Published in FEBS Lett on November 06, 2003
C-terminal regions of topoisomerase IIalpha and IIbeta determine isoform-specific functioning of the enzymes in vivo. Nucleic Acids Res (2007) 1.17
DNA cleavage and opening reactions of human topoisomerase IIα are regulated via Mg2+-mediated dynamic bending of gate-DNA. Proc Natl Acad Sci U S A (2012) 0.99
Immobilizing topoisomerase I on a surface plasmon resonance biosensor chip to screen for inhibitors. J Biomed Sci (2010) 0.82
The impact of the C-terminal domain on the interaction of human DNA topoisomerase II α and β with DNA. PLoS One (2011) 0.77
Exome sequencing identifies GATA-2 mutation as the cause of dendritic cell, monocyte, B and NK lymphoid deficiency. Blood (2011) 3.16
gammaH2AX foci form preferentially in euchromatin after ionising-radiation. PLoS One (2007) 2.07
The structure of DNA-bound human topoisomerase II alpha: conformational mechanisms for coordinating inter-subunit interactions with DNA cleavage. J Mol Biol (2012) 1.87
A novel DNA-dependent protein kinase inhibitor, NU7026, potentiates the cytotoxicity of topoisomerase II poisons used in the treatment of leukemia. Blood (2004) 1.65
Digitoxin inhibits the growth of cancer cell lines at concentrations commonly found in cardiac patients. J Nat Prod (2005) 1.42
Surface plasmon resonance in protein-membrane interactions. Chem Phys Lipids (2006) 1.38
The novel poly(ADP-Ribose) polymerase inhibitor, AG14361, sensitizes cells to topoisomerase I poisons by increasing the persistence of DNA strand breaks. Clin Cancer Res (2005) 1.35
mtRF1a is a human mitochondrial translation release factor decoding the major termination codons UAA and UAG. Mol Cell (2007) 1.33
Disparate proteins use similar architectures to damage membranes. Trends Biochem Sci (2008) 1.33
Model for MLL translocations in therapy-related leukemia involving topoisomerase IIβ-mediated DNA strand breaks and gene proximity. Proc Natl Acad Sci U S A (2012) 1.29
Two-step membrane binding by Equinatoxin II, a pore-forming toxin from the sea anemone, involves an exposed aromatic cluster and a flexible helix. J Biol Chem (2002) 1.20
An ion-channel-containing model membrane: structural determination by magnetic contrast neutron reflectometry. Soft Matter (2009) 1.15
DNA-dependent protein kinase is a therapeutic target and an indicator of poor prognosis in B-cell chronic lymphocytic leukemia. Clin Cancer Res (2008) 1.13
Low resolution structure and dynamics of a colicin-receptor complex determined by neutron scattering. J Biol Chem (2011) 1.12
Molecular determinants of sphingomyelin specificity of a eukaryotic pore-forming toxin. J Biol Chem (2008) 1.09
Identification and characterization of the Pasteurella multocida toxin translocation domain. Mol Microbiol (2004) 1.04
NK314, a topoisomerase II inhibitor that specifically targets the alpha isoform. J Biol Chem (2008) 1.04
Pore formation by equinatoxin, a eukaryotic pore-forming toxin, requires a flexible N-terminal region and a stable beta-sandwich. J Biol Chem (2004) 1.03
Effect of divalent cation removal on the structure of gram-negative bacterial outer membrane models. Langmuir (2014) 1.02
Properties of nonfused liposomes immobilized on an L1 Biacore chip and their permeabilization by a eukaryotic pore-forming toxin. Anal Biochem (2005) 1.02
A novel mechanism of pore formation: membrane penetration by the N-terminal amphipathic region of equinatoxin. J Biol Chem (2003) 1.02
Colicin N binds to the periphery of its receptor and translocator, outer membrane protein F. Structure (2008) 1.01
Engineering hyperthermostability into a GH11 xylanase is mediated by subtle changes to protein structure. J Biol Chem (2008) 1.00
A toxin-based probe reveals cytoplasmic exposure of Golgi sphingomyelin. J Biol Chem (2010) 0.99
The structural orientation of antibody layers bound to engineered biosensor surfaces. Biomaterials (2011) 0.99
Sterol and pH interdependence in the binding, oligomerization, and pore formation of Listeriolysin O. Biochemistry (2007) 0.98
Differences in the longevity of topo IIalpha and topo IIbeta drug-stabilized cleavable complexes and the relationship to drug sensitivity. Cancer Chemother Pharmacol (2003) 0.98
Mechanism of generation of therapy related leukemia in response to anti-topoisomerase II agents. Int J Environ Res Public Health (2012) 0.97
Curcumin induces high levels of topoisomerase I- and II-DNA complexes in K562 leukemia cells. J Nat Prod (2007) 0.96
Stable self-assembly of a protein engineering scaffold on gold surfaces. Protein Sci (2002) 0.96
Guanidine-reactive agent phenylglyoxal induces DNA damage and cancer cell death. Pharmacol Rep (2012) 0.96
An approach to prepare membrane proteins for single-molecule imaging. Angew Chem Int Ed Engl (2006) 0.95
pH dependence of listeriolysin O aggregation and pore-forming ability. FEBS J (2011) 0.94
The role of topoisomerase II in the excision of DNA loop domains during apoptosis. J Biol Chem (2002) 0.93
Poly(ADP-ribose) polymerases PARP1 and PARP2 modulate topoisomerase II beta (TOP2B) function during chromatin condensation in mouse spermiogenesis. Biol Reprod (2011) 0.93
Probing the orientation of yeast VDAC1 in vivo. FEBS Lett (2009) 0.93
Alchemix: a novel alkylating anthraquinone with potent activity against anthracycline- and cisplatin-resistant ovarian cancer. Mol Cancer Ther (2003) 0.93
Single peptide bonds exhibit poly(pro)II ("random coil") circular dichroism spectra. J Am Chem Soc (2005) 0.92
Concerted folding and binding of a flexible colicin domain to its periplasmic receptor TolA. J Biol Chem (2003) 0.92
The antibacterial toxin colicin N binds to the inner core of lipopolysaccharide and close to its translocator protein. Mol Microbiol (2014) 0.92
Controlled spatial and conformational display of immobilised bone morphogenetic protein-2 and osteopontin signalling motifs regulates osteoblast adhesion and differentiation in vitro. BMC Biol (2010) 0.92
The alpha-glucuronidase, GlcA67A, of Cellvibrio japonicus utilizes the carboxylate and methyl groups of aldobiouronic acid as important substrate recognition determinants. J Biol Chem (2003) 0.91
Asymmetric phospholipid: lipopolysaccharide bilayers; a Gram-negative bacterial outer membrane mimic. J R Soc Interface (2013) 0.90
Green tea constituents (-)-epigallocatechin-3-gallate (EGCG) and gallic acid induce topoisomerase I- and topoisomerase II-DNA complexes in cells mediated by pyrogallol-induced hydrogen peroxide. Mutagenesis (2011) 0.89
Expression of proteins using the third domain of the Escherichia coli periplasmic-protein TolA as a fusion partner. Protein Expr Purif (2003) 0.89
The pasteurella multocida toxin interacts with signalling pathways to perturb cell growth and differentiation. Int J Med Microbiol (2004) 0.89
Monitoring the assembly of antibody-binding membrane protein arrays using polarised neutron reflection. Eur Biophys J (2008) 0.88
MRE11 facilitates the removal of human topoisomerase II complexes from genomic DNA. Biol Open (2012) 0.88
Refolding of Escherichia coli outer membrane protein F in detergent creates LPS-free trimers and asymmetric dimers. Biochem J (2005) 0.87
Unfolding transitions of Bacillus anthracis protective antigen. Arch Biochem Biophys (2007) 0.87
The use of forced protein evolution to investigate and improve stability of family 10 xylanases. The production of Ca2+-independent stable xylanases. J Biol Chem (2004) 0.87
Cells lacking DNA topoisomerase II beta are resistant to genistein. J Nat Prod (2007) 0.86
Mutation P732L in human DNA topoisomerase IIbeta abolishes DNA cleavage in the presence of calcium and confers drug resistance. Mol Pharmacol (2005) 0.86
Structural characterization of a model gram-negative bacterial surface using lipopolysaccharides from rough strains of Escherichia coli. Biomacromolecules (2013) 0.85
High level expression of His-tagged colicin pore-forming domains and reflections on the sites for pore formation in the inner membrane. Biochimie (2002) 0.85
The dietary flavonoids myricetin and fisetin act as dual inhibitors of DNA topoisomerases I and II in cells. Mutat Res (2009) 0.85
Circular dichroism spectroscopy of folding in a protein monolayer. Angew Chem Int Ed Engl (2005) 0.85
Alhydrogel® adjuvant, ultrasonic dispersion and protein binding: a TEM and analytical study. Micron (2011) 0.85
Position-specific trapping of topoisomerase II by benzo[a]pyrene diol epoxide adducts: implications for interactions with intercalating anticancer agents. Proc Natl Acad Sci U S A (2003) 0.85
A natively unfolded toxin domain uses its receptor as a folding template. J Biol Chem (2004) 0.84
Probing the structural basis for the difference in thermostability displayed by family 10 xylanases. J Mol Biol (2006) 0.84
Role of Topoisomerase IIβ in DNA Damage Response following IR and Etoposide. J Nucleic Acids (2010) 0.84
The unstructured domain of colicin N kills Escherichia coli. Mol Microbiol (2013) 0.84
Poly(ADP-ribose) metabolism is essential for proper nucleoprotein exchange during mouse spermiogenesis. Biol Reprod (2010) 0.84
The structure of Yersinia pestis Caf1 polymer in free and adjuvant bound states. Vaccine (2010) 0.83
A common interaction for the entry of colicin N and filamentous phage into Escherichia coli. J Mol Biol (2009) 0.83
Phage display selection of efficient glutamine-donor substrate peptides for transglutaminase 2. Protein Sci (2006) 0.83
Immunogenicity of a Yersinia pestis vaccine antigen monomerized by circular permutation. Infect Immun (2006) 0.83
An overview of the visualisation and quantitation of low and high MW DNA adducts using the trapped in agarose DNA immunostaining (TARDIS) assay. Mutagenesis (2010) 0.83
Examining protein-lipid complexes using neutron scattering. Methods Mol Biol (2013) 0.82
Anthrax sub-unit vaccine: the structural consequences of binding rPA83 to Alhydrogel®. Eur J Pharm Biopharm (2011) 0.82
Outer membrane protein F stabilised with minimal amphipol forms linear arrays and LPS-dependent 2D crystals. J Membr Biol (2014) 0.82
Histone deacetylase inhibition redistributes topoisomerase IIβ from heterochromatin to euchromatin. Nucleus (2011) 0.82
Membrane binding of zebrafish actinoporin-like protein: AF domains, a novel superfamily of cell membrane binding domains. Biochem J (2006) 0.82
Determining OMP topology by computation, surface plasmon resonance and cysteine labelling: the test case of OMPG. Biochem Biophys Res Commun (2006) 0.81
Maintenance and stabilization of mtDNA can be facilitated by the DNA-binding activity of Ilv5p. Biochim Biophys Acta (2007) 0.81
Formation and longevity of idarubicin-induced DNA topoisomerase II cleavable complexes in K562 human leukaemia cells. Biochem Pharmacol (2002) 0.81
A generic expression system to produce proteins that co-assemble with alkane thiol SAM. Int J Nanomedicine (2008) 0.80
Characterisation of the DNA-dependent ATPase activity of human DNA topoisomerase IIbeta: mutation of Ser165 in the ATPase domain reduces the ATPase activity and abolishes the in vivo complementation ability. Nucleic Acids Res (2002) 0.80
Simple detection of protein soft structure changes. Anal Chem (2010) 0.80
Helix orientations in membrane-associated Bcl-X(L) determined by 15N-solid-state NMR spectroscopy. Eur Biophys J (2007) 0.80
The impact of the human DNA topoisomerase II C-terminal domain on activity. PLoS One (2008) 0.80
Discovery of biphasic thermal unfolding of ompc with implications for surface loop stability. Biochemistry (2010) 0.79
Peeking into a secret world of pore-forming toxins: membrane binding processes studied by surface plasmon resonance. Toxicon (2003) 0.79
Alpha, beta-unsaturated lactones 2-furanone and 2-pyrone induce cellular DNA damage, formation of topoisomerase I- and II-DNA complexes and cancer cell death. Toxicol Lett (2013) 0.79
Salicylate, a catalytic inhibitor of topoisomerase II, inhibits DNA cleavage and is selective for the α isoform. Mol Pharmacol (2013) 0.79
Insertion of the enteropathogenic Escherichia coli Tir virulence protein into membranes in vitro. J Biol Chem (2006) 0.79
Self-recognition by an intrinsically disordered protein. FEBS Lett (2008) 0.78
mAMSA resistant human topoisomerase IIbeta mutation G465D has reduced ATP hydrolysis activity. Nucleic Acids Res (2006) 0.78
The role of topoisomerase II beta on breakage and proximity of RUNX1 to partner alleles RUNX1T1 and EVI1. Genes Chromosomes Cancer (2013) 0.78
Interfacial interactions of pore-forming colicins. Adv Exp Med Biol (2010) 0.78
Increasing the potency of an alhydrogel-formulated anthrax vaccine by minimizing antigen-adjuvant interactions. Clin Vaccine Immunol (2013) 0.77
The impact of the C-terminal domain on the interaction of human DNA topoisomerase II α and β with DNA. PLoS One (2011) 0.77
High-yield expression and purification of soluble forms of the anti-apoptotic Bcl-x(L) and Bcl-2 as TolAIII-fusion proteins. Protein Expr Purif (2008) 0.77