Published in Biochem J on July 01, 2005
Lipid rafts: contentious only from simplistic standpoints. Nat Rev Mol Cell Biol (2006) 4.94
H-ras, K-ras, and inner plasma membrane raft proteins operate in nanoclusters with differential dependence on the actin cytoskeleton. Proc Natl Acad Sci U S A (2005) 3.78
Signalling ballet in space and time. Nat Rev Mol Cell Biol (2010) 3.32
Therapeutic strategies for targeting ras proteins. Genes Cancer (2011) 2.45
Individual palmitoyl residues serve distinct roles in H-ras trafficking, microlocalization, and signaling. Mol Cell Biol (2005) 2.24
A novel switch region regulates H-ras membrane orientation and signal output. EMBO J (2008) 2.06
Therapeutic intervention based on protein prenylation and associated modifications. Nat Chem Biol (2006) 1.96
Evolution of the Rho family of ras-like GTPases in eukaryotes. Mol Biol Evol (2006) 1.96
Identifying optimal lipid raft characteristics required to promote nanoscale protein-protein interactions on the plasma membrane. Mol Cell Biol (2006) 1.81
Mapping the nucleotide and isoform-dependent structural and dynamical features of Ras proteins. Structure (2008) 1.75
Dynamic recruitment of phospholipase C gamma at transiently immobilized GPI-anchored receptor clusters induces IP3-Ca2+ signaling: single-molecule tracking study 2. J Cell Biol (2007) 1.70
Ras conformational switching: simulating nucleotide-dependent conformational transitions with accelerated molecular dynamics. PLoS Comput Biol (2009) 1.67
Ras nanoclusters: molecular structure and assembly. Semin Cell Dev Biol (2007) 1.56
Activated Kras, but not Hras or Nras, may initiate tumors of endodermal origin via stem cell expansion. Mol Cell Biol (2008) 1.53
Ras/MAPK signaling from endomembranes. Mol Oncol (2009) 1.51
Ras trafficking, localization and compartmentalized signalling. Semin Cell Dev Biol (2011) 1.48
Using plasma membrane nanoclusters to build better signaling circuits. Trends Cell Biol (2008) 1.41
Galectin-1 is a novel structural component and a major regulator of h-ras nanoclusters. Mol Biol Cell (2008) 1.39
Electrostatic interactions positively regulate K-Ras nanocluster formation and function. Mol Cell Biol (2008) 1.34
Ras acylation, compartmentalization and signaling nanoclusters (Review). Mol Membr Biol (2008) 1.33
Sources of anomalous diffusion on cell membranes: a Monte Carlo study. Biophys J (2006) 1.33
Functional specificity of ras isoforms: so similar but so different. Genes Cancer (2011) 1.30
K-ras nanoclustering is subverted by overexpression of the scaffold protein galectin-3. Cancer Res (2008) 1.29
Activation of the MAPK module from different spatial locations generates distinct system outputs. Mol Biol Cell (2008) 1.25
Ras nanoclusters: combining digital and analog signaling. Cell Cycle (2007) 1.21
Temperature-dependent phase behavior and protein partitioning in giant plasma membrane vesicles. Biochim Biophys Acta (2010) 1.20
Clustering of raft-associated proteins in the external membrane leaflet modulates internal leaflet H-ras diffusion and signaling. Mol Cell Biol (2006) 1.18
H-ras protein in a bilayer: interaction and structure perturbation. J Am Chem Soc (2007) 1.16
Cholesterol depletion associated with Leishmania major infection alters macrophage CD40 signalosome composition and effector function. Nat Immunol (2009) 1.15
Caveolae regulate the nanoscale organization of the plasma membrane to remotely control Ras signaling. J Cell Biol (2014) 1.10
Nucleophosmin and nucleolin regulate K-Ras plasma membrane interactions and MAPK signal transduction. J Biol Chem (2009) 1.07
Plasma membrane-associated annexin A6 reduces Ca2+ entry by stabilizing the cortical actin cytoskeleton. J Biol Chem (2009) 1.07
Fendiline inhibits K-Ras plasma membrane localization and blocks K-Ras signal transmission. Mol Cell Biol (2012) 1.04
Quantitative microscopy and systems biology: seeing the whole picture. Histochem Cell Biol (2008) 1.02
Cholesterol loss enhances TrkB signaling in hippocampal neurons aging in vitro. Mol Biol Cell (2008) 1.01
Death pathways triggered by activated Ras in cancer cells. Front Biosci (Landmark Ed) (2011) 1.00
Src kinase activity and SH2 domain regulate the dynamics of Src association with lipid and protein targets. J Cell Biol (2007) 1.00
Spatiotemporal organization of Ras signaling: rasosomes and the galectin switch. Cell Mol Neurobiol (2006) 0.99
Signal integration by lipid-mediated spatial cross talk between Ras nanoclusters. Mol Cell Biol (2013) 0.98
Membrane curvature enables N-Ras lipid anchor sorting to liquid-ordered membrane phases. Nat Chem Biol (2015) 0.98
APC +/- alters colonic fibroblast proteome in FAP. Oncotarget (2011) 0.96
Nonsteroidal anti-inflammatory drugs alter the spatiotemporal organization of Ras proteins on the plasma membrane. J Biol Chem (2012) 0.94
Use of microarray technology to assess the time course of liver stress response after confinement exposure in gilthead sea bream (Sparus aurata L.). BMC Genomics (2010) 0.94
Biophysical mechanism for ras-nanocluster formation and signaling in plasma membrane. PLoS One (2009) 0.94
Ras, an actor on many stages: posttranslational modifications, localization, and site-specified events. Genes Cancer (2011) 0.93
Mathematical modeling of K-Ras nanocluster formation on the plasma membrane. Biophys J (2010) 0.92
The role of G-domain orientation and nucleotide state on the Ras isoform-specific membrane interaction. Eur Biophys J (2012) 0.90
Therapeutic levels of the hydroxmethylglutaryl-coenzyme A reductase inhibitor lovastatin activate ras signaling via phospholipase D2. Mol Cell Biol (2011) 0.88
The anti-inflammatory drug indomethacin alters nanoclustering in synthetic and cell plasma membranes. J Biol Chem (2010) 0.88
Insertion of lipidated Ras proteins into lipid monolayers studied by infrared reflection absorption spectroscopy (IRRAS). Biophys J (2006) 0.88
The efficacy of Raf kinase recruitment to the GTPase H-ras depends on H-ras membrane conformer-specific nanoclustering. J Biol Chem (2014) 0.87
Ultrafast diffusion of a fluorescent cholesterol analog in compartmentalized plasma membranes. Traffic (2014) 0.85
The nonsteroidal anti-inflammatory drug indomethacin induces heterogeneity in lipid membranes: potential implication for its diverse biological action. PLoS One (2010) 0.85
Direct activation of human phospholipase C by its well known inhibitor u73122. J Biol Chem (2011) 0.85
The small GTPase RhoH is an atypical regulator of haematopoietic cells. Cell Commun Signal (2008) 0.84
Rac1 recruitment to the archipelago structure of the focal adhesion through the fluid membrane as revealed by single-molecule analysis. Cytoskeleton (Hoboken) (2013) 0.84
Influence of the lipid anchor motif of N-ras on the interaction with lipid membranes: a surface plasmon resonance study. Biophys J (2010) 0.82
H-ras distribution and signaling in plasma membrane microdomains are regulated by acylation and deacylation events. Mol Cell Biol (2015) 0.82
Galectin-1 dimers can scaffold Raf-effectors to increase H-ras nanoclustering. Sci Rep (2016) 0.81
Nucleophosmin and nucleolin regulate K-Ras signaling. Commun Integr Biol (2010) 0.80
Adenylyl cyclase AC8 directly controls its micro-environment by recruiting the actin cytoskeleton in a cholesterol-rich milieu. J Cell Sci (2012) 0.80
Ras family small GTPase-mediated neuroprotective signaling in stroke. Cent Nerv Syst Agents Med Chem (2011) 0.79
Ras nanoclusters: a new drug target? Small GTPases (2013) 0.79
Computational Equilibrium Thermodynamic and Kinetic Analysis of K-Ras Dimerization through an Effector Binding Surface Suggests Limited Functional Role. J Phys Chem B (2016) 0.77
Effect of angiotensin II and small GTPase Ras signaling pathway inhibition on early renal changes in a murine model of obstructive nephropathy. Biomed Res Int (2014) 0.77
Multi-Compartmentalisation in the MAPK Signalling Pathway Contributes to the Emergence of Oscillatory Behaviour and to Ultrasensitivity. PLoS One (2016) 0.77
Visualization of HRas Domains in the Plasma Membrane of Fibroblasts. Biophys J (2015) 0.75
Farnesyl transferase inhibitor FTI-277 inhibits breast cell invasion and migration by blocking H-Ras activation. Oncol Lett (2016) 0.75
Generation of self-clusters of galectin-1 in the farnesyl-bound form. Sci Rep (2016) 0.75
Functional rafts in cell membranes. Nature (1997) 38.89
Lipid rafts and signal transduction. Nat Rev Mol Cell Biol (2000) 25.87
Partitioning of lipid-modified monomeric GFPs into membrane microdomains of live cells. Science (2002) 18.89
All ras proteins are polyisoprenylated but only some are palmitoylated. Cell (1989) 9.68
The state of lipid rafts: from model membranes to cells. Annu Rev Biophys Biomol Struct (2003) 8.51
Lipid rafts: elusive or illusive? Cell (2003) 7.99
Sphingolipid-cholesterol rafts diffuse as small entities in the plasma membrane of mammalian cells. J Cell Biol (2000) 7.22
Fatty acylation of proteins: new insights into membrane targeting of myristoylated and palmitoylated proteins. Biochim Biophys Acta (1999) 6.98
Endomembrane trafficking of ras: the CAAX motif targets proteins to the ER and Golgi. Cell (1999) 6.42
A polybasic domain or palmitoylation is required in addition to the CAAX motif to localize p21ras to the plasma membrane. Cell (1990) 6.08
An acylation cycle regulates localization and activity of palmitoylated Ras isoforms. Science (2005) 5.99
Nanoscale organization of multiple GPI-anchored proteins in living cell membranes. Cell (2004) 5.61
Ras proteins: different signals from different locations. Nat Rev Mol Cell Biol (2003) 5.55
Direct visualization of Ras proteins in spatially distinct cell surface microdomains. J Cell Biol (2003) 5.45
Structure of the guanine-nucleotide-binding domain of the Ha-ras oncogene product p21 in the triphosphate conformation. Nature (1989) 5.38
Dominant-negative caveolin inhibits H-Ras function by disrupting cholesterol-rich plasma membrane domains. Nat Cell Biol (1999) 4.94
Ras signalling on the endoplasmic reticulum and the Golgi. Nat Cell Biol (2002) 4.91
p21ras is modified by a farnesyl isoprenoid. Proc Natl Acad Sci U S A (1989) 4.80
Dynamics of putative raft-associated proteins at the cell surface. J Cell Biol (2004) 4.52
GTP-dependent segregation of H-ras from lipid rafts is required for biological activity. Nat Cell Biol (2001) 4.42
Phospholipase Cgamma activates Ras on the Golgi apparatus by means of RasGRP1. Nature (2003) 3.66
A CAAX or a CAAL motif and a second signal are sufficient for plasma membrane targeting of ras proteins. EMBO J (1991) 3.64
Ultrafine membrane compartments for molecular diffusion as revealed by single molecule techniques. Biophys J (2004) 3.54
Molecular dynamics and interactions for creation of stimulation-induced stabilized rafts from small unstable steady-state rafts. Traffic (2004) 3.45
Localized Ras signaling at the leading edge regulates PI3K, cell polarity, and directional cell movement. J Cell Biol (2004) 3.44
Identification of a Ras palmitoyltransferase in Saccharomyces cerevisiae. J Biol Chem (2002) 3.27
H-ras but not K-ras traffics to the plasma membrane through the exocytic pathway. Mol Cell Biol (2000) 3.24
Binding of small basic peptides to membranes containing acidic lipids: theoretical models and experimental results. Biophys J (1996) 2.89
Single-molecule imaging analysis of Ras activation in living cells. Proc Natl Acad Sci U S A (2004) 2.84
Three-dimensional structures of H-ras p21 mutants: molecular basis for their inability to function as signal switch molecules. Cell (1990) 2.77
Activated K-Ras and H-Ras display different interactions with saturable nonraft sites at the surface of live cells. J Cell Biol (2002) 2.62
Mammalian prenylcysteine carboxyl methyltransferase is in the endoplasmic reticulum. J Biol Chem (1998) 2.52
NGF signaling from clathrin-coated vesicles: evidence that signaling endosomes serve as a platform for the Ras-MAPK pathway. Neuron (2001) 2.51
Galectin-1 binds oncogenic H-Ras to mediate Ras membrane anchorage and cell transformation. Oncogene (2001) 2.33
The complex of Arl2-GTP and PDE delta: from structure to function. EMBO J (2002) 2.24
Lateral sequestration of phosphatidylinositol 4,5-bisphosphate by the basic effector domain of myristoylated alanine-rich C kinase substrate is due to nonspecific electrostatic interactions. J Biol Chem (2002) 2.16
Erf2, a novel gene product that affects the localization and palmitoylation of Ras2 in Saccharomyces cerevisiae. Mol Cell Biol (1999) 2.14
Amino-terminal basic residues of Src mediate membrane binding through electrostatic interaction with acidic phospholipids. Proc Natl Acad Sci U S A (1994) 2.12
Three separable domains regulate GTP-dependent association of H-ras with the plasma membrane. Mol Cell Biol (2004) 2.09
Fluorimetric evaluation of the affinities of isoprenylated peptides for lipid bilayers. Biochemistry (1994) 1.99
Membrane binding of myristylated peptides corresponding to the NH2 terminus of Src. Biochemistry (1994) 1.99
Single-molecule imaging of the H-ras membrane-anchor reveals domains in the cytoplasmic leaflet of the cell membrane. Biophys J (2004) 1.95
Lipid rafts and plasma membrane microorganization: insights from Ras. Trends Cell Biol (2004) 1.92
Phosphorylation, high ionic strength, and calmodulin reverse the binding of MARCKS to phospholipid vesicles. J Biol Chem (1994) 1.78
Electrostatics and the membrane association of Src: theory and experiment. Biochemistry (1998) 1.78
Electrostatic properties of membranes containing acidic lipids and adsorbed basic peptides: theory and experiment. Biophys J (1999) 1.77
Coordinated traffic of Grb2 and Ras during epidermal growth factor receptor endocytosis visualized in living cells. Mol Biol Cell (2002) 1.77
Galectin-3 augments K-Ras activation and triggers a Ras signal that attenuates ERK but not phosphoinositide 3-kinase activity. J Biol Chem (2004) 1.76
Compartmentalization of Ras proteins. J Cell Sci (2001) 1.72
Membrane binding of peptides containing both basic and aromatic residues. Experimental studies with peptides corresponding to the scaffolding region of caveolin and the effector region of MARCKS. Biochemistry (2000) 1.67
Ras activation in Jurkat T cells following low-grade stimulation of the T-cell receptor is specific to N-Ras and occurs only on the Golgi apparatus. Mol Cell Biol (2004) 1.66
Ras and relatives--job sharing and networking keep an old family together. Exp Hematol (2002) 1.59
Electrostatic binding of proteins to membranes. Theoretical predictions and experimental results with charybdotoxin and phospholipid vesicles. Biophys J (1997) 1.58
H-Ras signaling and K-Ras signaling are differentially dependent on endocytosis. Mol Cell Biol (2002) 1.55
Galectin-1 augments Ras activation and diverts Ras signals to Raf-1 at the expense of phosphoinositide 3-kinase. J Biol Chem (2002) 1.53
Fatty acylation and prenylation of proteins: what's hot in fat. Curr Opin Cell Biol (2005) 1.50
Membrane trafficking of heterotrimeric G proteins via the endoplasmic reticulum and Golgi. Mol Biol Cell (2002) 1.48
Distinct rates of palmitate turnover on membrane-bound cellular and oncogenic H-ras. J Biol Chem (2003) 1.43
Ras interaction with two distinct binding domains in Raf-1 may be required for Ras transformation. J Biol Chem (1996) 1.42
The delta subunit of rod specific cyclic GMP phosphodiesterase, PDE delta, interacts with the Arf-like protein Arl3 in a GTP specific manner. FEBS Lett (1999) 1.40
The delta subunit of retinal rod cGMP phosphodiesterase regulates the membrane association of Ras and Rap GTPases. J Biol Chem (2002) 1.38
Ras pathway signaling on endomembranes. Curr Opin Cell Biol (2003) 1.38
An intact Raf zinc finger is required for optimal binding to processed Ras and for ras-dependent Raf activation in situ. Mol Cell Biol (1997) 1.37
Calmodulin binds to K-Ras, but not to H- or N-Ras, and modulates its downstream signaling. Mol Cell Biol (2001) 1.37
Galectin-1(L11A) predicted from a computed galectin-1 farnesyl-binding pocket selectively inhibits Ras-GTP. Cancer Res (2004) 1.36
Observing cell surface signaling domains using electron microscopy. Sci STKE (2003) 1.32
Erf4p and Erf2p form an endoplasmic reticulum-associated complex involved in the plasma membrane localization of yeast Ras proteins. J Biol Chem (2002) 1.31
Mutational and biochemical analysis of plasma membrane targeting mediated by the farnesylated, polybasic carboxy terminus of K-ras4B. Biochemistry (2000) 1.29
Palmitoylation and plasma membrane localization of Ras2p by a nonclassical trafficking pathway in Saccharomyces cerevisiae. Mol Cell Biol (2003) 1.29
Membrane localization and flexibility of a lipidated ras peptide studied by molecular dynamics simulations. J Am Chem Soc (2004) 1.27
Single- and multiple-molecule dynamics of the signaling from H-Ras to cRaf-1 visualized on the plasma membrane of living cells. Chemphyschem (2003) 1.26
NMR characterization of full-length farnesylated and non-farnesylated H-Ras and its implications for Raf activation. J Mol Biol (2004) 1.25
S-Acylation and plasma membrane targeting of the farnesylated carboxyl-terminal peptide of N-ras in mammalian fibroblasts. Biochemistry (1997) 1.22
Crystal structure of a myristoylated CAP-23/NAP-22 N-terminal domain complexed with Ca2+/calmodulin. EMBO J (2004) 1.22
Isolated endosomes from quiescent rat liver contain the signal transduction machinery. Differential distribution of activated Raf-1 and Mek in the endocytic compartment. FEBS Lett (1998) 1.21
Activity of plasma membrane-recruited Raf-1 is regulated by Ras via the Raf zinc finger. J Biol Chem (1997) 1.20
Targeting Ras signaling through inhibition of carboxyl methylation: an unexpected property of methotrexate. Proc Natl Acad Sci U S A (2003) 1.17
S-Nitrosocysteine increases palmitate turnover on Ha-Ras in NIH 3T3 cells. J Biol Chem (2000) 1.12
Membrane insertion of a lipidated ras peptide studied by FTIR, solid-state NMR, and neutron diffraction spectroscopy. J Am Chem Soc (2003) 1.12
Agonist-dependent traffic of raft-associated Ras and Raf-1 is required for activation of the mitogen-activated protein kinase cascade. J Biol Chem (2001) 1.08
Kinetics of interaction of the myristoylated alanine-rich C kinase substrate, membranes, and calmodulin. J Biol Chem (1997) 1.06
Direct involvement of protein myristoylation in myristoylated alanine-rich C kinase substrate (MARCKS)-calmodulin interaction. J Biol Chem (2003) 1.03
Carboxyl methylation of Ras regulates membrane targeting and effector engagement. J Biol Chem (2003) 0.99
A designed probe for acidic phospholipids reveals the unique enriched anionic character of the cytosolic face of the mammalian plasma membrane. J Biol Chem (2004) 0.99
Partitioning of dual-lipidated peptides into membrane microdomains: lipid sorting vs peptide aggregation. J Am Chem Soc (2004) 0.97
Ca2+/calmodulin binds and dissociates K-RasB from membrane. Biochem Biophys Res Commun (2003) 0.96
Visualizing Ras signalling in real-time. J Cell Sci (2004) 0.93
Calmodulin prevents activation of Ras by PKC in 3T3 fibroblasts. J Biol Chem (2002) 0.91
Myristoylation-regulated direct interaction between calcium-bound calmodulin and N-terminal region of pp60v-src. J Mol Biol (2004) 0.90
Replacement of the H-Ras farnesyl group by lipid analogues: implications for downstream processing and effector activation in Xenopus oocytes. Biochemistry (1997) 0.78
Lipid droplets: a unified view of a dynamic organelle. Nat Rev Mol Cell Biol (2006) 6.85
Direct visualization of Ras proteins in spatially distinct cell surface microdomains. J Cell Biol (2003) 5.45
PTRF-Cavin, a conserved cytoplasmic protein required for caveola formation and function. Cell (2008) 4.42
Role of LBPA and Alix in multivesicular liposome formation and endosome organization. Science (2004) 4.35
GPI-anchored proteins are delivered to recycling endosomes via a distinct cdc42-regulated, clathrin-independent pinocytic pathway. Dev Cell (2002) 4.28
APPL proteins link Rab5 to nuclear signal transduction via an endosomal compartment. Cell (2004) 3.95
Plasma membrane nanoswitches generate high-fidelity Ras signal transduction. Nat Cell Biol (2007) 3.90
H-ras, K-ras, and inner plasma membrane raft proteins operate in nanoclusters with differential dependence on the actin cytoskeleton. Proc Natl Acad Sci U S A (2005) 3.78
Cells respond to mechanical stress by rapid disassembly of caveolae. Cell (2011) 3.55
Endosome-to-cytosol transport of viral nucleocapsids. Nat Cell Biol (2005) 2.98
Fld1p, a functional homologue of human seipin, regulates the size of lipid droplets in yeast. J Cell Biol (2008) 2.85
Caveolin-1 is essential for liver regeneration. Science (2006) 2.77
Ultrastructural identification of uncoated caveolin-independent early endocytic vehicles. J Cell Biol (2005) 2.74
Sequence-dependent sorting of recycling proteins by actin-stabilized endosomal microdomains. Cell (2010) 2.67
The Rab5 effector Rabankyrin-5 regulates and coordinates different endocytic mechanisms. PLoS Biol (2004) 2.59
Myosin II isoforms identify distinct functional modules that support integrity of the epithelial zonula adherens. Nat Cell Biol (2010) 2.51
Membrane insertion of anthrax protective antigen and cytoplasmic delivery of lethal factor occur at different stages of the endocytic pathway. J Cell Biol (2004) 2.31
Individual palmitoyl residues serve distinct roles in H-ras trafficking, microlocalization, and signaling. Mol Cell Biol (2005) 2.24
Regulated localization of Rab18 to lipid droplets: effects of lipolytic stimulation and inhibition of lipid droplet catabolism. J Biol Chem (2005) 2.15
Differential sorting and fate of endocytosed GPI-anchored proteins. EMBO J (2002) 2.15
Cholesterol manipulation by West Nile virus perturbs the cellular immune response. Cell Host Microbe (2007) 2.14
Three separable domains regulate GTP-dependent association of H-ras with the plasma membrane. Mol Cell Biol (2004) 2.09
Not just fat: the structure and function of the lipid droplet. Cold Spring Harb Perspect Biol (2011) 2.07
A novel switch region regulates H-ras membrane orientation and signal output. EMBO J (2008) 2.06
Characterization of E-cadherin endocytosis in isolated MCF-7 and chinese hamster ovary cells: the initial fate of unbound E-cadherin. J Biol Chem (2003) 2.05
Flotillins and the PHB domain protein family: rafts, worms and anaesthetics. Traffic (2005) 2.01
Rab23, a negative regulator of hedgehog signaling, localizes to the plasma membrane and the endocytic pathway. Traffic (2003) 1.88
Association of stomatin with lipid bodies. J Biol Chem (2004) 1.88
MURC/Cavin-4 and cavin family members form tissue-specific caveolar complexes. J Cell Biol (2009) 1.87
Clathrin-independent endocytosis: new insights into caveolae and non-caveolar lipid raft carriers. Biochim Biophys Acta (2005) 1.87
Selective stimulation of caveolar endocytosis by glycosphingolipids and cholesterol. Mol Biol Cell (2004) 1.86
Cholesterol and fatty acids regulate dynamic caveolin trafficking through the Golgi complex and between the cell surface and lipid bodies. Mol Biol Cell (2005) 1.86
Hrs and SNX3 functions in sorting and membrane invagination within multivesicular bodies. PLoS Biol (2008) 1.85
Annexin II regulates multivesicular endosome biogenesis in the degradation pathway of animal cells. EMBO J (2003) 1.85
N4WBP5, a potential target for ubiquitination by the Nedd4 family of proteins, is a novel Golgi-associated protein. J Biol Chem (2001) 1.84
Clathrin-independent carriers form a high capacity endocytic sorting system at the leading edge of migrating cells. J Cell Biol (2010) 1.84
Fsp27 promotes lipid droplet growth by lipid exchange and transfer at lipid droplet contact sites. J Cell Biol (2011) 1.84
Clathrin-independent endocytosis: new insights into caveolae and non-caveolar lipid raft carriers. Biochim Biophys Acta (2005) 1.83
Identifying optimal lipid raft characteristics required to promote nanoscale protein-protein interactions on the plasma membrane. Mol Cell Biol (2006) 1.81
Lipid droplet-organelle interactions; sharing the fats. Biochim Biophys Acta (2008) 1.77
Molecules, mechanisms, and cellular roles of clathrin-independent endocytosis. Curr Opin Cell Biol (2010) 1.70
A role for phosphatidic acid in the formation of "supersized" lipid droplets. PLoS Genet (2011) 1.69
Dynamic microtubules regulate the local concentration of E-cadherin at cell-cell contacts. J Cell Sci (2006) 1.68
Annexin A2-dependent polymerization of actin mediates endosome biogenesis. Dev Cell (2009) 1.67
Cell-to-cell heterogeneity in lipid droplets suggests a mechanism to reduce lipotoxicity. Curr Biol (2013) 1.66
Lysobisphosphatidic acid controls endosomal cholesterol levels. J Biol Chem (2008) 1.62
The GTPase-activating protein GRAF1 regulates the CLIC/GEEC endocytic pathway. Curr Biol (2008) 1.62
Dynamic and regulated association of caveolin with lipid bodies: modulation of lipid body motility and function by a dominant negative mutant. Mol Biol Cell (2003) 1.62
Cholesterol-sensitive Cdc42 activation regulates actin polymerization for endocytosis via the GEEC pathway. Traffic (2007) 1.55
Inhibitors of COP-mediated transport and cholera toxin action inhibit simian virus 40 infection. Mol Biol Cell (2002) 1.53
Glucose principally regulates insulin secretion in mouse islets by controlling the numbers of granule fusion events per cell. Diabetologia (2013) 1.51
Flotillin-1/reggie-2 traffics to surface raft domains via a novel golgi-independent pathway. Identification of a novel membrane targeting domain and a role for palmitoylation. J Biol Chem (2002) 1.51
Late endosomal cholesterol accumulation leads to impaired intra-endosomal trafficking. PLoS One (2007) 1.50
High-resolution mapping reveals topologically distinct cellular pools of phosphatidylserine. J Cell Biol (2011) 1.49
A role for oxysterol-binding protein-related protein 5 in endosomal cholesterol trafficking. J Cell Biol (2011) 1.48
A single method for cryofixation and correlative light, electron microscopy and tomography of zebrafish embryos. Traffic (2008) 1.48
Cholesterol-induced caveolin targeting to lipid droplets in adipocytes: a role for caveolar endocytosis. Traffic (2006) 1.48
Review: biogenesis of the multifunctional lipid droplet: lipids, proteins, and sites. J Cell Biol (2014) 1.45
Caveolin, cholesterol, and lipid bodies. Semin Cell Dev Biol (2005) 1.41
Caveolin regulates endocytosis of the muscle repair protein, dysferlin. J Biol Chem (2007) 1.37
Electrostatic interactions positively regulate K-Ras nanocluster formation and function. Mol Cell Biol (2008) 1.34
Zebrafish as a model for caveolin-associated muscle disease; caveolin-3 is required for myofibril organization and muscle cell patterning. Hum Mol Genet (2005) 1.34
High-resolution 3D quantitative analysis of caveolar ultrastructure and caveola-cytoskeleton interactions. Traffic (2008) 1.32
Observing cell surface signaling domains using electron microscopy. Sci STKE (2003) 1.32
Caveolae at a glance. J Cell Sci (2010) 1.31
Pore-forming toxins induce multiple cellular responses promoting survival. Cell Microbiol (2011) 1.28
A novel hook-related protein family and the characterization of hook-related protein 1. Traffic (2005) 1.27
Activation of the MAPK module from different spatial locations generates distinct system outputs. Mol Biol Cell (2008) 1.25
Evolutionary analysis and molecular dissection of caveola biogenesis. J Cell Sci (2008) 1.25
Epidermal growth factor receptor activation remodels the plasma membrane lipid environment to induce nanocluster formation. Mol Cell Biol (2010) 1.25
Visualisation of macropinosome maturation by the recruitment of sorting nexins. J Cell Sci (2006) 1.25
Expression of caveolin-1 enhances cholesterol efflux in hepatic cells. J Biol Chem (2004) 1.24
Caveolin interacts with the angiotensin II type 1 receptor during exocytic transport but not at the plasma membrane. J Biol Chem (2003) 1.22
Hydrophobic and basic domains target proteins to lipid droplets. Traffic (2009) 1.22
Arf6-independent GPI-anchored protein-enriched early endosomal compartments fuse with sorting endosomes via a Rab5/phosphatidylinositol-3'-kinase-dependent machinery. Mol Biol Cell (2006) 1.21
The endocytic protein GRAF1 is directed to cell-matrix adhesion sites and regulates cell spreading. Mol Biol Cell (2011) 1.20
Quantitative analysis of lipid droplet fusion: inefficient steady state fusion but rapid stimulation by chemical fusogens. PLoS One (2010) 1.19
Adaptor proteins MiD49 and MiD51 can act independently of Mff and Fis1 in Drp1 recruitment and are specific for mitochondrial fission. J Biol Chem (2013) 1.19
Mutant huntingtin inhibits clathrin-independent endocytosis and causes accumulation of cholesterol in vitro and in vivo. Hum Mol Genet (2006) 1.19
EHD2 regulates caveolar dynamics via ATP-driven targeting and oligomerization. Mol Biol Cell (2012) 1.18
RORalpha regulates the expression of genes involved in lipid homeostasis in skeletal muscle cells: caveolin-3 and CPT-1 are direct targets of ROR. J Biol Chem (2004) 1.17
Staurosporines disrupt phosphatidylserine trafficking and mislocalize Ras proteins. J Biol Chem (2012) 1.15
Building a better dynasore: the dyngo compounds potently inhibit dynamin and endocytosis. Traffic (2013) 1.14
Aberrant dysferlin trafficking in cells lacking caveolin or expressing dystrophy mutants of caveolin-3. Hum Mol Genet (2005) 1.14
Characterization of Rab18, a lipid droplet-associated small GTPase. Methods Enzymol (2008) 1.14
Human Miltons associate with mitochondria and induce microtubule-dependent remodeling of mitochondrial networks. Biochim Biophys Acta (2010) 1.14
Acyl-CoA synthetase 3 promotes lipid droplet biogenesis in ER microdomains. J Cell Biol (2013) 1.11
Caveolae regulate the nanoscale organization of the plasma membrane to remotely control Ras signaling. J Cell Biol (2014) 1.10
Rab18 binds to hepatitis C virus NS5A and promotes interaction between sites of viral replication and lipid droplets. PLoS Pathog (2013) 1.10
Involvement of caveolin-2 in caveolar biogenesis in MDCK cells. FEBS Lett (2003) 1.08
Clathrin isoform CHC22, a component of neuromuscular and myotendinous junctions, binds sorting nexin 5 and has increased expression during myogenesis and muscle regeneration. Mol Biol Cell (2004) 1.08
PTRF-cavin-1 expression decreases the migration of PC3 prostate cancer cells: role of matrix metalloprotease 9. Eur J Cell Biol (2010) 1.07
Abnormal nuclear pore formation triggers apoptosis in the intestinal epithelium of elys-deficient zebrafish. Gastroenterology (2008) 1.07
Nucleophosmin and nucleolin regulate K-Ras plasma membrane interactions and MAPK signal transduction. J Biol Chem (2009) 1.07
Redistribution of caveolae during mitosis. J Cell Sci (2011) 1.05
Diversity of raft-like domains in late endosomes. PLoS One (2007) 1.05
Ca2+-regulated pool of phosphatidylinositol-3-phosphate produced by phosphatidylinositol 3-kinase C2alpha on neurosecretory vesicles. Mol Biol Cell (2008) 1.05
Structure-based reassessment of the caveolin signaling model: do caveolae regulate signaling through caveolin-protein interactions? Dev Cell (2012) 1.04
Fendiline inhibits K-Ras plasma membrane localization and blocks K-Ras signal transmission. Mol Cell Biol (2012) 1.04