Published in PLoS Genet on June 17, 2010
Nutrition-responsive glia control exit of neural stem cells from quiescence. Cell (2010) 3.19
TOR and ageing: a complex pathway for a complex process. Philos Trans R Soc Lond B Biol Sci (2011) 1.25
Proteomic and functional genomic landscape of receptor tyrosine kinase and ras to extracellular signal-regulated kinase signaling. Sci Signal (2011) 1.20
Evolution of the TOR pathway. J Mol Evol (2011) 0.95
Multifaceted roles of PTEN and TSC orchestrate growth and differentiation of Drosophila blood progenitors. Development (2012) 0.94
Using answer set programming to integrate RNA expression with signalling pathway information to infer how mutations affect ageing. PLoS One (2012) 0.91
Drosophila RNAi screening in a postgenomic world. Brief Funct Genomics (2011) 0.91
Noncanonical control of C. elegans germline apoptosis by the insulin/IGF-1 and Ras/MAPK signaling pathways. Cell Death Differ (2012) 0.90
Altered regulation of sleep and feeding contributes to starvation resistance in Drosophila melanogaster. J Exp Biol (2014) 0.87
Genome-scale RNAi on living-cell microarrays identifies novel regulators of Drosophila melanogaster TORC1-S6K pathway signaling. Genome Res (2011) 0.87
Signaling pathways involved in 1-octen-3-ol-mediated neurotoxicity in Drosophila melanogaster: implication in Parkinson’s disease. Neurotox Res (2014) 0.83
Unkempt is negatively regulated by mTOR and uncouples neuronal differentiation from growth control. PLoS Genet (2014) 0.83
Diet and energy-sensing inputs affect TorC1-mediated axon misrouting but not TorC2-directed synapse growth in a Drosophila model of tuberous sclerosis. PLoS One (2012) 0.82
Nutrient restriction enhances the proliferative potential of cells lacking the tumor suppressor PTEN in mitotic tissues. Elife (2013) 0.81
Using Drosophila to discover mechanisms underlying type 2 diabetes. Dis Model Mech (2016) 0.80
Cyclin G Functions as a Positive Regulator of Growth and Metabolism in Drosophila. PLoS Genet (2015) 0.80
Loss of the tumor suppressor Pten promotes proliferation of Drosophila melanogaster cells in vitro and gives rise to continuous cell lines. PLoS One (2012) 0.78
Drosophila Longevity Assurance Conferred by Reduced Insulin Receptor Substrate Chico Partially Requires d4eBP. PLoS One (2015) 0.77
The TSC1/2 complex controls Drosophila pigmentation through TORC1-dependent regulation of catecholamine biosynthesis. PLoS One (2012) 0.76
A systems-level interrogation identifies regulators of Drosophila blood cell number and survival. PLoS Genet (2015) 0.76
An Integrative Analysis of the InR/PI3K/Akt Network Identifies the Dynamic Response to Insulin Signaling. Cell Rep (2016) 0.75
Drosophila Spidey/Kar Regulates Oenocyte Growth via PI3-Kinase Signaling. PLoS Genet (2016) 0.75
Primer3 on the WWW for general users and for biologist programmers. Methods Mol Biol (2000) 128.08
Targeted gene expression as a means of altering cell fates and generating dominant phenotypes. Development (1993) 58.26
Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex. Science (2005) 38.99
TOR signaling in growth and metabolism. Cell (2006) 35.29
AKT/PKB signaling: navigating downstream. Cell (2007) 31.26
Database resources of the National Center for Biotechnology Information. Nucleic Acids Res (2005) 22.98
Defining the role of mTOR in cancer. Cancer Cell (2007) 21.63
TSC2 mediates cellular energy response to control cell growth and survival. Cell (2003) 20.21
TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling. Nat Cell Biol (2002) 17.41
Cellular survival: a play in three Akts. Genes Dev (1999) 17.05
The tumor suppressor LKB1 kinase directly activates AMP-activated kinase and regulates apoptosis in response to energy stress. Proc Natl Acad Sci U S A (2004) 12.30
Ras, PI(3)K and mTOR signalling controls tumour cell growth. Nature (2006) 12.13
Identification of the tuberous sclerosis complex-2 tumor suppressor gene product tuberin as a target of the phosphoinositide 3-kinase/akt pathway. Mol Cell (2002) 11.65
Ablation in mice of the mTORC components raptor, rictor, or mLST8 reveals that mTORC2 is required for signaling to Akt-FOXO and PKCalpha, but not S6K1. Dev Cell (2006) 11.48
SIN1/MIP1 maintains rictor-mTOR complex integrity and regulates Akt phosphorylation and substrate specificity. Cell (2006) 10.50
Inparanoid: a comprehensive database of eukaryotic orthologs. Nucleic Acids Res (2005) 9.90
The TSC1-2 tumor suppressor controls insulin-PI3K signaling via regulation of IRS proteins. J Cell Biol (2004) 9.71
PRAS40 is an insulin-regulated inhibitor of the mTORC1 protein kinase. Mol Cell (2007) 9.68
Insulin signalling to mTOR mediated by the Akt/PKB substrate PRAS40. Nat Cell Biol (2007) 8.07
Akt regulates growth by directly phosphorylating Tsc2. Nat Cell Biol (2002) 8.04
The LKB1 tumor suppressor negatively regulates mTOR signaling. Cancer Cell (2004) 7.77
Genome-wide RNAi analysis of growth and viability in Drosophila cells. Science (2004) 7.75
Inappropriate activation of the TSC/Rheb/mTOR/S6K cassette induces IRS1/2 depletion, insulin resistance, and cell survival deficiencies. Curr Biol (2004) 7.59
Targeting the PI3K-Akt pathway in human cancer: rationale and promise. Cancer Cell (2003) 7.42
Dysregulation of the TSC-mTOR pathway in human disease. Nat Genet (2005) 7.15
Drosophila S6 kinase: a regulator of cell size. Science (1999) 6.76
Drosophila dFOXO controls lifespan and regulates insulin signalling in brain and fat body. Nature (2004) 6.38
The FoxO code. Oncogene (2008) 6.22
The two TORCs and Akt. Dev Cell (2007) 6.17
Rheb binds and regulates the mTOR kinase. Curr Biol (2005) 6.09
Autonomous control of cell and organ size by CHICO, a Drosophila homolog of vertebrate IRS1-4. Cell (1999) 5.38
Tsc tumour suppressor proteins antagonize amino-acid-TOR signalling. Nat Cell Biol (2002) 5.37
The Akt-mTOR tango and its relevance to cancer. Cancer Cell (2005) 5.34
GbetaL, a positive regulator of the rapamycin-sensitive pathway required for the nutrient-sensitive interaction between raptor and mTOR. Mol Cell (2003) 5.21
Multiallelic disruption of the rictor gene in mice reveals that mTOR complex 2 is essential for fetal growth and viability. Dev Cell (2006) 5.19
The Drosophila tuberous sclerosis complex gene homologs restrict cell growth and cell proliferation. Cell (2001) 5.14
Function and biological roles of the Dickkopf family of Wnt modulators. Oncogene (2006) 5.12
Control of cell number by Drosophila FOXO: downstream and feedback regulation of the insulin receptor pathway. Genes Dev (2003) 5.10
mSin1 is necessary for Akt/PKB phosphorylation, and its isoforms define three distinct mTORC2s. Curr Biol (2006) 5.06
Rheb promotes cell growth as a component of the insulin/TOR signalling network. Nat Cell Biol (2003) 5.01
Cell-autonomous regulation of cell and organ growth in Drosophila by Akt/PKB. Nat Cell Biol (1999) 5.00
Nutrient overload, insulin resistance, and ribosomal protein S6 kinase 1, S6K1. Cell Metab (2006) 4.98
Drosophila Tsc1 functions with Tsc2 to antagonize insulin signaling in regulating cell growth, cell proliferation, and organ size. Cell (2001) 4.98
The Drosophila forkhead transcription factor FOXO mediates the reduction in cell number associated with reduced insulin signaling. J Biol (2003) 4.85
TSC1 and TSC2 tumor suppressors antagonize insulin signaling in cell growth. Genes Dev (2001) 4.68
Mechanisms of life span extension by rapamycin in the fruit fly Drosophila melanogaster. Cell Metab (2010) 4.44
A rapamycin-sensitive pathway down-regulates insulin signaling via phosphorylation and proteasomal degradation of insulin receptor substrate-1. Mol Endocrinol (2000) 4.25
Rheb is an essential regulator of S6K in controlling cell growth in Drosophila. Nat Cell Biol (2003) 4.20
Protein phosphatases and the regulation of mitogen-activated protein kinase signalling. Curr Opin Cell Biol (2000) 4.16
Feedback control of intercellular signalling in development. Nature (2000) 4.04
Regulation of neuronal morphology and function by the tumor suppressors Tsc1 and Tsc2. Nat Neurosci (2005) 4.00
Rheb fills a GAP between TSC and TOR. Trends Biochem Sci (2003) 3.90
Akt deficiency impairs normal cell proliferation and suppresses oncogenesis in a p53-independent and mTORC1-dependent manner. Cancer Cell (2006) 3.83
The Drosophila phosphoinositide 3-kinase Dp110 promotes cell growth. EMBO J (1996) 3.78
mTOR complex 2 is required for the development of prostate cancer induced by Pten loss in mice. Cancer Cell (2009) 3.78
Nutrients suppress phosphatidylinositol 3-kinase/Akt signaling via raptor-dependent mTOR-mediated insulin receptor substrate 1 phosphorylation. Mol Cell Biol (2006) 3.67
mTOR Complex1-S6K1 signaling: at the crossroads of obesity, diabetes and cancer. Trends Mol Med (2007) 3.66
Tumours with PI3K activation are resistant to dietary restriction. Nature (2009) 3.60
How flies get their size: genetics meets physiology. Nat Rev Genet (2006) 3.52
The TSC1-TSC2 complex is required for proper activation of mTOR complex 2. Mol Cell Biol (2008) 3.50
Mutations in the NF-kappaB signaling pathway: implications for human disease. Oncogene (2006) 3.49
The rapamycin-sensitive signal transduction pathway as a target for cancer therapy. Oncogene (2000) 3.40
Feedback inhibition of Akt signaling limits the growth of tumors lacking Tsc2. Genes Dev (2005) 3.25
Will mTOR inhibitors make it as cancer drugs? Cancer Cell (2003) 3.15
Sprouty proteins: multifaceted negative-feedback regulators of receptor tyrosine kinase signaling. Trends Cell Biol (2005) 3.14
Identification of Protor as a novel Rictor-binding component of mTOR complex-2. Biochem J (2007) 3.08
Crosstalk between the EGFR and LIN-12/Notch pathways in C. elegans vulval development. Science (2004) 3.03
Drosophila tumor suppressor PTEN controls cell size and number by antagonizing the Chico/PI3-kinase signaling pathway. Genes Dev (1999) 2.87
Lethality of Drosophila lacking TSC tumor suppressor function rescued by reducing dS6K signaling. Genes Dev (2002) 2.87
Identification of S6 kinase 1 as a novel mammalian target of rapamycin (mTOR)-phosphorylating kinase. J Biol Chem (2005) 2.84
Regulation of imaginal disc cell size, cell number and organ size by Drosophila class I(A) phosphoinositide 3-kinase and its adaptor. Curr Biol (1999) 2.76
Rheb binding to mammalian target of rapamycin (mTOR) is regulated by amino acid sufficiency. J Biol Chem (2005) 2.70
A new mutational AKTivation in the PI3K pathway. Cancer Cell (2007) 2.62
Vector and parameters for targeted transgenic RNA interference in Drosophila melanogaster. Nat Methods (2007) 2.59
Foxo transcription factors blunt cardiac hypertrophy by inhibiting calcineurin signaling. Circulation (2006) 2.55
PRAS40 is a target for mammalian target of rapamycin complex 1 and is required for signaling downstream of this complex. J Biol Chem (2007) 2.50
dS6K-regulated cell growth is dPKB/dPI(3)K-independent, but requires dPDK1. Nat Cell Biol (2002) 2.31
Transcriptional feedback control of insulin receptor by dFOXO/FOXO1. Genes Dev (2005) 2.30
The principal rapamycin-sensitive p70(s6k) phosphorylation sites, T-229 and T-389, are differentially regulated by rapamycin-insensitive kinase kinases. Mol Cell Biol (1996) 2.28
4E-BP functions as a metabolic brake used under stress conditions but not during normal growth. Genes Dev (2005) 2.28
FoxO transcription factors activate Akt and attenuate insulin signaling in heart by inhibiting protein phosphatases. Proc Natl Acad Sci U S A (2007) 2.08
PRAS40 and PRR5-like protein are new mTOR interactors that regulate apoptosis. PLoS One (2007) 2.07
TSC1/TSC2 and Rheb have different effects on TORC1 and TORC2 activity. Proc Natl Acad Sci U S A (2006) 2.06
Role of dietary proteins and amino acids in the pathogenesis of insulin resistance. Annu Rev Nutr (2007) 2.03
Akt inhibitor A-443654 induces rapid Akt Ser-473 phosphorylation independent of mTORC1 inhibition. Oncogene (2007) 2.03
Patching the gaps in Hedgehog signalling. Nat Cell Biol (2007) 2.01
Drosophila TCTP is essential for growth and proliferation through regulation of dRheb GTPase. Nature (2007) 2.01
Genetic analysis of Pten and Tsc2 functional interactions in the mouse reveals asymmetrical haploinsufficiency in tumor suppression. Genes Dev (2005) 1.99
The amino acid sensitive TOR pathway from yeast to mammals. FEBS Lett (2006) 1.97
Genetic analysis of protein kinase B (AKT) in Drosophila. Curr Biol (1998) 1.85
Re-evaluating AKT regulation: role of TOR complex 2 in tissue growth. Genes Dev (2007) 1.83
Turnover of the active fraction of IRS1 involves raptor-mTOR- and S6K1-dependent serine phosphorylation in cell culture models of tuberous sclerosis. Mol Cell Biol (2006) 1.82
PI3-kinase and TOR: PIKTORing cell growth. Semin Cell Dev Biol (2004) 1.78
A protocol for mosaic analysis with a repressible cell marker (MARCM) in Drosophila. Nat Protoc (2006) 1.68
Genetic mosaic techniques for studying Drosophila development. Development (2003) 1.66
Phosphorylation sites in the autoinhibitory domain participate in p70(s6k) activation loop phosphorylation. J Biol Chem (1998) 1.64
Rhebbing up mTOR: new insights on TSC1 and TSC2, and the pathogenesis of tuberous sclerosis. Cancer Biol Ther (2003) 1.58
Re-evaluating the roles of proposed modulators of mammalian target of rapamycin complex 1 (mTORC1) signaling. J Biol Chem (2008) 1.57
Tsc2 is not a critical target of Akt during normal Drosophila development. Genes Dev (2004) 1.57
Altering Drosophila S6 kinase activity is consistent with a role for S6 kinase in growth. Genesis (2002) 1.51
Identification of functional elements and regulatory circuits by Drosophila modENCODE. Science (2010) 12.39
The developmental transcriptome of Drosophila melanogaster. Nature (2010) 11.85
Hedgehog is an early and late mediator of pancreatic cancer tumorigenesis. Nature (2003) 10.33
An endogenous small interfering RNA pathway in Drosophila. Nature (2008) 7.88
Genome-wide RNAi analysis of growth and viability in Drosophila cells. Science (2004) 7.75
The promise and perils of Wnt signaling through beta-catenin. Science (2002) 6.11
Minimizing the risk of reporting false positives in large-scale RNAi screens. Nat Methods (2006) 5.96
Evidence that stem cells reside in the adult Drosophila midgut epithelium. Nature (2005) 5.86
Exploiting position effects and the gypsy retrovirus insulator to engineer precisely expressed transgenes. Nat Genet (2008) 5.50
Hedgehog signalling in cancer formation and maintenance. Nat Rev Cancer (2003) 4.86
Incomplete DNA methylation underlies a transcriptional memory of somatic cells in human iPS cells. Nat Cell Biol (2011) 4.77
Functional genomic analysis of the Wnt-wingless signaling pathway. Science (2005) 4.73
A genome-scale shRNA resource for transgenic RNAi in Drosophila. Nat Methods (2011) 4.24
GLI1 is regulated through Smoothened-independent mechanisms in neoplastic pancreatic ducts and mediates PDAC cell survival and transformation. Genes Dev (2009) 4.21
Sequential activation of signaling pathways during innate immune responses in Drosophila. Dev Cell (2002) 4.08
Heparan sulphate proteoglycans: the sweet side of development. Nat Rev Mol Cell Biol (2005) 3.92
Droplet microfluidic technology for single-cell high-throughput screening. Proc Natl Acad Sci U S A (2009) 3.85
Quantitative morphological signatures define local signaling networks regulating cell morphology. Science (2007) 3.76
Functional genomics reveals genes involved in protein secretion and Golgi organization. Nature (2006) 3.72
Drosophila RNAi screen reveals CD36 family member required for mycobacterial infection. Science (2005) 3.49
Stat3 and MMP7 contribute to pancreatic ductal adenocarcinoma initiation and progression. Cancer Cell (2011) 3.47
Parallel chemical genetic and genome-wide RNAi screens identify cytokinesis inhibitors and targets. PLoS Biol (2004) 3.39
Integrated activity of PDZ protein complexes regulates epithelial polarity. Nat Cell Biol (2003) 3.38
Identification of Sox9-dependent acinar-to-ductal reprogramming as the principal mechanism for initiation of pancreatic ductal adenocarcinoma. Cancer Cell (2012) 3.36
Evidence of off-target effects associated with long dsRNAs in Drosophila melanogaster cell-based assays. Nat Methods (2006) 3.29
Genome-wide RNAi screen for host factors required for intracellular bacterial infection. Science (2005) 3.28
KRAS, Hedgehog, Wnt and the twisted developmental biology of pancreatic ductal adenocarcinoma. Nat Rev Cancer (2010) 3.27
High-throughput RNAi screening in cultured cells: a user's guide. Nat Rev Genet (2006) 3.22
Hierarchical rules for Argonaute loading in Drosophila. Mol Cell (2009) 3.20
The emergence of geometric order in proliferating metazoan epithelia. Nature (2006) 3.13
Hedgehog/Ras interactions regulate early stages of pancreatic cancer. Genes Dev (2006) 3.09
Genomic screening with RNAi: results and challenges. Annu Rev Biochem (2010) 3.08
Signaling role of hemocytes in Drosophila JAK/STAT-dependent response to septic injury. Dev Cell (2003) 3.05
A functional RNAi screen for regulators of receptor tyrosine kinase and ERK signalling. Nature (2006) 3.00
GFP reporters detect the activation of the Drosophila JAK/STAT pathway in vivo. Gene Expr Patterns (2006) 2.96
Beta-catenin blocks Kras-dependent reprogramming of acini into pancreatic cancer precursor lesions in mice. J Clin Invest (2010) 2.90
Genome-wide RNAi screen reveals a specific sensitivity of IRES-containing RNA viruses to host translation inhibition. Genes Dev (2005) 2.83
FOXO/4E-BP signaling in Drosophila muscles regulates organism-wide proteostasis during aging. Cell (2010) 2.66
Genome-wide RNAi analysis of JAK/STAT signaling components in Drosophila. Genes Dev (2005) 2.63
Temperature-sensitive control of protein activity by conditionally splicing inteins. Nat Biotechnol (2004) 2.62
Wnt signaling regulates pancreatic beta cell proliferation. Proc Natl Acad Sci U S A (2007) 2.61
Vector and parameters for targeted transgenic RNA interference in Drosophila melanogaster. Nat Methods (2007) 2.59
A screen for morphological complexity identifies regulators of switch-like transitions between discrete cell shapes. Nat Cell Biol (2013) 2.59
Deep annotation of Drosophila melanogaster microRNAs yields insights into their processing, modification, and emergence. Genome Res (2010) 2.56
The transcriptional diversity of 25 Drosophila cell lines. Genome Res (2010) 2.47
Diversity and dynamics of the Drosophila transcriptome. Nature (2014) 2.47
A Drosophila resource of transgenic RNAi lines for neurogenetics. Genetics (2009) 2.45
Stabilization of beta-catenin impacts pancreas growth. Development (2006) 2.44
FlyRNAi: the Drosophila RNAi screening center database. Nucleic Acids Res (2006) 2.43
The roles of JAK/STAT signaling in Drosophila immune responses. Immunol Rev (2004) 2.37
Common activation of canonical Wnt signaling in pancreatic adenocarcinoma. PLoS One (2007) 2.26
A genome-wide RNA interference screen in Drosophila melanogaster cells for new components of the Hh signaling pathway. Nat Genet (2005) 2.26
Muscle mitohormesis promotes longevity via systemic repression of insulin signaling. Cell (2013) 2.21
Probing cell type-specific functions of Gi in vivo identifies GPCR regulators of insulin secretion. J Clin Invest (2007) 2.20
Genetic screening for signal transduction in the era of network biology. Cell (2007) 2.19
Sonic hedgehog acts at multiple stages during pancreatic tumorigenesis. Proc Natl Acad Sci U S A (2007) 2.17
Optimized gene editing technology for Drosophila melanogaster using germ line-specific Cas9. Proc Natl Acad Sci U S A (2013) 2.13
Extracellular sulfatases, elements of the Wnt signaling pathway, positively regulate growth and tumorigenicity of human pancreatic cancer cells. PLoS One (2007) 2.08
Drosophila cytokine unpaired 2 regulates physiological homeostasis by remotely controlling insulin secretion. Cell (2012) 2.06
The PDGF/VEGF receptor controls blood cell survival in Drosophila. Dev Cell (2004) 2.06
The Jak/STAT pathway in model organisms: emerging roles in cell movement. Dev Cell (2002) 2.05
Design and implementation of high-throughput RNAi screens in cultured Drosophila cells. Nat Protoc (2007) 2.05
Control of the mitotic cleavage plane by local epithelial topology. Cell (2011) 2.04
Molecular mechanisms of epithelial morphogenesis. Annu Rev Cell Dev Biol (2002) 2.00
Wld S requires Nmnat1 enzymatic activity and N16-VCP interactions to suppress Wallerian degeneration. J Cell Biol (2009) 1.98
Comparative analysis of argonaute-dependent small RNA pathways in Drosophila. Mol Cell (2008) 1.95
COPI activity coupled with fatty acid biosynthesis is required for viral replication. PLoS Pathog (2006) 1.95
Entry is a rate-limiting step for viral infection in a Drosophila melanogaster model of pathogenesis. Nat Immunol (2003) 1.90
The Hippo tumor suppressor pathway regulates intestinal stem cell regeneration. Development (2010) 1.89
Synergy between bacterial infection and genetic predisposition in intestinal dysplasia. Proc Natl Acad Sci U S A (2009) 1.88
Disruption of Dicer1 induces dysregulated fetal gene expression and promotes hepatocarcinogenesis. Gastroenterology (2009) 1.86
Phosphorylation networks regulating JNK activity in diverse genetic backgrounds. Science (2008) 1.86
Complementary genomic screens identify SERCA as a therapeutic target in NOTCH1 mutated cancer. Cancer Cell (2013) 1.86
High-throughput RNA interference screens in Drosophila tissue culture cells. Methods Enzymol (2005) 1.83
Extrusion and death of DPP/BMP-compromised epithelial cells in the developing Drosophila wing. Science (2005) 1.81
Stabilization of beta-catenin induces pancreas tumor formation. Gastroenterology (2008) 1.81
Drosophila and the genetics of the internal milieu. Nature (2007) 1.79
An integrative approach to ortholog prediction for disease-focused and other functional studies. BMC Bioinformatics (2011) 1.79
Coordinate regulation of small temporal RNAs at the onset of Drosophila metamorphosis. Dev Biol (2003) 1.79
In vivo imaging of Drosophila melanogaster pupae with mesoscopic fluorescence tomography. Nat Methods (2007) 1.78
Primary cilia deletion in pancreatic epithelial cells results in cyst formation and pancreatitis. Gastroenterology (2006) 1.77
Comparative RNAi screening identifies a conserved core metazoan actinome by phenotype. J Cell Biol (2011) 1.75
How does type 1 diabetes develop?: the notion of homicide or β-cell suicide revisited. Diabetes (2011) 1.74
Orpk mouse model of polycystic kidney disease reveals essential role of primary cilia in pancreatic tissue organization. Development (2004) 1.73
Liver-specific loss of beta-catenin blocks glutamine synthesis pathway activity and cytochrome p450 expression in mice. Hepatology (2006) 1.69
Regulated beta-cell regeneration in the adult mouse pancreas. Diabetes (2007) 1.67
A sensitized genetic screen to identify novel regulators and components of the Drosophila janus kinase/signal transducer and activator of transcription pathway. Genetics (2003) 1.63
Pancreatic development and disease. Gastroenterology (2007) 1.62
Notch modulates Wnt signalling by associating with Armadillo/beta-catenin and regulating its transcriptional activity. Development (2005) 1.62
Conserved microRNA targeting in Drosophila is as widespread in coding regions as in 3'UTRs. Proc Natl Acad Sci U S A (2010) 1.62
neurotic, a novel maternal neurogenic gene, encodes an O-fucosyltransferase that is essential for Notch-Delta interactions. Development (2003) 1.60
Identification of neural outgrowth genes using genome-wide RNAi. PLoS Genet (2008) 1.60
Role of autophagy in glycogen breakdown and its relevance to chloroquine myopathy. PLoS Biol (2013) 1.59
Nr5a2 maintains acinar cell differentiation and constrains oncogenic Kras-mediated pancreatic neoplastic initiation. Gut (2013) 1.58
Cellular plasticity within the pancreas--lessons learned from development. Dev Cell (2010) 1.58
Processing of Drosophila endo-siRNAs depends on a specific Loquacious isoform. RNA (2009) 1.57
Functional screening identifies miR-315 as a potent activator of Wingless signaling. Proc Natl Acad Sci U S A (2007) 1.53
Unusually effective microRNA targeting within repeat-rich coding regions of mammalian mRNAs. Genome Res (2011) 1.53
Analysis of twenty-four Gal4 lines in Drosophila melanogaster. Genesis (2002) 1.51
A genome-wide RNA interference screen identifies putative chromatin regulators essential for E2F repression. Proc Natl Acad Sci U S A (2007) 1.50