Published in Chem Res Toxicol on March 10, 2011
Beyond oxidative stress: an immunologist's guide to reactive oxygen species. Nat Rev Immunol (2013) 2.31
Hydrogen peroxide sensing, signaling and regulation of transcription factors. Redox Biol (2014) 1.54
Manganese superoxide dismutase, MnSOD and its mimics. Biochim Biophys Acta (2011) 1.46
The redox biochemistry of protein sulfenylation and sulfinylation. J Biol Chem (2013) 1.30
SOD therapeutics: latest insights into their structure-activity relationships and impact on the cellular redox-based signaling pathways. Antioxid Redox Signal (2013) 1.29
Peroxynitrite, a stealthy biological oxidant. J Biol Chem (2013) 1.27
Sulfenic acid chemistry, detection and cellular lifetime. Biochim Biophys Acta (2013) 1.23
Oxidant sensing by reversible disulfide bond formation. J Biol Chem (2013) 1.18
The thiol pool in human plasma: the central contribution of albumin to redox processes. Free Radic Biol Med (2013) 1.18
Peroxiredoxins: guardians against oxidative stress and modulators of peroxide signaling. Trends Biochem Sci (2015) 1.14
The basics of thiols and cysteines in redox biology and chemistry. Free Radic Biol Med (2014) 1.11
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Tuning of peroxiredoxin catalysis for various physiological roles. Biochemistry (2014) 1.02
Peroxiredoxins in parasites. Antioxid Redox Signal (2012) 1.01
Kinetic and thermodynamic features reveal that Escherichia coli BCP is an unusually versatile peroxiredoxin. Biochemistry (2011) 1.01
The cysteine proteome. Free Radic Biol Med (2015) 1.00
Design, mechanism of action, bioavailability and therapeutic effects of mn porphyrin-based redox modulators. Med Princ Pract (2012) 0.99
Kinetics and mechanisms of thiol-disulfide exchange covering direct substitution and thiol oxidation-mediated pathways. Antioxid Redox Signal (2013) 0.99
Kinetic and mechanistic considerations to assess the biological fate of peroxynitrite. Biochim Biophys Acta (2013) 0.91
Hydrogen peroxide - production, fate and role in redox signaling of tumor cells. Cell Commun Signal (2015) 0.91
Structural details of the OxyR peroxide-sensing mechanism. Proc Natl Acad Sci U S A (2015) 0.90
The Roles of Peroxiredoxin and Thioredoxin in Hydrogen Peroxide Sensing and in Signal Transduction. Mol Cells (2016) 0.88
Dissecting peroxiredoxin catalysis: separating binding, peroxidation, and resolution for a bacterial AhpC. Biochemistry (2015) 0.87
Molecular basis of intramolecular electron transfer in proteins during radical-mediated oxidations: computer simulation studies in model tyrosine-cysteine peptides in solution. Arch Biochem Biophys (2012) 0.87
S-nitrosylation: specificity, occupancy, and interaction with other post-translational modifications. Antioxid Redox Signal (2013) 0.87
Transcription Factors That Defend Bacteria Against Reactive Oxygen Species. Annu Rev Microbiol (2015) 0.86
The extraordinary catalytic ability of peroxiredoxins: a combined experimental and QM/MM study on the fast thiol oxidation step. Chem Commun (Camb) (2014) 0.85
Nitration transforms a sensitive peroxiredoxin 2 into a more active and robust peroxidase. J Biol Chem (2014) 0.84
Multiple Roles of Peroxiredoxins in Inflammation. Mol Cells (2016) 0.83
Estimation of kinetic parameters related to biochemical interactions between hydrogen peroxide and signal transduction proteins. Front Chem (2014) 0.81
Paradoxical Roles of Antioxidant Enzymes: Basic Mechanisms and Health Implications. Physiol Rev (2016) 0.81
The cysteine-rich protein thimet oligopeptidase as a model of the structural requirements for S-glutathiolation and oxidative oligomerization. PLoS One (2012) 0.79
S-sulfhydration as a cellular redox regulation. Biosci Rep (2015) 0.79
Analysis of naphthalene adduct binding sites in model proteins by tandem mass spectrometry. Chem Biol Interact (2012) 0.79
Molecular basis of the mechanism of thiol oxidation by hydrogen peroxide in aqueous solution: challenging the SN2 paradigm. Chem Res Toxicol (2012) 0.79
Oxygen in human health from life to death - An approach to teaching redox biology and signaling to graduate and medical students. Redox Biol (2015) 0.79
Distribution and Features of the Six Classes of Peroxiredoxins. Mol Cells (2016) 0.78
Regulated methionine oxidation by monooxygenases. Free Radic Biol Med (2017) 0.78
Biological chemistry and functionality of protein sulfenic acids and related thiol modifications. Free Radic Res (2015) 0.77
Characterization of model peptide adducts with reactive metabolites of naphthalene by mass spectrometry. PLoS One (2012) 0.77
An Atlas of Peroxiredoxins Created Using an Active Site Profile-Based Approach to Functionally Relevant Clustering of Proteins. PLoS Comput Biol (2017) 0.77
Evidence that glutathione and the glutathione system efficiently recycle 1-cys sulfiredoxin in vivo. Antioxid Redox Signal (2015) 0.76
Copper-zinc superoxide dismutase is activated through a sulfenic acid intermediate at a copper-ion entry site. J Biol Chem (2017) 0.75
Redox-Active Sensing by Bacterial DksA Transcription Factors Is Determined by Cysteine and Zinc Content. MBio (2016) 0.75
Structural basis of redox-dependent modulation of galectin-1 dynamics and function. Glycobiology (2014) 0.75
Reactivity of disulfide bonds is markedly affected by structure and environment: implications for protein modification and stability. Sci Rep (2016) 0.75
Catalytic Thr or Ser Residue Modulates Structural Switches in 2-Cys Peroxiredoxin by Distinct Mechanisms. Sci Rep (2016) 0.75
Biochemical mechanisms and therapeutic potential of pseudohalide thiocyanate in human health. Free Radic Res (2015) 0.75
Quantitative biology of hydrogen peroxide signaling. Redox Biol (2017) 0.75
Cysteines as Redox Molecular Switches and Targets of Disease. Front Mol Neurosci (2017) 0.75
Peroxynitrite: biochemistry, pathophysiology and development of therapeutics. Nat Rev Drug Discov (2007) 5.65
Chemical biology of peroxynitrite: kinetics, diffusion, and radicals. ACS Chem Biol (2009) 1.99
Nitro-fatty acid reaction with glutathione and cysteine. Kinetic analysis of thiol alkylation by a Michael addition reaction. J Biol Chem (2007) 1.78
Mitochondrial dysfunction in SOD1G93A-bearing astrocytes promotes motor neuron degeneration: prevention by mitochondrial-targeted antioxidants. J Neurosci (2008) 1.72
Pure MnTBAP selectively scavenges peroxynitrite over superoxide: comparison of pure and commercial MnTBAP samples to MnTE-2-PyP in two models of oxidative stress injury, an SOD-specific Escherichia coli model and carrageenan-induced pleurisy. Free Radic Biol Med (2008) 1.65
Reactions of manganese porphyrins with peroxynitrite and carbonate radical anion. J Biol Chem (2003) 1.64
Protein tyrosine nitration--functional alteration or just a biomarker? Free Radic Biol Med (2008) 1.61
Mitochondrial superoxide radicals mediate programmed cell death in Trypanosoma cruzi: cytoprotective action of mitochondrial iron superoxide dismutase overexpression. Biochem J (2007) 1.55
Biochemistry of protein tyrosine nitration in cardiovascular pathology. Cardiovasc Res (2007) 1.48
Sulfenic acid formation in human serum albumin by hydrogen peroxide and peroxynitrite. Biochemistry (2003) 1.46
Evaluating the antioxidant capacity of natural products: a review on chemical and cellular-based assays. Anal Chim Acta (2012) 1.44
Mitochondrial superoxide production and nuclear factor erythroid 2-related factor 2 activation in p75 neurotrophin receptor-induced motor neuron apoptosis. J Neurosci (2007) 1.40
Reactivity of sulfenic acid in human serum albumin. Biochemistry (2007) 1.37
Acceleration of nitric oxide autoxidation and nitrosation by membranes. IUBMB Life (2007) 1.26
Multiple thioredoxin-mediated routes to detoxify hydroperoxides in Mycobacterium tuberculosis. Arch Biochem Biophys (2004) 1.25
Reduction of manganese porphyrins by flavoenzymes and submitochondrial particles: a catalytic cycle for the reduction of peroxynitrite. Free Radic Biol Med (2006) 1.24
Kinetics of peroxiredoxins and their role in the decomposition of peroxynitrite. Subcell Biochem (2007) 1.23
Platyhelminth mitochondrial and cytosolic redox homeostasis is controlled by a single thioredoxin glutathione reductase and dependent on selenium and glutathione. J Biol Chem (2008) 1.22
The peroxidase and peroxynitrite reductase activity of human erythrocyte peroxiredoxin 2. Arch Biochem Biophys (2008) 1.22
Membrane "lens" effect: focusing the formation of reactive nitrogen oxides from the *NO/O2 reaction. Chem Res Toxicol (2007) 1.20
Reactivity of hydrogen sulfide with peroxynitrite and other oxidants of biological interest. Free Radic Biol Med (2010) 1.19
The thiol pool in human plasma: the central contribution of albumin to redox processes. Free Radic Biol Med (2013) 1.18
Intraphagosomal peroxynitrite as a macrophage-derived cytotoxin against internalized Trypanosoma cruzi: consequences for oxidative killing and role of microbial peroxiredoxins in infectivity. J Biol Chem (2010) 1.17
Enhanced mitochondrial superoxide in hyperglycemic endothelial cells: direct measurements and formation of hydrogen peroxide and peroxynitrite. Am J Physiol Heart Circ Physiol (2007) 1.15
Macrophage-derived peroxynitrite diffusion and toxicity to Trypanosoma cruzi. Arch Biochem Biophys (2004) 1.14
Inactivation of human Cu,Zn superoxide dismutase by peroxynitrite and formation of histidinyl radical. Free Radic Biol Med (2004) 1.13
Thiol and sulfenic acid oxidation of AhpE, the one-cysteine peroxiredoxin from Mycobacterium tuberculosis: kinetics, acidity constants, and conformational dynamics. Biochemistry (2009) 1.12
Inactivation and nitration of human superoxide dismutase (SOD) by fluxes of nitric oxide and superoxide. Free Radic Biol Med (2007) 1.12
Febuxostat inhibition of endothelial-bound XO: implications for targeting vascular ROS production. Free Radic Biol Med (2011) 1.09
Binding of xanthine oxidase to glycosaminoglycans limits inhibition by oxypurinol. J Biol Chem (2004) 1.09
Direct measurement of nitric oxide and oxygen partitioning into liposomes and low density lipoprotein. J Biol Chem (2005) 1.09
Trypanosoma brucei and Trypanosoma cruzi tryparedoxin peroxidases catalytically detoxify peroxynitrite via oxidation of fast reacting thiols. J Biol Chem (2004) 1.08
Cytochrome c: a catalyst and target of nitrite-hydrogen peroxide-dependent protein nitration. Arch Biochem Biophys (2004) 1.08
Pre-steady state kinetic characterization of human peroxiredoxin 5: taking advantage of Trp84 fluorescence increase upon oxidation. Arch Biochem Biophys (2007) 1.08
Fighting the oxidative assault: the Trypanosoma cruzi journey to infection. Curr Opin Microbiol (2009) 1.07
Mitochondrial aconitase reaction with nitric oxide, S-nitrosoglutathione, and peroxynitrite: mechanisms and relative contributions to aconitase inactivation. Free Radic Biol Med (2007) 1.05
Synthesis, isomer characterization, and anti-inflammatory properties of nitroarachidonate. Biochemistry (2007) 1.05
Peroxynitrite and drug-dependent toxicity. Toxicology (2005) 1.04
Tyrosine nitration by superoxide and nitric oxide fluxes in biological systems: modeling the impact of superoxide dismutase and nitric oxide diffusion. Free Radic Biol Med (2005) 1.04
Structural and enzymatic insights into the ATP binding and autophosphorylation mechanism of a sensor histidine kinase. J Biol Chem (2010) 1.03
Involvement of inducible nitric oxide synthase in hydroxyl radical-mediated lipid peroxidation in streptozotocin-induced diabetes. Free Radic Biol Med (2008) 1.03
Protein and lipid nitration: role in redox signaling and injury. Biochim Biophys Acta (2008) 1.02
Mitochondrial protein tyrosine nitration. Free Radic Res (2010) 1.02
Superoxide-mediated inactivation of nitric oxide and peroxynitrite formation by tobacco smoke in vascular endothelium: studies in cultured cells and smokers. Am J Physiol Heart Circ Physiol (2009) 1.02
Prevention of peroxynitrite-induced apoptosis of motor neurons and PC12 cells by tyrosine-containing peptides. J Biol Chem (2007) 1.02
Reactions of manganese porphyrins and manganese-superoxide dismutase with peroxynitrite. Methods Enzymol (2002) 1.01
Peroxiredoxins play a major role in protecting Trypanosoma cruzi against macrophage- and endogenously-derived peroxynitrite. Biochem J (2008) 1.01
Peroxynitrite reaction with the reduced and the oxidized forms of lipoic acid: new insights into the reaction of peroxynitrite with thiols. Arch Biochem Biophys (2002) 1.01
Novel antitrypanosomal agents based on palladium nitrofurylthiosemicarbazone complexes: DNA and redox metabolism as potential therapeutic targets. J Med Chem (2006) 1.00
Disruption of the M80-Fe ligation stimulates the translocation of cytochrome c to the cytoplasm and nucleus in nonapoptotic cells. Proc Natl Acad Sci U S A (2009) 1.00
Solubility and permeation of hydrogen sulfide in lipid membranes. PLoS One (2012) 1.00
Time course and site(s) of cytochrome c tyrosine nitration by peroxynitrite. Biochemistry (2005) 1.00
Reaction of human hemoglobin with peroxynitrite. Isomerization to nitrate and secondary formation of protein radicals. J Biol Chem (2003) 0.99
Mitochondrial calcium overload triggers complement-dependent superoxide-mediated programmed cell death in Trypanosoma cruzi. Biochem J (2009) 0.99
Albumin and hydroxyethyl starch modulate oxidative inflammatory injury to vascular endothelium. Anesthesiology (2004) 0.98
Septic diaphragmatic dysfunction is prevented by Mn(III)porphyrin therapy and inducible nitric oxide synthase inhibition. Intensive Care Med (2004) 0.98
Mode of action of nifurtimox and N-oxide-containing heterocycles against Trypanosoma cruzi: is oxidative stress involved? Biochem Pharmacol (2010) 0.97
Insights into the redox biology of Trypanosoma cruzi: Trypanothione metabolism and oxidant detoxification. Free Radic Biol Med (2008) 0.97
Mechanistic studies of peroxynitrite-mediated tyrosine nitration in membranes using the hydrophobic probe N-t-BOC-L-tyrosine tert-butyl ester. Biochemistry (2006) 0.96
Trypanosoma cruzi antioxidant enzymes as virulence factors in Chagas disease. Antioxid Redox Signal (2012) 0.95
Nitration of solvent-exposed tyrosine 74 on cytochrome c triggers heme iron-methionine 80 bond disruption. Nuclear magnetic resonance and optical spectroscopy studies. J Biol Chem (2008) 0.95
Sulfenic acid--a key intermediate in albumin thiol oxidation. J Chromatogr B Analyt Technol Biomed Life Sci (2009) 0.95
Peroxynitrite detoxification and its biologic implications. Antioxid Redox Signal (2008) 0.94
Critical role of hydrogen peroxide signaling in the sequential activation of p38 MAPK and eNOS in laminar shear stress. Free Radic Biol Med (2012) 0.94
Kinetic studies on peroxynitrite reduction by peroxiredoxins. Methods Enzymol (2008) 0.94
Dioxygen reactivity and heme redox potential of truncated human cystathionine beta-synthase. Biochemistry (2008) 0.93
Peroxynitrite flux-mediated LDL oxidation is inhibited by manganese porphyrins in the presence of uric acid. Free Radic Biol Med (2003) 0.93
Formation of protein tyrosine ortho-semiquinone radical and nitrotyrosine from cytochrome c-derived tyrosyl radical. J Biol Chem (2004) 0.93
Cyclosporine A-induced nitration of tyrosine 34 MnSOD in endothelial cells: role of mitochondrial superoxide. Cardiovasc Res (2010) 0.93
Diffusion of nitric oxide into low density lipoprotein. J Biol Chem (2001) 0.93
Discovery of novel inhibitors of Trypanosoma cruzi trans-sialidase from in silico screening. Bioorg Med Chem Lett (2008) 0.92
Linked thioredoxin-glutathione systems in platyhelminth parasites: alternative pathways for glutathione reduction and deglutathionylation. J Biol Chem (2010) 0.91
Peroxynitrite-mediated alpha-tocopherol oxidation in low-density lipoprotein: a mechanistic approach. Free Radic Biol Med (2004) 0.91
Kinetic and mechanistic considerations to assess the biological fate of peroxynitrite. Biochim Biophys Acta (2013) 0.91
Nitric oxide inhibits prooxidant actions of uric acid during copper-mediated LDL oxidation. Arch Biochem Biophys (2004) 0.91
Inactivation of cystathionine beta-synthase with peroxynitrite. Arch Biochem Biophys (2009) 0.91
Lipid peroxyl radicals mediate tyrosine dimerization and nitration in membranes. Chem Res Toxicol (2010) 0.90
Nitroarachidonic acid, a novel peroxidase inhibitor of prostaglandin endoperoxide H synthases 1 and 2. J Biol Chem (2011) 0.90
Modulation of astrocytic mitochondrial function by dichloroacetate improves survival and motor performance in inherited amyotrophic lateral sclerosis. PLoS One (2012) 0.90
Peroxiredoxins as preferential targets in H2O2-induced signaling. Methods Enzymol (2013) 0.89
The trypanothione-thiol system in Trypanosoma cruzi as a key antioxidant mechanism against peroxynitrite-mediated cytotoxicity. Arch Biochem Biophys (2003) 0.89
Intragastric nitration by dietary nitrite: implications for modulation of protein and lipid signaling. Free Radic Biol Med (2011) 0.89