetes. Clin Exp Immunol (2007) 2.28
Prediction and pathogenesis in type 1 diabetes. Immunity (2010) 2.26
Evidence for superantigen involvement in insulin-dependent diabetes mellitus aetiology. Nature (1994) 2.25
Molecular cloning and identification of a receptor-type protein tyrosine phosphatase, IA-2, from human insulinoma. DNA Cell Biol (1994) 2.13
A randomized trial of intensive insulin therapy in newly diagnosed insulin-dependent diabetes mellitus. N Engl J Med (1989) 2.08
Oral insulin administration and residual beta-cell function in recent-onset type 1 diabetes: a multicentre randomised controlled trial. Diabète Insuline Orale group. Lancet (2000) 2.07
The frequency and immunodominance of islet-specific CD8+ T-cell responses change after type 1 diabetes diagnosis and treatment. Diabetes (2008) 2.04
Detection of GAD65-specific T-cells by major histocompatibility complex class II tetramers in type 1 diabetic patients and at-risk subjects. Diabetes (2002) 2.01
Acceleration of type 1 diabetes mellitus in proinsulin 2-deficient NOD mice. J Clin Invest (2003) 2.00
Antigen-specific tolerance strategies for the prevention and treatment of autoimmune disease. Nat Rev Immunol (2007) 2.00
CD8+ T-cell responses identify beta-cell autoimmunity in human type 1 diabetes. Diabetes (2007) 1.98
GAD65-reactive T cells are activated in patients with autoimmune type 1a diabetes. J Clin Invest (2002) 1.95
Simultaneous detection of circulating autoreactive CD8+ T-cells specific for different islet cell-associated epitopes using combinatorial MHC multimers. Diabetes (2010) 1.91
Defects in IL-2R signaling contribute to diminished maintenance of FOXP3 expression in CD4(+)CD25(+) regulatory T-cells of type 1 diabetic subjects. Diabetes (2009) 1.88
Macrophages, T cell receptor usage, and endothelial cell activation in the pancreas at the onset of insulin-dependent diabetes mellitus. J Clin Invest (1992) 1.80
Recurrent diabetes mellitus in the pancreas iso- and allograft. A light and electron microscopic and immunohistochemical analysis of four cases. Lab Invest (1985) 1.80
Immunodominant epitopes of glutamic acid decarboxylase 65 and 67 in insulin-dependent diabetes mellitus. Lancet (1994) 1.77
Islet cell antigen 512 is a diabetes-specific islet autoantigen related to protein tyrosine phosphatases. J Immunol (1994) 1.77
Evidence for a primary islet autoantigen (preproinsulin 1) for insulitis and diabetes in the nonobese diabetic mouse. Proc Natl Acad Sci U S A (2003) 1.75
Response of peripheral-blood mononuclear cells to glutamate decarboxylase in insulin-dependent diabetes. Lancet (1992) 1.73
A disease-associated cellular immune response in type 1 diabetics to an immunodominant epitope of insulin. J Clin Invest (2001) 1.70
Development of spontaneous autoimmune peripheral polyneuropathy in B7-2-deficient NOD mice. J Exp Med (2001) 1.70
Insulin intervention in slowly progressive insulin-dependent (type 1) diabetes mellitus. J Clin Endocrinol Metab (2008) 1.67
Cytotoxic T cells specific for glutamic acid decarboxylase in autoimmune diabetes. J Exp Med (1995) 1.67
Pancreas in recent onset insulin-dependent diabetes mellitus. Changes in HLA, adhesion molecules and autoantigens, restricted T cell receptor V beta usage, and cytokine profile. J Immunol (1994) 1.60
Cause-specific mortality trends in a large population-based cohort with long-standing childhood-onset type 1 diabetes. Diabetes (2010) 1.60
HLA-A*0201-restricted T cells from humanized NOD mice recognize autoantigens of potential clinical relevance to type 1 diabetes. J Immunol (2006) 1.58
Islet-specific glucose-6-phosphatase catalytic subunit-related protein-reactive CD4+ T cells in human subjects. J Immunol (2006) 1.55
The insulin A-chain epitope recognized by human T cells is posttranslationally modified. J Exp Med (2005) 1.55
Evidence for in vivo primed and expanded autoreactive T cells as a specific feature of patients with type 1 diabetes. J Immunol (2007) 1.49
Naturally processed T cell epitopes from human glutamic acid decarboxylase identified using mice transgenic for the type 1 diabetes-associated human MHC class II allele, DRB1*0401. J Clin Invest (1996) 1.49
No effect of oral insulin on residual beta-cell function in recent-onset type I diabetes (the IMDIAB VII). IMDIAB Group. Diabetologia (2000) 1.48
Priming and effector dependence on insulin B:9-23 peptide in NOD islet autoimmunity. J Clin Invest (2007) 1.44
Immunological responses to exogenous insulin. Endocr Rev (2007) 1.43
Clinical evidence for the safety of GAD65 immunomodulation in adult-onset autoimmune diabetes. J Diabetes Complications (2005) 1.42
Functional avidity directs T-cell fate in autoreactive CD4+ T cells. Blood (2005) 1.39
Reduction of disulfide bonds during antigen processing: evidence from a thiol-dependent insulin determinant. J Exp Med (1991) 1.36
Recognition of a subregion of human proinsulin by class I-restricted T cells in type 1 diabetic patients. Proc Natl Acad Sci U S A (2005) 1.35
Insulitis in type 1 (insulin-dependent) diabetes mellitus in man--macrophages, lymphocytes, and interferon-gamma containing cells. J Pathol (1991) 1.34
Identification of immunodominant T cell epitopes of human glutamic acid decarboxylase 65 by using HLA-DR(alpha1*0101,beta1*0401) transgenic mice. Proc Natl Acad Sci U S A (1997) 1.34
GAD-reactive CD4+ Th1 cells induce diabetes in NOD/SCID mice. J Clin Invest (1998) 1.32
Identification of a beta-cell-specific HLA class I restricted epitope in type 1 diabetes. Diabetes (2003) 1.30
Comparative study of GAD65-specific CD4+ T cells in healthy and type 1 diabetic subjects. J Autoimmun (2005) 1.28
Similar peptides from two beta cell autoantigens, proinsulin and glutamic acid decarboxylase, stimulate T cells of individuals at risk for insulin-dependent diabetes. Mol Med (1995) 1.28
T cell epitopes of insulin defined in HLA-DR4 transgenic mice are derived from preproinsulin and proinsulin. Proc Natl Acad Sci U S A (1998) 1.28
GAD65- and proinsulin-specific CD4+ T-cells detected by MHC class II tetramers in peripheral blood of type 1 diabetes patients and at-risk subjects. J Autoimmun (2005) 1.26
Surrogate end points in the design of immunotherapy trials: emerging lessons from type 1 diabetes. Nat Rev Immunol (2010) 1.22
Identification of Novel HLA-A*0201-restricted epitopes in recent-onset type 1 diabetic subjects and antibody-positive relatives. Diabetes (2006) 1.21
Pancreatic beta-cell function and immune responses to insulin after administration of intranasal insulin to humans at risk for type 1 diabetes. Diabetes Care (2004) 1.21
Recognition of HLA class I-restricted beta-cell epitopes in type 1 diabetes. Diabetes (2006) 1.20
IA-2 is not required for the development of diabetes in NOD mice. Diabetologia (2003) 1.19
Naturally arising human CD4 T-cells that recognize islet autoantigens and secrete interleukin-10 regulate proinflammatory T-cell responses via linked suppression. Diabetes (2010) 1.18
Identification and modulation of a naturally processed T cell epitope from the diabetes-associated autoantigen human glutamic acid decarboxylase 65 (hGAD65). Proc Natl Acad Sci U S A (2001) 1.17
T-cell epitopes in type 1 diabetes autoantigen tyrosine phosphatase IA-2: potential for mimicry with rotavirus and other environmental agents. Mol Med (1998) 1.17
Predominantly recognized proinsulin T helper cell epitopes in individuals with and without islet cell autoimmunity. J Autoimmun (2002) 1.15
Identification of naturally processed T cell epitopes from glutamic acid decarboxylase presented in the context of HLA-DR alleles by T lymphocytes of recent onset IDDM patients. J Clin Invest (1997) 1.14
Pro- and anti-inflammatory cytokine production by autoimmune T cells against preproinsulin in HLA-DRB1*04, DQ8 Type 1 diabetes. Diabetologia (2004) 1.13
Effects of insulin vs. glibenclamide in recently diagnosed patients with type 2 diabetes: a 4-year follow-up. Diabetes Obes Metab (2007) 1.13
Glutamic acid decarboxylase 67-reactive T cells: a marker of insulin-dependent diabetes. J Exp Med (1993) 1.13
COOH-terminal clustering of autoantibody and T-cell determinants on the structure of GAD65 provide insights into the molecular basis of autoreactivity. Diabetes (2008) 1.11
Altered immune response to insulin in newly diagnosed compared to insulin-treated diabetic patients and healthy control subjects. Diabetologia (1997) 1.11
Cellular immune response to diverse islet cell antigens in IDDM. Diabetes (1996) 1.11
Autoantigen-specific regulatory T cells induced in patients with type 1 diabetes mellitus by insulin B-chain immunotherapy. J Autoimmun (2010) 1.10
Induction of insulitis by glutamic acid decarboxylase peptide-specific and HLA-DQ8-restricted CD4(+) T cells from human DQ transgenic mice. J Clin Invest (1998) 1.07
Identification of naturally processed HLA-A2--restricted proinsulin epitopes by reverse immunology. Diabetes (2005) 1.06
Pancreatic islet beta cells drive T cell-immune responses in the nonobese diabetic mouse model. J Exp Med (1995) 1.05
DRB1*0401-restricted human T cell clone specific for the major proinsulin73-90 epitope expresses a down-regulatory T helper 2 phenotype. Proc Natl Acad Sci U S A (2006) 1.04
Immunization of HLA class I transgenic mice identifies autoantigenic epitopes eliciting dominant responses in type 1 diabetes patients. J Immunol (2007) 1.01
Changes in autoreactive T cell avidity during type 1 diabetes development. Clin Immunol (2009) 1.01
Clinical spectrum associated with hepatocyte nuclear factor-1beta mutations. Ann Intern Med (2004) 3.32
Acceleration of type 1 diabetes mellitus in proinsulin 2-deficient NOD mice. J Clin Invest (2003) 2.00
Recognition of a subregion of human proinsulin by class I-restricted T cells in type 1 diabetic patients. Proc Natl Acad Sci U S A (2005) 1.35
Antibodies recognizing Mycobacterium avium paratuberculosis epitopes cross-react with the beta-cell antigen ZnT8 in Sardinian type 1 diabetic patients. PLoS One (2011) 1.34
Changes in microRNA expression contribute to pancreatic β-cell dysfunction in prediabetic NOD mice. Diabetes (2012) 1.32
Role of miR-155 in the regulation of lymphocyte immune function and disease. Immunology (2014) 1.23
Mucosal-associated invariant T cell alterations in obese and type 2 diabetic patients. J Clin Invest (2015) 1.15
T cell response to preproinsulin I and II in the nonobese diabetic mouse. J Immunol (2002) 1.15
Microglial changes occur without neural cell death in diabetic retinopathy. Vision Res (2006) 1.06
Serum-free culture medium and IL-7 costimulation increase the sensitivity of ELISpot detection. J Immunol Methods (2008) 1.06
Beyond the hormone: insulin as an autoimmune target in type 1 diabetes. Endocr Rev (2011) 1.04
Insulin secretion: movement at all levels. Diabetes (2002) 0.99
acDCs enhance human antigen-specific T-cell responses. Blood (2011) 0.98
Recognition of human proinsulin leader sequence by class I-restricted T-cells in HLA-A*0201 transgenic mice and in human type 1 diabetes. Diabetes (2008) 0.98
Viral infection prevents diabetes by inducing regulatory T cells through NKT cell-plasmacytoid dendritic cell interplay. J Exp Med (2011) 0.97
CD4(+) type II NKT cells mediate ICOS and programmed death-1-dependent regulation of type 1 diabetes. J Immunol (2012) 0.96
Pancreatic beta-cell mass or beta-cell function? That is the question! Diabetes Obes Metab (2008) 0.93
Tolerance to proinsulin-2 is due to radioresistant thymic cells. J Immunol (2006) 0.92
Altered dendritic cells (DC) might be responsible for regulatory T cell imbalance and autoimmunity in nonobese diabetic (NOD) mice. Eur Cytokine Netw (2002) 0.92
Measurement of CD8 T cell responses in human type 1 diabetes. Ann N Y Acad Sci (2008) 0.91
Role of beta-cells in type 1 diabetes pathogenesis. Diabetes (2005) 0.91
Antigen-based immune therapeutics for type 1 diabetes: magic bullets or ordinary blanks? Clin Dev Immunol (2011) 0.90
HLA class I epitope discovery in type 1 diabetes: independent and reproducible identification of proinsulin epitopes of CD8 T cells--report of the IDS T Cell Workshop Committee. Ann N Y Acad Sci (2006) 0.88
Low SAMHD1 expression following T-cell activation and proliferation renders CD4+ T cells susceptible to HIV-1. AIDS (2015) 0.88
Abrogation of ICOS/ICOS ligand costimulation in NOD mice results in autoimmune deviation toward the neuromuscular system. Eur J Immunol (2010) 0.85
Granulocyte-dendritic cell unbalance in the non-obese diabetic mice. Cell Immunol (2003) 0.85
Evaluation of impaired beta-cell function in nonobese-diabetic (NOD) mouse model using bioluminescence imaging. FASEB J (2010) 0.84
Diagnosing diabetic foot osteomyelitis in patients without signs of soft tissue infection by coupling hybrid 67Ga SPECT/CT with bedside percutaneous bone puncture. Diabetes Care (2013) 0.84
Expression of preproinsulin-2 gene shapes the immune response to preproinsulin in normal mice. J Immunol (2004) 0.84
To B or not to B: (anti)bodies of evidence on the crime scene of type 1 diabetes? Diabetes (2011) 0.84
Cell exhaustion in HIV-1 infection: role of suppressor cells. Curr Opin HIV AIDS (2014) 0.84
Normal renal function 8 to 13 years after cyclosporin A therapy in 285 diabetic patients. Diabetes Metab Res Rev (2002) 0.83
Normal insulin sensitivity during the late preclinical stage of type 1 diabetes. Diabetes Care (2004) 0.83
Pancreatic volume and endocrine and exocrine functions in patients with diabetes. Pancreas (2011) 0.82
Hyperparathyroidism in a patient with autoimmune polyglandular syndrome. Intern Med (2008) 0.82
Insulin and type 1 diabetes: immune connections. Eur J Endocrinol (2013) 0.81
Proinsulin 2 knockout NOD mice: a model for genetic variation of insulin gene expression in type 1 diabetes. Diabetes (2002) 0.81
A tale of two cousins: type 1 and type 2 diabetes. Diabetes (2005) 0.80
Plasmacytoid dendritic cells license regulatory T cells, upon iNKT-cell stimulation, to prevent autoimmune diabetes. Eur J Immunol (2014) 0.80
Inhibition of type 1 diabetes by upregulation of the circadian rhythm-related aryl hydrocarbon receptor nuclear translocator-like 2. Immunogenetics (2010) 0.80
Single insulin-specific CD8+ T cells show characteristic gene expression profiles in human type 1 diabetes. Diabetes (2011) 0.79
HLA-B7-restricted islet epitopes are differentially recognized in type 1 diabetic children and adults and form weak peptide-HLA complexes. Diabetes (2012) 0.79
In obese and non-obese adults, the cis-regulatory rs361072 promoter variant of PIK3CB is associated with insulin resistance not with type 2 diabetes. Mol Genet Metab (2008) 0.79
Mapping of the murine type 1 diabetes locus Idd20 by genetic interaction. Mamm Genome (2006) 0.79
Downregulation of the circadian rhythm related gene Arntl2 suppresses diabetes protection in Idd6 NOD.C3H congenic mice. Clin Exp Pharmacol Physiol (2010) 0.78
A simple and fast non-radioactive bridging immunoassay for insulin autoantibodies. PLoS One (2013) 0.78
The type 1 diabetes locus Idd6 controls TLR1 expression. J Immunol (2007) 0.78
An 8-bp deletion in mNOTCH4 intron 10 leads to its retention in mRNA and to synthesis of a truncated protein. Exp Cell Res (2005) 0.78
The hyperstimulated β-cell: prelude to diabetes? Diabetes Obes Metab (2012) 0.77
The diabetes type 1 locus Idd6 modulates activity of CD4+CD25+ regulatory T-cells. Diabetes (2006) 0.77
Novel factors in the regulation of beta-cell function. Diabetes (2004) 0.75
Influence of a non-NK complex region of chromosome 6 on CD4+ invariant NK T cell homeostasis. J Immunol (2008) 0.75
Of mighty mice and diabetic men: animal models of islet dysfunction. Diabetes Obes Metab (2007) 0.75
Impact of treatment on islet function in type 2 diabetes. Diabetes (2004) 0.75
β-Cell research - A decade of rapid growth. Diabetes Obes Metab (2009) 0.75