Published in Biochemistry on February 16, 2008
PLP-dependent H(2)S biogenesis. Biochim Biophys Acta (2011) 1.29
Modulation of the heme electronic structure and cystathionine beta-synthase activity by second coordination sphere ligands: The role of heme ligand switching in redox regulation. J Inorg Biochem (2009) 1.22
Hydrogen sulfide and hemeproteins: knowledge and mysteries. Antioxid Redox Signal (2011) 1.10
Reversible heme-dependent regulation of human cystathionine β-synthase by a flavoprotein oxidoreductase. Biochemistry (2011) 0.99
Heme regulation of human cystathionine beta-synthase activity: insights from fluorescence and Raman spectroscopy. J Am Chem Soc (2009) 0.98
Inactivation of cystathionine beta-synthase with peroxynitrite. Arch Biochem Biophys (2009) 0.91
Kinetics of reversible reductive carbonylation of heme in human cystathionine β-synthase. Biochemistry (2013) 0.85
NO* binds human cystathionine β-synthase quickly and tightly. J Biol Chem (2014) 0.81
S-Adenosyl-l-methionine Modulates CO and NO• Binding to the Human H2S-generating Enzyme Cystathionine β-Synthase. J Biol Chem (2015) 0.79
Purification and characterization of cystathionine β-synthase bearing a cobalt protoporphyrin. Arch Biochem Biophys (2011) 0.79
Cystathionine β-synthase inhibition is a potential therapeutic approach to treatment of ischemic injury. ASN Neuro (2015) 0.77
Catalytic promiscuity and heme-dependent redox regulation of H2S synthesis. Curr Opin Chem Biol (2017) 0.75
Kinetics of Nitrite Reduction and Peroxynitrite Formation by Ferrous Heme in Human Cystathionine β-Synthase. J Biol Chem (2016) 0.75
A Clinically Relevant Variant of the Human Hydrogen Sulfide-Synthesizing Enzyme Cystathionine β-Synthase: Increased CO Reactivity as a Novel Molecular Mechanism of Pathogenicity? Oxid Med Cell Longev (2017) 0.75
Peroxynitrite: biochemistry, pathophysiology and development of therapeutics. Nat Rev Drug Discov (2007) 5.65
Redox biochemistry of hydrogen sulfide. J Biol Chem (2010) 3.64
Relative contributions of cystathionine beta-synthase and gamma-cystathionase to H2S biogenesis via alternative trans-sulfuration reactions. J Biol Chem (2009) 2.49
H2S biogenesis by human cystathionine gamma-lyase leads to the novel sulfur metabolites lanthionine and homolanthionine and is responsive to the grade of hyperhomocysteinemia. J Biol Chem (2009) 2.28
Chemical biology of peroxynitrite: kinetics, diffusion, and radicals. ACS Chem Biol (2009) 1.99
Aerobiosis increases the genomic guanine plus cytosine content (GC%) in prokaryotes. J Mol Evol (2002) 1.85
Nitro-fatty acid reaction with glutathione and cysteine. Kinetic analysis of thiol alkylation by a Michael addition reaction. J Biol Chem (2007) 1.78
Mitochondrial dysfunction in SOD1G93A-bearing astrocytes promotes motor neuron degeneration: prevention by mitochondrial-targeted antioxidants. J Neurosci (2008) 1.72
S-adenosylmethionine stabilizes cystathionine beta-synthase and modulates redox capacity. Proc Natl Acad Sci U S A (2006) 1.66
Pure MnTBAP selectively scavenges peroxynitrite over superoxide: comparison of pure and commercial MnTBAP samples to MnTE-2-PyP in two models of oxidative stress injury, an SOD-specific Escherichia coli model and carrageenan-induced pleurisy. Free Radic Biol Med (2008) 1.65
Reactions of manganese porphyrins with peroxynitrite and carbonate radical anion. J Biol Chem (2003) 1.64
Protein tyrosine nitration--functional alteration or just a biomarker? Free Radic Biol Med (2008) 1.61
A functional transsulfuration pathway in the brain links to glutathione homeostasis. J Biol Chem (2006) 1.61
Decyanation of vitamin B12 by a trafficking chaperone. Proc Natl Acad Sci U S A (2008) 1.60
The quantitative significance of the transsulfuration enzymes for H2S production in murine tissues. Antioxid Redox Signal (2011) 1.60
Mitochondrial superoxide radicals mediate programmed cell death in Trypanosoma cruzi: cytoprotective action of mitochondrial iron superoxide dismutase overexpression. Biochem J (2007) 1.55
Selective fluorescent probes for live-cell monitoring of sulphide. Nat Commun (2011) 1.51
Biochemistry of protein tyrosine nitration in cardiovascular pathology. Cardiovasc Res (2007) 1.48
Perturbations in homocysteine-linked redox homeostasis in a murine model for hyperhomocysteinemia. Am J Physiol Regul Integr Comp Physiol (2004) 1.47
Human cystathionine beta-synthase is a heme sensor protein. Evidence that the redox sensor is heme and not the vicinal cysteines in the CXXC motif seen in the crystal structure of the truncated enzyme. Biochemistry (2002) 1.46
Sulfenic acid formation in human serum albumin by hydrogen peroxide and peroxynitrite. Biochemistry (2003) 1.46
Extracellular redox modulation by regulatory T cells. Nat Chem Biol (2009) 1.45
High turnover rates for hydrogen sulfide allow for rapid regulation of its tissue concentrations. Antioxid Redox Signal (2012) 1.44
Processing of alkylcobalamins in mammalian cells: A role for the MMACHC (cblC) gene product. Mol Genet Metab (2009) 1.40
Mitochondrial superoxide production and nuclear factor erythroid 2-related factor 2 activation in p75 neurotrophin receptor-induced motor neuron apoptosis. J Neurosci (2007) 1.40
Enzymology of H2S biogenesis, decay and signaling. Antioxid Redox Signal (2013) 1.39
Prognostic value of 1p, 19q, 9p, 10q, and EGFR-FISH analyses in recurrent oligodendrogliomas. J Neuropathol Exp Neurol (2004) 1.39
Reactivity of sulfenic acid in human serum albumin. Biochemistry (2007) 1.37
Differential NF1, p16, and EGFR patterns by interphase cytogenetics (FISH) in malignant peripheral nerve sheath tumor (MPNST) and morphologically similar spindle cell neoplasms. J Neuropathol Exp Neurol (2002) 1.36
Structural basis for substrate activation and regulation by cystathionine beta-synthase (CBS) domains in cystathionine {beta}-synthase. Proc Natl Acad Sci U S A (2010) 1.30
Alleviation of intrasteric inhibition by the pathogenic activation domain mutation, D444N, in human cystathionine beta-synthase. Biochemistry (2002) 1.29
PLP-dependent H(2)S biogenesis. Biochim Biophys Acta (2011) 1.29
Spectroscopic evidence for the formation of a four-coordinate Co2+ cobalamin species upon binding to the human ATP:cobalamin adenosyltransferase. J Am Chem Soc (2005) 1.29
Factors affecting protein thiol reactivity and specificity in peroxide reduction. Chem Res Toxicol (2011) 1.28
A human vitamin B12 trafficking protein uses glutathione transferase activity for processing alkylcobalamins. J Biol Chem (2009) 1.27
Navigating the B(12) road: assimilation, delivery, and disorders of cobalamin. J Biol Chem (2013) 1.27
Characterization of patient mutations in human persulfide dioxygenase (ETHE1) involved in H2S catabolism. J Biol Chem (2012) 1.26
Multiple thioredoxin-mediated routes to detoxify hydroperoxides in Mycobacterium tuberculosis. Arch Biochem Biophys (2004) 1.25
Differences in the efficiency of reductive activation of methionine synthase and exogenous electron acceptors between the common polymorphic variants of human methionine synthase reductase. Biochemistry (2002) 1.24
Reduction of manganese porphyrins by flavoenzymes and submitochondrial particles: a catalytic cycle for the reduction of peroxynitrite. Free Radic Biol Med (2006) 1.24
Kinetics of peroxiredoxins and their role in the decomposition of peroxynitrite. Subcell Biochem (2007) 1.23
Neuroprotective immunity: T cell-derived glutamate endows astrocytes with a neuroprotective phenotype. J Immunol (2008) 1.22
Dose-occupancy study of striatal and extrastriatal dopamine D2 receptors by aripiprazole in schizophrenia with PET and [18F]fallypride. Neuropsychopharmacology (2008) 1.22
Modulation of the heme electronic structure and cystathionine beta-synthase activity by second coordination sphere ligands: The role of heme ligand switching in redox regulation. J Inorg Biochem (2009) 1.22
Adenosyltransferase tailors and delivers coenzyme B12. Nat Chem Biol (2008) 1.21
Crystal structure and mutagenesis of the metallochaperone MeaB: insight into the causes of methylmalonic aciduria. J Biol Chem (2007) 1.19
Reactivity of hydrogen sulfide with peroxynitrite and other oxidants of biological interest. Free Radic Biol Med (2010) 1.19
A G-protein editor gates coenzyme B12 loading and is corrupted in methylmalonic aciduria. Proc Natl Acad Sci U S A (2009) 1.19
Clinical utility of fluorescence in situ hybridization (FISH) in morphologically ambiguous gliomas with hybrid oligodendroglial/astrocytic features. J Neuropathol Exp Neurol (2003) 1.18
Energetics of interaction between the G-protein chaperone, MeaB, and B12-dependent methylmalonyl-CoA mutase. J Biol Chem (2006) 1.18
The thiol pool in human plasma: the central contribution of albumin to redox processes. Free Radic Biol Med (2013) 1.18
Intraphagosomal peroxynitrite as a macrophage-derived cytotoxin against internalized Trypanosoma cruzi: consequences for oxidative killing and role of microbial peroxiredoxins in infectivity. J Biol Chem (2010) 1.17
Ion channel blockade attenuates aggregated alpha synuclein induction of microglial reactive oxygen species: relevance for the pathogenesis of Parkinson's disease. J Neurochem (2007) 1.15
Nitrated alpha-synuclein and microglial neuroregulatory activities. J Neuroimmune Pharmacol (2008) 1.15
Enhanced mitochondrial superoxide in hyperglycemic endothelial cells: direct measurements and formation of hydrogen peroxide and peroxynitrite. Am J Physiol Heart Circ Physiol (2007) 1.15
Human ATP:Cob(I)alamin adenosyltransferase and its interaction with methionine synthase reductase. J Biol Chem (2004) 1.15
Properties of an unusual heme cofactor in PLP-dependent cystathionine beta-synthase. Nat Prod Rep (2007) 1.14
Macrophage-derived peroxynitrite diffusion and toxicity to Trypanosoma cruzi. Arch Biochem Biophys (2004) 1.14
Increased transsulfuration mediates longevity and dietary restriction in Drosophila. Proc Natl Acad Sci U S A (2011) 1.14
Ancillary FISH analysis for 1p and 19q status: preliminary observations in 287 gliomas and oligodendroglioma mimics. Front Biosci (2003) 1.13
Inactivation of human Cu,Zn superoxide dismutase by peroxynitrite and formation of histidinyl radical. Free Radic Biol Med (2004) 1.13
Assembly and protection of the radical enzyme, methylmalonyl-CoA mutase, by its chaperone. Biochemistry (2006) 1.13
Structure and kinetic analysis of H2S production by human mercaptopyruvate sulfurtransferase. J Biol Chem (2013) 1.13
Thiol and sulfenic acid oxidation of AhpE, the one-cysteine peroxiredoxin from Mycobacterium tuberculosis: kinetics, acidity constants, and conformational dynamics. Biochemistry (2009) 1.12
Inactivation and nitration of human superoxide dismutase (SOD) by fluxes of nitric oxide and superoxide. Free Radic Biol Med (2007) 1.12
Visualization of PLP-bound intermediates in hemeless variants of human cystathionine beta-synthase: evidence that lysine 119 is a general base. Arch Biochem Biophys (2004) 1.11
Homocysteine and redox signaling. Antioxid Redox Signal (2005) 1.10
Time line of redox events in aging postmitotic cells. Elife (2013) 1.10
Integrated stress response modulates cellular redox state via induction of cystathionine γ-lyase: cross-talk between integrated stress response and thiol metabolism. J Biol Chem (2012) 1.10
Febuxostat inhibition of endothelial-bound XO: implications for targeting vascular ROS production. Free Radic Biol Med (2011) 1.09
Binding of xanthine oxidase to glycosaminoglycans limits inhibition by oxypurinol. J Biol Chem (2004) 1.09
Direct measurement of nitric oxide and oxygen partitioning into liposomes and low density lipoprotein. J Biol Chem (2005) 1.09
Differential dependence on cysteine from transsulfuration versus transport during T cell activation. Antioxid Redox Signal (2010) 1.09
Cytochrome c: a catalyst and target of nitrite-hydrogen peroxide-dependent protein nitration. Arch Biochem Biophys (2004) 1.08
Trypanosoma brucei and Trypanosoma cruzi tryparedoxin peroxidases catalytically detoxify peroxynitrite via oxidation of fast reacting thiols. J Biol Chem (2004) 1.08
Structural basis of multifunctionality in a vitamin B12-processing enzyme. J Biol Chem (2011) 1.08
Pre-steady state kinetic characterization of human peroxiredoxin 5: taking advantage of Trp84 fluorescence increase upon oxidation. Arch Biochem Biophys (2007) 1.08
Redox remodeling as an immunoregulatory strategy. Biochemistry (2010) 1.08
Fighting the oxidative assault: the Trypanosoma cruzi journey to infection. Curr Opin Microbiol (2009) 1.07
Integrative expression system for delivery of antibody fragments by lactobacilli. Appl Environ Microbiol (2011) 1.06
Mirror "base-off" conformation of coenzyme B12 in human adenosyltransferase and its downstream target, methylmalonyl-CoA mutase. J Am Chem Soc (2005) 1.06
Kinetic and thermodynamic characterization of the common polymorphic variants of human methionine synthase reductase. Biochemistry (2004) 1.06
Coupling of hydrogenic tunneling to active-site motion in the hydrogen radical transfer catalyzed by a coenzyme B12-dependent mutase. Proc Natl Acad Sci U S A (2007) 1.05
Dynamics of carbon monoxide binding to cystathionine beta-synthase. J Biol Chem (2006) 1.05
Mitochondrial aconitase reaction with nitric oxide, S-nitrosoglutathione, and peroxynitrite: mechanisms and relative contributions to aconitase inactivation. Free Radic Biol Med (2007) 1.05
Characterization of a succinyl-CoA radical-cob(II)alamin spin triplet intermediate in the reaction catalyzed by adenosylcobalamin-dependent methylmalonyl-CoA mutase. Biochemistry (2005) 1.05
Human cystathionine beta-synthase is a target for sumoylation. Biochemistry (2006) 1.05
Peroxynitrite and drug-dependent toxicity. Toxicology (2005) 1.04
Tyrosine nitration by superoxide and nitric oxide fluxes in biological systems: modeling the impact of superoxide dismutase and nitric oxide diffusion. Free Radic Biol Med (2005) 1.04
Sulfur as a signaling nutrient through hydrogen sulfide. Annu Rev Nutr (2014) 1.04
Involvement of inducible nitric oxide synthase in hydroxyl radical-mediated lipid peroxidation in streptozotocin-induced diabetes. Free Radic Biol Med (2008) 1.03
Protein and lipid nitration: role in redox signaling and injury. Biochim Biophys Acta (2008) 1.02