Molecular mechanism of insulin resistance and obesity.

PubWeight™: 1.19‹?› | Rank: Top 10%

🔗 View Article (PMID 14610248)

Published in Exp Biol Med (Maywood) on November 01, 2003

Authors

Takashi Kadowaki1, Kazuo Hara, Toshimasa Yamauchi, Yasuo Terauchi, Kazuyuki Tobe, Ryozo Nagai

Author Affiliations

1: Department of Metabolic Diseases, Graduate School of Medicine, University of Tokyo, Tokyo 113-8655, Japan. kadowaki-3im@h.u-tokyo.ac.jp

Articles citing this

Metabolic liver disease of obesity and role of adipose tissue in the pathogenesis of nonalcoholic fatty liver disease. World J Gastroenterol (2007) 1.61

Olfaction under metabolic influences. Chem Senses (2012) 1.20

Metabolic syndrome and gastrointestinal diseases. J Gastroenterol (2007) 1.12

Activation of peroxisome proliferator-activated receptor-alpha stimulates both differentiation and fatty acid oxidation in adipocytes. J Lipid Res (2011) 1.11

NAFLD, Estrogens, and Physical Exercise: The Animal Model. J Nutr Metab (2011) 0.97

BRD7 regulates XBP1s' activity and glucose homeostasis through its interaction with the regulatory subunits of PI3K. Cell Metab (2014) 0.97

Olfactory ability and object memory in three mouse models of varying body weight, metabolic hormones, and adiposity. Physiol Behav (2012) 0.90

ApoA1: mimetic peptide reverses adipocyte dysfunction in vivo and in vitro via an increase in heme oxygenase (HO-1) and Wnt10b. Cell Cycle (2012) 0.89

Microvascular responsiveness in obesity: implications for therapeutic intervention. Br J Pharmacol (2012) 0.88

17β-Estradiol inhibition of PPARγ-induced adipogenesis and adipocyte-specific gene expression. Acta Pharmacol Sin (2011) 0.86

Impact of a Booklet about Diabetes Genetic Susceptibility and Its Prevention on Attitudes towards Prevention and Perceived Behavioral Change in Patients with Type 2 Diabetes and Their Offspring. Adv Prev Med (2010) 0.85

Preventive advice given by patients with type 2 diabetes to their offspring. Br J Gen Pract (2009) 0.84

ALOX12 polymorphisms are associated with fat mass but not peak bone mineral density in Chinese nuclear families. Int J Obes (Lond) (2010) 0.84

Obesity and coronary microvascular disease - implications for adipose tissue-mediated remote inflammatory response. Curr Vasc Pharmacol (2014) 0.82

The effect of calorie restriction on insulin signaling in skeletal muscle and adipose tissue of Ames dwarf mice. Aging (Albany NY) (2014) 0.82

Metabolic syndrome, obesity, and gastrointestinal cancer. Gastroenterol Res Pract (2012) 0.82

Correlation of adiponectin and leptin with insulin resistance: a pilot study in healthy north Indian population. Indian J Clin Biochem (2011) 0.82

Influence of Acute and Chronic Exercise on Glucose Uptake. J Diabetes Res (2016) 0.81

The insulin regulatory network in adult hippocampus and pancreatic endocrine system. Stem Cells Int (2012) 0.81

Metabolic Functions of Peroxisome Proliferator-Activated Receptor beta/delta in Skeletal Muscle. PPAR Res (2007) 0.80

Pancreatic expression and mitochondrial localization of the progestin-adipoQ receptor PAQR10. Mol Med (2008) 0.80

HCV synergizes with body weight in the promotion of insulin resistance. J Viral Hepat (2011) 0.78

Swertiamarin: An Active Lead from Enicostemma littorale Regulates Hepatic and Adipose Tissue Gene Expression by Targeting PPAR- γ and Improves Insulin Sensitivity in Experimental NIDDM Rat Model. Evid Based Complement Alternat Med (2013) 0.78

Mifepristone promotes adiponectin production and improves insulin sensitivity in a mouse model of diet-induced-obesity. PLoS One (2013) 0.76

The association of PBX1 polymorphisms with overweight/obesity and metabolic alterations in the Korean population. Nutr Res Pract (2008) 0.75

Protracted Administration of L-Asparaginase in Maintenance Phase Is the Risk Factor for Hyperglycemia in Older Patients with Pediatric Acute Lymphoblastic Leukemia. PLoS One (2015) 0.75

Randomized controlled trial of the effectiveness of genetic counseling and a distance, computer-based, lifestyle intervention program for adult offspring of patients with type 2 diabetes: background, study protocol, and baseline patient characteristics. J Nutr Metab (2012) 0.75

PTPIP51: a new interaction partner of the insulin receptor and PKA in adipose tissue. J Obes (2013) 0.75

Critical role of leukotriene B4 receptor signaling in mouse 3T3-L1 preadipocyte differentiation. Lipids Health Dis (2013) 0.75

Egg white hydrolysate shows insulin mimetic and sensitizing effects in 3T3-F442A pre-adipocytes. PLoS One (2017) 0.75

Articles by these authors

CD8+ effector T cells contribute to macrophage recruitment and adipose tissue inflammation in obesity. Nat Med (2009) 11.28

Cloning of adiponectin receptors that mediate antidiabetic metabolic effects. Nature (2003) 9.79

Adiponectin and adiponectin receptors in insulin resistance, diabetes, and the metabolic syndrome. J Clin Invest (2006) 9.49

Variants in KCNQ1 are associated with susceptibility to type 2 diabetes mellitus. Nat Genet (2008) 9.39

SNPs in KCNQ1 are associated with susceptibility to type 2 diabetes in East Asian and European populations. Nat Genet (2008) 8.63

Adiponectin and adiponectin receptors. Endocr Rev (2005) 8.46

Targeted disruption of AdipoR1 and AdipoR2 causes abrogation of adiponectin binding and metabolic actions. Nat Med (2007) 5.89

Overexpression of monocyte chemoattractant protein-1 in adipose tissues causes macrophage recruitment and insulin resistance. J Biol Chem (2006) 5.57

PPARgamma insufficiency enhances osteogenesis through osteoblast formation from bone marrow progenitors. J Clin Invest (2004) 5.29

Disruption of adiponectin causes insulin resistance and neointimal formation. J Biol Chem (2002) 4.79

Meta-analysis of genome-wide association studies identifies eight new loci for type 2 diabetes in east Asians. Nat Genet (2011) 4.50

Hematopoietic stem cells differentiate into vascular cells that participate in the pathogenesis of atherosclerosis. Nat Med (2002) 4.25

Globular adiponectin protected ob/ob mice from diabetes and ApoE-deficient mice from atherosclerosis. J Biol Chem (2002) 4.16

Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility. Nat Genet (2014) 4.13

Adiponectin and AdipoR1 regulate PGC-1alpha and mitochondria by Ca(2+) and AMPK/SIRT1. Nature (2010) 4.12

Impaired multimerization of human adiponectin mutants associated with diabetes. Molecular structure and multimer formation of adiponectin. J Biol Chem (2003) 4.08

Adipogenesis in obesity requires close interplay between differentiating adipocytes, stromal cells, and blood vessels. Diabetes (2007) 3.87

A two-step method for marking polypectomy sites in the colon and rectum. Gastrointest Endosc (2003) 3.63

Krüppel-like transcription factor KLF5 is a key regulator of adipocyte differentiation. Cell Metab (2005) 3.49

Adiponectin stimulates AMP-activated protein kinase in the hypothalamus and increases food intake. Cell Metab (2007) 3.43

PI3K-mediated negative feedback regulation of IL-12 production in DCs. Nat Immunol (2002) 3.37

Regulatory mechanisms for adipose tissue M1 and M2 macrophages in diet-induced obese mice. Diabetes (2009) 3.27

Expression-based genome-wide association study links the receptor CD44 in adipose tissue with type 2 diabetes. Proc Natl Acad Sci U S A (2012) 3.27

Role of adiponectin in preventing vascular stenosis. The missing link of adipo-vascular axis. J Biol Chem (2002) 3.05

Genetic variation in the gene encoding adiponectin is associated with an increased risk of type 2 diabetes in the Japanese population. Diabetes (2002) 3.04

Glucokinase and IRS-2 are required for compensatory beta cell hyperplasia in response to high-fat diet-induced insulin resistance. J Clin Invest (2007) 2.81

A genome-wide association study in the Japanese population identifies susceptibility loci for type 2 diabetes at UBE2E2 and C2CD4A-C2CD4B. Nat Genet (2010) 2.81

In vivo imaging in mice reveals local cell dynamics and inflammation in obese adipose tissue. J Clin Invest (2008) 2.78

Measurement of the high-molecular weight form of adiponectin in plasma is useful for the prediction of insulin resistance and metabolic syndrome. Diabetes Care (2006) 2.77

A small-molecule AdipoR agonist for type 2 diabetes and short life in obesity. Nature (2013) 2.74

Severe hypoglycaemia and cardiovascular disease: systematic review and meta-analysis with bias analysis. BMJ (2013) 2.74

Single-nucleotide polymorphism haplotypes in the both proximal promoter and exon 3 of the APM1 gene modulate adipocyte-secreted adiponectin hormone levels and contribute to the genetic risk for type 2 diabetes in French Caucasians. Hum Mol Genet (2002) 2.72

Diagnostic utility of EUS-guided FNA in patients with gastric submucosal tumors. Gastrointest Endosc (2010) 2.67

Krüppel-like zinc-finger transcription factor KLF5/BTEB2 is a target for angiotensin II signaling and an essential regulator of cardiovascular remodeling. Nat Med (2002) 2.61

Gene expression in fibroblasts and fibrosis: involvement in cardiac hypertrophy. Circ Res (2002) 2.59

Polyunsaturated fatty acids ameliorate hepatic steatosis in obese mice by SREBP-1 suppression. Hepatology (2003) 2.52

Cardiac fibroblasts are essential for the adaptive response of the murine heart to pressure overload. J Clin Invest (2009) 2.46

Role of Krüppel-like factor 15 (KLF15) in transcriptional regulation of adipogenesis. J Biol Chem (2005) 2.45

Impaired insulin signaling in endothelial cells reduces insulin-induced glucose uptake by skeletal muscle. Cell Metab (2011) 2.42

Absence of sterol regulatory element-binding protein-1 (SREBP-1) ameliorates fatty livers but not obesity or insulin resistance in Lep(ob)/Lep(ob) mice. J Biol Chem (2002) 2.40

Clinical profiles and outcomes of acute type B aortic dissection in the current era: lessons from the International Registry of Aortic Dissection (IRAD). Circulation (2003) 2.32

High-sensitivity C-reactive protein is an independent clinical feature of nonalcoholic steatohepatitis (NASH) and also of the severity of fibrosis in NASH. J Gastroenterol (2007) 2.29

SUMOylation of Krüppel-like transcription factor 5 acts as a molecular switch in transcriptional programs of lipid metabolism involving PPAR-delta. Nat Med (2008) 2.16

Insulin/Foxo1 pathway regulates expression levels of adiponectin receptors and adiponectin sensitivity. J Biol Chem (2004) 2.15

G-CSF stimulates angiogenesis and promotes tumor growth: potential contribution of bone marrow-derived endothelial progenitor cells. Biochem Biophys Res Commun (2002) 2.13

Transient activation of c-MYC expression is critical for efficient platelet generation from human induced pluripotent stem cells. J Exp Med (2010) 2.08

Mid-term results and costs of coronary artery bypass vs drug-eluting stents for unprotected left main coronary artery disease. Circ J (2010) 2.08

Retracted Cytokines suppress adipogenesis and PPAR-gamma function through the TAK1/TAB1/NIK cascade. Nat Cell Biol (2003) 2.08

Pioglitazone ameliorates insulin resistance and diabetes by both adiponectin-dependent and -independent pathways. J Biol Chem (2006) 1.93

Selective loss of gastrointestinal mast cells and impaired immunity in PI3K-deficient mice. Nat Immunol (2002) 1.92

Association between hepatitis C virus seropositivity, carotid-artery plaque, and intima-media thickening. Lancet (2002) 1.92

Direct reciprocal effects of resistin and adiponectin on vascular endothelial cells: a new insight into adipocytokine-endothelial cell interactions. Biochem Biophys Res Commun (2004) 1.92

The critical role of neutral cholesterol ester hydrolase 1 in cholesterol removal from human macrophages. Circ Res (2010) 1.92

A novel PPAR gamma gene therapy to control inflammation associated with inflammatory bowel disease in a murine model. Gastroenterology (2003) 1.91

Age and preoperative total bilirubin level can stratify prognosis after extracorporeal pulsatile left ventricular assist device implantation. Circ J (2010) 1.91

Insulin receptor substrate 2 plays a crucial role in beta cells and the hypothalamus. J Clin Invest (2004) 1.88

In vivo klotho gene transfer ameliorates angiotensin II-induced renal damage. Hypertension (2002) 1.88

Dynamic functional relay between insulin receptor substrate 1 and 2 in hepatic insulin signaling during fasting and feeding. Cell Metab (2008) 1.86