X-ray structure of a voltage-dependent K+ channel.

Inositol trisphosphate receptor Ca2+ release channels. Physiol Rev (2007) 5.95

Light-activated ion channels for remote control of neuronal firing. Nat Neurosci (2004) 4.42

A gating charge transfer center in voltage sensors. Science (2010) 3.60

Structural mechanism of C-type inactivation in K(+) channels. Nature (2010) 3.30

Structure of the KvAP voltage-dependent K+ channel and its dependence on the lipid membrane. Proc Natl Acad Sci U S A (2005) 3.25

Sodium channel mutations in epilepsy and other neurological disorders. J Clin Invest (2005) 3.17

Ion channel voltage sensors: structure, function, and pathophysiology. Neuron (2010) 3.16

Structure of a eukaryotic CLC transporter defines an intermediate state in the transport cycle. Science (2010) 3.00

Crystal structure of an orthologue of the NaChBac voltage-gated sodium channel. Nature (2012) 2.97

Interface connections of a transmembrane voltage sensor. Proc Natl Acad Sci U S A (2005) 2.92

Intracellular Ca2+ and the phospholipid PIP2 regulate the taste transduction ion channel TRPM5. Proc Natl Acad Sci U S A (2003) 2.91

Voltage sensor conformations in the open and closed states in ROSETTA structural models of K(+) channels. Proc Natl Acad Sci U S A (2006) 2.81

Crystal structure of the mammalian GIRK2 K+ channel and gating regulation by G proteins, PIP2, and sodium. Cell (2011) 2.69

Nanoliter microfluidic hybrid method for simultaneous screening and optimization validated with crystallization of membrane proteins. Proc Natl Acad Sci U S A (2006) 2.66

Sensing voltage across lipid membranes. Nature (2008) 2.66

Molecular diversity and regulation of renal potassium channels. Physiol Rev (2005) 2.56

Distribution of amino acids in a lipid bilayer from computer simulations. Biophys J (2008) 2.53

Modelling insecticide-binding sites in the voltage-gated sodium channel. Biochem J (2006) 2.43

Portability of paddle motif function and pharmacology in voltage sensors. Nature (2007) 2.43

The pore structure of the closed RyR1 channel. Structure (2005) 2.42

Tuning ion coordination architectures to enable selective partitioning. Biophys J (2007) 2.38

Crystal structure of full-length KcsA in its closed conformation. Proc Natl Acad Sci U S A (2009) 2.35

Deconstructing voltage sensor function and pharmacology in sodium channels. Nature (2008) 2.32

The voltage-gated proton channel Hv1 has two pores, each controlled by one voltage sensor. Neuron (2008) 2.26

Partitioning of amino acid side chains into lipid bilayers: results from computer simulations and comparison to experiment. J Gen Physiol (2007) 2.25

Organic compatible solutes of halotolerant and halophilic microorganisms. Saline Systems (2005) 2.22

The structure of an open form of an E. coli mechanosensitive channel at 3.45 A resolution. Science (2008) 2.21

Small vertical movement of a K+ channel voltage sensor measured with luminescence energy transfer. Nature (2005) 2.18

Structure and hydration of membranes embedded with voltage-sensing domains. Nature (2009) 2.15

Thermosensitive TRP channel pore turret is part of the temperature activation pathway. Proc Natl Acad Sci U S A (2010) 2.15

Two separate interfaces between the voltage sensor and pore are required for the function of voltage-dependent K(+) channels. PLoS Biol (2009) 2.12

Dynamics of the Kv1.2 voltage-gated K+ channel in a membrane environment. Biophys J (2007) 2.10

Structure of the BK potassium channel in a lipid membrane from electron cryomicroscopy. Nature (2009) 2.08

NMR study of the tetrameric KcsA potassium channel in detergent micelles. Protein Sci (2006) 2.07

Structure of the full-length Shaker potassium channel Kv1.2 by normal-mode-based X-ray crystallographic refinement. Proc Natl Acad Sci U S A (2010) 2.02

X-ray structure of the mammalian GIRK2-βγ G-protein complex. Nature (2013) 2.02

Engineering of a genetically encodable fluorescent voltage sensor exploiting fast Ci-VSP voltage-sensing movements. PLoS One (2008) 2.01

Molecular dynamics study of gating in the mechanosensitive channel of small conductance MscS. Biophys J (2004) 2.00

A shaker K+ channel with a miniature engineered voltage sensor. Cell (2010) 2.00

A monoclonal antibody that targets a NaV1.7 channel voltage sensor for pain and itch relief. Cell (2014) 1.99

Dimeric subunit stoichiometry of the human voltage-dependent proton channel Hv1. Proc Natl Acad Sci U S A (2008) 1.95

The design of guanidinium-rich transporters and their internalization mechanisms. Adv Drug Deliv Rev (2007) 1.91

The cooperative voltage sensor motion that gates a potassium channel. J Gen Physiol (2005) 1.89

Measurement of single macromolecule orientation by total internal reflection fluorescence polarization microscopy. Biophys J (2005) 1.88

Calculation of the gating charge for the Kv1.2 voltage-activated potassium channel. Biophys J (2010) 1.87

The structure of the prokaryotic cyclic nucleotide-modulated potassium channel MloK1 at 16 A resolution. Structure (2007) 1.86

The pore helix dipole has a minor role in inward rectifier channel function. Neuron (2005) 1.86

Conformational dynamics of the KcsA potassium channel governs gating properties. Nat Struct Mol Biol (2007) 1.86

Gating of the bacterial sodium channel, NaChBac: voltage-dependent charge movement and gating currents. J Gen Physiol (2004) 1.83

Regulation of sodium channel function by bilayer elasticity: the importance of hydrophobic coupling. Effects of Micelle-forming amphiphiles and cholesterol. J Gen Physiol (2004) 1.83

The role of loop 5 in acetylcholine receptor channel gating. J Gen Physiol (2003) 1.82

Role of charged residues in the S1-S4 voltage sensor of BK channels. J Gen Physiol (2006) 1.82

Mapping the BKCa channel's "Ca2+ bowl": side-chains essential for Ca2+ sensing. J Gen Physiol (2004) 1.82

A quantitative description of KcsA gating I: macroscopic currents. J Gen Physiol (2007) 1.78

Coordinated movement of cytoplasmic and transmembrane domains of RyR1 upon gating. PLoS Biol (2009) 1.77

Structure of TRPV1 channel revealed by electron cryomicroscopy. Proc Natl Acad Sci U S A (2008) 1.77

Side-chain hydrophobicity scale derived from transmembrane protein folding into lipid bilayers. Proc Natl Acad Sci U S A (2011) 1.77

Detection of the opening of the bundle crossing in KcsA with fluorescence lifetime spectroscopy reveals the existence of two gates for ion conduction. J Gen Physiol (2006) 1.71

Tarantula toxins interacting with voltage sensors in potassium channels. Toxicon (2006) 1.69

Structural basis for gating charge movement in the voltage sensor of a sodium channel. Proc Natl Acad Sci U S A (2011) 1.68

The membrane potential and its representation by a constant electric field in computer simulations. Biophys J (2008) 1.68

Interaction of KCNE subunits with the KCNQ1 K+ channel pore. J Physiol (2005) 1.66

Structural dynamics of an isolated voltage-sensor domain in a lipid bilayer. Structure (2008) 1.64

A voltage-sensor water pore. Biophys J (2006) 1.63

Transient outward potassium current, 'Ito', phenotypes in the mammalian left ventricle: underlying molecular, cellular and biophysical mechanisms. J Physiol (2005) 1.63

A quantitative assessment of models for voltage-dependent gating of ion channels. Proc Natl Acad Sci U S A (2004) 1.63

Neurological perspectives on voltage-gated sodium channels. Brain (2012) 1.62

Structure of a mammalian ryanodine receptor. Nature (2014) 1.61

Specificity of charge-carrying residues in the voltage sensor of potassium channels. J Gen Physiol (2004) 1.60

Bilayer deformation by the Kv channel voltage sensor domain revealed by self-assembly simulations. Proc Natl Acad Sci U S A (2007) 1.59

Charges in the hydrophobic interior of proteins. Proc Natl Acad Sci U S A (2010) 1.59

Arginine in membranes: the connection between molecular dynamics simulations and translocon-mediated insertion experiments. J Membr Biol (2010) 1.58

Mechanosensitivity of Nav1.5, a voltage-sensitive sodium channel. J Physiol (2010) 1.58

Structure and function of the voltage sensor of sodium channels probed by a beta-scorpion toxin. J Biol Chem (2006) 1.58

Tarantula toxins interact with voltage sensors within lipid membranes. J Gen Physiol (2007) 1.58

Membrane protein structure determination using crystallography and lipidic mesophases: recent advances and successes. Biochemistry (2012) 1.57

Genetically encoded fluorescent sensors of membrane potential. Brain Cell Biol (2008) 1.57

State-independent block of BK channels by an intracellular quaternary ammonium. J Gen Physiol (2006) 1.57

Overcoming the challenges of membrane protein crystallography. Curr Opin Struct Biol (2008) 1.57

Crystal structure of the ternary complex of a NaV C-terminal domain, a fibroblast growth factor homologous factor, and calmodulin. Structure (2012) 1.56

Interactions between lipids and voltage sensor paddles detected with tarantula toxins. Nat Struct Mol Biol (2009) 1.56

Coupling interactions between voltage sensors of the sodium channel as revealed by site-specific measurements. J Gen Physiol (2004) 1.55

Molecular modeling and dynamics studies with explicit inclusion of electronic polarizability. Theory and applications. Theor Chem Acc (2009) 1.54

A semisynthetic Eph receptor tyrosine kinase provides insight into ligand-induced kinase activation. Chem Biol (2011) 1.54

Stoichiometry of the KCNQ1 - KCNE1 ion channel complex. Proc Natl Acad Sci U S A (2010) 1.54

K+ channel modulators for the treatment of neurological disorders and autoimmune diseases. Chem Rev (2008) 1.52

Structural mechanism of voltage-dependent gating in an isolated voltage-sensing domain. Nat Struct Mol Biol (2014) 1.51

Investigating the putative glycine hinge in Shaker potassium channel. J Gen Physiol (2005) 1.50

Unique inner pore properties of BK channels revealed by quaternary ammonium block. J Gen Physiol (2004) 1.50

Functional reconstitution of purified human Hv1 H+ channels. J Mol Biol (2009) 1.50

Intermediate states of the Kv1.2 voltage sensor from atomistic molecular dynamics simulations. Proc Natl Acad Sci U S A (2011) 1.49

Mechanosensitive ion channels and the peptide inhibitor GsMTx-4: history, properties, mechanisms and pharmacology. Toxicon (2006) 1.49

Cryo-EM Structures of the Magnesium Channel CorA Reveal Symmetry Break upon Gating. Cell (2016) 1.48

Structural analysis of ion selectivity in the NaK channel. Nat Struct Mol Biol (2008) 1.48

Constitutive activation of the Shaker Kv channel. J Gen Physiol (2003) 1.47

How does a voltage sensor interact with a lipid bilayer? Simulations of a potassium channel domain. Structure (2007) 1.46

Solution structure and phospholipid interactions of the isolated voltage-sensor domain from KvAP. J Mol Biol (2010) 1.45

Molecular movement of the voltage sensor in a K channel. J Gen Physiol (2003) 1.44

Reversed voltage-dependent gating of a bacterial sodium channel with proline substitutions in the S6 transmembrane segment. Proc Natl Acad Sci U S A (2004) 1.44

An aqueous H+ permeation pathway in the voltage-gated proton channel Hv1. Nat Struct Mol Biol (2010) 1.44

Atomic structure of a voltage-dependent K+ channel in a lipid membrane-like environment. Nature (2007) 12.35

A PHD finger of NURF couples histone H3 lysine 4 trimethylation with chromatin remodelling. Nature (2006) 10.73

Crystal structure and mechanism of a calcium-gated potassium channel. Nature (2002) 10.03

X-ray structure of a ClC chloride channel at 3.0 A reveals the molecular basis of anion selectivity. Nature (2002) 9.96

The open pore conformation of potassium channels. Nature (2002) 9.09

Sequence and structural convergence of broad and potent HIV antibodies that mimic CD4 binding. Science (2011) 9.00

The principle of gating charge movement in a voltage-dependent K+ channel. Nature (2003) 6.94

The molecular architecture of the nuclear pore complex. Nature (2007) 6.93

Distinct regulation of autophagic activity by Atg14L and Rubicon associated with Beclin 1-phosphatidylinositol-3-kinase complex. Nat Cell Biol (2009) 6.69

Proteomic analysis of the mammalian nuclear pore complex. J Cell Biol (2002) 6.38

Physical association and coordinate function of the H3 K4 methyltransferase MLL1 and the H4 K16 acetyltransferase MOF. Cell (2005) 6.12

Association between endometriosis and risk of histological subtypes of ovarian cancer: a pooled analysis of case-control studies. Lancet Oncol (2012) 5.70

Ezh2 controls B cell development through histone H3 methylation and Igh rearrangement. Nat Immunol (2002) 5.67

Gating the selectivity filter in ClC chloride channels. Science (2003) 5.55

Determining the architectures of macromolecular assemblies. Nature (2007) 4.94

The N-CoR-HDAC3 nuclear receptor corepressor complex inhibits the JNK pathway through the integral subunit GPS2. Mol Cell (2002) 3.99

Phospholipids and the origin of cationic gating charges in voltage sensors. Nature (2006) 3.99

Essential role for autophagy protein Atg7 in the maintenance of axonal homeostasis and the prevention of axonal degeneration. Proc Natl Acad Sci U S A (2007) 3.92

Yng1 PHD finger binding to H3 trimethylated at K4 promotes NuA3 HAT activity at K14 of H3 and transcription at a subset of targeted ORFs. Mol Cell (2006) 3.87

The Drosophila pheromone cVA activates a sexually dimorphic neural circuit. Nature (2008) 3.65

A gating charge transfer center in voltage sensors. Science (2010) 3.60

Methylation of a histone mimic within the histone methyltransferase G9a regulates protein complex assembly. Mol Cell (2007) 3.51

Crystal structure of the eukaryotic strong inward-rectifier K+ channel Kir2.2 at 3.1 A resolution. Science (2009) 3.48

Energetics of pore opening in a voltage-gated K(+) channel. Cell (2002) 3.36

Crystal structure of a Kir3.1-prokaryotic Kir channel chimera. EMBO J (2007) 3.31

ABI5 acts downstream of ABI3 to execute an ABA-dependent growth arrest during germination. Plant J (2002) 3.28

Induction of autophagy in axonal dystrophy and degeneration. J Neurosci (2006) 3.28

Structural basis of inward rectification: cytoplasmic pore of the G protein-gated inward rectifier GIRK1 at 1.8 A resolution. Cell (2002) 3.26

POT1-interacting protein PIP1: a telomere length regulator that recruits POT1 to the TIN2/TRF1 complex. Genes Dev (2004) 3.25

Structure of the KvAP voltage-dependent K+ channel and its dependence on the lipid membrane. Proc Natl Acad Sci U S A (2005) 3.25

Structural basis of PIP2 activation of the classical inward rectifier K+ channel Kir2.2. Nature (2011) 3.14

The occupancy of ions in the K+ selectivity filter: charge balance and coupling of ion binding to a protein conformational change underlie high conduction rates. J Mol Biol (2003) 3.08

Structure of the human BK channel Ca2+-activation apparatus at 3.0 A resolution. Science (2010) 3.03

Rif1 prevents resection of DNA breaks and promotes immunoglobulin class switching. Science (2013) 3.02

Structure of a eukaryotic CLC transporter defines an intermediate state in the transport cycle. Science (2010) 3.00

Fluorescent proteins as proteomic probes. Mol Cell Proteomics (2005) 2.98

Calibrated measurement of gating-charge arginine displacement in the KvAP voltage-dependent K+ channel. Cell (2005) 2.97

Crystal structure of the human K2P TRAAK, a lipid- and mechano-sensitive K+ ion channel. Science (2012) 2.94

Components of coated vesicles and nuclear pore complexes share a common molecular architecture. PLoS Biol (2004) 2.90

A membrane-access mechanism of ion channel inhibition by voltage sensor toxins from spider venom. Nature (2004) 2.74

Crystal structure of the mammalian GIRK2 K+ channel and gating regulation by G proteins, PIP2, and sodium. Cell (2011) 2.69

Virtual gating and nuclear transport: the hole picture. Trends Cell Biol (2003) 2.68

Comprehensive analysis of diverse ribonucleoprotein complexes. Nat Methods (2007) 2.55

Long-distance combinatorial linkage between methylation and acetylation on histone H3 N termini. Proc Natl Acad Sci U S A (2007) 2.43

Functional analysis of an archaebacterial voltage-dependent K+ channel. Nature (2003) 2.42

Treatment responses in Asians and Caucasians with chronic hepatitis C infection. World J Gastroenterol (2008) 2.39

Lipids in the structure, folding, and function of the KcsA K+ channel. Biochemistry (2002) 2.37

TIN2 binds TRF1 and TRF2 simultaneously and stabilizes the TRF2 complex on telomeres. J Biol Chem (2004) 2.36

Simple fold composition and modular architecture of the nuclear pore complex. Proc Natl Acad Sci U S A (2006) 2.35

A conserved coatomer-related complex containing Sec13 and Seh1 dynamically associates with the vacuole in Saccharomyces cerevisiae. Mol Cell Proteomics (2011) 2.34

Chromosomal enrichment and activation of the aurora B pathway are coupled to spatially regulate spindle assembly. Dev Cell (2007) 2.25

Random convergence of olfactory inputs in the Drosophila mushroom body. Nature (2013) 2.12

Two separate interfaces between the voltage sensor and pore are required for the function of voltage-dependent K(+) channels. PLoS Biol (2009) 2.12

Structural and thermodynamic properties of selective ion binding in a K+ channel. PLoS Biol (2007) 2.10

Chromatin-bound Xenopus Dppa2 shapes the nucleus by locally inhibiting microtubule assembly. Dev Cell (2013) 2.09

Voltage-dependent K+ channel gating and voltage sensor toxin sensitivity depend on the mechanical state of the lipid membrane. Proc Natl Acad Sci U S A (2008) 2.07

DAS181, a novel sialidase fusion protein, protects mice from lethal avian influenza H5N1 virus infection. J Infect Dis (2007) 2.02

X-ray structure of the mammalian GIRK2-βγ G-protein complex. Nature (2013) 2.02

Tracking and elucidating alphavirus-host protein interactions. J Biol Chem (2006) 2.01

Polyglutamine-expanded ataxin-7 inhibits STAGA histone acetyltransferase activity to produce retinal degeneration. Proc Natl Acad Sci U S A (2005) 1.97

Regulation of hypermutation by activation-induced cytidine deaminase phosphorylation. Proc Natl Acad Sci U S A (2006) 1.95

Proteomic and genomic characterization of chromatin complexes at a boundary. J Cell Biol (2005) 1.92

E protein silencing by the leukemogenic AML1-ETO fusion protein. Science (2004) 1.89

Artificial nanopores that mimic the transport selectivity of the nuclear pore complex. Nature (2008) 1.89

I-DIRT, a general method for distinguishing between specific and nonspecific protein interactions. J Proteome Res (2005) 1.87

MED1/TRAP220 exists predominantly in a TRAP/ Mediator subpopulation enriched in RNA polymerase II and is required for ER-mediated transcription. Mol Cell (2005) 1.85

Human cytomegalovirus protein UL38 inhibits host cell stress responses by antagonizing the tuberous sclerosis protein complex. Cell Host Microbe (2008) 1.85

A modular cross-linking approach for exploring protein interactions. J Am Chem Soc (2003) 1.85

Regulation of class switch recombination and somatic mutation by AID phosphorylation. J Exp Med (2008) 1.78

Simple kinetic relationships and nonspecific competition govern nuclear import rates in vivo. J Cell Biol (2006) 1.78

Human cytomegalovirus pUL83 stimulates activity of the viral immediate-early promoter through its interaction with the cellular IFI16 protein. J Virol (2010) 1.78

Identification of SMARCAL1 as a component of the DNA damage response. J Biol Chem (2009) 1.74

Evidence for a shared nuclear pore complex architecture that is conserved from the last common eukaryotic ancestor. Mol Cell Proteomics (2009) 1.74

Long range allosteric control of cytoplasmic dynein ATPase activity by the stalk and C-terminal domains. J Biol Chem (2005) 1.68

Ku80 removal from DNA through double strand break-induced ubiquitylation. J Cell Biol (2008) 1.64

Cell-cycle-dependent phosphorylation of the nuclear pore Nup107-160 subcomplex. Proc Natl Acad Sci U S A (2007) 1.64

Detection of secreted peptides by using hypothesis-driven multistage mass spectrometry. Proc Natl Acad Sci U S A (2003) 1.63

Electron microscopic analysis of KvAP voltage-dependent K+ channels in an open conformation. Nature (2004) 1.61