Published in J Biol Chem on November 18, 2003
Role of Tyr348 in Tyr385 radical dynamics and cyclooxygenase inhibitor interactions in prostaglandin H synthase-2. Biochemistry (2006) 0.88
Peroxide-induced radical formation at TYR385 and TYR504 in human PGHS-1. J Inorg Biochem (2009) 0.88
Cyclooxygenase competitive inhibitors alter tyrosyl radical dynamics in prostaglandin H synthase-2. Biochemistry (2009) 0.81
His92 and His110 selectively affect different heme centers of adrenal cytochrome b(561). Biochim Biophys Acta (2008) 0.80
Polymorphic human prostaglandin H synthase-2 proteins and their interactions with cyclooxygenase substrates and inhibitors. Pharmacogenomics J (2010) 0.79
In Silico Screening of Nonsteroidal Anti-Inflammatory Drugs and Their Combined Action on Prostaglandin H Synthase-1. Pharmaceuticals (Basel) (2010) 0.75
Structural and functional bases for broad-spectrum neutralization of avian and human influenza A viruses. Nat Struct Mol Biol (2009) 12.13
The Fas-FADD death domain complex structure unravels signalling by receptor clustering. Nature (2008) 2.11
Between order and disorder in protein structures: analysis of "dual personality" fragments in proteins. Structure (2007) 1.88
Reactions of the diiron enzyme stearoyl-acyl carrier protein desaturase. Acc Chem Res (2004) 1.83
Pharmacological inhibition of PHOSPHO1 suppresses vascular smooth muscle cell calcification. J Bone Miner Res (2013) 1.60
Structural basis of neutralization by a human anti-severe acute respiratory syndrome spike protein antibody, 80R. J Biol Chem (2006) 1.53
Vaccinia virus N1L protein resembles a B cell lymphoma-2 (Bcl-2) family protein. Protein Sci (2006) 1.45
The cyclooxygenase reaction mechanism. Biochemistry (2002) 1.38
Sampling of the native conformational ensemble of myoglobin via structures in different crystalline environments. Proteins (2008) 1.34
Comment on Stereochemical restraints revisited: how accurate are refinement targets and how much should protein structures be allowed to deviate from them? by Jaskolski, Gilski, Dauter & Wlodawer (2007). Acta Crystallogr D Biol Crystallogr (2007) 1.20
Genomic identification and in vitro reconstitution of a complete biosynthetic pathway for the osmolyte di-myo-inositol-phosphate. Proc Natl Acad Sci U S A (2007) 1.19
Prostaglandin H synthase: resolved and unresolved mechanistic issues. Arch Biochem Biophys (2009) 1.18
Global distribution of conformational states derived from redundant models in the PDB points to non-uniqueness of the protein structure. Proc Natl Acad Sci U S A (2009) 1.12
Crystal structure of a dual activity IMPase/FBPase (AF2372) from Archaeoglobus fulgidus. The story of a mobile loop. J Biol Chem (2002) 1.10
Synthesis of isotopically labeled arachidonic acids to probe the reaction mechanism of prostaglandin H synthase. J Am Chem Soc (2002) 1.09
Time passes yet errors remain: comments on the structure of N10-formyltetrahydrofolate synthetase. Protein Sci (2013) 1.08
Insight into the mechanism of aromatic hydroxylation by toluene 4-monooxygenase by use of specifically deuterated toluene and p-xylene. Proc Natl Acad Sci U S A (2003) 1.07
Identification of Tyr504 as an alternative tyrosyl radical site in human prostaglandin H synthase-2. Biochemistry (2004) 1.05
Structure of complement C6 suggests a mechanism for initiation and unidirectional, sequential assembly of membrane attack complex (MAC). J Biol Chem (2012) 1.04
Structural basis of membrane targeting by the Dock180 family of Rho family guanine exchange factors (Rho-GEFs). J Biol Chem (2010) 1.04
Divergent cyclooxygenase responses to fatty acid structure and peroxide level in fish and mammalian prostaglandin H synthases. FASEB J (2006) 1.03
Monitoring the transition from the T to the R state in E.coli aspartate transcarbamoylase by X-ray crystallography: crystal structures of the E50A mutant enzyme in four distinct allosteric states. J Mol Biol (2004) 1.01
Autocatalytic activation of the furin zymogen requires removal of the emerging enzyme's N-terminus from the active site. PLoS One (2009) 0.97
The temperature dependence of the inositol monophosphatase Km correlates with accumulation of di-myo-inositol 1,1'-phosphate in Archaeoglobus fulgidus. Biochemistry (2006) 0.97
Structures of thermophilic and mesophilic adenylate kinases from the genus Methanococcus. J Mol Biol (2003) 0.97
IκBKβ and NFκB1, NSAID use and risk of colorectal cancer in the Colon Cancer Family Registry. Carcinogenesis (2012) 0.95
Genetic variability in prostaglandin synthesis, fish intake and risk of colorectal polyps. Carcinogenesis (2007) 0.95
Genetic variation in prostaglandin E2 synthesis and signaling, prostaglandin dehydrogenase, and the risk of colorectal adenoma. Cancer Epidemiol Biomarkers Prev (2010) 0.94
Structural characterization of arachidonyl radicals formed by aspirin-treated prostaglandin H synthase-2. J Biol Chem (2002) 0.93
The cation-π box is a specific phosphatidylcholine membrane targeting motif. J Biol Chem (2013) 0.92
COX-1 (PTGS1) and COX-2 (PTGS2) polymorphisms, NSAID interactions, and risk of colon and rectal cancers in two independent populations. Cancer Causes Control (2013) 0.92
Characterization of the heme environment in Arabidopsis thaliana fatty acid alpha-dioxygenase-1. J Biol Chem (2004) 0.90
Structure of the S. aureus PI-specific phospholipase C reveals modulation of active site access by a titratable π-cation latched loop. Biochemistry (2012) 0.89
Crystal and solution structures of a prokaryotic M16B peptidase: an open and shut case. Structure (2009) 0.88
Role of Tyr348 in Tyr385 radical dynamics and cyclooxygenase inhibitor interactions in prostaglandin H synthase-2. Biochemistry (2006) 0.88
Peroxide-induced radical formation at TYR385 and TYR504 in human PGHS-1. J Inorg Biochem (2009) 0.88
Reaching for mechanistic consensus across life kingdoms: structure and insights into catalysis of the myo-inositol-1-phosphate synthase (mIPS) from Archaeoglobus fulgidus. Biochemistry (2005) 0.87
Cytotoxic amphiphiles and phosphoinositides bind to two discrete sites on the Akt1 PH domain. Biochemistry (2014) 0.86
Crystal structure of C5b-6 suggests structural basis for priming assembly of the membrane attack complex. J Biol Chem (2012) 0.86
Probing the mechanism of the Archaeoglobus fulgidus inositol-1-phosphate synthase. J Biol Chem (2005) 0.86
Purification and characterization of bovine adrenal cytochrome b561 expressed in insect and yeast cell systems. Protein Expr Purif (2005) 0.85
Phospholipase A2G1B polymorphisms and risk of colorectal neoplasia. Int J Mol Epidemiol Genet (2013) 0.85
Thromboxane synthase: structure and function of protein and gene. Prostaglandins Other Lipid Mediat (2002) 0.84
Structural basis of biological nitrile reduction. J Biol Chem (2012) 0.83
Axial ligation and stoichiometry of heme centers in adrenal cytochrome b561. Biochemistry (2007) 0.83
Crystal structure of alpha-hordothionin at 1.9 Angstrom resolution. FEBS Lett (2005) 0.83
Cyclooxygenase reaction mechanism of prostaglandin H synthase from deuterium kinetic isotope effects. J Inorg Biochem (2011) 0.82
Development of a bacterial system for high yield expression of fully functional adrenal cytochrome b561. Protein Expr Purif (2007) 0.82
Competition between anion binding and dimerization modulates Staphylococcus aureus phosphatidylinositol-specific phospholipase C enzymatic activity. J Biol Chem (2012) 0.82
Oxyferryl heme and not tyrosyl radical is the likely culprit in prostaglandin H synthase-1 peroxidase inactivation. Biochemistry (2007) 0.81
Mobile loop mutations in an archaeal inositol monophosphatase: modulating three-metal ion assisted catalysis and lithium inhibition. Protein Sci (2010) 0.81
Dynamic interdomain interactions contribute to the inhibition of matrix metalloproteinases by tissue inhibitors of metalloproteinases. J Biol Chem (2011) 0.81
Phospholipid actions on PGHS-1 and -2 cyclooxygenase kinetics. Prostaglandins Other Lipid Mediat (2007) 0.81
Genetic variability in EGFR, Src and HER2 and risk of colorectal adenoma and cancer. Int J Mol Epidemiol Genet (2011) 0.81
Glutathione peroxidase tagSNPs: associations with rectal cancer but not with colon cancer. Genes Chromosomes Cancer (2012) 0.81
Cyclooxygenase competitive inhibitors alter tyrosyl radical dynamics in prostaglandin H synthase-2. Biochemistry (2009) 0.81
Decreased cyclooxygenase inhibition by aspirin in polymorphic variants of human prostaglandin H synthase-1. Pharmacogenet Genomics (2012) 0.80
Crystal structure of the tetrameric inositol 1-phosphate phosphatase (TM1415) from the hyperthermophile, Thermotoga maritima. FEBS J (2007) 0.80
His92 and His110 selectively affect different heme centers of adrenal cytochrome b(561). Biochim Biophys Acta (2008) 0.80
Cyclooxygenase inactivation kinetics during reaction of prostaglandin H synthase-1 with peroxide. Biochemistry (2003) 0.79
Not so clear on oxygen. Comment on Structural basis for cofactor-independent dioxygenation in vancomycin biosynthesis by Widboom et al. (2007), Nature (London), 447, 342-345. Acta Crystallogr D Biol Crystallogr (2008) 0.78
The structure of the R184A mutant of the inositol monophosphatase encoded by suhB and implications for its functional interactions in Escherichia coli. J Biol Chem (2007) 0.78
Allosteric transition and binding of small molecule effectors causes curvature change in central β-sheets of selected enzymes. J Mol Model (2010) 0.78
Chinese hamster AP endonuclease operates by a two-metal ion assisted catalytic mechanism. FEBS Lett (2011) 0.78
High-yield production, purification and characterization of functional human duodenal cytochrome b in an Escherichia coli system. Protein Expr Purif (2011) 0.77
Isolation and characterization of selective and potent human Fab inhibitors directed to the active-site region of the two-component NS2B-NS3 proteinase of West Nile virus. Biochem J (2010) 0.77
Crystal structure of a trapped catalytic intermediate suggests that forced atomic proximity drives the catalysis of mIPS. Biophys J (2011) 0.76
X-ray scattering studies of model lipid membrane interacting with purothionin provide support for a previously proposed mechanism of membrane lysis. Eur Biophys J (2009) 0.76
Composition of the heme centers in chromaffin granule cytochrome b(561). Ann N Y Acad Sci (2002) 0.76
Genetic variation in UGT genes modify the associations of NSAIDs with risk of colorectal cancer: colon cancer family registry. Genes Chromosomes Cancer (2014) 0.76
Cyclooxygenase reaction mechanism of PGHS--evidence for a reversible transition between a pentadienyl radical and a new tyrosyl radical by nitric oxide trapping. J Inorg Biochem (2011) 0.76
Unexpected similarity in regulation between an archaeal inositol monophosphatase/fructose bisphosphatase and chloroplast fructose bisphosphatase. Protein Sci (2003) 0.76
Structural comparisons of arachidonic acid-induced radicals formed by prostaglandin H synthase-1 and -2. J Inorg Biochem (2010) 0.75
Chinese hamster apurinic/apyrimidinic endonuclease (chAPE1) expressed in sf9 cells reveals that its endonuclease activity is regulated by phosphorylation. FEBS J (2010) 0.75
Functional and structural roles of residues in the third extramembrane segment of adrenal cytochrome b561. Biochemistry (2011) 0.75
Living and nonliving matter. Science (2004) 0.75
Functional analysis of human thromboxane synthase polymorphic variants. Pharmacogenet Genomics (2012) 0.75
Heritable Thoracic Aortic Disease Genes in Sporadic Aortic Dissection. J Am Coll Cardiol (2017) 0.75
Structure of the inositol-1-phosphate cytidylyltransferase from Thermotoga maritima. Acta Crystallogr D Biol Crystallogr (2013) 0.75