Published in Nature on February 17, 2000
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SIRT5 Deacetylates carbamoyl phosphate synthetase 1 and regulates the urea cycle. Cell (2009) 3.91
A systematic RNAi screen for longevity genes in C. elegans. Genes Dev (2005) 3.78
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Suppression of oxidative stress by β-hydroxybutyrate, an endogenous histone deacetylase inhibitor. Science (2012) 3.52
The NAD(+)/Sirtuin Pathway Modulates Longevity through Activation of Mitochondrial UPR and FOXO Signaling. Cell (2013) 3.50
Genomewide studies of histone deacetylase function in yeast. Proc Natl Acad Sci U S A (2000) 3.46
AMP-activated protein kinase-deficient mice are resistant to the metabolic effects of resveratrol. Diabetes (2009) 3.39
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Inhibition of SIRT1 catalytic activity increases p53 acetylation but does not alter cell survival following DNA damage. Mol Cell Biol (2006) 3.37
SIRT1 controls endothelial angiogenic functions during vascular growth. Genes Dev (2007) 3.34
SIRT3 deficiency and mitochondrial protein hyperacetylation accelerate the development of the metabolic syndrome. Mol Cell (2011) 3.33
Chemical probes for histone-modifying enzymes. Nat Chem Biol (2008) 3.30
The secret life of NAD+: an old metabolite controlling new metabolic signaling pathways. Endocr Rev (2009) 3.23
RNA polymerase III and RNA polymerase II promoter complexes are heterochromatin barriers in Saccharomyces cerevisiae. EMBO J (2001) 3.20
Sir2-independent life span extension by calorie restriction in yeast. PLoS Biol (2004) 3.20
The NAD(+) precursor nicotinamide riboside enhances oxidative metabolism and protects against high-fat diet-induced obesity. Cell Metab (2012) 3.18
SirT2 is a histone deacetylase with preference for histone H4 Lys 16 during mitosis. Genes Dev (2006) 3.12
Lysine-79 of histone H3 is hypomethylated at silenced loci in yeast and mammalian cells: a potential mechanism for position-effect variegation. Proc Natl Acad Sci U S A (2003) 3.09
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Elevated histone expression promotes life span extension. Mol Cell (2010) 3.09
Ten years of NAD-dependent SIR2 family deacetylases: implications for metabolic diseases. Trends Pharmacol Sci (2010) 3.05
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Steps in assembly of silent chromatin in yeast: Sir3-independent binding of a Sir2/Sir4 complex to silencers and role for Sir2-dependent deacetylation. Mol Cell Biol (2002) 2.93
Metabolism and cancer: the circadian clock connection. Nat Rev Cancer (2009) 2.91
Ordered nucleation and spreading of silenced chromatin in Saccharomyces cerevisiae. Mol Biol Cell (2002) 2.80
Analysis of histone acetyltransferase and histone deacetylase families of Arabidopsis thaliana suggests functional diversification of chromatin modification among multicellular eukaryotes. Nucleic Acids Res (2002) 2.79
SirT3 is a nuclear NAD+-dependent histone deacetylase that translocates to the mitochondria upon cellular stress. Genes Dev (2007) 2.77
The S. cerevisiae SET3 complex includes two histone deacetylases, Hos2 and Hst1, and is a meiotic-specific repressor of the sporulation gene program. Genes Dev (2001) 2.76
Regulation of histone deacetylase 4 by binding of 14-3-3 proteins. Mol Cell Biol (2000) 2.69
hMOF histone acetyltransferase is required for histone H4 lysine 16 acetylation in mammalian cells. Mol Cell Biol (2005) 2.69
The histone deacetylase inhibitor SAHA arrests cancer cell growth, up-regulates thioredoxin-binding protein-2, and down-regulates thioredoxin. Proc Natl Acad Sci U S A (2002) 2.69
Coupling of histone deacetylation to NAD breakdown by the yeast silencing protein Sir2: Evidence for acetyl transfer from substrate to an NAD breakdown product. Proc Natl Acad Sci U S A (2000) 2.61
Dot1a-AF9 complex mediates histone H3 Lys-79 hypermethylation and repression of ENaCalpha in an aldosterone-sensitive manner. J Biol Chem (2006) 2.59
Association of the RENT complex with nontranscribed and coding regions of rDNA and a regional requirement for the replication fork block protein Fob1 in rDNA silencing. Genes Dev (2003) 2.58
Life extension in Drosophila by feeding a drug. Proc Natl Acad Sci U S A (2002) 2.57
Replicative and chronological aging in Saccharomyces cerevisiae. Cell Metab (2012) 2.56
Metabolic regulation of epigenetics. Cell Metab (2012) 2.55
Double strand breaks can initiate gene silencing and SIRT1-dependent onset of DNA methylation in an exogenous promoter CpG island. PLoS Genet (2008) 2.55
Can autophagy promote longevity? Nat Cell Biol (2010) 2.55
SIRT6 regulates TNF-α secretion through hydrolysis of long-chain fatty acyl lysine. Nature (2013) 2.52
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The updated biology of hypoxia-inducible factor. EMBO J (2012) 2.49
Metabolic checkpoints in activated T cells. Nat Immunol (2012) 2.47
SIRT1 sumoylation regulates its deacetylase activity and cellular response to genotoxic stress. Nat Cell Biol (2007) 2.47
Nampt: linking NAD biology, metabolism and cancer. Trends Endocrinol Metab (2008) 2.47
Tandem bromodomains in the chromatin remodeler RSC recognize acetylated histone H3 Lys14. EMBO J (2004) 2.46
Liver-specific deletion of histone deacetylase 3 disrupts metabolic transcriptional networks. EMBO J (2008) 2.44
SIRT2 regulates adipocyte differentiation through FoxO1 acetylation/deacetylation. Cell Metab (2007) 2.42
Histone acetylation at promoters is differentially affected by specific activators and repressors. Mol Cell Biol (2001) 2.40
The neuroprotective properties of calorie restriction, the ketogenic diet, and ketone bodies. Brain Res Rev (2008) 2.39
Sir2 deacetylates histone H3 lysine 56 to regulate telomeric heterochromatin structure in yeast. Mol Cell (2007) 2.38
Small molecule SIRT1 activators for the treatment of aging and age-related diseases. Trends Pharmacol Sci (2014) 2.37
The cAMP/PKA pathway rapidly activates SIRT1 to promote fatty acid oxidation independently of changes in NAD(+). Mol Cell (2011) 2.36
Regulation of intermediary metabolism by protein acetylation. Trends Biochem Sci (2010) 2.36
The Emerging Hallmarks of Cancer Metabolism. Cell Metab (2016) 2.32
Phosphorylation regulates SIRT1 function. PLoS One (2008) 2.30
SIRT1 regulates HIV transcription via Tat deacetylation. PLoS Biol (2005) 2.24
Acetylation of TAF(I)68, a subunit of TIF-IB/SL1, activates RNA polymerase I transcription. EMBO J (2001) 2.24
Identification of a small molecule inhibitor of Sir2p. Proc Natl Acad Sci U S A (2001) 2.23
Potent histone deacetylase inhibitors built from trichostatin A and cyclic tetrapeptide antibiotics including trapoxin. Proc Natl Acad Sci U S A (2001) 2.23
Are sirtuins viable targets for improving healthspan and lifespan? Nat Rev Drug Discov (2012) 2.22
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