Published in Cancer Biol Ther on November 17, 2003
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Tumor-promoting phorbol esters and activated Ras inactivate the tuberous sclerosis tumor suppressor complex via p90 ribosomal S6 kinase. Proc Natl Acad Sci U S A (2004) 5.16
TSC2 modulates actin cytoskeleton and focal adhesion through TSC1-binding domain and the Rac1 GTPase. J Cell Biol (2004) 1.66
Mechanisms of epileptogenesis in tuberous sclerosis complex and related malformations of cortical development with abnormal glioneuronal proliferation. Epilepsia (2007) 1.48
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Activation of lysosomal function in the course of autophagy via mTORC1 suppression and autophagosome-lysosome fusion. Cell Res (2013) 1.42
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Abnormal growth of smooth muscle-like cells in lymphangioleiomyomatosis: Role for tumor suppressor TSC2. Am J Respir Cell Mol Biol (2006) 1.24
p53 regulation of the IGF-1/AKT/mTOR pathways and the endosomal compartment. Cold Spring Harb Perspect Biol (2010) 1.20
Gene expression analysis of tuberous sclerosis complex cortical tubers reveals increased expression of adhesion and inflammatory factors. Brain Pathol (2009) 1.12
Hepatitis C virus activates the mTOR/S6K1 signaling pathway in inhibiting IRS-1 function for insulin resistance. J Virol (2012) 1.09
Roles for PI3K/AKT/PTEN Pathway in Cell Signaling of Nonalcoholic Fatty Liver Disease. ISRN Endocrinol (2013) 1.08
Amino acids as regulators of gene expression. Nutr Metab (Lond) (2004) 1.07
Dynamic switch of negative feedback regulation in Drosophila Akt-TOR signaling. PLoS Genet (2010) 1.04
Stromal liver kinase B1 [STK11] signaling loss induces oviductal adenomas and endometrial cancer by activating mammalian Target of Rapamycin Complex 1. PLoS Genet (2012) 1.01
ERK and Akt signaling pathways function through parallel mechanisms to promote mTORC1 signaling. Am J Physiol Cell Physiol (2011) 0.99
Phosphatases: the new brakes for cancer development? Enzyme Res (2011) 0.97
A circuitry and biochemical basis for tuberous sclerosis symptoms: from epilepsy to neurocognitive deficits. Int J Dev Neurosci (2013) 0.96
Spatiotemporal characterization of mTOR kinase activity following kainic acid induced status epilepticus and analysis of rat brain response to chronic rapamycin treatment. PLoS One (2013) 0.88
Everolimus - a new approach in the treatment of renal cell carcinoma. Cancer Manag Res (2010) 0.87
Constitutive Activation of mTORC1 in Endothelial Cells Leads to the Development and Progression of Lymphangiosarcoma through VEGF Autocrine Signaling. Cancer Cell (2015) 0.87
Histone deacetylase inhibitors induce autophagy through FOXO1-dependent pathways. Autophagy (2015) 0.85
TSC1 and TSC2 gene mutations and their implications for treatment in Tuberous Sclerosis Complex: a review. Genet Mol Biol (2017) 0.84
Irradiation exacerbates cortical cytopathology in the Eker rat model of tuberous sclerosis complex, but does not induce hyperexcitability. Epilepsy Res (2006) 0.83
Brief report: S6 ribosomal protein phosphorylation in autistic frontal cortex and cerebellum: a tissue array analysis. J Autism Dev Disord (2006) 0.82
Tsc2, a positional candidate gene underlying a quantitative trait locus for hepatic steatosis. J Lipid Res (2012) 0.81
Tuberous sclerosis complex: a brave new world? Curr Opin Neurol (2010) 0.80
Cooperative benefit for the combination of rapamycin and imatinib in tuberous sclerosis complex neoplasia. Vasc Cell (2012) 0.80
PAK2 is an effector of TSC1/2 signaling independent of mTOR and a potential therapeutic target for Tuberous Sclerosis Complex. Sci Rep (2015) 0.79
Prognostic markers in renal cell carcinoma: A focus on the 'mammalian target of rapamycin' pathway. Arab J Urol (2012) 0.79
Congenital subependymal giant cell astrocytomas in patients with tuberous sclerosis complex. Childs Nerv Syst (2014) 0.77
Global gene expression analysis of lenses from different mouse strains and in the alpha3Cx46 knockout mouse. Mol Vis (2010) 0.76
Certain Diet and Lifestyle May Contribute to Islet β-cells Protection in Type-2 Diabetes via the Modulation of Cellular PI3K/AKT Pathway. Open Biochem J (2014) 0.76
Tuberous sclerosis complex: everything old is new again. J Neurodev Disord (2009) 0.76
Curcumin targets the TFEB-lysosome pathway for induction of autophagy. Oncotarget (2016) 0.75