Published in Biol Reprod on January 12, 2011
Quantitative proteomics profiling of the poly(ADP-ribose)-related response to genotoxic stress. Nucleic Acids Res (2012) 1.25
Regulation of chromatin structure by poly(ADP-ribosyl)ation. Front Genet (2012) 1.03
Mechanisms and clinical correlates of sperm DNA damage. Asian J Androl (2011) 0.96
Paternal poly (ADP-ribose) metabolism modulates retention of inheritable sperm histones and early embryonic gene expression. PLoS Genet (2014) 0.91
Increased negative supercoiling of mtDNA in TOP1mt knockout mice and presence of topoisomerases IIα and IIβ in vertebrate mitochondria. Nucleic Acids Res (2014) 0.85
Spermatid head elongation with normal nuclear shaping requires ADP-ribosyltransferase PARP11 (ARTD11) in mice. Biol Reprod (2015) 0.85
Alteration of poly(ADP-ribose) metabolism affects murine sperm nuclear architecture by impairing pericentric heterochromatin condensation. Chromosoma (2013) 0.84
Epigenetic regulation of the histone-to-protamine transition during spermiogenesis. Reproduction (2016) 0.83
Chromatin remodelling initiation during human spermiogenesis. Biol Open (2012) 0.81
Topoisomerase II beta interacts with cohesin and CTCF at topological domain borders. Genome Biol (2016) 0.80
Regulating DNA supercoiling: sperm points the way. Biol Reprod (2011) 0.78
mRNA and DNA selection via protein multimerization: YB-1 as a case study. Nucleic Acids Res (2015) 0.77
"Breaking news" from spermatids. Basic Clin Androl (2013) 0.77
Association of common SNP rs1136410 in PARP1 gene with the susceptibility to male infertility with oligospermia. J Assist Reprod Genet (2014) 0.77
Topoisomerase II regulates yeast genes with singular chromatin architectures. Nucleic Acids Res (2013) 0.77
Mammalian sperm nuclear organization: resiliencies and vulnerabilities. Basic Clin Androl (2016) 0.75
Improvement of gamete quality by stimulating and feeding the endogenous antioxidant system: mechanisms, clinical results, insights on gene-environment interactions and the role of diet. J Assist Reprod Genet (2016) 0.75
Density dependent re-tuning of autoreactive T cells alleviates their pathogenicity in a lymphopenic environment. Immunol Lett (2017) 0.75
A topoisomerase IIbeta-mediated dsDNA break required for regulated transcription. Science (2006) 6.71
Distinctive chromatin in human sperm packages genes for embryo development. Nature (2009) 6.18
DNA topoisomerases and their poisoning by anticancer and antibacterial drugs. Chem Biol (2010) 5.61
The PARP side of the nucleus: molecular actions, physiological outcomes, and clinical targets. Mol Cell (2010) 5.06
Mice lacking ADPRT and poly(ADP-ribosyl)ation develop normally but are susceptible to skin disease. Genes Dev (1995) 4.54
The macro domain is an ADP-ribose binding module. EMBO J (2005) 4.07
Chromatin loosening by poly(ADP)-ribose polymerase (PARP) at Drosophila puff loci. Science (2003) 3.97
Poly(ADP-ribose)-binding zinc finger motifs in DNA repair/checkpoint proteins. Nature (2008) 3.67
The diverse biological roles of mammalian PARPS, a small but powerful family of poly-ADP-ribose polymerases. Front Biosci (2008) 3.56
Nuclear ADP-ribosylation reactions in mammalian cells: where are we today and where are we going? Microbiol Mol Biol Rev (2006) 3.31
Transcriptional control by PARP-1: chromatin modulation, enhancer-binding, coregulation, and insulation. Curr Opin Cell Biol (2008) 3.18
DNA oxidation as triggered by H3K9me2 demethylation drives estrogen-induced gene expression. Science (2008) 3.09
Repressive and active histone methylation mark distinct promoters in human and mouse spermatozoa. Nat Struct Mol Biol (2010) 3.07
Functional interaction between PARP-1 and PARP-2 in chromosome stability and embryonic development in mouse. EMBO J (2003) 2.94
PARP-2, A novel mammalian DNA damage-dependent poly(ADP-ribose) polymerase. J Biol Chem (1999) 2.92
Proteome-wide identification of poly(ADP-ribose) binding proteins and poly(ADP-ribose)-associated protein complexes. Nucleic Acids Res (2008) 2.70
Role of sperm chromatin abnormalities and DNA damage in male infertility. Hum Reprod Update (2003) 2.47
Failure to degrade poly(ADP-ribose) causes increased sensitivity to cytotoxicity and early embryonic lethality. Proc Natl Acad Sci U S A (2004) 2.20
The role of poly(ADP-ribose) in the DNA damage signaling network. Biochem Cell Biol (2005) 2.14
PARP-1 regulates chromatin structure and transcription through a KDM5B-dependent pathway. Mol Cell (2010) 2.06
Preparation, isolation and characterization of stage-specific spermatogenic cells for cellular and molecular analysis. Nat Methods (2004) 1.91
Importance of poly(ADP-ribose) glycohydrolase in the control of poly(ADP-ribose) metabolism. Exp Cell Res (2001) 1.85
Endonuclease-sensitive regions of human spermatozoal chromatin are highly enriched in promoter and CTCF binding sequences. Genome Res (2009) 1.79
Depletion of the 110-kilodalton isoform of poly(ADP-ribose) glycohydrolase increases sensitivity to genotoxic and endotoxic stress in mice. Mol Cell Biol (2004) 1.61
On the possible origins of DNA damage in human spermatozoa. Mol Hum Reprod (2009) 1.52
Roles of transition nuclear proteins in spermiogenesis. Chromosoma (2003) 1.44
Regulation of chromatin structure and gene activity by poly(ADP-ribose) polymerases. Curr Top Dev Biol (2003) 1.40
Biological and clinical significance of DNA damage in the male germ line. Int J Androl (2008) 1.40
Transition nuclear proteins are required for normal chromatin condensation and functional sperm development. Genesis (2004) 1.32
Etoposide targets topoisomerase IIalpha and IIbeta in leukemic cells: isoform-specific cleavable complexes visualized and quantified in situ by a novel immunofluorescence technique. Mol Pharmacol (1998) 1.26
Novel HeLa topoisomerase II is the II beta isoform: complete coding sequence and homology with other type II topoisomerases. Biochim Biophys Acta (1993) 1.24
Protective effects of PJ34, a novel, potent inhibitor of poly(ADP-ribose) polymerase (PARP) in in vitro and in vivo models of stroke. Int J Mol Med (2001) 1.24
Specific binding of poly(ADP-ribose) polymerase-1 to cruciform hairpins. J Mol Biol (2005) 1.22
Transient DNA strand breaks during mouse and human spermiogenesis new insights in stage specificity and link to chromatin remodeling. Biol Reprod (2003) 1.21
Two small enzyme isoforms mediate mammalian mitochondrial poly(ADP-ribose) glycohydrolase (PARG) activity. Exp Cell Res (2007) 1.15
A human poly(ADP-ribose) polymerase gene family (ADPRTL): cDNA cloning of two novel poly(ADP-ribose) polymerase homologues. Genomics (1999) 1.14
Poly(ADP-ribose) polymerases: managing genome stability. Int J Biochem Cell Biol (2004) 1.14
Poly(ADP-ribose) polymerase-2 contributes to the fidelity of male meiosis I and spermiogenesis. Proc Natl Acad Sci U S A (2006) 1.13
Expression, domain structure, and enzymatic properties of an active recombinant human DNA topoisomerase II beta. J Biol Chem (1995) 1.09
DNA damage response during chromatin remodeling in elongating spermatids of mice. Biol Reprod (2007) 1.08
A breaking strategy for topoisomerase IIbeta/PARP-1-dependent regulated transcription. Cell Cycle (2006) 1.06
Sperm DNA damage and its clinical relevance in assessing reproductive outcome. Asian J Androl (2004) 1.05
On the nature and origin of DNA strand breaks in elongating spermatids. Biol Reprod (2005) 1.04
Histone shuttling by poly ADP-ribosylation. Mol Cell Biochem (1994) 1.00
Mouse spermatozoa contain a nuclease that is activated by pretreatment with EGTA and subsequent calcium incubation. J Cell Biochem (2008) 1.00
Poly(ADP-ribosyl)ation during chromatin remodeling steps in rat spermiogenesis. Chromosoma (2005) 0.97
Relationship between the presence of endogenous nicks and sperm chromatin packaging in maturing and fertilizing mouse spermatozoa. Biol Reprod (1995) 0.97
Topoisomerase IIB and an extracellular nuclease interact to digest sperm DNA in an apoptotic-like manner. Biol Reprod (2006) 0.96
Regulation of chromatin structure and chromatin-dependent transcription by poly(ADP-ribose) polymerase-1: possible targets for drug-based therapies. Subcell Biochem (2007) 0.94
DNA nicks and increased sensitivity of DNA to fluorescence in situ end labeling during functional spermiogenesis. Biotechniques (1998) 0.94
Topoisomerase II-mediated breaks in spermatozoa cause the specific degradation of paternal DNA in fertilized oocytes. Biol Reprod (2006) 0.92
Inhibition of calf thymus type II DNA topoisomerase by poly(ADP-ribosylation). EMBO J (1985) 0.92
Characterization of nucleohistone and nucleoprotamine components in the mature human sperm nucleus. Asian J Androl (2008) 0.92
Disruption of poly(ADP-ribose) homeostasis affects spermiogenesis and sperm chromatin integrity in mice. Biol Reprod (2009) 0.90
A journey in the world of DNA rings and beyond. Annu Rev Biochem (2009) 0.89
Histone shuttle driven by the automodification cycle of poly(ADP-ribose)polymerase. Environ Mol Mutagen (1993) 0.88
A specific isoform of poly(ADP-ribose) glycohydrolase is targeted to the mitochondrial matrix by a N-terminal mitochondrial targeting sequence. Exp Cell Res (2009) 0.88
Formation and rejoining of deoxyribonucleic acid double-strand breaks induced in isolated cell nuclei by antineoplastic intercalating agents. Biochemistry (1984) 0.88
DNA topoisomerase II activity in nonreplicating, transcriptionally inactive, chicken late spermatids. EMBO J (1989) 0.85
Poly(ADP-ribose) metabolism is essential for proper nucleoprotein exchange during mouse spermiogenesis. Biol Reprod (2010) 0.84
Nicking of rat spermatid and spermatozoa DNA: possible involvement of DNA topoisomerase II. Dev Biol (1993) 0.83
Data analysis of two in vivo fertility studies using Sperm Chromatin Structure Assay-derived DNA fragmentation index vs. pregnancy outcome. Fertil Steril (2008) 0.81
Poly(ADP-ribose) binding properties of histone H1 variants. Biochim Biophys Acta (1998) 0.81
Camptothecin-stabilised topoisomerase I-DNA complexes in leukaemia cells visualised and quantified in situ by the TARDIS assay (trapped in agarose DNA immunostaining). Biochem Pharmacol (2000) 0.81
Expression and localization of DNA topoisomerase II during rat spermatogenesis. Mol Reprod Dev (1996) 0.79
Purification of non-histone acceptor proteins for ADP-ribose from mouse testis nuclei. Biochem J (1984) 0.77
Site-directed mutagenesis of human DNA topoisomerase II beta. Biochem Soc Trans (1997) 0.76
Rhox: a new homeobox gene cluster. Cell (2005) 2.62
gammaH2AX foci form preferentially in euchromatin after ionising-radiation. PLoS One (2007) 2.07
The structure of DNA-bound human topoisomerase II alpha: conformational mechanisms for coordinating inter-subunit interactions with DNA cleavage. J Mol Biol (2012) 1.87
Human poly(ADP-ribose) glycohydrolase is expressed in alternative splice variants yielding isoforms that localize to different cell compartments. Exp Cell Res (2004) 1.66
A novel DNA-dependent protein kinase inhibitor, NU7026, potentiates the cytotoxicity of topoisomerase II poisons used in the treatment of leukemia. Blood (2004) 1.65
Sumoylation is involved in beta-catenin-dependent activation of Tcf-4. EMBO J (2003) 1.61
Depletion of the 110-kilodalton isoform of poly(ADP-ribose) glycohydrolase increases sensitivity to genotoxic and endotoxic stress in mice. Mol Cell Biol (2004) 1.61
Identification of a bone marrow-derived CD8αα+ dendritic cell-like population in inflamed autoimmune target tissue with capability of inducing T cell apoptosis. J Leukoc Biol (2010) 1.61
Digitoxin inhibits the growth of cancer cell lines at concentrations commonly found in cardiac patients. J Nat Prod (2005) 1.42
Hormad1 mutation disrupts synaptonemal complex formation, recombination, and chromosome segregation in mammalian meiosis. PLoS Genet (2010) 1.42
Estrogen-regulated genes in rat testes and their relationship to recovery of spermatogenesis after irradiation. Biol Reprod (2011) 1.42
The novel poly(ADP-Ribose) polymerase inhibitor, AG14361, sensitizes cells to topoisomerase I poisons by increasing the persistence of DNA strand breaks. Clin Cancer Res (2005) 1.35
Transition nuclear proteins are required for normal chromatin condensation and functional sperm development. Genesis (2004) 1.32
Model for MLL translocations in therapy-related leukemia involving topoisomerase IIβ-mediated DNA strand breaks and gene proximity. Proc Natl Acad Sci U S A (2012) 1.29
Molecular markers of outcome after radiotherapy in patients with prostate carcinoma: Ki-67, bcl-2, bax, and bcl-x. Cancer (2003) 1.26
The radiation-induced block in spermatogonial differentiation is due to damage to the somatic environment, not the germ cells. J Cell Physiol (2007) 1.18
Nucleoprotein transitions during spermiogenesis in mice with transition nuclear protein Tnp1 and Tnp2 mutations. Biol Reprod (2004) 1.17
Abnormalities and reduced reproductive potential of sperm from Tnp1- and Tnp2-null double mutant mice. Biol Reprod (2004) 1.16
Poly(ADP-ribose) polymerases: managing genome stability. Int J Biochem Cell Biol (2004) 1.14
Utp14b: a unique retrogene within a gene that has acquired multiple promoters and a specific function in spermatogenesis. Dev Biol (2007) 1.14
Altered poly(ADP-ribose) metabolism impairs cellular responses to genotoxic stress in a hypomorphic mutant of poly(ADP-ribose) glycohydrolase. Exp Cell Res (2007) 1.13
DNA-dependent protein kinase is a therapeutic target and an indicator of poor prognosis in B-cell chronic lymphocytic leukemia. Clin Cancer Res (2008) 1.13
Pem homeobox gene promoter sequences that direct transcription in a Sertoli cell-specific, stage-specific, and androgen-dependent manner in the testis in vivo. Mol Endocrinol (2003) 1.12
Ki-67 staining is an independent correlate of biochemical failure in prostate cancer treated with radiotherapy. Clin Cancer Res (2002) 1.07
Cisplatin-induced long-term failure of spermatogenesis in adult C57/Bl/6J mice. J Androl (2004) 1.05
The testis-enriched histone demethylase, KDM4D, regulates methylation of histone H3 lysine 9 during spermatogenesis in the mouse but is dispensable for fertility. Biol Reprod (2011) 1.04
NK314, a topoisomerase II inhibitor that specifically targets the alpha isoform. J Biol Chem (2008) 1.04
Expression of c-Kit receptor mRNA and protein in the developing, adult and irradiated rodent testis. Reproduction (2006) 1.02
Spermatogonial morphology and kinetics during testis development in mice: a high-resolution light microscopy approach. Reproduction (2011) 1.01
The mouse dead-end gene isoform alpha is necessary for germ cell and embryonic viability. Biochem Biophys Res Commun (2007) 1.00
Differences in the longevity of topo IIalpha and topo IIbeta drug-stabilized cleavable complexes and the relationship to drug sensitivity. Cancer Chemother Pharmacol (2003) 0.98
Poly(ADP-ribosyl)ation during chromatin remodeling steps in rat spermiogenesis. Chromosoma (2005) 0.97
Hormonal approaches to preservation and restoration of male fertility after cancer treatment. J Natl Cancer Inst Monogr (2005) 0.97
Spermatogonial differentiation in juvenile spermatogonial depletion (jsd) mice with androgen receptor or follicle-stimulating hormone mutations. Endocrinology (2006) 0.97
Mechanism of generation of therapy related leukemia in response to anti-topoisomerase II agents. Int J Environ Res Public Health (2012) 0.97
Curcumin induces high levels of topoisomerase I- and II-DNA complexes in K562 leukemia cells. J Nat Prod (2007) 0.96
Irradiated mouse testes efficiently support spermatogenesis derived from donor germ cells of mice and rats. J Androl (2005) 0.96
Guanidine-reactive agent phenylglyoxal induces DNA damage and cancer cell death. Pharmacol Rep (2012) 0.96
Testicular edema is associated with spermatogonial arrest in irradiated rats. Endocrinology (2005) 0.96
Protamine 2 precursors, protamine 1/protamine 2 ratio, DNA integrity and other sperm parameters in infertile patients. Hum Reprod (2006) 0.95
Changes in gene expression in somatic cells of rat testes resulting from hormonal modulation and radiation-induced germ cell depletion. Biol Reprod (2009) 0.94
Androgen receptor in Sertoli cells is not required for testosterone-induced suppression of spermatogenesis, but contributes to Sertoli cell organization in Utp14b jsd mice. J Androl (2009) 0.94
The role of topoisomerase II in the excision of DNA loop domains during apoptosis. J Biol Chem (2002) 0.93
Alchemix: a novel alkylating anthraquinone with potent activity against anthracycline- and cisplatin-resistant ovarian cancer. Mol Cancer Ther (2003) 0.93
NOVP chemotherapy for Hodgkin's disease transiently induces sperm aneuploidies associated with the major clinical aneuploidy syndromes involving chromosomes X, Y, 18, and 21. Cancer Res (2003) 0.93
Both testosterone and follicle-stimulating hormone independently inhibit spermatogonial differentiation in irradiated rats. Endocrinology (2005) 0.92
Genetic factors contributing to defective spermatogonial differentiation in juvenile spermatogonial depletion (Utp14bjsd) mice. Biol Reprod (2007) 0.90
Disruption of poly(ADP-ribose) homeostasis affects spermiogenesis and sperm chromatin integrity in mice. Biol Reprod (2009) 0.90
Dynamic expression pattern and subcellular localization of the Rhox10 homeobox transcription factor during early germ cell development. Reproduction (2012) 0.89
Decline in fertility of mouse sperm with abnormal chromatin during epididymal passage as revealed by ICSI. Hum Reprod (2005) 0.89
The missing niche for spermatogonial stem cells: do blood vessels point the way? Cell Stem Cell (2007) 0.89
Green tea constituents (-)-epigallocatechin-3-gallate (EGCG) and gallic acid induce topoisomerase I- and topoisomerase II-DNA complexes in cells mediated by pyrogallol-induced hydrogen peroxide. Mutagenesis (2011) 0.89
Genetic disease in offspring of long-term survivors of childhood and adolescent cancer treated with potentially mutagenic therapies. Am J Hum Genet (2002) 0.89
Estrogen enhances recovery from radiation-induced spermatogonial arrest in rat testes. J Androl (2009) 0.88
A specific isoform of poly(ADP-ribose) glycohydrolase is targeted to the mitochondrial matrix by a N-terminal mitochondrial targeting sequence. Exp Cell Res (2009) 0.88
MRE11 facilitates the removal of human topoisomerase II complexes from genomic DNA. Biol Open (2012) 0.88
Gene expression alterations by conditional knockout of androgen receptor in adult Sertoli cells of Utp14b jsd/jsd (jsd) mice. Biol Reprod (2011) 0.87
Age and insertion site dependence of repeat number instability of a human DM1 transgene in individual mouse sperm. Hum Mol Genet (2002) 0.86
Cells lacking DNA topoisomerase II beta are resistant to genistein. J Nat Prod (2007) 0.86
Fetal radiation exposure induces testicular cancer in genetically susceptible mice. PLoS One (2012) 0.86
Mutation P732L in human DNA topoisomerase IIbeta abolishes DNA cleavage in the presence of calcium and confers drug resistance. Mol Pharmacol (2005) 0.86
Donor Sertoli cells transplanted into irradiated rat testes stimulate partial recovery of endogenous spermatogenesis. Reproduction (2008) 0.85
The dietary flavonoids myricetin and fisetin act as dual inhibitors of DNA topoisomerases I and II in cells. Mutat Res (2009) 0.85
Position-specific trapping of topoisomerase II by benzo[a]pyrene diol epoxide adducts: implications for interactions with intercalating anticancer agents. Proc Natl Acad Sci U S A (2003) 0.85
Defining the cellular and molecular mechanisms of toxicant action in the testis. Toxicol Lett (2002) 0.84
Alteration of poly(ADP-ribose) metabolism affects murine sperm nuclear architecture by impairing pericentric heterochromatin condensation. Chromosoma (2013) 0.84
Role of Topoisomerase IIβ in DNA Damage Response following IR and Etoposide. J Nucleic Acids (2010) 0.84
Inhibition of recovery of spermatogenesis in irradiated rats by different androgens. Endocrinology (2002) 0.84
Poly(ADP-ribose) metabolism is essential for proper nucleoprotein exchange during mouse spermiogenesis. Biol Reprod (2010) 0.84
Changes in the journal of andrology in the electronic age. J Androl (2008) 0.83
Effects of medroxyprogesterone and estradiol on the recovery of spermatogenesis in irradiated rats. Endocrinology (2004) 0.83
Gonadotropin-releasing hormone antagonist (Cetrorelix) therapy fails to protect nonhuman primates (Macaca arctoides) from radiation-induced spermatogenic failure. J Androl (2005) 0.83
An overview of the visualisation and quantitation of low and high MW DNA adducts using the trapped in agarose DNA immunostaining (TARDIS) assay. Mutagenesis (2010) 0.83
Histone deacetylase inhibition redistributes topoisomerase IIβ from heterochromatin to euchromatin. Nucleus (2011) 0.82
C-terminal phosphorylation of murine testis-specific histone H1t in elongating spermatids. J Proteome Res (2008) 0.82
Separation of spermatogenic cell types using STA-PUT velocity sedimentation. J Vis Exp (2013) 0.82
Differences in radiation sensitivity of recovery of spermatogenesis between rat strains. Toxicol Sci (2012) 0.82
Androgen suppression-induced stimulation of spermatogonial differentiation in juvenile spermatogonial depletion mice acts by elevating the testicular temperature. Endocrinology (2011) 0.81
Kinetic analysis of human topoisomerase IIalpha and beta DNA binding by surface plasmon resonance. FEBS Lett (2003) 0.81
Gene expression alterations by conditional knockout of androgen receptor in adult sertoli cells of Utp14b(jsd/jsd) (jsd) mice. Biol Reprod (2010) 0.81
Formation and longevity of idarubicin-induced DNA topoisomerase II cleavable complexes in K562 human leukaemia cells. Biochem Pharmacol (2002) 0.81
Characterisation of the DNA-dependent ATPase activity of human DNA topoisomerase IIbeta: mutation of Ser165 in the ATPase domain reduces the ATPase activity and abolishes the in vivo complementation ability. Nucleic Acids Res (2002) 0.80
Effects of multiple doses of cyclophosphamide on mouse testes: accessing the germ cells lost, and the functional damage of stem cells. Reprod Toxicol (2011) 0.80
The impact of the human DNA topoisomerase II C-terminal domain on activity. PLoS One (2008) 0.80
Salicylate, a catalytic inhibitor of topoisomerase II, inhibits DNA cleavage and is selective for the α isoform. Mol Pharmacol (2013) 0.79
Alpha, beta-unsaturated lactones 2-furanone and 2-pyrone induce cellular DNA damage, formation of topoisomerase I- and II-DNA complexes and cancer cell death. Toxicol Lett (2013) 0.79
Protamine 2 precursors (Pre-P2), protamine 1 to protamine 2 ratio (P1/P2), and assisted reproduction outcome. Fertil Steril (2008) 0.79
Nicotinic acid receptor abnormalities in human skin cancer: implications for a role in epidermal differentiation. PLoS One (2011) 0.79
Detection of radiation and cyclophosphamide-induced mutations in individual mouse sperm at a human expanded trinucleotide repeat locus transgene. Mutat Res (2002) 0.79
XSENP1, a novel sumo-specific protease in Xenopus, inhibits normal head formation by down-regulation of Wnt/beta-catenin signalling. Genes Cells (2004) 0.79
Comparative analysis of inducible expression systems in transient transfection studies. Anal Biochem (2004) 0.79
The role of topoisomerase II beta on breakage and proximity of RUNX1 to partner alleles RUNX1T1 and EVI1. Genes Chromosomes Cancer (2013) 0.78