Published in Nat Immunol on November 01, 2003
Defective B cell tolerance checkpoints in systemic lupus erythematosus. J Exp Med (2005) 4.16
Casein kinase 1alpha governs antigen-receptor-induced NF-kappaB activation and human lymphoma cell survival. Nature (2008) 1.91
A scaffold protein, AHNAK1, is required for calcium signaling during T cell activation. Immunity (2008) 1.78
PKC beta regulates BCR-mediated IKK activation by facilitating the interaction between TAK1 and CARMA1. J Exp Med (2005) 1.57
BDCA2/Fc epsilon RI gamma complex signals through a novel BCR-like pathway in human plasmacytoid dendritic cells. PLoS Biol (2007) 1.49
Discs large (Dlg1) complexes in lymphocyte activation. J Cell Biol (2004) 1.43
Regulation of autoreactive B cell responses to endogenous TLR ligands. Autoimmunity (2010) 1.35
Monophosphorylation of CD79a and CD79b ITAM motifs initiates a SHIP-1 phosphatase-mediated inhibitory signaling cascade required for B cell anergy. Immunity (2011) 1.27
Suppression of phosphatidylinositol 3,4,5-trisphosphate production is a key determinant of B cell anergy. Immunity (2009) 1.23
A novel pathway down-modulating T cell activation involves HPK-1-dependent recruitment of 14-3-3 proteins on SLP-76. J Exp Med (2007) 1.17
The quantal theory of how the immune system discriminates between "self and non-self" Med Immunol (2004) 1.13
A CD38/CD203a/CD73 ectoenzymatic pathway independent of CD39 drives a novel adenosinergic loop in human T lymphocytes. Oncoimmunology (2013) 1.07
Endocytic sequestration of the B cell antigen receptor and toll-like receptor 9 in anergic cells. Proc Natl Acad Sci U S A (2009) 1.06
Signaling and ligand interaction of ILT7: receptor-mediated regulatory mechanisms for plasmacytoid dendritic cells. Immunol Rev (2010) 1.02
The riddle of the dual expression of IgM and IgD. Immunology (2006) 0.99
Axotrophin and leukaemia inhibitory factor (LIF) in transplantation tolerance. Philos Trans R Soc Lond B Biol Sci (2005) 0.98
Modulation of peripheral B cell tolerance by CD72 in a murine model. Arthritis Rheum (2008) 0.92
Flow cytometric assessment of the signaling status of human B lymphocytes from normal and autoimmune individuals. Arthritis Res Ther (2004) 0.91
Molecular characterization of human plasmacytoid dendritic cells. J Clin Immunol (2009) 0.91
Continuous inhibitory signaling by both SHP-1 and SHIP-1 pathways is required to maintain unresponsiveness of anergic B cells. J Exp Med (2016) 0.90
Molecular basis of lysophosphatidic acid-induced NF-κB activation. Cell Signal (2010) 0.89
B-cell receptor activation inhibits AID expression through calmodulin inhibition of E-proteins. Proc Natl Acad Sci U S A (2008) 0.86
CIN85 drives B cell responses by linking BCR signals to the canonical NF-kappaB pathway. J Exp Med (2011) 0.85
Receptors, subcellular compartments and the regulation of peripheral B cell responses: the illuminating state of anergy. Mol Immunol (2010) 0.84
Protein kinase C-δ negatively regulates T cell receptor-induced NF-κB activation by inhibiting the assembly of CARMA1 signalosome. J Biol Chem (2012) 0.82
B cells in glomerulonephritis: focus on lupus nephritis. Semin Immunopathol (2007) 0.82
A phosphorylation site in Bruton's tyrosine kinase selectively regulates B cell calcium signaling efficiency by altering phospholipase C-gamma activation. Proc Natl Acad Sci U S A (2004) 0.80
Bcl10 can promote survival of antigen-stimulated B lymphocytes. Blood (2005) 0.79
Ovalbumin sensitization of guinea pig at birth prevents the ontogenetic decrease in airway smooth muscle responsiveness. Physiol Rep (2014) 0.75
A RING-type ubiquitin ligase family member required to repress follicular helper T cells and autoimmunity. Nature (2005) 6.31
Aire regulates negative selection of organ-specific T cells. Nat Immunol (2003) 5.85
Two levels of protection for the B cell genome during somatic hypermutation. Nature (2008) 5.32
DNA repair is limiting for haematopoietic stem cells during ageing. Nature (2007) 4.71
Aberrant mucin assembly in mice causes endoplasmic reticulum stress and spontaneous inflammation resembling ulcerative colitis. PLoS Med (2008) 4.24
Expansion of circulating T cells resembling follicular helper T cells is a fixed phenotype that identifies a subset of severe systemic lupus erythematosus. Arthritis Rheum (2010) 3.76
Identifying the MAGUK protein Carma-1 as a central regulator of humoral immune responses and atopy by genome-wide mouse mutagenesis. Immunity (2003) 3.36
Roquin represses autoimmunity by limiting inducible T-cell co-stimulator messenger RNA. Nature (2007) 3.08
Burst-enhancing role of the IgG membrane tail as a molecular determinant of memory. Nat Immunol (2002) 2.84
Developmental kinetics, turnover, and stimulatory capacity of thymic epithelial cells. Blood (2006) 2.72
Gene dosage--limiting role of Aire in thymic expression, clonal deletion, and organ-specific autoimmunity. J Exp Med (2004) 2.43
Dock8 mutations cripple B cell immunological synapses, germinal centers and long-lived antibody production. Nat Immunol (2009) 2.29
Aire regulates the transfer of antigen from mTECs to dendritic cells for induction of thymic tolerance. Blood (2011) 2.25
ATP11C is critical for the internalization of phosphatidylserine and differentiation of B lymphocytes. Nat Immunol (2011) 2.21
Memory T cell RNA rearrangement programmed by heterogeneous nuclear ribonucleoprotein hnRNPLL. Immunity (2008) 2.13
The actin regulator coronin 1A is mutant in a thymic egress-deficient mouse strain and in a patient with severe combined immunodeficiency. Nat Immunol (2008) 1.97
Themis is a member of a new metazoan gene family and is required for the completion of thymocyte positive selection. Nat Immunol (2009) 1.84
Opposing functions of the T cell receptor kinase ZAP-70 in immunity and tolerance differentially titrate in response to nucleotide substitutions. Immunity (2007) 1.83
Enhancement and suppression of signaling by the conserved tail of IgG memory-type B cell antigen receptors. J Exp Med (2007) 1.82
DOCK8 deficiency impairs CD8 T cell survival and function in humans and mice. J Exp Med (2011) 1.79
A mouse forward genetics screen identifies LISTERIN as an E3 ubiquitin ligase involved in neurodegeneration. Proc Natl Acad Sci U S A (2009) 1.74
Axon growth and guidance genes identify T-dependent germinal centre B cells. Immunol Cell Biol (2007) 1.60
Failure to censor forbidden clones of CD4 T cells in autoimmune diabetes. J Exp Med (2002) 1.58
Generalized resistance to thymic deletion in the NOD mouse; a polygenic trait characterized by defective induction of Bim. Immunity (2004) 1.57
Widespread failure of hematolymphoid differentiation caused by a recessive niche-filling allele of the Ikaros transcription factor. Immunity (2003) 1.51
CD83 increases MHC II and CD86 on dendritic cells by opposing IL-10-driven MARCH1-mediated ubiquitination and degradation. J Exp Med (2011) 1.42
CD45-Csk phosphatase-kinase titration uncouples basal and inducible T cell receptor signaling during thymic development. Immunity (2010) 1.39
ENU-mutagenesis: insight into immune function and pathology. Curr Opin Immunol (2006) 1.35
Resistance to CpG DNA-induced autoimmunity through tolerogenic B cell antigen receptor ERK signaling. Nat Immunol (2003) 1.26
Helios marks strongly autoreactive CD4+ T cells in two major waves of thymic deletion distinguished by induction of PD-1 or NF-κB. J Exp Med (2013) 1.26
Roquin-2 shares functions with its paralog Roquin-1 in the repression of mRNAs controlling T follicular helper cells and systemic inflammation. Immunity (2013) 1.19
Fat aussie--a new Alström syndrome mouse showing a critical role for ALMS1 in obesity, diabetes, and spermatogenesis. Mol Endocrinol (2006) 1.18
DOCK8 is critical for the survival and function of NKT cells. Blood (2013) 1.17
Bulk segregation mapping of mutations in closely related strains of mice. Genetics (2010) 1.15
Unlocking the bottleneck in forward genetics using whole-genome sequencing and identity by descent to isolate causative mutations. PLoS Genet (2013) 1.14
A mutation in a chromosome condensin II subunit, kleisin beta, specifically disrupts T cell development. Proc Natl Acad Sci U S A (2007) 1.11
B cell survival, surface BCR and BAFFR expression, CD74 metabolism, and CD8- dendritic cells require the intramembrane endopeptidase SPPL2A. J Exp Med (2012) 1.10
Thrombocytopenia and kidney disease in mice with a mutation in the C1galt1 gene. Proc Natl Acad Sci U S A (2006) 1.09
ERK signaling is a molecular switch integrating opposing inputs from B cell receptor and T cell cytokines to control TLR4-driven plasma cell differentiation. J Immunol (2006) 1.09
The ROQUIN family of proteins localizes to stress granules via the ROQ domain and binds target mRNAs. FEBS J (2010) 1.06
Identification of a Steap3 endosomal targeting motif essential for normal iron metabolism. Blood (2008) 1.05
Adaptive failure to high-fat diet characterizes steatohepatitis in Alms1 mutant mice. Biochem Biophys Res Commun (2006) 1.04
Analysis of an ethylnitrosourea-generated mouse mutation defines a cell intrinsic role of nuclear factor kappaB2 in regulating circulating B cell numbers. J Exp Med (2002) 1.04
Anti-islet autoantibodies trigger autoimmune diabetes in the presence of an increased frequency of islet-reactive CD4 T cells. Diabetes (2011) 1.04
Illuminating autoimmune regulators through controlled variation of the mouse genome sequence. Immunity (2004) 1.03
Foxp3⁺ regulatory T cells exert asymmetric control over murine helper responses by inducing Th2 cell apoptosis. Blood (2011) 1.02
Essential role of membrane cholesterol in accelerated BCR internalization and uncoupling from NF-kappa B in B cell clonal anergy. J Exp Med (2006) 1.01
Cell-intrinsic effects of non-MHC NOD genes on dendritic cell generation in vivo. Int Immunol (2002) 1.01
RAB-like 2 has an essential role in male fertility, sperm intra-flagellar transport, and tail assembly. PLoS Genet (2012) 1.00
A mechanism for Ikaros regulation of human globin gene switching. Br J Haematol (2008) 1.00
Connecting mammalian genome with phenome by ENU mouse mutagenesis: gene combinations specifying the immune system. Annu Rev Genet (2005) 0.99
Impairment of organ-specific T cell negative selection by diabetes susceptibility genes: genomic analysis by mRNA profiling. Genome Biol (2007) 0.98
Genetic lesions in T-cell tolerance and thresholds for autoimmunity. Immunol Rev (2005) 0.98
Consequences of the recurrent MYD88(L265P) somatic mutation for B cell tolerance. J Exp Med (2014) 0.94
Lymphoma and the control of B cell growth and differentiation. Curr Mol Med (2006) 0.92
Analysis of Lyn/CD22 double-deficient B cells in vivo demonstrates Lyn- and CD22-independent pathways affecting BCR regulation and B cell survival. Eur J Immunol (2005) 0.92
Genes, pathways and checkpoints in lymphocyte development and homeostasis. Immunol Cell Biol (2005) 0.91
Human lymphoma mutations reveal CARD11 as the switch between self-antigen-induced B cell death or proliferation and autoantibody production. J Exp Med (2012) 0.91
Intrinsic in vitro abnormalities in dendritic cell generation caused by non-MHC non-obese diabetic genes. Immunol Cell Biol (2002) 0.91
RBM5 is a male germ cell splicing factor and is required for spermatid differentiation and male fertility. PLoS Genet (2013) 0.90
Rasgrp1 mutation increases naive T-cell CD44 expression and drives mTOR-dependent accumulation of Helios⁺ T cells and autoantibodies. Elife (2013) 0.90
Impaired lymphocyte development and antibody class switching and increased malignancy in a murine model of DNA ligase IV syndrome. J Clin Invest (2009) 0.89
T-cell regulation by casitas B-lineage lymphoma (Cblb) is a critical failsafe against autoimmune disease due to autoimmune regulator (Aire) deficiency. Proc Natl Acad Sci U S A (2010) 0.88
The RNA-binding protein hnRNPLL induces a T cell alternative splicing program delineated by differential intron retention in polyadenylated RNA. Genome Biol (2014) 0.87
Spontaneous B cell hyperactivity in autoimmune-prone MRL mice. Int Immunol (2006) 0.87
Tracing the action of IL-2 in tolerance to islet-specific antigen. Immunol Cell Biol (2007) 0.87
The use of genomewide ENU mutagenesis screens to unravel complex mammalian traits: identifying genes that regulate organ-specific and systemic autoimmunity. Immunol Rev (2006) 0.87
Analysis of B cell memory formation using DNA microarrays. Ann N Y Acad Sci (2002) 0.86
How host defense is encoded in the mammalian genome. Mamm Genome (2010) 0.85
Decreased T-cell receptor signaling through CARD11 differentially compromises forkhead box protein 3-positive regulatory versus T(H)2 effector cells to cause allergy. J Allergy Clin Immunol (2011) 0.85
Immunology: DNA drives autoimmunity. Nature (2002) 0.85
Zinc-finger protein ZFP318 is essential for expression of IgD, the alternatively spliced Igh product made by mature B lymphocytes. Proc Natl Acad Sci U S A (2014) 0.83
Consequences of increased CD45RA and RC isoforms for TCR signaling and peripheral T cell deficiency resulting from heterogeneous nuclear ribonucleoprotein L-like mutation. J Immunol (2010) 0.82
Differential requirement for the CD45 splicing regulator hnRNPLL for accumulation of NKT and conventional T cells. PLoS One (2011) 0.81
Ndfip1 mediates peripheral tolerance to self and exogenous antigen by inducing cell cycle exit in responding CD4+ T cells. Proc Natl Acad Sci U S A (2014) 0.81
Defective T-cell function leading to reduced antibody production in a kleisin-beta mutant mouse. Immunology (2008) 0.81
Identification of a pathogenic variant in TREX1 in early-onset cerebral systemic lupus erythematosus by Whole-exome sequencing. Arthritis Rheumatol (2014) 0.80
Mouse strains with point mutations in TAP1 and TAP2. Immunol Cell Biol (2009) 0.80
Visualizing the role of Cbl-b in control of islet-reactive CD4 T cells and susceptibility to type 1 diabetes. J Immunol (2011) 0.80
A ZAP-70 kinase domain variant prevents thymocyte-positive selection despite signalling CD69 induction. Immunology (2014) 0.80
Altered immunoglobulin expression and functional silencing of self-reactive B lymphocytes in transgenic mice. J Immunol (2009) 0.80
A DOCK8-WIP-WASp complex links T cell receptors to the actin cytoskeleton. J Clin Invest (2016) 0.79
Lyn/CD22/SHP-1 and their importance in autoimmunity. Curr Dir Autoimmun (2002) 0.77
Genetic lesions in thymic T cell clonal deletion and thresholds for autoimmunity. Novartis Found Symp (2005) 0.77
Novel approaches for identifying genes regulating lymphocyte development and function. Curr Opin Immunol (2002) 0.77
Cooperation between somatic Ikaros and Notch1 mutations at the inception of T-ALL. Leuk Res (2011) 0.76
Correction: HENMT1 and piRNA Stability Are Required for Adult Male Germ Cell Transposon Repression and to Define the Spermatogenic Program in the Mouse. PLoS Genet (2015) 0.75
Erratum: Phosphorylation and linear ubiquitin direct A20 inhibition of inflammation. Nature (2016) 0.75
Next-generation sequencing to dissect hereditary nephrotic syndrome in mice identifies a hypomorphic mutation in Lamb2 and models Pierson's syndrome. J Pathol (2014) 0.75
A missense mutation in the transcription factor ETV5 leads to sterility, increased embryonic and perinatal death, postnatal growth restriction, renal asymmetry and polydactyly in the mouse. PLoS One (2013) 0.75