Published in Science on November 06, 2003
SIRT1 deacetylase protects against neurodegeneration in models for Alzheimer's disease and amyotrophic lateral sclerosis. EMBO J (2007) 4.66
Sir2-independent life span extension by calorie restriction in yeast. PLoS Biol (2004) 3.20
SIRT1 and other sirtuins in metabolism. Trends Endocrinol Metab (2013) 1.90
Mitochondria-ros crosstalk in the control of cell death and aging. J Signal Transduct (2011) 1.89
Increased life span due to calorie restriction in respiratory-deficient yeast. PLoS Genet (2005) 1.86
Stitching together multiple data dimensions reveals interacting metabolomic and transcriptomic networks that modulate cell regulation. PLoS Biol (2012) 1.82
Gene expression profiling reveals a signaling role of glutathione in redox regulation. Proc Natl Acad Sci U S A (2005) 1.57
Nicotinamide prevents NAD+ depletion and protects neurons against excitotoxicity and cerebral ischemia: NAD+ consumption by SIRT1 may endanger energetically compromised neurons. Neuromolecular Med (2009) 1.53
SIRT1-dependent regulation of chromatin and transcription: linking NAD(+) metabolism and signaling to the control of cellular functions. Biochim Biophys Acta (2009) 1.41
Reduced oxidant stress and extended lifespan in mice exposed to a low glycotoxin diet: association with increased AGER1 expression. Am J Pathol (2007) 1.35
SIRT1 contributes in part to cisplatin resistance in cancer cells by altering mitochondrial metabolism. Mol Cancer Res (2008) 1.30
Autophagy failure in Alzheimer's disease and the role of defective lysosomal acidification. Eur J Neurosci (2013) 1.27
Life span extension and neuronal cell protection by Drosophila nicotinamidase. J Biol Chem (2008) 1.23
Metabolic network topology reveals transcriptional regulatory signatures of type 2 diabetes. PLoS Comput Biol (2010) 1.18
The deacetylase enzyme SIRT1 is not associated with oxidative capacity in rat heart and skeletal muscle and its overexpression reduces mitochondrial biogenesis. J Physiol (2009) 1.17
Protective effects and mechanisms of sirtuins in the nervous system. Prog Neurobiol (2011) 1.14
Single sample extraction protocol for the quantification of NAD and NADH redox states in Saccharomyces cerevisiae. J Sep Sci (2008) 1.09
NAD+ metabolite levels as a function of vitamins and calorie restriction: evidence for different mechanisms of longevity. BMC Chem Biol (2010) 1.04
Regulation of yeast sirtuins by NAD(+) metabolism and calorie restriction. Biochim Biophys Acta (2009) 1.02
Leptin attenuates BACE1 expression and amyloid-β genesis via the activation of SIRT1 signaling pathway. Biochim Biophys Acta (2014) 1.00
Calorie restriction: what recent results suggest for the future of ageing research. Eur J Clin Invest (2010) 0.95
An increase in mitochondrial DNA promotes nuclear DNA replication in yeast. PLoS Genet (2008) 0.93
Yeast sirtuins and the regulation of aging. FEMS Yeast Res (2013) 0.92
The SIRT1 modulators AROS and DBC1 regulate HSF1 activity and the heat shock response. PLoS One (2013) 0.90
NQR1 controls lifespan by regulating the promotion of respiratory metabolism in yeast. Aging Cell (2009) 0.90
Molecular Links between Caloric Restriction and Sir2/SIRT1 Activation. Diabetes Metab J (2014) 0.89
Leptin signaling and Alzheimer's disease. Am J Neurodegener Dis (2012) 0.88
The fat-1 transgene in mice increases antioxidant potential, reduces pro-inflammatory cytokine levels, and enhances PPAR-gamma and SIRT-1 expression on a calorie restricted diet. Oxid Med Cell Longev (2010) 0.87
Yeast Tdh3 (glyceraldehyde 3-phosphate dehydrogenase) is a Sir2-interacting factor that regulates transcriptional silencing and rDNA recombination. PLoS Genet (2013) 0.86
Pnc1p-mediated nicotinamide clearance modifies the epigenetic properties of rDNA silencing in Saccharomyces cerevisiae. Genetics (2008) 0.86
Sirtuins as regulators of the yeast metabolic network. Front Pharmacol (2012) 0.86
Transcriptional impact of dietary methionine restriction on systemic inflammation: relevance to biomarkers of metabolic disease during aging. Biofactors (2013) 0.84
Nutrition, sirtuins and aging. Genes Nutr (2006) 0.83
Stress Inducibility of SIRT1 and Its Role in Cytoprotection and Cancer. Genes Cancer (2013) 0.83
The yeast PNC1 longevity gene is up-regulated by mRNA mistranslation. PLoS One (2009) 0.82
CYB5R3: a key player in aerobic metabolism and aging? Aging (Albany NY) (2009) 0.82
Calorie restriction-mediated replicative lifespan extension in yeast is non-cell autonomous. PLoS Biol (2015) 0.80
Quantification of protein copy number in yeast: the NAD+ metabolome. PLoS One (2014) 0.79
Characterization of the respiration-induced yeast mitochondrial permeability transition pore. Yeast (2013) 0.79
Looking for putative functions of the Leishmania cytosolic SIR2 deacetylase. Parasitol Res (2006) 0.79
Skeletal muscle SIRT1 and the genetics of metabolic health: therapeutic activation by pharmaceuticals and exercise. Appl Clin Genet (2012) 0.79
Serum from calorie-restricted animals delays senescence and extends the lifespan of normal human fibroblasts in vitro. Aging (Albany NY) (2015) 0.78
The Nuts and Bolts of Transcriptionally Silent Chromatin in Saccharomyces cerevisiae. Genetics (2016) 0.77
Caloric restriction reduced 1, 2-dimethylhydrazine-induced aberrant crypt foci and induces the expression of Sirtuins in colonic mucosa of F344 rats. J Carcinog (2012) 0.76
Functions for diverse metabolic activities in heterochromatin. Proc Natl Acad Sci U S A (2016) 0.76
New function for Escherichia coli xanthosine phophorylase (xapA): genetic and biochemical evidences on its participation in NAD(+) salvage from nicotinamide. BMC Microbiol (2014) 0.76
The contentious history of sirtuin debates. Rambam Maimonides Med J (2012) 0.76
Effects of an unusual poison identify a lifespan role for Topoisomerase 2 in Saccharomyces cerevisiae. Aging (Albany NY) (2017) 0.75
Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase. Nature (2000) 20.54
Requirement of NAD and SIR2 for life-span extension by calorie restriction in Saccharomyces cerevisiae. Science (2000) 12.98
The silencing protein SIR2 and its homologs are NAD-dependent protein deacetylases. Proc Natl Acad Sci U S A (2000) 7.92
A phylogenetically conserved NAD+-dependent protein deacetylase activity in the Sir2 protein family. Proc Natl Acad Sci U S A (2000) 6.49
Nicotinamide and PNC1 govern lifespan extension by calorie restriction in Saccharomyces cerevisiae. Nature (2003) 6.25
Sir2 regulates skeletal muscle differentiation as a potential sensor of the redox state. Mol Cell (2003) 5.23
Regulation of corepressor function by nuclear NADH. Science (2002) 3.83
Genetics and the specificity of the aging process. Science (2003) 3.20
An intervention resembling caloric restriction prolongs life span and retards aging in yeast. FASEB J (2000) 3.19
Manipulation of a nuclear NAD+ salvage pathway delays aging without altering steady-state NAD+ levels. J Biol Chem (2002) 2.91
Nicotinamide adenine dinucleotide, a metabolic regulator of transcription, longevity and disease. Curr Opin Cell Biol (2003) 2.77
High osmolarity extends life span in Saccharomyces cerevisiae by a mechanism related to calorie restriction. Mol Cell Biol (2002) 2.08
Nucleocytoplasmic movement of fluorescent tracers microinjected into living salivary gland cells. J Cell Biol (1975) 1.92
The yeast glycerol 3-phosphatases Gpp1p and Gpp2p are required for glycerol biosynthesis and differentially involved in the cellular responses to osmotic, anaerobic, and oxidative stress. J Biol Chem (2000) 1.64
Is the glycolytic flux in Lactococcus lactis primarily controlled by the redox charge? Kinetics of NAD(+) and NADH pools determined in vivo by 13C NMR. J Biol Chem (2002) 1.62
Telomeric and rDNA silencing in Saccharomyces cerevisiae are dependent on a nuclear NAD(+) salvage pathway. Genetics (2002) 1.60
Heat stress-induced life span extension in yeast. Exp Cell Res (1998) 1.38
NAD-dependent DNA-binding activity of the bifunctional NadR regulator of Salmonella typhimurium. J Bacteriol (1999) 1.23
Effect of stress on the life span of the yeast Saccharomyces cerevisiae. Acta Biochim Pol (2000) 1.06
In vivo studies of pyridine nucleotide metabolism in Escherichia coli and Saccharomyces cerevisiae by carbon-13 NMR spectroscopy. J Biol Chem (1984) 1.04
13C NMR analysis of electrostatic interactions between NAD+ and active site residues of UDP-galactose 4-epimerase: implications for the activation induced by uridine nucleotides. Biochemistry (2001) 0.82