Pseudomonas aeruginosa flagella activate airway epithelial cells through asialoGM1 and toll-like receptor 2 as well as toll-like receptor 5.

PubWeight™: 2.09‹?› | Rank: Top 2%

🔗 View Article (PMID 14607814)

Published in Am J Respir Cell Mol Biol on November 07, 2003

Authors

Robert Adamo1, Sach Sokol, Grace Soong, Marisa I Gomez, Alice Prince

Author Affiliations

1: Department of Pediatrics, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA.

Articles citing this

Pathogen-host interactions in Pseudomonas aeruginosa pneumonia. Am J Respir Crit Care Med (2005) 3.52

Host interactions of probiotic bacterial surface molecules: comparison with commensals and pathogens. Nat Rev Microbiol (2010) 3.45

Involvement of Toll-like receptor 5 in the recognition of flagellated bacteria. Proc Natl Acad Sci U S A (2006) 2.75

Innate immunity in the respiratory epithelium. Am J Respir Cell Mol Biol (2011) 2.04

Role of motility in the colonization of uropathogenic Escherichia coli in the urinary tract. Infect Immun (2005) 1.80

IL-17-induced CXCL12 recruits B cells and induces follicle formation in BALT in the absence of differentiated FDCs. J Exp Med (2014) 1.67

Human airway epithelial cells sense Pseudomonas aeruginosa infection via recognition of flagellin by Toll-like receptor 5. Infect Immun (2005) 1.51

Sensing gram-negative bacterial lipopolysaccharides: a human disease determinant? Infect Immun (2007) 1.50

No longer an innocent bystander: epithelial toll-like receptor signaling in the development of mucosal inflammation. Mol Med (2008) 1.46

Control of Pseudomonas aeruginosa in the lung requires the recognition of either lipopolysaccharide or flagellin. J Immunol (2008) 1.45

Activation of inflammasome signaling mediates pathology of acute P. aeruginosa pneumonia. J Clin Invest (2013) 1.43

Components of the Legionella pneumophila flagellar regulon contribute to multiple virulence traits, including lysosome avoidance and macrophage death. Infect Immun (2005) 1.41

In vivo imaging and genetic analysis link bacterial motility and symbiosis in the zebrafish gut. Proc Natl Acad Sci U S A (2007) 1.40

Lung epithelium as a sentinel and effector system in pneumonia--molecular mechanisms of pathogen recognition and signal transduction. Respir Res (2006) 1.39

Roles of specific amino acids in the N terminus of Pseudomonas aeruginosa flagellin and of flagellin glycosylation in the innate immune response. Infect Immun (2005) 1.38

An essential role for non-bone marrow-derived cells in control of Pseudomonas aeruginosa pneumonia. Am J Respir Cell Mol Biol (2005) 1.34

Staphylococcus aureus protein A activates TACE through EGFR-dependent signaling. EMBO J (2007) 1.32

The role of Src kinase in macrophage-mediated inflammatory responses. Mediators Inflamm (2012) 1.30

Resistance to Pseudomonas aeruginosa chronic lung infection requires cystic fibrosis transmembrane conductance regulator-modulated interleukin-1 (IL-1) release and signaling through the IL-1 receptor. Infect Immun (2007) 1.30

A double-blind randomized placebo-controlled phase III study of a Pseudomonas aeruginosa flagella vaccine in cystic fibrosis patients. Proc Natl Acad Sci U S A (2007) 1.27

Oxidative epithelial host defense is regulated by infectious and inflammatory stimuli. Free Radic Biol Med (2009) 1.17

The role of the bacterial flagellum in adhesion and virulence. Biology (Basel) (2013) 1.15

Flagellin stimulates protective lung mucosal immunity: role of cathelicidin-related antimicrobial peptide. J Immunol (2010) 1.15

How flagellin and toll-like receptor 5 contribute to enteric infection. Infect Immun (2006) 1.11

Toll-like receptors and damage-associated molecular patterns: novel links between inflammation and hypertension. Am J Physiol Heart Circ Physiol (2013) 1.08

Role of Toll-like receptor 5 in the innate immune response to acute P. aeruginosa pneumonia. Am J Physiol Lung Cell Mol Physiol (2009) 1.07

Airway epithelial cell tolerance to Pseudomonas aeruginosa. Respir Res (2005) 1.05

Pattern recognition receptor-dependent mechanisms of acute lung injury. Mol Med (2009) 1.04

Differential effects of cytokines and corticosteroids on toll-like receptor 2 expression and activity in human airway epithelia. Respir Res (2009) 1.02

Dual-seq transcriptomics reveals the battle for iron during Pseudomonas aeruginosa acute murine pneumonia. Sci Rep (2016) 0.99

Th2 allergic immune response to inhaled fungal antigens is modulated by TLR-4-independent bacterial products. Eur J Immunol (2009) 0.99

The myeloid differentiation factor 88 is dispensable for the development of a delayed host response to Pseudomonas aeruginosa lung infection in mice. Clin Exp Immunol (2006) 0.98

Elevated furin levels in human cystic fibrosis cells result in hypersusceptibility to exotoxin A-induced cytotoxicity. J Clin Invest (2007) 0.98

AsialoGM1 and TLR5 cooperate in flagellin-induced nucleotide signaling to activate Erk1/2. Am J Respir Cell Mol Biol (2006) 0.98

Neutrophil elastase, an innate immunity effector molecule, represses flagellin transcription in Pseudomonas aeruginosa. Infect Immun (2006) 0.97

Burkholderia cenocepacia ET12 strain activates TNFR1 signalling in cystic fibrosis airway epithelial cells. Cell Microbiol (2007) 0.97

The monocarboxylate transporter 4 is required for glycolytic reprogramming and inflammatory response in macrophages. J Biol Chem (2014) 0.96

TLR2 regulates gap junction intercellular communication in airway cells. J Immunol (2008) 0.94

NEU1 sialidase expressed in human airway epithelia regulates epidermal growth factor receptor (EGFR) and MUC1 protein signaling. J Biol Chem (2012) 0.92

Human Langerhans' cells and dermal-type dendritic cells generated from CD34 stem cells express different toll-like receptors and secrete different cytokines in response to toll-like receptor ligands. Immunology (2008) 0.92

Dictyostelium transcriptional responses to Pseudomonas aeruginosa: common and specific effects from PAO1 and PA14 strains. BMC Microbiol (2008) 0.92

MUC1 expression by human airway epithelial cells mediates Pseudomonas aeruginosa adhesion. Front Biosci (Elite Ed) (2010) 0.91

Pneumocystis cell wall beta-glucan stimulates calcium-dependent signaling of IL-8 secretion by human airway epithelial cells. Respir Res (2010) 0.90

Role of lipid rafts and flagellin in invasion of colonic epithelial cells by Shiga-toxigenic Escherichia coli O113:H21. Infect Immun (2012) 0.90

Pyruvate dehydrogenase kinase 1 participates in macrophage polarization via regulating glucose metabolism. J Immunol (2015) 0.90

Ca2+ signaling in airway epithelial cells facilitates leukocyte recruitment and transepithelial migration. J Leukoc Biol (2009) 0.89

Flagellin-stimulated Cl- secretion and innate immune responses in airway epithelia: role for p38. Am J Physiol Lung Cell Mol Physiol (2008) 0.89

Dampening Host Sensing and Avoiding Recognition in Pseudomonas aeruginosa Pneumonia. J Biomed Biotechnol (2011) 0.88

Inhibition of Toll-like receptor 2-mediated interleukin-8 production in Cystic Fibrosis airway epithelial cells via the alpha7-nicotinic acetylcholine receptor. Mediators Inflamm (2010) 0.88

In silico detection of virulence gene homologues in the human pathogen sphingomonas spp. Evol Bioinform Online (2014) 0.87

Toll-like receptor 2 represses nonpilus adhesin-induced signaling in acute infections with the Pseudomonas aeruginosa pilA mutant. Infect Immun (2004) 0.87

IL-1 receptor antagonist ameliorates inflammasome-dependent inflammation in murine and human cystic fibrosis. Nat Commun (2016) 0.87

The Pseudomonas aeruginosa flagellum confers resistance to pulmonary surfactant protein-A by impacting the production of exoproteases through quorum-sensing. Mol Microbiol (2011) 0.86

CFTR and Ca Signaling in Cystic Fibrosis. Front Pharmacol (2011) 0.86

Tlr5 is not primarily associated with susceptibility to Salmonella Typhimurium infection in MOLF/Ei mice. Mamm Genome (2006) 0.86

Epithelial uptake of flagella initiates proinflammatory signaling. PLoS One (2013) 0.83

Host evasion by Burkholderia cenocepacia. Front Cell Infect Microbiol (2012) 0.82

Phospholipase C-β3 is a key modulator of IL-8 expression in cystic fibrosis bronchial epithelial cells. J Immunol (2011) 0.82

Efficacy of a conjugate vaccine containing polymannuronic acid and flagellin against experimental Pseudomonas aeruginosa lung infection in mice. Infect Immun (2011) 0.82

Nonclassical pathway of Pseudomonas aeruginosa DNA-induced interleukin-8 secretion in cystic fibrosis airway epithelial cells. Infect Immun (2006) 0.82

Innate Immune Signaling Activated by MDR Bacteria in the Airway. Physiol Rev (2016) 0.81

Pseudomonas aeruginosa mucoid strain 8830 binds glycans containing the sialyl-Lewis x epitope. Glycoconj J (2007) 0.80

Pseudomonas aeruginosa Inhibition of Flagellin-activated NF-kappaB and interleukin-8 by human airway epithelial cells. Infect Immun (2009) 0.80

Redundant and cooperative interactions between TLR5 and NLRC4 in protective lung mucosal immunity against Pseudomonas aeruginosa. J Innate Immun (2014) 0.80

Lung infections and innate host defense. Drug Discov Today Dis Mech (2007) 0.79

Distinctive Recognition of Flagellin by Human and Mouse Toll-Like Receptor 5. PLoS One (2016) 0.78

NEU1 Sialidase Regulates Membrane-tethered Mucin (MUC1) Ectodomain Adhesiveness for Pseudomonas aeruginosa and Decoy Receptor Release. J Biol Chem (2015) 0.78

Flagellin concentrations in expectorations from cystic fibrosis patients. BMC Pulm Med (2014) 0.78

Inactivated Pseudomonas aeruginosa inhibits hypoxia-induced pulmonary hypertension by preventing TGF-β1/Smad signaling. Braz J Med Biol Res (2016) 0.77

Distal NF-kB binding motif functions as an enhancer for nontypeable H. influenzae-induced DEFB4 regulation in epithelial cells. Biochem Biophys Res Commun (2013) 0.77

Human airway epithelia express catalytically active NEU3 sialidase. Am J Physiol Lung Cell Mol Physiol (2014) 0.76

Differential Contribution of the Aryl-Hydrocarbon Receptor and Toll-Like Receptor Pathways to IL-8 Expression in Normal and Cystic Fibrosis Airway Epithelial Cells Exposed to Pseudomonas aeruginosa. Front Cell Dev Biol (2016) 0.75

High Yield Overexpression, Refolding, Purification and Characterization of Pseudomonas aeruginosa Type B-Flagellin: An Improved Method Without Sonication. Int J Mol Cell Med (2016) 0.75

Presence of Bacterial Virulence Gene Homologues in the dibenzo-p-dioxins degrading bacterium Sphingomonas wittichii. Bioinformation (2016) 0.75

The Use of Next-Generation Sequencing in the Identification of a Fastidious Pathogen: A Lesson From a Clinical Setup. Evol Bioinform Online (2017) 0.75

Host cell surfaces induce a Type IV pili-dependent alteration of bacterial swimming. Sci Rep (2016) 0.75

Plasticity of airway epithelial cell transcriptome in response to flagellin. PLoS One (2015) 0.75

Location of lectin exhibiting specificity for N-acetyl-D-galactosamine in cells of the symbiotic marine bacteria Photobacterium phosphoreum. Dokl Biochem Biophys (2008) 0.75

Corticosteroid-resistant inflammatory signalling in Pseudomonas-infected bronchial cells. ERJ Open Res (2017) 0.75

The Relationship between Airway Inflammation and Exacerbation in Chronic Obstructive Pulmonary Disease. Tuberc Respir Dis (Seoul) (2017) 0.75

Articles by these authors

Staphylococcus aureus protein A induces airway epithelial inflammatory responses by activating TNFR1. Nat Med (2004) 3.84

A postinfluenza model of Staphylococcus aureus pneumonia. J Infect Dis (2010) 2.09

Innate immunity in the respiratory epithelium. Am J Respir Cell Mol Biol (2011) 2.04

Cystic fibrosis: a mucosal immunodeficiency syndrome. Nat Med (2012) 2.03

Toll-like receptors in normal and cystic fibrosis airway epithelial cells. Am J Respir Cell Mol Biol (2003) 2.00

TLR2-induced calpain cleavage of epithelial junctional proteins facilitates leukocyte transmigration. Cell Host Microbe (2009) 1.87

Staphylococcus aureus activates type I IFN signaling in mice and humans through the Xr repeated sequences of protein A. J Clin Invest (2009) 1.77

TLR2 is mobilized into an apical lipid raft receptor complex to signal infection in airway epithelial cells. J Clin Invest (2004) 1.70

Staphylococcus aureus activation of caspase 1/calpain signaling mediates invasion through human keratinocytes. J Infect Dis (2012) 1.66

Opportunistic infections in lung disease: Pseudomonas infections in cystic fibrosis. Curr Opin Pharmacol (2007) 1.62

Bacterial neuraminidase facilitates mucosal infection by participating in biofilm production. J Clin Invest (2006) 1.54

The NanA neuraminidase of Streptococcus pneumoniae is involved in biofilm formation. Infect Immun (2009) 1.36

Staphylococcus aureus agr and sarA functions are required for invasive infection but not inflammatory responses in the lung. Infect Immun (2002) 1.36

Streptococcus pneumoniae DNA initiates type I interferon signaling in the respiratory tract. MBio (2011) 1.34

Staphylococcus aureus induces type I IFN signaling in dendritic cells via TLR9. J Immunol (2012) 1.16

Emergence of the epidemic methicillin-resistant Staphylococcus aureus strain USA300 coincides with horizontal transfer of the arginine catabolic mobile element and speG-mediated adaptations for survival on skin. MBio (2013) 1.15

Molecular characterization of the capsule locus from non-typeable Staphylococcus aureus. Mol Microbiol (2006) 1.15

Bacterial stimulation of epithelial G-CSF and GM-CSF expression promotes PMN survival in CF airways. Am J Respir Cell Mol Biol (2002) 1.15

Participation of CD11c(+) leukocytes in methicillin-resistant Staphylococcus aureus clearance from the lung. Infect Immun (2011) 1.14

Immunopathogenesis of Staphylococcus aureus pulmonary infection. Semin Immunopathol (2011) 1.12

Staphylococcus aureus protein A mediates invasion across airway epithelial cells through activation of RhoA GTPase signaling and proteolytic activity. J Biol Chem (2011) 1.11

Immunostimulatory properties of the emerging pathogen Stenotrophomonas maltophilia. Infect Immun (2007) 1.11

Activation of Ca2+-dependent signaling by TLR2. J Immunol (2006) 1.09

Bacterial induction of TNF-alpha converting enzyme expression and IL-6 receptor alpha shedding regulates airway inflammatory signaling. J Immunol (2005) 1.07

Type I interferon response to extracellular bacteria in the airway epithelium. Trends Immunol (2011) 1.05

Induction of type I interferon signaling by Pseudomonas aeruginosa is diminished in cystic fibrosis epithelial cells. Am J Respir Cell Mol Biol (2012) 1.05

Effects of azithromycin on clinical isolates of Pseudomonas aeruginosa from cystic fibrosis patients. Chest (2005) 1.03

Airway epithelial cell signaling in response to bacterial pathogens. Pediatr Pulmonol (2008) 1.02

Crystal structures of respiratory pathogen neuraminidases. Biochem Biophys Res Commun (2009) 0.92

Genome Sequence of Bacterial Interference Strain Staphylococcus aureus 502A. Genome Announc (2014) 0.91

Shedding of tumor necrosis factor receptor 1 induced by protein A decreases tumor necrosis factor alpha availability and inflammation during systemic Staphylococcus aureus infection. Infect Immun (2013) 0.90

Ca2+ signaling in airway epithelial cells facilitates leukocyte recruitment and transepithelial migration. J Leukoc Biol (2009) 0.89

The effect of cyclosporin A on airway cell proinflammatory signaling and pneumonia. Am J Respir Cell Mol Biol (2005) 0.88

Epithelial uptake of flagella initiates proinflammatory signaling. PLoS One (2013) 0.83

Participation of Necroptosis in the Host Response to Acute Bacterial Pneumonia. J Innate Immun (2017) 0.75

Cystic fibrosis: an-ion transport issue? Nat Med (2011) 0.75

Cerebral abscess associated with meningococcal meningitis. Pediatr Infect Dis J (2006) 0.75

Neural tuning changes underlying visual shape learning. J Vis (2015) 0.75

In Vitro infection of human dura-mater fibroblasts with Staphylococcus aureus: colonization and reactive production of IL-1beta. Neurol Res (2015) 0.75

Bacterial-epithelial interactions. Methods Mol Med (2002) 0.75

Airway epithelium, inflammation, and mechanisms of disease: A tribute to Carol B. Basbaum. Am J Respir Cell Mol Biol (2006) 0.75