PubRank

Dean Sheppard

Author PubWeight™ 166.23‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 The importance of race and ethnic background in biomedical research and clinical practice. N Engl J Med 2003 7.94
2 Alveolar epithelial cell mesenchymal transition develops in vivo during pulmonary fibrosis and is regulated by the extracellular matrix. Proc Natl Acad Sci U S A 2006 7.08
3 Loss of integrin alpha(v)beta8 on dendritic cells causes autoimmunity and colitis in mice. Nature 2007 4.94
4 Enhanced pathological angiogenesis in mice lacking beta3 integrin or beta3 and beta5 integrins. Nat Med 2002 4.87
5 Direct effects of interleukin-13 on epithelial cells cause airway hyperreactivity and mucus overproduction in asthma. Nat Med 2002 4.65
6 The integrin alpha(v)beta8 mediates epithelial homeostasis through MT1-MMP-dependent activation of TGF-beta1. J Cell Biol 2002 4.60
7 Loss of integrin alpha(v)beta6-mediated TGF-beta activation causes Mmp12-dependent emphysema. Nature 2003 4.02
8 Gene expression analysis reveals matrilysin as a key regulator of pulmonary fibrosis in mice and humans. Proc Natl Acad Sci U S A 2002 4.00
9 Targeting of αv integrin identifies a core molecular pathway that regulates fibrosis in several organs. Nat Med 2013 3.35
10 Population stratification confounds genetic association studies among Latinos. Hum Genet 2005 3.19
11 Genetic admixture and asthma-related phenotypes in Mexican American and Puerto Rican asthmatics. Genet Epidemiol 2005 3.03
12 Src-mediated coupling of focal adhesion kinase to integrin alpha(v)beta5 in vascular endothelial growth factor signaling. J Cell Biol 2002 2.84
13 Therapy for fibrotic diseases: nearing the starting line. Sci Transl Med 2013 2.72
14 Pharmacogenetic differences in response to albuterol between Puerto Ricans and Mexicans with asthma. Am J Respir Crit Care Med 2004 2.62
15 Transcriptional activation of integrin beta6 during the epithelial-mesenchymal transition defines a novel prognostic indicator of aggressive colon carcinoma. J Clin Invest 2005 2.61
16 Retracted Induction of a homeostatic circuit in lung tissue by microbial compounds. Immunity 2006 2.49
17 IL-17A produced by αβ T cells drives airway hyper-responsiveness in mice and enhances mouse and human airway smooth muscle contraction. Nat Med 2012 2.47
18 Loss of synchronized retinal phagocytosis and age-related blindness in mice lacking alphavbeta5 integrin. J Exp Med 2004 2.42
19 Integrin-alpha9 is required for fibronectin matrix assembly during lymphatic valve morphogenesis. Dev Cell 2009 2.41
20 Ligation of protease-activated receptor 1 enhances alpha(v)beta6 integrin-dependent TGF-beta activation and promotes acute lung injury. J Clin Invest 2006 2.40
21 Lower bronchodilator responsiveness in Puerto Rican than in Mexican subjects with asthma. Am J Respir Crit Care Med 2003 2.39
22 Partial inhibition of integrin alpha(v)beta6 prevents pulmonary fibrosis without exacerbating inflammation. Am J Respir Crit Care Med 2007 2.17
23 Transforming growth factor-beta-dependent and -independent pathways of induction of tubulointerstitial fibrosis in beta6(-/-) mice. Am J Pathol 2003 2.05
24 Spatiotemporally separated antigen uptake by alveolar dendritic cells and airway presentation to T cells in the lung. J Exp Med 2012 2.03
25 Essential role for MFG-E8 as ligand for alphavbeta5 integrin in diurnal retinal phagocytosis. Proc Natl Acad Sci U S A 2007 1.97
26 Calcium-activated chloride channel TMEM16A modulates mucin secretion and airway smooth muscle contraction. Proc Natl Acad Sci U S A 2012 1.97
27 An essential role for fibronectin extra type III domain A in pulmonary fibrosis. Am J Respir Crit Care Med 2007 1.91
28 Transforming growth factor-beta1 decreases expression of the epithelial sodium channel alphaENaC and alveolar epithelial vectorial sodium and fluid transport via an ERK1/2-dependent mechanism. J Biol Chem 2003 1.90
29 Interleukin-1beta decreases expression of the epithelial sodium channel alpha-subunit in alveolar epithelial cells via a p38 MAPK-dependent signaling pathway. J Biol Chem 2005 1.86
30 The EIIIA segment of fibronectin is a ligand for integrins alpha 9beta 1 and alpha 4beta 1 providing a novel mechanism for regulating cell adhesion by alternative splicing. J Biol Chem 2002 1.81
31 Alphav beta6 integrin regulates renal fibrosis and inflammation in Alport mouse. Am J Pathol 2007 1.79
32 Future research directions in idiopathic pulmonary fibrosis: summary of a National Heart, Lung, and Blood Institute working group. Am J Respir Crit Care Med 2002 1.76
33 Interleukin-1beta causes acute lung injury via alphavbeta5 and alphavbeta6 integrin-dependent mechanisms. Circ Res 2008 1.73
34 Squamous metaplasia amplifies pathologic epithelial-mesenchymal interactions in COPD patients. J Clin Invest 2007 1.73
35 Function-blocking integrin alphavbeta6 monoclonal antibodies: distinct ligand-mimetic and nonligand-mimetic classes. J Biol Chem 2004 1.72
36 The lymphangiogenic vascular endothelial growth factors VEGF-C and -D are ligands for the integrin alpha9beta1. J Biol Chem 2004 1.69
37 Mfge8 diminishes the severity of tissue fibrosis in mice by binding and targeting collagen for uptake by macrophages. J Clin Invest 2009 1.68
38 Absence of integrin αvβ3 enhances vascular leak in mice by inhibiting endothelial cortical actin formation. Am J Respir Crit Care Med 2012 1.64
39 TGF-β activation and function in immunity. Annu Rev Immunol 2013 1.63
40 Expression of αvβ8 integrin on dendritic cells regulates Th17 cell development and experimental autoimmune encephalomyelitis in mice. J Clin Invest 2010 1.63
41 Cross talk among TGF-β signaling pathways, integrins, and the extracellular matrix. Cold Spring Harb Perspect Biol 2011 1.60
42 Integrin alphavbeta1 is a receptor for foot-and-mouth disease virus. J Virol 2002 1.60
43 Future directions in idiopathic pulmonary fibrosis research. An NHLBI workshop report. Am J Respir Crit Care Med 2014 1.54
44 Mfge8 is critical for mammary gland remodeling during involution. Mol Biol Cell 2005 1.53
45 Thrombin-cleaved osteopontin regulates hemopoietic stem and progenitor cell functions through interactions with alpha9beta1 and alpha4beta1 integrins. Blood 2009 1.53
46 Lysophosphatidic acid induces alphavbeta6 integrin-mediated TGF-beta activation via the LPA2 receptor and the small G protein G alpha(q). Am J Pathol 2009 1.50
47 Functional classification of ADAMs based on a conserved motif for binding to integrin alpha 9beta 1: implications for sperm-egg binding and other cell interactions. J Biol Chem 2002 1.49
48 Integrin alphavbeta5 regulates lung vascular permeability and pulmonary endothelial barrier function. Am J Respir Cell Mol Biol 2006 1.47
49 ADAM33 is not associated with asthma in Puerto Rican or Mexican populations. Am J Respir Crit Care Med 2003 1.47
50 Effective treatment of mouse sepsis with an inhibitory antibody targeting integrin αvβ5. Crit Care Med 2013 1.44
51 Eosinophils secrete IL-4 to facilitate liver regeneration. Proc Natl Acad Sci U S A 2013 1.33
52 Alternaria induces STAT6-dependent acute airway eosinophilia and epithelial FIZZ1 expression that promotes airway fibrosis and epithelial thickness. J Immunol 2012 1.30
53 Integrin alpha9beta1 directly binds to vascular endothelial growth factor (VEGF)-A and contributes to VEGF-A-induced angiogenesis. J Biol Chem 2007 1.29
54 Loss of integrin alpha9beta1 results in defects in proliferation, causing poor re-epithelialization during cutaneous wound healing. J Invest Dermatol 2008 1.17
55 Integrin alpha v beta 6 is an RGD-dependent receptor for coxsackievirus A9. J Virol 2004 1.16
56 Epithelial cells utilize cortical actin/myosin to activate latent TGF-β through integrin α(v)β(6)-dependent physical force. Exp Cell Res 2012 1.15
57 ADAM33 is not essential for growth and development and does not modulate allergic asthma in mice. Mol Cell Biol 2006 1.15
58 The alpha9beta1 integrin enhances cell migration by polyamine-mediated modulation of an inward-rectifier potassium channel. Proc Natl Acad Sci U S A 2008 1.15
59 The αvβ6 integrin modulates airway hyperresponsiveness in mice by regulating intraepithelial mast cells. J Clin Invest 2012 1.13
60 Integrin-mediated regulation of TGFβ in fibrosis. Biochim Biophys Acta 2012 1.12
61 Integrin αvβ5-mediated TGF-β activation by airway smooth muscle cells in asthma. J Immunol 2011 1.11
62 Enteric expression of the integrin alpha(v)beta(6) is essential for nematode-induced mucosal mast cell hyperplasia and expression of the granule chymase, mouse mast cell protease-1. Am J Pathol 2002 1.10
63 Spermidine/spermine N1-acetyltransferase specifically binds to the integrin alpha9 subunit cytoplasmic domain and enhances cell migration. J Cell Biol 2004 1.10
64 Mice lacking the integrin beta5 subunit have accelerated osteoclast maturation and increased activity in the estrogen-deficient state. J Bone Miner Res 2004 1.10
65 Differential enzymatic activity of common haplotypic versions of the human acidic Mammalian chitinase protein. J Biol Chem 2009 1.08
66 Alpha9beta1: a novel osteoclast integrin that regulates osteoclast formation and function. J Bone Miner Res 2006 1.06
67 Integrin α9β1 in airway smooth muscle suppresses exaggerated airway narrowing. J Clin Invest 2012 0.98
68 Induction of an epithelial integrin alphavbeta6 in human cytomegalovirus-infected endothelial cells leads to activation of transforming growth factor-beta1 and increased collagen production. Am J Pathol 2008 0.96
69 Activation of transforming growth factor-beta by the integrin alphavbeta8 delays epithelial wound closure. Am J Respir Cell Mol Biol 2006 0.96
70 Osteopontin undergoes polymerization in vivo and gains chemotactic activity for neutrophils mediated by integrin alpha9beta1. J Biol Chem 2011 0.95
71 Structural requirements of MLD-containing disintegrins for functional interaction with alpha 4 beta 1 and alpha 9 beta1 integrins. Biochemistry 2004 0.95
72 Integrin beta6 mediates phospholipid and collectin homeostasis by activation of latent TGF-beta1. Am J Respir Cell Mol Biol 2007 0.94
73 Roles of the innate immune system in mammary gland remodeling during involution. J Mammary Gland Biol Neoplasia 2007 0.94
74 The Integrin alpha9beta1 contributes to granulopoiesis by enhancing granulocyte colony-stimulating factor receptor signaling. Immunity 2006 0.94
75 Phosphorylation of Trask by Src kinases inhibits integrin clustering and functions in exclusion with focal adhesion signaling. Mol Cell Biol 2010 0.94
76 ADAM disintegrin-like domain recognition by the lymphocyte integrins alpha4beta1 and alpha4beta7. Biochem J 2005 0.91
77 Role of multiple beta1 integrins in cell adhesion to the disintegrin domains of ADAMs 2 and 3. Exp Cell Res 2003 0.90
78 Genomics and proteomics of lung disease: conference summary. Am J Physiol Lung Cell Mol Physiol 2007 0.88
79 Blocking TGFβ via Inhibition of the αvβ6 Integrin: A Possible Therapy for Systemic Sclerosis Interstitial Lung Disease. Int J Rheumatol 2011 0.87
80 Identification and molecular characterization of multiple phenotypes in integrin knockout mice. Methods Enzymol 2007 0.87
81 The phosphatase CD148 promotes airway hyperresponsiveness through SRC family kinases. J Clin Invest 2013 0.86
82 beta6 Integrin subunit deficiency alleviates lung injury in a mouse model of bronchopulmonary dysplasia. Am J Respir Cell Mol Biol 2009 0.86
83 Use of oligonucleotide microarrays to analyze gene expression patterns in pulmonary fibrosis reveals distinct patterns of gene expression in mice and humans. Chest 2002 0.85
84 Epistatic interactions between Tgfb1 and genetic loci, Tgfbm2 and Tgfbm3, determine susceptibility to an asthmatic stimulus. Proc Natl Acad Sci U S A 2012 0.84
85 Heparin-binding epidermal growth factor cleavage mediates zinc-induced epidermal growth factor receptor phosphorylation. Am J Respir Cell Mol Biol 2003 0.83
86 Inhibition of the αvβ6 integrin leads to limited alteration of TGF-α-induced pulmonary fibrosis. Am J Physiol Lung Cell Mol Physiol 2014 0.83
87 Pulmonary emphysema: when more is less. Physiology (Bethesda) 2006 0.81
88 Killed by leukocytes that don't know when to leave. Nat Immunol 2002 0.80
89 Integrin α9 on lymphatic endothelial cells regulates lymphocyte egress. Proc Natl Acad Sci U S A 2014 0.80
90 IQGAP1-dependent scaffold suppresses RhoA and inhibits airway smooth muscle contraction. J Clin Invest 2014 0.79
91 Short form of α9 promotes α9β1 integrin-dependent cell adhesion by modulating the function of the full-length α9 subunit. Exp Cell Res 2011 0.78
92 An Official American Thoracic Society Workshop Report: Use of Animal Models for the Preclinical Assessment of Potential Therapies for Pulmonary Fibrosis. Am J Respir Cell Mol Biol 2017 0.77
93 Dust mites' dirty dealings with dendritic cells. Nat Med 2008 0.76
94 Fishing in the bloodstream: insights into the mechanisms of pulmonary hypertension? Am J Respir Crit Care Med 2004 0.75
95 Targeting integrin α5β1 ameliorates severe airway hyperresponsiveness in experimental asthma. J Clin Invest 2016 0.75
96 Retraction. Induction of a homeostatic circuit in lung tissue by microbial compounds. Immunity 2008 0.75