Published in Nature on October 24, 1991
Shaker potassium channel gating. III: Evaluation of kinetic models for activation. J Gen Physiol (1994) 7.23
Shaker potassium channel gating. II: Transitions in the activation pathway. J Gen Physiol (1994) 4.98
Allosteric gating of a large conductance Ca-activated K+ channel. J Gen Physiol (1997) 3.57
Intrinsic voltage dependence and Ca2+ regulation of mslo large conductance Ca-activated K+ channels. J Gen Physiol (1997) 3.54
Shaker potassium channel gating. I: Transitions near the open state. J Gen Physiol (1994) 3.48
Mutations in the S4 region isolate the final voltage-dependent cooperative step in potassium channel activation. J Gen Physiol (1999) 3.42
Coupling between voltage sensors and activation gate in voltage-gated K+ channels. J Gen Physiol (2002) 3.16
Spectrum of HERG K+-channel dysfunction in an inherited cardiac arrhythmia. Proc Natl Acad Sci U S A (1996) 2.63
Uncharged S4 residues and cooperativity in voltage-dependent potassium channel activation. J Gen Physiol (1998) 2.59
A membrane-based force generation mechanism in auditory sensory cells. Proc Natl Acad Sci U S A (1992) 2.58
Molecular diversity and regulation of renal potassium channels. Physiol Rev (2005) 2.56
Activation of shaker potassium channels. I. Characterization of voltage-dependent transitions. J Gen Physiol (1998) 2.49
alpha-helical structural elements within the voltage-sensing domains of a K(+) channel. J Gen Physiol (2000) 2.46
Role of the S4 in cooperativity of voltage-dependent potassium channel activation. J Gen Physiol (1998) 2.31
Voltage sensitivity and gating charge in Shaker and Shab family potassium channels. J Gen Physiol (1999) 2.27
Total charge movement per channel. The relation between gating charge displacement and the voltage sensitivity of activation. J Gen Physiol (1997) 2.26
A shaker K+ channel with a miniature engineered voltage sensor. Cell (2010) 2.00
Modeling the structure of agitoxin in complex with the Shaker K+ channel: a computational approach based on experimental distance restraints extracted from thermodynamic mutant cycles. Biophys J (2002) 1.98
S4 mutations alter gating currents of Shaker K channels. Biophys J (1994) 1.97
Activation-dependent subconductance levels in the drk1 K channel suggest a subunit basis for ion permeation and gating. Biophys J (1997) 1.77
Localization and molecular determinants of the Hanatoxin receptors on the voltage-sensing domains of a K(+) channel. J Gen Physiol (2000) 1.77
Sodium channel activation gating is affected by substitutions of voltage sensor positive charges in all four domains. J Gen Physiol (1997) 1.72
Transfer of rapid inactivation and sensitivity to the class III antiarrhythmic drug E-4031 from HERG to M-eag channels. J Physiol (1998) 1.72
Characterization of a Shaw-related potassium channel family in rat brain. EMBO J (1992) 1.66
Long QT and ventricular arrhythmias in transgenic mice expressing the N terminus and first transmembrane segment of a voltage-gated potassium channel. Proc Natl Acad Sci U S A (1998) 1.64
Mutation of conserved negatively charged residues in the S2 and S3 transmembrane segments of a mammalian K+ channel selectively modulates channel gating. Proc Natl Acad Sci U S A (1995) 1.56
Mechanism of voltage-dependent gating in skeletal muscle chloride channels. Biophys J (1996) 1.56
Coupling interactions between voltage sensors of the sodium channel as revealed by site-specific measurements. J Gen Physiol (2004) 1.55
Mapping of residues forming the voltage sensor of the voltage-dependent anion-selective channel. Proc Natl Acad Sci U S A (1993) 1.52
Extracellular Mg(2+) modulates slow gating transitions and the opening of Drosophila ether-à-Go-Go potassium channels. J Gen Physiol (2000) 1.39
Changes in local S4 environment provide a voltage-sensing mechanism for mammalian hyperpolarization-activated HCN channels. J Gen Physiol (2003) 1.37
Mg(2+) modulates voltage-dependent activation in ether-à-go-go potassium channels by binding between transmembrane segments S2 and S3. J Gen Physiol (2000) 1.36
Voltage-gated proton channels: molecular biology, physiology, and pathophysiology of the H(V) family. Physiol Rev (2013) 1.35
Electrostatic model of S4 motion in voltage-gated ion channels. Biophys J (2003) 1.32
Role of transmembrane segment S5 on gating of voltage-dependent K+ channels. J Gen Physiol (1997) 1.32
Peptide models for membrane channels. Biochem J (1996) 1.31
Block of the Kir2.1 channel pore by alkylamine analogues of endogenous polyamines. J Gen Physiol (1998) 1.30
Substitution of a hydrophobic residue alters the conformational stability of Shaker K+ channels during gating and assembly. Biophys J (1993) 1.24
Transfer of voltage independence from a rat olfactory channel to the Drosophila ether-à-go-go K+ channel. J Gen Physiol (1997) 1.22
Voltage-insensitive gating after charge-neutralizing mutations in the S4 segment of Shaker channels. J Gen Physiol (1999) 1.22
Determinants of voltage-dependent gating and open-state stability in the S5 segment of Shaker potassium channels. J Gen Physiol (1999) 1.18
Topology of the Shaker potassium channel probed with hydrophilic epitope insertions. J Cell Biol (1997) 1.14
Proper restoration of excitation-contraction coupling in the dihydropyridine receptor beta1-null zebrafish relaxed is an exclusive function of the beta1a subunit. J Biol Chem (2008) 1.14
PIP2 controls voltage-sensor movement and pore opening of Kv channels through the S4-S5 linker. Proc Natl Acad Sci U S A (2012) 1.13
Hill coefficient for estimating the magnitude of cooperativity in gating transitions of voltage-dependent ion channels. Biophys J (2004) 1.13
Voltage-dependent gating characteristics of the K+ channel KAT1 depend on the N and C termini. Proc Natl Acad Sci U S A (1997) 1.11
Mechanism of electromechanical coupling in voltage-gated potassium channels. Front Pharmacol (2012) 1.09
Role of S4 segments and the leucine heptad motif in the activation of an L-type calcium channel. Biophys J (1997) 1.07
Mutations at the GABA receptor selectivity filter: a possible role for effective charges. J Physiol (2003) 1.05
Voltage-gated proton channel in a dinoflagellate. Proc Natl Acad Sci U S A (2011) 1.05
Biophysical characterization of the fluorescent protein voltage probe VSFP2.3 based on the voltage-sensing domain of Ci-VSP. Eur Biophys J (2010) 1.02
Evolutionary imprint of activation: the design principles of VSDs. J Gen Physiol (2014) 1.02
Voltage-dependent gating of single wild-type and S4 mutant KAT1 inward rectifier potassium channels. J Gen Physiol (1998) 1.01
Role of arginine residues on the S4 segment of the Bacillus halodurans Na+ channel in voltage-sensing. J Membr Biol (2004) 1.00
Modulation of 4-AP block of a mammalian A-type K channel clone by channel gating and membrane voltage. Biophys J (1994) 0.97
Effects of Kv1.2 intracellular regions on activation of Kv2.1 channels. Biophys J (2004) 0.95
Internal aluminum block of plant inward K(+) channels. Plant Cell (2001) 0.95
Functional analysis of the Kv1.1 N255D mutation associated with autosomal dominant hypomagnesemia. J Biol Chem (2009) 0.94
Voltage-dependent gating of HERG potassium channels. Front Pharmacol (2012) 0.93
Characterization of the gating brake in the I-II loop of CaV3 T-type calcium channels. Channels (Austin) (2010) 0.92
Energetic role of the paddle motif in voltage gating of Shaker K(+) channels. Nat Struct Mol Biol (2013) 0.92
Action of internal pronase on the f-channel kinetics in the rabbit SA node. J Physiol (1999) 0.90
Functional interactions of voltage sensor charges with an S2 hydrophobic plug in hERG channels. J Gen Physiol (2013) 0.89
Coupling between residues on S4 and S1 defines the voltage-sensor resting conformation in NaChBac. Biophys J (2010) 0.89
Domain cooperativity in the β1a subunit is essential for dihydropyridine receptor voltage sensing in skeletal muscle. Proc Natl Acad Sci U S A (2013) 0.89
Charge scan reveals an extended region at the intracellular end of the GABA receptor pore that can influence ion selectivity. J Gen Physiol (2007) 0.87
Role of Domain IV/S4 outermost arginines in gating of T-type calcium channels. Pflugers Arch (2005) 0.87
A limited 4 Å radial displacement of the S4-S5 linker is sufficient for internal gate closing in Kv channels. J Biol Chem (2012) 0.87
Glutamine substitution at alanine1649 in the S4-S5 cytoplasmic loop of domain 4 removes the voltage sensitivity of fast inactivation in the human heart sodium channel. J Gen Physiol (1998) 0.86
An activation gating switch in Kv1.2 is localized to a threonine residue in the S2-S3 linker. Biophys J (2007) 0.85
Rate-limiting reactions determining different activation kinetics of Kv1.2 and Kv2.1 channels. J Membr Biol (2004) 0.85
Conduits of life's spark: a perspective on ion channel research since the birth of neuron. Neuron (2013) 0.84
A scheme to account for the effects of Rb+ and K+ on inward rectifier K channels of bovine artery endothelial cells. J Gen Physiol (1994) 0.84
Local movement in the S2 region of the voltage-gated potassium channel hKv2.1 studied using cysteine mutagenesis. Biophys J (2000) 0.83
Regulation by external K+ in a maize inward shaker channel targets transport activity in the high concentration range. Plant Cell (2005) 0.83
Probing S4 and S5 segment proximity in mammalian hyperpolarization-activated HCN channels by disulfide bridging and Cd2+ coordination. Pflugers Arch (2008) 0.82
Ins and outs of T-channel structure function. Pflugers Arch (2013) 0.82
Single mutations convert an outward K+ channel into an inward K+ channel. Proc Natl Acad Sci U S A (2008) 0.80
Voltage Sensing in Membranes: From Macroscopic Currents to Molecular Motions. J Membr Biol (2015) 0.80
Revisiting the role of Ca2+ in Shaker K+ channel gating. Biophys J (2001) 0.80
Identification and analysis of cation channel homologues in human pathogenic fungi. PLoS One (2012) 0.79
Drosophila KCNQ channel displays evolutionarily conserved electrophysiology and pharmacology with mammalian KCNQ channels. PLoS One (2011) 0.78
Polarization: A Key Difference between Man-made and Natural Electromagnetic Fields, in regard to Biological Activity. Sci Rep (2015) 0.77
Grafting voltage and pharmacological sensitivity in potassium channels. Cell Res (2016) 0.75
A theoretical model for calculating voltage sensitivity of ion channels and the application on Kv1.2 potassium channel. Biophys J (2012) 0.75
Different modes of Ca channel gating behaviour favoured by dihydropyridine Ca agonists and antagonists. Nature (1984) 10.27
Subunit stoichiometry of a mammalian K+ channel determined by construction of multimeric cDNAs. Neuron (1992) 10.25
Mechanism of ion permeation through calcium channels. Nature (1984) 9.82
Requirement of JNK for stress-induced activation of the cytochrome c-mediated death pathway. Science (2000) 8.56
Calcium channel selectivity for divalent and monovalent cations. Voltage and concentration dependence of single channel current in ventricular heart cells. J Gen Physiol (1986) 6.76
Measurement of Ca2+ concentrations in living cells. Prog Biophys Mol Biol (1982) 6.40
Blockade of current through single calcium channels by Cd2+, Mg2+, and Ca2+. Voltage and concentration dependence of calcium entry into the pore. J Gen Physiol (1986) 5.38
Effect of neonatal circumcision on pain response during subsequent routine vaccination. Lancet (1997) 5.35
A novel type of cardiac calcium channel in ventricular cells. Nature (1985) 5.33
Survival in medically treated patients with homozygous beta-thalassemia. N Engl J Med (1994) 5.32
Prevention of myocardial damage in acute myocardial ischemia by early treatment with intravenous streptokinase. N Engl J Med (1985) 4.87
Efficacy and safety of lidocaine-prilocaine cream for pain during circumcision. N Engl J Med (1997) 4.37
Iron-chelation therapy with oral deferipronein patients with thalassemia major. N Engl J Med (1995) 3.88
Calcium channels: mechanisms of selectivity, permeation, and block. Annu Rev Biophys Biophys Chem (1987) 3.72
Pregnancy outcome following maternal use of the new selective serotonin reuptake inhibitors: a prospective controlled multicenter study. JAMA (1998) 3.67
Measurement of heart rate and Q-T interval in the conscious mouse. Am J Physiol (1998) 3.58
Elementary properties and pharmacological sensitivities of calcium channels in mammalian peripheral neurons. Neuron (1989) 3.45
Fall in mean arterial pressure and fetal growth restriction in pregnancy hypertension: a meta-analysis. Lancet (2000) 3.36
Effect of neonatal circumcision on pain responses during vaccination in boys. Lancet (1995) 3.31
Mechanisms of calcium channel modulation by beta-adrenergic agents and dihydropyridine calcium agonists. J Mol Cell Cardiol (1986) 3.31
Evaluation of penetrating injuries of the neck: prospective study of 223 patients. World J Surg (1997) 3.08
Direct measurement of proton transfer rates to a group controlling the dihydropyridine-sensitive Ca2+ channel. Nature (1987) 3.05
Piracetam therapy does not enhance cognitive functioning in children with down syndrome. Arch Pediatr Adolesc Med (2001) 2.72
Evidence for cooperative interactions in potassium channel gating. Nature (1992) 2.61
Benzodiazepine use in pregnancy and major malformations or oral cleft: meta-analysis of cohort and case-control studies. BMJ (1998) 2.61
Pregnancy outcome following gestational exposure to organic solvents: a prospective controlled study. JAMA (1999) 2.47
Novel mechanism of voltage-dependent gating in L-type calcium channels. Nature (1990) 2.45
Maternal ginseng use associated with neonatal androgenization. JAMA (1990) 2.43
Myosin heavy chain messenger RNA and protein isoform transitions during cardiac hypertrophy. Interaction between hemodynamic and thyroid hormone-induced signals. J Clin Invest (1987) 2.37
Use of misoprostol during pregnancy and Möbius' syndrome in infants. N Engl J Med (1998) 2.35
Chemotherapy with focal therapy can cure intraocular retinoblastoma without radiotherapy. Arch Ophthalmol (1996) 2.35
Directly measured second hand smoke exposure and asthma health outcomes. Thorax (2005) 2.32
Pharmacogenetics of neonatal opioid toxicity following maternal use of codeine during breastfeeding: a case-control study. Clin Pharmacol Ther (2008) 2.31
Neurodevelopment of children exposed in utero to antidepressant drugs. N Engl J Med (1997) 2.21
Gating mechanism of a cloned potassium channel expressed in frog oocytes and mammalian cells. Neuron (1990) 2.20
Socio-economic disparities in preterm birth: causal pathways and mechanisms. Paediatr Perinat Epidemiol (2001) 2.19
Hair concentrations of nicotine and cotinine in women and their newborn infants. JAMA (1994) 2.18
Free magnesium in sheep, ferret and frog striated muscle at rest measured with ion-selective micro-electrodes. J Physiol (1982) 2.17
Combined analgesia and local anesthesia to minimize pain during circumcision. Arch Pediatr Adolesc Med (2000) 2.16
Toxic effects of atenolol consumed during breast feeding. J Pediatr (1989) 2.11
A randomized trial of the cost effectiveness of VA hospital-based home care for the terminally ill. Health Serv Res (1992) 2.09
Neonatal paroxetine withdrawal syndrome. Arch Dis Child Fetal Neonatal Ed (2001) 2.08
Empirical examination of the ability of children to consent to clinical research. J Med Ethics (1998) 2.03
Tenfold errors in administration of drug doses: a neglected iatrogenic disease in pediatrics. Pediatrics (1986) 2.01
Errors by paediatric residents in calculating drug doses. Arch Dis Child (1998) 1.99
Abrupt discontinuation of psychotropic drugs during pregnancy: fear of teratogenic risk and impact of counselling. J Psychiatry Neurosci (2001) 1.99
Enhanced dispersion of repolarization and refractoriness in transgenic mouse hearts promotes reentrant ventricular tachycardia. Circ Res (2000) 1.97
Interactions of protons with single open L-type calcium channels. pH dependence of proton-induced current fluctuations with Cs+, K+, and Na+ as permeant ions. J Gen Physiol (1989) 1.95
Ion permeation through the L-type Ca2+ channel in rat phaeochromocytoma cells: two sets of ion binding sites in the pore. J Physiol (1993) 1.86
Cardiac calcium channels in planar lipid bilayers. L-type channels and calcium-permeable channels open at negative membrane potentials. J Gen Physiol (1988) 1.85
Excitation-contraction coupling in cardiac Purkinje fibers. Effects of cardiotonic steroids on the intracellular [Ca2+] transient, membrane potential, and contraction. J Gen Physiol (1984) 1.85
Characterization of the high-affinity Ca2+ binding sites in the L-type Ca2+ channel pore in rat phaeochromocytoma cells. J Physiol (1993) 1.81
Pharmacokinetic changes during pregnancy and their clinical relevance. Clin Pharmacokinet (1997) 1.80
Birth defects after maternal exposure to corticosteroids: prospective cohort study and meta-analysis of epidemiological studies. Teratology (2000) 1.78
The safety of mesalamine in human pregnancy: a prospective controlled cohort study. Gastroenterology (1998) 1.76
Regulation of vascular endothelial growth factor in cardiac myocytes. Circ Res (1995) 1.75
Safety of the new quinolones in pregnancy. Obstet Gynecol (1994) 1.75
Moderate to heavy caffeine consumption during pregnancy and relationship to spontaneous abortion and abnormal fetal growth: a meta-analysis. Reprod Toxicol (1998) 1.73
Interactions of protons with single open L-type calcium channels. Location of protonation site and dependence of proton-induced current fluctuations on concentration and species of permeant ion. J Gen Physiol (1989) 1.72
Mechanism of gating of T-type calcium channels. J Gen Physiol (1990) 1.70
Penetrating injuries of the neck in patients in stable condition. Physical examination, angiography, or color flow Doppler imaging. Arch Surg (1995) 1.69
Ocular toxicity and antenatal exposure to chloroquine or hydroxychloroquine for rheumatic diseases. Lancet (2001) 1.69
Elevated content of cortisol in hair of patients with severe chronic pain: a novel biomarker for stress. Stress (2008) 1.68
Use of antidepressants by pregnant women: evaluation of perception of risk, efficacy of evidence based counseling and determinants of decision making. Arch Womens Ment Health (2005) 1.68
An assessment of cortisol analysis in hair and its clinical applications. Forensic Sci Int (2010) 1.66
Postoperative morphine infusion in newborn infants: assessment of disposition characteristics and safety. J Pediatr (1985) 1.65
Long QT and ventricular arrhythmias in transgenic mice expressing the N terminus and first transmembrane segment of a voltage-gated potassium channel. Proc Natl Acad Sci U S A (1998) 1.64
Calcium channels in planar lipid bilayers: insights into mechanisms of ion permeation and gating. Science (1986) 1.63
Determination of gestational cocaine exposure by hair analysis. JAMA (1989) 1.63
The reproductive effects of beta interferon therapy in pregnancy: a longitudinal cohort. Neurology (2005) 1.62
Repeated doses of porcine secretin in the treatment of autism: a randomized, placebo-controlled trial. Pediatrics (2001) 1.62
Arthropathy in thalassaemia patients receiving deferiprone. Lancet (1994) 1.62
Excitation-contraction coupling in cardiac Purkinje fibers. Effects of caffeine on the intracellular [Ca2+] transient, membrane currents, and contraction. J Gen Physiol (1984) 1.60
Efficacy of prilocaine-lidocaine cream in the treatment of premature ejaculation. J Urol (1995) 1.60
Therapeutic abortions due to severe morning sickness. Unacceptable combination. Can Fam Physician (1997) 1.59
Camphorated oil: still endangering the lives of Canadian children. CMAJ (1995) 1.58
Combining cyclosporin with chemotherapy controls intraocular retinoblastoma without requiring radiation. Clin Cancer Res (1996) 1.57
Accidental electric shock in pregnancy: a prospective cohort study. Am J Obstet Gynecol (1997) 1.55
Characteristics of pregnant women who engage in binge alcohol consumption. CMAJ (1997) 1.53
Safety of metronidazole in pregnancy: a meta-analysis. Am J Obstet Gynecol (1995) 1.53
Outpatient treatment of croup with nebulized dexamethasone. Arch Pediatr Adolesc Med (1996) 1.52
Tibial hemimelia and tetralogy of Fallot associated with first trimester exposure to amantadine. Reprod Toxicol (1994) 1.52
Methotrexate-nonsteroidal antiinflammatory drug interaction in children with arthritis. J Rheumatol (1990) 1.48
Conformational changes associated with ion permeation in L-type calcium channels. Nature (1988) 1.48
Gastric-outlet obstruction induced by prostaglandin therapy in neonates. N Engl J Med (1992) 1.47
Reversible uncoupling of inactivation in N-type calcium channels. Nature (1991) 1.47
The association between maternal cigarette smoking and psychiatric diseases or criminal outcome in the offspring: a precautionary note about the assumption of causation. Reprod Toxicol (1999) 1.47
Intranasal midazolam for febrile seizures. A step forward in treating a common and distressing condition. BMJ (2000) 1.45
Communicating pharmacogenetic research results to breastfeeding mothers taking codeine: a pilot study of perceptions and benefits. Clin Pharmacol Ther (2010) 1.44
Hair analysis provides a historical record of cortisol levels in Cushing's syndrome. Exp Clin Endocrinol Diabetes (2009) 1.44
Mechanism of anaphylactoid reactions: improper preparation of high-dose intravenous cyclosporine leads to bolus infusion of Cremophor EL and cyclosporine. Ann Pharmacother (1997) 1.43
Does fibrin glue reduce complications after femoral artery surgery? A randomised trial. Eur J Vasc Endovasc Surg (2002) 1.43
The safety of dextromethorphan in pregnancy : results of a controlled study. Chest (2001) 1.42
Tumor seeding from percutaneous biliary catheters. Ann Surg (1989) 1.41
The safety of astemizole in pregnancy. J Allergy Clin Immunol (1996) 1.41
Relationship between gestational cocaine use and pregnancy outcome: a meta-analysis. Teratology (1991) 1.40
Pregnancy outcome of women transfused during pregnancy with blood products inadvertently obtained from donors treated with acitretin. J Obstet Gynaecol (2009) 1.39
Maternal and fetal effects of intravenous patient-controlled fentanyl analgesia during labour in a thrombocytopenic parturient. Can J Anaesth (1992) 1.39
Carbamazepine interference with an immune assay for tricyclic antidepressants in plasma. J Toxicol Clin Toxicol (1998) 1.39