Published in Biophys J on November 01, 2003
The cooperative voltage sensor motion that gates a potassium channel. J Gen Physiol (2005) 1.89
A quantitative assessment of models for voltage-dependent gating of ion channels. Proc Natl Acad Sci U S A (2004) 1.63
Specificity of charge-carrying residues in the voltage sensor of potassium channels. J Gen Physiol (2004) 1.60
Molecular models of voltage sensing. J Gen Physiol (2002) 1.53
Conformational changes and slow dynamics through microsecond polarized atomistic molecular simulation of an integral Kv1.2 ion channel. PLoS Comput Biol (2009) 1.51
Voltage-gated proton channels: molecular biology, physiology, and pathophysiology of the H(V) family. Physiol Rev (2013) 1.35
State-dependent electrostatic interactions of S4 arginines with E1 in S2 during Kv7.1 activation. J Gen Physiol (2010) 1.30
An electrostatic potassium channel opener targeting the final voltage sensor transition. J Gen Physiol (2011) 1.25
Alpha-scorpion toxin impairs a conformational change that leads to fast inactivation of muscle sodium channels. J Gen Physiol (2008) 1.17
Molecular dynamics simulation of Kv channel voltage sensor helix in a lipid membrane with applied electric field. Biophys J (2008) 1.13
Coarse grained model for exploring voltage dependent ion channels. Biochim Biophys Acta (2011) 1.02
Modeling subunit cooperativity in opening of tetrameric ion channels. Biophys J (2008) 1.02
Deconstructing thermodynamic parameters of a coupled system from site-specific observables. Proc Natl Acad Sci U S A (2010) 0.97
Membrane bending is critical for the stability of voltage sensor segments in the membrane. J Gen Physiol (2012) 0.97
Multi-scale electrophysiology modeling: from atom to organ. J Gen Physiol (2010) 0.90
Voltage-dependent displacement of the scorpion toxin Ts3 from sodium channels and its implication on the control of inactivation. Br J Pharmacol (2004) 0.90
Coupling between residues on S4 and S1 defines the voltage-sensor resting conformation in NaChBac. Biophys J (2010) 0.89
Molecular dynamics simulations of voltage-gated cation channels: insights on voltage-sensor domain function and modulation. Front Pharmacol (2012) 0.87
Coarse-grained simulations of the gating current in the voltage-activated Kv1.2 channel. Proc Natl Acad Sci U S A (2014) 0.87
Coupling of S4 helix translocation and S6 gating analyzed by molecular-dynamics simulations of mutated Kv channels. Biophys J (2009) 0.86
Continuum molecular simulation of large conformational changes during ion-channel gating. PLoS One (2011) 0.81
How S4 segments move charge. Let me count the ways. J Gen Physiol (2003) 0.81
A Microscopic Capacitor Model of Voltage Coupling in Membrane Proteins: Gating Charge Fluctuations in Ci-VSD. J Phys Chem B (2016) 0.79
The sliding-helix voltage sensor: mesoscale views of a robust structure-function relationship. Eur Biophys J (2012) 0.78
Equilibrium fluctuation relations for voltage coupling in membrane proteins. Biochim Biophys Acta (2015) 0.78
Insights into the structure and function of HV1 from a meta-analysis of mutation studies. J Gen Physiol (2016) 0.78
Electrostatic interaction between dipoles and side chains in the voltage sensor domain of K(+) channel. J Nat Sci Biol Med (2013) 0.78
Effect of dielectric interface on charge aggregation in the voltage-gated K(+) ion channel. J Nat Sci Biol Med (2015) 0.75
A theoretical model for calculating voltage sensitivity of ion channels and the application on Kv1.2 potassium channel. Biophys J (2012) 0.75
X-ray structure of a voltage-dependent K+ channel. Nature (2003) 14.50
Currents related to movement of the gating particles of the sodium channels. Nature (1973) 9.80
Voltage-sensing residues in the S2 and S4 segments of the Shaker K+ channel. Neuron (1996) 8.20
Contribution of the S4 segment to gating charge in the Shaker K+ channel. Neuron (1996) 8.11
Primary structure of Electrophorus electricus sodium channel deduced from cDNA sequence. Nature (1984) 8.02
Shaker potassium channel gating. III: Evaluation of kinetic models for activation. J Gen Physiol (1994) 7.23
The principle of gating charge movement in a voltage-dependent K+ channel. Nature (2003) 6.94
Molecular basis of charge movement in voltage-gated sodium channels. Neuron (1996) 6.61
Transmembrane movement of the shaker K+ channel S4. Neuron (1996) 6.61
Direct physical measure of conformational rearrangement underlying potassium channel gating. Science (1996) 6.31
Sodium channels and gating currents. Physiol Rev (1981) 5.73
Voltage gating of ion channels. Q Rev Biophys (1994) 5.52
Molecular model of the action potential sodium channel. Proc Natl Acad Sci U S A (1986) 4.61
Alteration of voltage-dependence of Shaker potassium channel by mutations in the S4 sequence. Nature (1991) 4.60
Activation of Shaker potassium channels. III. An activation gating model for wild-type and V2 mutant channels. J Gen Physiol (1998) 4.56
Electrostatic interactions of S4 voltage sensor in Shaker K+ channel. Neuron (1995) 4.49
Structure and function of voltage-sensitive ion channels. Science (1988) 4.48
Evidence for voltage-dependent S4 movement in sodium channels. Neuron (1995) 4.21
Molecular properties of voltage-sensitive sodium channels. Annu Rev Biochem (1986) 3.69
Voltage-dependent proton transport by the voltage sensor of the Shaker K+ channel. Neuron (1997) 3.29
Electrostatic interactions between transmembrane segments mediate folding of Shaker K+ channel subunits. Biophys J (1997) 3.17
Voltage-sensing residues in the S4 region of a mammalian K+ channel. Nature (1991) 3.01
Three transmembrane conformations and sequence-dependent displacement of the S4 domain in shaker K+ channel gating. Neuron (1998) 2.98
Histidine scanning mutagenesis of basic residues of the S4 segment of the shaker k+ channel. J Gen Physiol (2001) 2.79
Salt bridge stability in monomeric proteins. J Mol Biol (1999) 2.79
The structure of the voltage-sensitive sodium channel. Inferences derived from computer-aided analysis of the Electrophorus electricus channel primary structure. FEBS Lett (1985) 2.48
Probing protein electrostatics with a synthetic fluorescent amino acid. Science (2002) 2.46
General continuum analysis of transport through pores. I. Proof of Onsager's reciprocity postulate for uniform pore. Biophys J (1975) 2.43
Voltage-dependent structural interactions in the Shaker K(+) channel. J Gen Physiol (2000) 2.31
Measurement of the movement of the S4 segment during the activation of a voltage-gated potassium channel. Pflugers Arch (1997) 2.22
Hydrophobic substitution mutations in the S4 sequence alter voltage-dependent gating in Shaker K+ channels. Neuron (1991) 2.18
Incremental reductions of positive charge within the S4 region of a voltage-gated K+ channel result in corresponding decreases in gating charge. Neuron (1992) 2.09
Electrostatic effects in macromolecules: fundamental concepts and practical modeling. Curr Opin Struct Biol (1998) 2.01
Conformational switch between slow and fast gating modes: allosteric regulation of voltage sensor mobility in the EAG K+ channel. Neuron (2002) 1.95
Independence and cooperativity in rearrangements of a potassium channel voltage sensor revealed by single subunit fluorescence. J Gen Physiol (2000) 1.80
A fluorometric approach to local electric field measurements in a voltage-gated ion channel. Neuron (2003) 1.76
Electrostatics and the gating pore of Shaker potassium channels. J Gen Physiol (2001) 1.72
Structural basis of two-stage voltage-dependent activation in K+ channels. Proc Natl Acad Sci U S A (2003) 1.61
Voltage sensor movements. J Gen Physiol (2002) 1.59
The dielectric properties of water within model transbilayer pores. Biophys J (1997) 1.55
Molecular models of voltage sensing. J Gen Physiol (2002) 1.53
Structural models of the transmembrane region of voltage-gated and other K+ channels in open, closed, and inactivated conformations. J Struct Biol (1998) 1.47
Answers and questions from the KvAP structures. Neuron (2003) 1.30
Divalent cation effects on the Shaker K channel suggest a pentapeptide sequence as determinant of functional surface charge density. J Membr Biol (1998) 1.03
Effect of cysteine substitutions on the topology of the S4 segment of the Shaker potassium channel: implications for molecular models of gating. J Physiol (1999) 1.02
What can be deduced about the structure of Shaker from available data? Novartis Found Symp (2002) 0.89
Voltage-sensing mechanism is conserved among ion channels gated by opposite voltages. Nature (2002) 2.03
Multimeric nature of voltage-gated proton channels. Proc Natl Acad Sci U S A (2008) 2.00
Small-scale molecular motions accomplish glutamate uptake in human glutamate transporters. J Neurosci (2005) 1.93
Hysteresis in the voltage dependence of HCN channels: conversion between two modes affects pacemaker properties. J Gen Physiol (2005) 1.74
The mechanism of sodium and substrate release from the binding pocket of vSGLT. Nature (2010) 1.74
Raw sewage harbors diverse viral populations. MBio (2011) 1.50
Molecular movement of the voltage sensor in a K channel. J Gen Physiol (2003) 1.44
Strong cooperativity between subunits in voltage-gated proton channels. Nat Struct Mol Biol (2009) 1.36
S4 movement in a mammalian HCN channel. J Gen Physiol (2003) 1.36
KCNE1 alters the voltage sensor movements necessary to open the KCNQ1 channel gate. Proc Natl Acad Sci U S A (2010) 1.31
Answers and questions from the KvAP structures. Neuron (2003) 1.30
Slow conformational changes of the voltage sensor during the mode shift in hyperpolarization-activated cyclic-nucleotide-gated channels. J Neurosci (2007) 1.29
A continuum method for determining membrane protein insertion energies and the problem of charged residues. J Gen Physiol (2008) 1.27
Constraint-based, homology model of the extracellular domain of the epithelial Na+ channel α subunit reveals a mechanism of channel activation by proteases. J Biol Chem (2010) 1.23
Kinetic relationship between the voltage sensor and the activation gate in spHCN channels. J Gen Physiol (2007) 1.20
Electrostatic interactions in the channel cavity as an important determinant of potassium channel selectivity. Proc Natl Acad Sci U S A (2006) 1.19
Kv7.1 ion channels require a lipid to couple voltage sensing to pore opening. Proc Natl Acad Sci U S A (2013) 1.18
Mode shifts in the voltage gating of the mouse and human HCN2 and HCN4 channels. J Physiol (2006) 1.17
Meta-analysis: accuracy of quantitative ultrasound for identifying patients with osteoporosis. Ann Intern Med (2006) 1.17
The S4 voltage sensor packs against the pore domain in the KAT1 voltage-gated potassium channel. Neuron (2005) 1.15
Simulations of the alternating access mechanism of the sodium symporter Mhp1. Biophys J (2011) 1.15
APBSmem: a graphical interface for electrostatic calculations at the membrane. PLoS One (2010) 1.12
The electrostatics of VDAC: implications for selectivity and gating. J Mol Biol (2009) 1.11
Voltage-independent sodium-binding events reported by the 4B-4C loop in the human glutamate transporter excitatory amino acid transporter 3. J Biol Chem (2007) 1.08
Getting in sync with dimeric Eg5. Initiation and regulation of the processive run. J Biol Chem (2007) 1.08
Allosteric inhibition of the epithelial Na+ channel through peptide binding at peripheral finger and thumb domains. J Biol Chem (2010) 1.08
Opposite movement of the external gate of a glutamate transporter homolog upon binding cotransported sodium compared with substrate. J Neurosci (2011) 1.06
Allosteric gating mechanism underlies the flexible gating of KCNQ1 potassium channels. Proc Natl Acad Sci U S A (2012) 1.03
Water permeation through the sodium-dependent galactose cotransporter vSGLT. Biophys J (2010) 1.03
Hydrophobic plug functions as a gate in voltage-gated proton channels. Proc Natl Acad Sci U S A (2013) 1.01
Functional apical large conductance, Ca2+-activated, and voltage-dependent K+ channels are required for maintenance of airway surface liquid volume. J Biol Chem (2011) 1.00
Subunit interactions during cooperative opening of voltage-gated proton channels. Neuron (2013) 0.99
Molecular mechanism of voltage sensing in voltage-gated proton channels. J Gen Physiol (2013) 0.99
Membrane bending is critical for the stability of voltage sensor segments in the membrane. J Gen Physiol (2012) 0.97
WESTPA: an interoperable, highly scalable software package for weighted ensemble simulation and analysis. J Chem Theory Comput (2015) 0.96
Simulating rare events using a weighted ensemble-based string method. J Chem Phys (2013) 0.94
A model of lysosomal pH regulation. J Gen Physiol (2013) 0.94
An acid-activated nucleobase transporter from Leishmania major. J Biol Chem (2009) 0.90
Gating of the designed trimeric/tetrameric voltage-gated H+ channel. J Physiol (2012) 0.86
Neurotransmitter transporters: structure meets function. Structure (2013) 0.84
Conformational dynamics of the inner pore helix of voltage-gated potassium channels. J Chem Phys (2009) 0.84
Intracellular Mg2+ is a voltage-dependent pore blocker of HCN channels. Am J Physiol Cell Physiol (2008) 0.84
Continuum approaches to understanding ion and peptide interactions with the membrane. J Membr Biol (2014) 0.80
Simulating Current-Voltage Relationships for a Narrow Ion Channel Using the Weighted Ensemble Method. J Chem Theory Comput (2015) 0.79
Characterization of the PCMBS-dependent modification of KCa3.1 channel gating. J Gen Physiol (2010) 0.79
Permeation mechanism in voltage-activated proton channels: a new glimpse. Proc Natl Acad Sci U S A (2010) 0.75