Lipid rafts: elusive or illusive?

Single-molecule microscopy reveals plasma membrane microdomains created by protein-protein networks that exclude or trap signaling molecules in T cells. Cell (2005) 7.27

Direct observation of the nanoscale dynamics of membrane lipids in a living cell. Nature (2008) 6.38

Revitalizing membrane rafts: new tools and insights. Nat Rev Mol Cell Biol (2010) 5.03

Lipid rafts: contentious only from simplistic standpoints. Nat Rev Mol Cell Biol (2006) 4.94

The HIV lipidome: a raft with an unusual composition. Proc Natl Acad Sci U S A (2006) 4.15

Large-scale fluid/fluid phase separation of proteins and lipids in giant plasma membrane vesicles. Proc Natl Acad Sci U S A (2007) 4.09

Use of cyclodextrins to manipulate plasma membrane cholesterol content: evidence, misconceptions and control strategies. Biochim Biophys Acta (2007) 3.83

H-ras, K-ras, and inner plasma membrane raft proteins operate in nanoclusters with differential dependence on the actin cytoskeleton. Proc Natl Acad Sci U S A (2005) 3.78

The complex life of simple sphingolipids. EMBO Rep (2004) 3.10

Dynamic molecular confinement in the plasma membrane by microdomains and the cytoskeleton meshwork. EMBO J (2006) 2.87

Fluorescence correlation spectroscopy relates rafts in model and native membranes. Biophys J (2004) 2.73

Crosslinking a lipid raft component triggers liquid ordered-liquid disordered phase separation in model plasma membranes. Proc Natl Acad Sci U S A (2005) 2.60

Caveolae as organizers of pharmacologically relevant signal transduction molecules. Annu Rev Pharmacol Toxicol (2008) 2.57

Direct evidence for the role of caveolin-1 and caveolae in mechanotransduction and remodeling of blood vessels. J Clin Invest (2006) 2.47

The glycosylphosphatidylinositol anchor: a complex membrane-anchoring structure for proteins. Biochemistry (2008) 2.40

Gangliosides GM1 and GM3 in the living cell membrane form clusters susceptible to cholesterol depletion and chilling. Mol Biol Cell (2007) 2.38

Condensation of the plasma membrane at the site of T lymphocyte activation. J Cell Biol (2005) 2.33

Mechanisms for T cell receptor triggering. Nat Rev Immunol (2010) 2.30

Fluorescence probe partitioning between Lo/Ld phases in lipid membranes. Biochim Biophys Acta (2007) 2.25

Ras plasma membrane signalling platforms. Biochem J (2005) 2.15

Fast molecular tracking maps nanoscale dynamics of plasma membrane lipids. Proc Natl Acad Sci U S A (2010) 2.14

Phase coexistence and connectivity in the apical membrane of polarized epithelial cells. Proc Natl Acad Sci U S A (2006) 2.09

Three separable domains regulate GTP-dependent association of H-ras with the plasma membrane. Mol Cell Biol (2004) 2.09

Sterol structure determines the separation of phases and the curvature of the liquid-ordered phase in model membranes. Proc Natl Acad Sci U S A (2005) 2.09

Reconstitution of intramembrane proteolysis in vitro reveals that pure rhomboid is sufficient for catalysis and specificity. Proc Natl Acad Sci U S A (2005) 2.08

The SNARE motif is essential for the formation of syntaxin clusters in the plasma membrane. Biophys J (2006) 2.04

Spatial organization of transmembrane receptor signalling. EMBO J (2010) 2.03

HIV-1 envelope glycoprotein biosynthesis, trafficking, and incorporation. J Mol Biol (2011) 2.01

Different routes of bone morphogenic protein (BMP) receptor endocytosis influence BMP signaling. Mol Cell Biol (2006) 1.99

Membrane elasticity in giant vesicles with fluid phase coexistence. Biophys J (2005) 1.97

Palmitoylation regulates raft affinity for the majority of integral raft proteins. Proc Natl Acad Sci U S A (2010) 1.96

A curvature-mediated mechanism for localization of lipids to bacterial poles. PLoS Comput Biol (2006) 1.95

Integrin-mediated adhesion regulates membrane order. J Cell Biol (2006) 1.92

Remorin, a solanaceae protein resident in membrane rafts and plasmodesmata, impairs potato virus X movement. Plant Cell (2009) 1.91

Mechanisms of hybrid oligomer formation in the pathogenesis of combined Alzheimer's and Parkinson's diseases. PLoS One (2008) 1.84

Accumulation of raft lipids in T-cell plasma membrane domains engaged in TCR signalling. EMBO J (2009) 1.84

Membrane potential governs lateral segregation of plasma membrane proteins and lipids in yeast. EMBO J (2006) 1.83

Identifying optimal lipid raft characteristics required to promote nanoscale protein-protein interactions on the plasma membrane. Mol Cell Biol (2006) 1.81

Lipid microdomains and the regulation of ion channel function. J Physiol (2010) 1.79

SHP-1 and SHP-2 in T cells: two phosphatases functioning at many levels. Immunol Rev (2009) 1.78

Condensed complexes in vesicles containing cholesterol and phospholipids. Proc Natl Acad Sci U S A (2005) 1.77

The LAT story: a tale of cooperativity, coordination, and choreography. Cold Spring Harb Perspect Biol (2010) 1.77

Plasma membrane microdomains regulate turnover of transport proteins in yeast. J Cell Biol (2008) 1.77

Characterization of lipid rafts from Medicago truncatula root plasma membranes: a proteomic study reveals the presence of a raft-associated redox system. Plant Physiol (2007) 1.73

Molecular mechanisms of clathrin-independent endocytosis. J Cell Sci (2009) 1.72

Dynamic recruitment of phospholipase C gamma at transiently immobilized GPI-anchored receptor clusters induces IP3-Ca2+ signaling: single-molecule tracking study 2. J Cell Biol (2007) 1.70

Distinct ceramide synthases regulate polarized growth in the filamentous fungus Aspergillus nidulans. Mol Biol Cell (2006) 1.69

Lipid rafts/caveolae as microdomains of calcium signaling. Cell Calcium (2009) 1.65

Cytoskeleton-membrane interactions in membrane raft structure. Cell Mol Life Sci (2009) 1.59

PIP2 signaling in lipid domains: a critical re-evaluation. EMBO J (2005) 1.59

Minimal model of plasma membrane heterogeneity requires coupling cortical actin to criticality. Biophys J (2011) 1.58

Plasma membrane stress induces relocalization of Slm proteins and activation of TORC2 to promote sphingolipid synthesis. Nat Cell Biol (2012) 1.58

Requirement for ergosterol in V-ATPase function underlies antifungal activity of azole drugs. PLoS Pathog (2010) 1.58

Flicker spectroscopy of thermal lipid bilayer domain boundary fluctuations. Biophys J (2007) 1.57

Cholesterol sensitivity and lipid raft targeting of Kir2.1 channels. Biophys J (2004) 1.56

A GPI-anchored alkaline phosphatase is a functional midgut receptor of Cry11Aa toxin in Aedes aegypti larvae. Biochem J (2006) 1.56

Association of human immunodeficiency virus type 1 gag with membrane does not require highly basic sequences in the nucleocapsid: use of a novel Gag multimerization assay. J Virol (2005) 1.55

Coexisting domains in the plasma membranes of live cells characterized by spin-label ESR spectroscopy. Biophys J (2006) 1.51

Lipids and membrane microdomains in HIV-1 replication. Virus Res (2009) 1.51

Ergosterol promotes pheromone signaling and plasma membrane fusion in mating yeast. J Cell Biol (2008) 1.50

Lipid packing drives the segregation of transmembrane helices into disordered lipid domains in model membranes. Proc Natl Acad Sci U S A (2011) 1.50

Flagellar membrane localization via association with lipid rafts. J Cell Sci (2009) 1.49

Assembly and localization of Toll-like receptor signalling complexes. Nat Rev Immunol (2014) 1.48

Novel approaches to inhibiting HIV-1 replication. Antiviral Res (2009) 1.48

Plasma membrane microdomains: organization, function and trafficking. Mol Membr Biol (2004) 1.48

Intracellular triggering of Fas aggregation and recruitment of apoptotic molecules into Fas-enriched rafts in selective tumor cell apoptosis. J Exp Med (2004) 1.46

Positive and negative regulation of FcepsilonRI-mediated signaling by the adaptor protein LAB/NTAL. J Exp Med (2004) 1.44

(Un)confined diffusion of CD59 in the plasma membrane determined by high-resolution single molecule microscopy. Biophys J (2007) 1.43

Phosphatidylethanolamine domains and localization of phospholipid synthases in Bacillus subtilis membranes. J Bacteriol (2005) 1.43

The plant endosomal system--its structure and role in signal transduction and plant development. Planta (2004) 1.43

Using plasma membrane nanoclusters to build better signaling circuits. Trends Cell Biol (2008) 1.41

Membrane-bound basic peptides sequester multivalent (PIP2), but not monovalent (PS), acidic lipids. Biophys J (2006) 1.40

Interleaflet coupling mechanisms in bilayers of lipids and cholesterol. Biophys J (2007) 1.40

Regulatory activity of polyunsaturated fatty acids in T-cell signaling. Prog Lipid Res (2010) 1.39

Lipid rafts, cholesterol, and the brain. Neuropharmacology (2008) 1.38

Functional implications of plasma membrane condensation for T cell activation. PLoS One (2008) 1.37

Regulation of membrane trafficking, cytoskeleton dynamics, and cell polarity by ROP/RAC GTPases. Plant Physiol (2008) 1.37

BDNF-induced recruitment of TrkB receptor into neuronal lipid rafts: roles in synaptic modulation. J Cell Biol (2004) 1.35

Alzheimer disease Abeta production in the absence of S-palmitoylation-dependent targeting of BACE1 to lipid rafts. J Biol Chem (2008) 1.34

Lipid microdomains in cell nucleus. Mol Biol Cell (2008) 1.34

Ras acylation, compartmentalization and signaling nanoclusters (Review). Mol Membr Biol (2008) 1.33

Sources of anomalous diffusion on cell membranes: a Monte Carlo study. Biophys J (2006) 1.33

Ras proteins: paradigms for compartmentalised and isoform-specific signalling. Cell Mol Life Sci (2007) 1.30

Lipids and lipid modifications in the regulation of membrane traffic. Curr Opin Cell Biol (2007) 1.30

Depletion of cellular cholesterol inhibits membrane binding and higher-order multimerization of human immunodeficiency virus type 1 Gag. Virology (2006) 1.30

Lipid rafts and B cell signaling. Semin Cell Dev Biol (2007) 1.29

Lipid rafts in T cell signalling and disease. Semin Cell Dev Biol (2007) 1.29

Lipid rafts in T cell receptor signalling . Mol Membr Biol (2006) 1.28

Imaging techniques for assaying lymphocyte activation in action. Nat Rev Immunol (2011) 1.27

Biochemical characterization of rous sarcoma virus MA protein interaction with membranes. J Virol (2005) 1.27

Why is delta endocytosis required for effective activation of notch? Dev Dyn (2006) 1.27

CD13/APN regulates endothelial invasion and filopodia formation. Blood (2007) 1.26

Particle image correlation spectroscopy (PICS): retrieving nanometer-scale correlations from high-density single-molecule position data. Biophys J (2006) 1.26

Lipid rafts in plants. Planta (2005) 1.26

Docosahexaenoic acid alters the size and distribution of cell surface microdomains. Biochim Biophys Acta (2007) 1.26

Lipid localization in bacterial cells through curvature-mediated microphase separation. Biophys J (2008) 1.25

Taking the plunge: integrating structural, enzymatic and computational insights into a unified model for membrane-immersed rhomboid proteolysis. Biochem J (2010) 1.25

Insights into the role of specific lipids in the formation and delivery of lipid microdomains to the plasma membrane of plant cells. Plant Physiol (2006) 1.24

Characterization of the ternary mixture of sphingomyelin, POPC, and cholesterol: support for an inhomogeneous lipid distribution at high temperatures. Biophys J (2008) 1.23

Three pools of plasma membrane cholesterol and their relation to cholesterol homeostasis. Elife (2014) 1.22