PubRank

Kazuyuki Tobe

Author PubWeight™ 141.58‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Cloning of adiponectin receptors that mediate antidiabetic metabolic effects. Nature 2003 9.79
2 Adiponectin and adiponectin receptors in insulin resistance, diabetes, and the metabolic syndrome. J Clin Invest 2006 9.49
3 Targeted disruption of AdipoR1 and AdipoR2 causes abrogation of adiponectin binding and metabolic actions. Nat Med 2007 5.89
4 Overexpression of monocyte chemoattractant protein-1 in adipose tissues causes macrophage recruitment and insulin resistance. J Biol Chem 2006 5.57
5 Adipogenesis in obesity requires close interplay between differentiating adipocytes, stromal cells, and blood vessels. Diabetes 2007 3.87
6 Krüppel-like transcription factor KLF5 is a key regulator of adipocyte differentiation. Cell Metab 2005 3.49
7 Adiponectin stimulates AMP-activated protein kinase in the hypothalamus and increases food intake. Cell Metab 2007 3.43
8 Regulatory mechanisms for adipose tissue M1 and M2 macrophages in diet-induced obese mice. Diabetes 2009 3.27
9 Genetic variation in the gene encoding adiponectin is associated with an increased risk of type 2 diabetes in the Japanese population. Diabetes 2002 3.04
10 Glucokinase and IRS-2 are required for compensatory beta cell hyperplasia in response to high-fat diet-induced insulin resistance. J Clin Invest 2007 2.81
11 In vivo imaging in mice reveals local cell dynamics and inflammation in obese adipose tissue. J Clin Invest 2008 2.78
12 Krüppel-like zinc-finger transcription factor KLF5/BTEB2 is a target for angiotensin II signaling and an essential regulator of cardiovascular remodeling. Nat Med 2002 2.61
13 Impaired insulin signaling in endothelial cells reduces insulin-induced glucose uptake by skeletal muscle. Cell Metab 2011 2.42
14 SUMOylation of Krüppel-like transcription factor 5 acts as a molecular switch in transcriptional programs of lipid metabolism involving PPAR-delta. Nat Med 2008 2.16
15 Insulin/Foxo1 pathway regulates expression levels of adiponectin receptors and adiponectin sensitivity. J Biol Chem 2004 2.15
16 Pioglitazone ameliorates insulin resistance and diabetes by both adiponectin-dependent and -independent pathways. J Biol Chem 2006 1.93
17 Insulin receptor substrate 2 plays a crucial role in beta cells and the hypothalamus. J Clin Invest 2004 1.88
18 Dynamic functional relay between insulin receptor substrate 1 and 2 in hepatic insulin signaling during fasting and feeding. Cell Metab 2008 1.86
19 Production of functional classical brown adipocytes from human pluripotent stem cells using specific hemopoietin cocktail without gene transfer. Cell Metab 2012 1.84
20 Saturated fatty acid and TLR signaling link β cell dysfunction and islet inflammation. Cell Metab 2012 1.77
21 Treatment with SRT1720, a SIRT1 activator, ameliorates fatty liver with reduced expression of lipogenic enzymes in MSG mice. Am J Physiol Endocrinol Metab 2009 1.68
22 Genome-wide search for type 2 diabetes in Japanese affected sib-pairs confirms susceptibility genes on 3q, 15q, and 20q and identifies two new candidate Loci on 7p and 11p. Diabetes 2002 1.63
23 Akt1 in osteoblasts and osteoclasts controls bone remodeling. PLoS One 2007 1.56
24 Myeloid lineage cell-restricted insulin resistance protects apolipoproteinE-deficient mice against atherosclerosis. Cell Metab 2006 1.50
25 Nuclear factor-kappaB decoy oligodeoxynucleotides ameliorate impaired glucose tolerance and insulin resistance in mice with cecal ligation and puncture-induced sepsis. Crit Care Med 2009 1.49
26 Inhibition of tumor progression locus 2 protein kinase suppresses receptor activator of nuclear factor-kappaB ligand-induced osteoclastogenesis through down-regulation of the c-Fos and nuclear factor of activated T cells c1 genes. Biol Pharm Bull 2010 1.41
27 Efficacy and safety of monotherapy with the novel sodium/glucose cotransporter-2 inhibitor tofogliflozin in Japanese patients with type 2 diabetes mellitus: a combined Phase 2 and 3 randomized, placebo-controlled, double-blind, parallel-group comparative study. Cardiovasc Diabetol 2014 1.36
28 Genome-wide association study identifies a novel locus contributing to type 2 diabetes susceptibility in Sikhs of Punjabi origin from India. Diabetes 2013 1.36
29 Insulin receptor substrate-2 maintains predominance of anabolic function over catabolic function of osteoblasts. J Cell Biol 2002 1.30
30 Genome-wide association study identifies three novel loci for type 2 diabetes. Hum Mol Genet 2013 1.28
31 A single-nucleotide polymorphism in ANK1 is associated with susceptibility to type 2 diabetes in Japanese populations. Hum Mol Genet 2012 1.23
32 Genetic risk score constructed using 14 susceptibility alleles for type 2 diabetes is associated with the early onset of diabetes and may predict the future requirement of insulin injections among Japanese individuals. Diabetes Care 2012 1.19
33 Molecular mechanism of insulin resistance and obesity. Exp Biol Med (Maywood) 2003 1.19
34 Phosphatidylinositol 3-kinase suppresses glucose-stimulated insulin secretion by affecting post-cytosolic [Ca(2+)] elevation signals. Diabetes 2002 1.11
35 Dual roles of adiponectin/Acrp30 in vivo as an anti-diabetic and anti-atherogenic adipokine. Curr Drug Targets Immune Endocr Metabol Disord 2003 1.10
36 Lack of insulin receptor substrate-2 causes progressive neointima formation in response to vessel injury. Circulation 2003 1.09
37 Association of new loci identified in European genome-wide association studies with susceptibility to type 2 diabetes in the Japanese. PLoS One 2011 1.07
38 Pdx1 expression in Irs2-deficient mouse beta-cells is regulated in a strain-dependent manner. J Biol Chem 2003 1.07
39 Long-term safety and efficacy of tofogliflozin, a selective inhibitor of sodium-glucose cotransporter 2, as monotherapy or in combination with other oral antidiabetic agents in Japanese patients with type 2 diabetes mellitus: multicenter, open-label, randomized controlled trials. Expert Opin Pharmacother 2014 1.05
40 Both insulin signaling defects in the liver and obesity contribute to insulin resistance and cause diabetes in Irs2(-/-) mice. J Biol Chem 2004 1.05
41 Telmisartan improves insulin resistance and modulates adipose tissue macrophage polarization in high-fat-fed mice. Endocrinology 2011 1.04
42 SRT1720, a SIRT1 activator, promotes tumor cell migration, and lung metastasis of breast cancer in mice. Oncol Rep 2012 1.04
43 Respiratory involvement in IgG4-related Mikulicz's disease. Mod Rheumatol 2011 1.01
44 Rimonabant ameliorates insulin resistance via both adiponectin-dependent and adiponectin-independent pathways. J Biol Chem 2008 1.00
45 A novel IKKbeta inhibitor stimulates adiponectin levels and ameliorates obesity-linked insulin resistance. Biochem Biophys Res Commun 2004 0.99
46 The role of PPARgamma in high-fat diet-induced obesity and insulin resistance. J Diabetes Complications 2002 0.98
47 Expression of DGAT2 in white adipose tissue is regulated by central leptin action. J Biol Chem 2004 0.97
48 Efficacy and tolerability of vildagliptin as an add-on to glimepiride in Japanese patients with Type 2 diabetes mellitus. Diabetes Res Clin Pract 2010 0.97
49 Sirtuin 1 activator SRT1720 suppresses inflammation in an ovalbumin-induced mouse model of asthma. Respirology 2013 0.96
50 Mediator complex recruits epigenetic regulators via its two cyclin-dependent kinase subunits to repress transcription of immune response genes. J Biol Chem 2013 0.95
51 SH2-containing inositol phosphatase 2 predominantly regulates Akt2, and not Akt1, phosphorylation at the plasma membrane in response to insulin in 3T3-L1 adipocytes. J Biol Chem 2004 0.94
52 IRS-2 branch of IGF-1 receptor signaling is essential for appropriate timing of myelination. J Neurochem 2008 0.92
53 Replication study for the association of 9 East Asian GWAS-derived loci with susceptibility to type 2 diabetes in a Japanese population. PLoS One 2013 0.91
54 Roles of insulin receptor substrates in insulin-induced stimulation of renal proximal bicarbonate absorption. J Am Soc Nephrol 2005 0.90
55 The radioprotective 105/MD-1 complex contributes to diet-induced obesity and adipose tissue inflammation. Diabetes 2012 0.89
56 Impact of genetic background and ablation of insulin receptor substrate (IRS)-3 on IRS-2 knock-out mice. J Biol Chem 2002 0.87
57 Inhibitory effect of IL-8 on insulin action in human adipocytes via MAP kinase pathway. J Inflamm (Lond) 2009 0.87
58 Obesity in insulin receptor substrate-2-deficient mice: disrupted control of arcuate nucleus neuropeptides. Obes Res 2004 0.86
59 Reversible posterior leukoencephalopathy syndrome in a patient with systemic sclerosis. J Clin Rheumatol 2011 0.86
60 Tumoral calcinosis in systemic sclerosis. Joint Bone Spine 2012 0.86
61 Hepatocyte nuclear factor-4alpha P2 promoter haplotypes are associated with type 2 diabetes in the Japanese population. Diabetes 2006 0.86
62 Assessing the clinical utility of a genetic risk score constructed using 49 susceptibility alleles for type 2 diabetes in a Japanese population. J Clin Endocrinol Metab 2013 0.85
63 Outcome and prognostic factors in patients with small cell lung cancer who receive third-line chemotherapy. Tumori 2014 0.85
64 Impact of divergent effects of astaxanthin on insulin signaling in L6 cells. Endocrinology 2013 0.84
65 Loss of Pdk1-Foxo1 signaling in myeloid cells predisposes to adipose tissue inflammation and insulin resistance. Diabetes 2012 0.84
66 A single nucleotide polymorphism within DUSP9 is associated with susceptibility to type 2 diabetes in a Japanese population. PLoS One 2012 0.84
67 Primary pulmonary lymphoma presenting with multiple lung nodules. Am J Respir Crit Care Med 2014 0.82
68 Resistance to neointimal hyperplasia and fatty streak formation in mice with adrenomedullin overexpression. Arterioscler Thromb Vasc Biol 2002 0.82
69 Cloning, bacterial expression, and unique structure of adenosylhomocysteine hydrolase-like protein 1, or inositol 1,4,5-triphosphate receptor-binding protein from mouse kidney. Biochim Biophys Acta 2008 0.81
70 Variations with modest effects have an important role in the genetic background of type 2 diabetes and diabetes-related traits. J Hum Genet 2012 0.80
71 Inhibition of tumor progression locus 2 protein kinase decreases lipopolysaccharide-induced tumor necrosis factor alpha production due to the inhibition of the tip-associated protein induction in RAW264.7 cells. Biol Pharm Bull 2010 0.80
72 Severe autoimmune hemolytic anemia associated with IgM warm auto-antibodies in primary Sjögren's syndrome. Int J Rheum Dis 2010 0.80
73 Interstitial pneumonitis associated with infliximab therapy without methotrexate treatment. Rheumatol Int 2009 0.80
74 Pseudo-Behçet's disease associated with tuberculosis: a case report and review of the literature. Rheumatol Int 2014 0.80
75 Cytophagic histiocytic panniculitis in a 74-year-old man. Age Ageing 2013 0.79
76 PACAP attenuates NMDA-induced retinal damage in association with modulation of the microglia/macrophage status into an acquired deactivation subtype. J Mol Neurosci 2013 0.79
77 Inactivation of DNA-dependent protein kinase promotes heat-induced apoptosis independently of heat-shock protein induction in human cancer cell lines. PLoS One 2013 0.79
78 Yellow nail syndrome associated with rheumatoid arthritis, thiol-compound therapy and early gastric cancer. BMJ Case Rep 2012 0.79
79 Systemic dissemination of chronic necrotizing pulmonary aspergillosis in an elderly woman without comorbidity: a case report. J Med Case Rep 2012 0.79
80 Ontogenetic characteristics of enzyme activities and plasma metabolites in C57BL/6J:Jcl mice deficient in insulin receptor substrate 2. Comp Med 2006 0.79
81 Miliary brain metastasis presenting with calcification in a patient with lung cancer: a case report. J Med Case Rep 2012 0.78
82 Replication study for the association of a single-nucleotide polymorphism, rs3746876, within KCNJ15, with susceptibility to type 2 diabetes in a Japanese population. J Hum Genet 2013 0.78
83 [The role of PPARgamma in the onset of type 2 diabetes]. Nihon Yakurigaku Zasshi 2003 0.78
84 A novel model of insulin-dependent diabetes with renal and retinal lesions by transgenic expression of CaMKIIalpha (Thr286Asp) in pancreatic beta-cells. Diabetes Metab Res Rev 2008 0.78
85 Angiotensin II enhances the increase in monocyte chemoattractant protein-1 production induced by tumor necrosis factor-{alpha} from 3T3-L1 preadipocytes. J Endocrinol 2009 0.78
86 Characterization of diabetic nephropathy in CaM kinase IIalpha (Thr286Asp) transgenic mice. Biochem Biophys Res Commun 2008 0.77
87 A rare case of adrenocorticotropic hormone (ACTH)-independent macroadrenal hyperplasia showing ectopic production of ACTH. Intern Med 2012 0.77
88 Successful desensitization by glargine administration in a patient with insulin allergy: a case report. Diabetes Res Clin Pract 2009 0.77
89 [The role of inflammation in the development of insulin resistance in type 2 diabetes]. Nihon Rinsho 2011 0.77
90 A novel Y231del mutation of HFE in hereditary haemochromatosis provides in vivo evidence that the Huh-7 is a human haemochromatotic cell line. Liver Int 2011 0.77
91 Maturity-onset diabetes of the young resulting from a novel mutation in the HNF-4alpha gene. Intern Med 2002 0.77
92 IRS-2 deficiency in macrophages promotes their accumulation in the vascular wall. Biochem Biophys Res Commun 2011 0.76
93 Role of the liver in glucose homeostasis in PI 3-kinase p85alpha-deficient mice. Am J Physiol Endocrinol Metab 2009 0.76
94 Deforming arthropathy in a patient with IgG4-related systemic disease: comment on the article by Stone et al. Arthritis Care Res (Hoboken) 2010 0.75
95 Comment on: arthropathy with infiltrate IgG4-positive plasma cells in synovium. Rheumatology (Oxford) 2012 0.75
96 Simultaneously developed polymyositis and autoimmune hepatitis. BMJ Case Rep 2011 0.75
97 Page kidney in a patient with granulomatosis with polyangiitis (Wegener's). Postgrad Med J 2012 0.75
98 [Insulin resistance in central nerve system]. Nihon Rinsho 2006 0.75
99 Presenting manifestations of hemophagocytic syndrome in a male patient with systemic lupus erythematosus. Rheumatol Int 2009 0.75
100 Glimepiride-induced bronchial asthma: case report. Diabetes Care 2008 0.75
101 [Insulin action and its regulatory mechanisms]. Nihon Rinsho 2011 0.75
102 [History of research on diabetes mellitus]. Nihon Naika Gakkai Zasshi 2002 0.75
103 [Postprandial hyperglycemia]. Nihon Rinsho 2006 0.75
104 A history of ischemic heart disease is a common cause of wheezing in the elderly of a Japanese local community. Intern Med 2011 0.75
105 [Roles of chronic inflammation as a pathogenesis of insulin resistance]. Nihon Rinsho 2012 0.75
106 Accidental cannulation of a femoral central venous catheter into the iliolumbar vein: incidental detection by bone scintigraphy. Clin Nucl Med 2015 0.75
107 [Metabolic syndrome]. Nihon Rinsho 2010 0.75
108 Hypertrophic pachymeningitis in an individual with microscopic polyangiitis. J Am Geriatr Soc 2013 0.75
109 Phenotypes of IRS-2 deficient mice produced by reproductive technology are stable. Exp Anim 2007 0.75
110 [Pioglitazone and the risk of bladder cancer]. Nihon Rinsho 2016 0.75
111 Relationship of the urine cortisol level with the performance status of patients with lung cancer: a retrospective study. Support Care Cancer 2014 0.75
112 [Glucose metabolism in adipose tissue]. Nihon Rinsho 2002 0.75
113 [Gene targeting approaches for diabetes research]. Nihon Rinsho 2005 0.75
114 [A case of bronchiolitis with IgG4-positive plasma cells infiltration associated with Mikulicz's disease and autoimmune pancreatitis]. Nihon Kokyuki Gakkai Zasshi 2009 0.75
115 Systemic sarcoidosis with subcutaneous lesions in an 85-year-old female. J Am Geriatr Soc 2013 0.75
116 [Two cases of pulmonary sarcomatoid carcinoma mimicking malignant mesothelioma]. Nihon Kokyuki Gakkai Zasshi 2010 0.75
117 [A Retrospective Study Analyzing the Clinical Course of Patients with Non-Small Cell Lung Cancer Receiving Local or Systemic Therapy after Post-Operative Recurrence]. Gan To Kagaku Ryoho 2017 0.75
118 An Efficient reproductive method for Irs2-/- mice with C57BL/6JJcl genetic background. Exp Anim 2008 0.75
119 Elevated serum procalcitonin in anaphylaxis. J Antimicrob Chemother 2013 0.75
120 Detection of respiratory waveforms using non-contact electrodes during bathing. Conf Proc IEEE Eng Med Biol Soc 2010 0.75
121 Association of serum adiponectin with asthma and pulmonary function in the Japanese population. Endocr J 2015 0.75
122 [Efficacy and toxicity of pemetrexed monotherapy for previously untreated elderly patients with non-squamous cell lung cancer with wild-type(or unknown)EGFR status]. Gan To Kagaku Ryoho 2014 0.75
123 Usefulness of the Palliative Prognostic Index in patients with lung cancer. Med Oncol 2014 0.75
124 [Synchronous pulmonary hamartoma and lung cancer in a young patient]. Nihon Kokyuki Gakkai Zasshi 2011 0.75
125 [A Case of Lung Adenocarcinoma Presenting with Leptomeningeal Carcinomatosis Successfully Treated with Afatinib after Erlotinib-Induced Hepatotoxicity]. Gan To Kagaku Ryoho 2017 0.75