Published in Free Radic Biol Med on November 15, 2003
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SOD therapeutics: latest insights into their structure-activity relationships and impact on the cellular redox-based signaling pathways. Antioxid Redox Signal (2013) 1.29
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Oxidants, antioxidants and the ischemic brain. J Exp Biol (2004) 2.05
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Mitochondrial dysfunction in SOD1G93A-bearing astrocytes promotes motor neuron degeneration: prevention by mitochondrial-targeted antioxidants. J Neurosci (2008) 1.72
Pure MnTBAP selectively scavenges peroxynitrite over superoxide: comparison of pure and commercial MnTBAP samples to MnTE-2-PyP in two models of oxidative stress injury, an SOD-specific Escherichia coli model and carrageenan-induced pleurisy. Free Radic Biol Med (2008) 1.65
Reactions of manganese porphyrins with peroxynitrite and carbonate radical anion. J Biol Chem (2003) 1.64
Protein tyrosine nitration--functional alteration or just a biomarker? Free Radic Biol Med (2008) 1.61
Mitochondrial superoxide radicals mediate programmed cell death in Trypanosoma cruzi: cytoprotective action of mitochondrial iron superoxide dismutase overexpression. Biochem J (2007) 1.55
Biochemistry of protein tyrosine nitration in cardiovascular pathology. Cardiovasc Res (2007) 1.48
Characterization of linoleic acid nitration in human blood plasma by mass spectrometry. Biochemistry (2002) 1.48
Sulfenic acid formation in human serum albumin by hydrogen peroxide and peroxynitrite. Biochemistry (2003) 1.46
Pure manganese(III) 5,10,15,20-tetrakis(4-benzoic acid)porphyrin (MnTBAP) is not a superoxide dismutase mimic in aqueous systems: a case of structure-activity relationship as a watchdog mechanism in experimental therapeutics and biology. J Biol Inorg Chem (2007) 1.44
Mitochondrial superoxide production and nuclear factor erythroid 2-related factor 2 activation in p75 neurotrophin receptor-induced motor neuron apoptosis. J Neurosci (2007) 1.40
Mn porphyrin-based superoxide dismutase (SOD) mimic, MnIIITE-2-PyP5+, targets mouse heart mitochondria. Free Radic Biol Med (2007) 1.39
Reactivity of sulfenic acid in human serum albumin. Biochemistry (2007) 1.37
Lipophilicity of potent porphyrin-based antioxidants: comparison of ortho and meta isomers of Mn(III) N-alkylpyridylporphyrins. Free Radic Biol Med (2009) 1.30
Factors affecting protein thiol reactivity and specificity in peroxide reduction. Chem Res Toxicol (2011) 1.28
Impact of electrostatics in redox modulation of oxidative stress by Mn porphyrins: protection of SOD-deficient Escherichia coli via alternative mechanism where Mn porphyrin acts as a Mn carrier. Free Radic Biol Med (2008) 1.26
Complementation of SOD-deficient Escherichia coli by manganese porphyrin mimics of superoxide dismutase activity. Free Radic Biol Med (2004) 1.25
Multiple thioredoxin-mediated routes to detoxify hydroperoxides in Mycobacterium tuberculosis. Arch Biochem Biophys (2004) 1.25
Macrophage activation induces formation of the anti-inflammatory lipid cholesteryl-nitrolinoleate. Biochem J (2009) 1.24
Reduction of manganese porphyrins by flavoenzymes and submitochondrial particles: a catalytic cycle for the reduction of peroxynitrite. Free Radic Biol Med (2006) 1.24
Pharmacokinetics of the potent redox-modulating manganese porphyrin, MnTE-2-PyP(5+), in plasma and major organs of B6C3F1 mice. Free Radic Biol Med (2008) 1.24
Redox modulation of oxidative stress by Mn porphyrin-based therapeutics: the effect of charge distribution. Dalton Trans (2008) 1.23
Kinetics of peroxiredoxins and their role in the decomposition of peroxynitrite. Subcell Biochem (2007) 1.23
The peroxidase and peroxynitrite reductase activity of human erythrocyte peroxiredoxin 2. Arch Biochem Biophys (2008) 1.22
Reactivity of hydrogen sulfide with peroxynitrite and other oxidants of biological interest. Free Radic Biol Med (2010) 1.19
The thiol pool in human plasma: the central contribution of albumin to redox processes. Free Radic Biol Med (2013) 1.18
Effects of metalloporphyrin catalytic antioxidants in experimental brain ischemia. Free Radic Biol Med (2002) 1.17
Intraphagosomal peroxynitrite as a macrophage-derived cytotoxin against internalized Trypanosoma cruzi: consequences for oxidative killing and role of microbial peroxiredoxins in infectivity. J Biol Chem (2010) 1.17
Quality of potent Mn porphyrin-based SOD mimics and peroxynitrite scavengers for pre-clinical mechanistic/therapeutic purposes. J Pharm Biomed Anal (2008) 1.15
Enhanced mitochondrial superoxide in hyperglycemic endothelial cells: direct measurements and formation of hydrogen peroxide and peroxynitrite. Am J Physiol Heart Circ Physiol (2007) 1.15
Macrophage-derived peroxynitrite diffusion and toxicity to Trypanosoma cruzi. Arch Biochem Biophys (2004) 1.14
Inactivation of human Cu,Zn superoxide dismutase by peroxynitrite and formation of histidinyl radical. Free Radic Biol Med (2004) 1.13
Thiol and sulfenic acid oxidation of AhpE, the one-cysteine peroxiredoxin from Mycobacterium tuberculosis: kinetics, acidity constants, and conformational dynamics. Biochemistry (2009) 1.12
Inactivation and nitration of human superoxide dismutase (SOD) by fluxes of nitric oxide and superoxide. Free Radic Biol Med (2007) 1.12
Nitrated fatty acids: mechanisms of formation, chemical characterization, and biological properties. Free Radic Biol Med (2008) 1.12
Febuxostat inhibition of endothelial-bound XO: implications for targeting vascular ROS production. Free Radic Biol Med (2011) 1.09
Binding of xanthine oxidase to glycosaminoglycans limits inhibition by oxypurinol. J Biol Chem (2004) 1.09
Direct measurement of nitric oxide and oxygen partitioning into liposomes and low density lipoprotein. J Biol Chem (2005) 1.09
Cytochrome c: a catalyst and target of nitrite-hydrogen peroxide-dependent protein nitration. Arch Biochem Biophys (2004) 1.08
Trypanosoma brucei and Trypanosoma cruzi tryparedoxin peroxidases catalytically detoxify peroxynitrite via oxidation of fast reacting thiols. J Biol Chem (2004) 1.08
Pre-steady state kinetic characterization of human peroxiredoxin 5: taking advantage of Trp84 fluorescence increase upon oxidation. Arch Biochem Biophys (2007) 1.08
Fighting the oxidative assault: the Trypanosoma cruzi journey to infection. Curr Opin Microbiol (2009) 1.07
Mitochondrial aconitase reaction with nitric oxide, S-nitrosoglutathione, and peroxynitrite: mechanisms and relative contributions to aconitase inactivation. Free Radic Biol Med (2007) 1.05
Synthesis, isomer characterization, and anti-inflammatory properties of nitroarachidonate. Biochemistry (2007) 1.05
Peroxynitrite and drug-dependent toxicity. Toxicology (2005) 1.04
Tyrosine nitration by superoxide and nitric oxide fluxes in biological systems: modeling the impact of superoxide dismutase and nitric oxide diffusion. Free Radic Biol Med (2005) 1.04
Structural and enzymatic insights into the ATP binding and autophosphorylation mechanism of a sensor histidine kinase. J Biol Chem (2010) 1.03
Involvement of inducible nitric oxide synthase in hydroxyl radical-mediated lipid peroxidation in streptozotocin-induced diabetes. Free Radic Biol Med (2008) 1.03
Protein and lipid nitration: role in redox signaling and injury. Biochim Biophys Acta (2008) 1.02
Mitochondrial protein tyrosine nitration. Free Radic Res (2010) 1.02
Superoxide-mediated inactivation of nitric oxide and peroxynitrite formation by tobacco smoke in vascular endothelium: studies in cultured cells and smokers. Am J Physiol Heart Circ Physiol (2009) 1.02
Prevention of peroxynitrite-induced apoptosis of motor neurons and PC12 cells by tyrosine-containing peptides. J Biol Chem (2007) 1.02
Reactions of manganese porphyrins and manganese-superoxide dismutase with peroxynitrite. Methods Enzymol (2002) 1.01
Peroxynitrite reaction with the reduced and the oxidized forms of lipoic acid: new insights into the reaction of peroxynitrite with thiols. Arch Biochem Biophys (2002) 1.01
Peroxiredoxins play a major role in protecting Trypanosoma cruzi against macrophage- and endogenously-derived peroxynitrite. Biochem J (2008) 1.01
Disruption of the M80-Fe ligation stimulates the translocation of cytochrome c to the cytoplasm and nucleus in nonapoptotic cells. Proc Natl Acad Sci U S A (2009) 1.00
Time course and site(s) of cytochrome c tyrosine nitration by peroxynitrite. Biochemistry (2005) 1.00
SOD-like activity of Mn(II) beta-octabromo-meso-tetrakis(N-methylpyridinium-3-yl)porphyrin equals that of the enzyme itself. Arch Biochem Biophys (2008) 1.00
Mitochondrial calcium overload triggers complement-dependent superoxide-mediated programmed cell death in Trypanosoma cruzi. Biochem J (2009) 0.99
Reaction of human hemoglobin with peroxynitrite. Isomerization to nitrate and secondary formation of protein radicals. J Biol Chem (2003) 0.99
Septic diaphragmatic dysfunction is prevented by Mn(III)porphyrin therapy and inducible nitric oxide synthase inhibition. Intensive Care Med (2004) 0.98
Albumin and hydroxyethyl starch modulate oxidative inflammatory injury to vascular endothelium. Anesthesiology (2004) 0.98
Insights into the redox biology of Trypanosoma cruzi: Trypanothione metabolism and oxidant detoxification. Free Radic Biol Med (2008) 0.97
New approach to the activation of anti-cancer pro-drugs by metalloporphyrin-based cytochrome P450 mimics in all-aqueous biologically relevant system. J Inorg Biochem (2006) 0.96
Mechanistic studies of peroxynitrite-mediated tyrosine nitration in membranes using the hydrophobic probe N-t-BOC-L-tyrosine tert-butyl ester. Biochemistry (2006) 0.96
Nitration of solvent-exposed tyrosine 74 on cytochrome c triggers heme iron-methionine 80 bond disruption. Nuclear magnetic resonance and optical spectroscopy studies. J Biol Chem (2008) 0.95
Olives and olive oil are sources of electrophilic fatty acid nitroalkenes. PLoS One (2014) 0.95
Design and synthesis of manganese porphyrins with tailored lipophilicity: investigation of redox properties and superoxide dismutase activity. Bioorg Med Chem (2007) 0.95
Trypanosoma cruzi antioxidant enzymes as virulence factors in Chagas disease. Antioxid Redox Signal (2012) 0.95
Sulfenic acid--a key intermediate in albumin thiol oxidation. J Chromatogr B Analyt Technol Biomed Life Sci (2009) 0.95
Peroxynitrite detoxification and its biologic implications. Antioxid Redox Signal (2008) 0.94
Critical role of hydrogen peroxide signaling in the sequential activation of p38 MAPK and eNOS in laminar shear stress. Free Radic Biol Med (2012) 0.94
Kinetic studies on peroxynitrite reduction by peroxiredoxins. Methods Enzymol (2008) 0.94
Dioxygen reactivity and heme redox potential of truncated human cystathionine beta-synthase. Biochemistry (2008) 0.93
Formation of protein tyrosine ortho-semiquinone radical and nitrotyrosine from cytochrome c-derived tyrosyl radical. J Biol Chem (2004) 0.93
Cyclosporine A-induced nitration of tyrosine 34 MnSOD in endothelial cells: role of mitochondrial superoxide. Cardiovasc Res (2010) 0.93
Diffusion of nitric oxide into low density lipoprotein. J Biol Chem (2001) 0.93
Discovery of novel inhibitors of Trypanosoma cruzi trans-sialidase from in silico screening. Bioorg Med Chem Lett (2008) 0.92