Published in Proteins on February 01, 2008
A force field for virtual atom molecular mechanics of proteins. Proc Natl Acad Sci U S A (2009) 0.99
Cooperative macromolecular device revealed by meta-analysis of static and time-resolved structures. Proc Natl Acad Sci U S A (2011) 0.93
PCDB: a database of protein conformational diversity. Nucleic Acids Res (2010) 0.92
Comparison of NMR and crystal structures for the proteins TM1112 and TM1367. Acta Crystallogr Sect F Struct Biol Cryst Commun (2010) 0.91
A comparative analysis of the equilibrium dynamics of a designed protein inferred from NMR, X-ray, and computations. Proteins (2009) 0.89
Positively selected sites in cetacean myoglobins contribute to protein stability. PLoS Comput Biol (2013) 0.89
Native state conformational heterogeneity of HP35 revealed by time-resolved FRET. J Phys Chem B (2012) 0.88
Straight-chain alkyl isocyanides open the distal histidine gate in crystal structures of myoglobin . Biochemistry (2010) 0.86
Polymorphism of the epidermal growth factor receptor extracellular ligand binding domain: the dimer interface depends on domain stabilization. Biochemistry (2011) 0.84
Molecular dynamics simulation of the neuroglobin crystal: comparison with the simulation in solution. Biophys J (2008) 0.83
You are lost without a map: Navigating the sea of protein structures. Biochim Biophys Acta (2014) 0.82
REACH coarse-grained normal mode analysis of protein dimer interaction dynamics. Biophys J (2009) 0.81
Packing interface energetics in different crystal forms of the λ Cro dimer. Proteins (2013) 0.79
Describing protein conformational ensembles: beyond static snapshots. F1000 Biol Rep (2009) 0.78
A composite approach towards a complete model of the myosin rod. Proteins (2015) 0.77
Unfolding simulations of holomyoglobin from four mammals: identification of intermediates and β-sheet formation from partially unfolded states. PLoS One (2013) 0.77
Factors correlating with significant differences between X-ray structures of myoglobin. Acta Crystallogr D Biol Crystallogr (2014) 0.76
Weak conservation of structural features in the interfaces of homologous transient protein-protein complexes. Protein Sci (2015) 0.75
A Systematic Analysis of the Structures of Heterologously Expressed Proteins and Those from Their Native Hosts in the RCSB PDB Archive. PLoS One (2016) 0.75
Radiation Damage of Myoglobin Crystals in Weak Stationary Electric and Magnetic Fields. J Phys Conf Ser (2014) 0.75
A point-charge force field for molecular mechanics simulations of proteins based on condensed-phase quantum mechanical calculations. J Comput Chem (2003) 15.88
Tumor stem cells derived from glioblastomas cultured in bFGF and EGF more closely mirror the phenotype and genotype of primary tumors than do serum-cultured cell lines. Cancer Cell (2006) 15.16
Integrated genomic characterization of endometrial carcinoma. Nature (2013) 14.29
Structural and functional bases for broad-spectrum neutralization of avian and human influenza A viruses. Nat Struct Mol Biol (2009) 12.13
The somatic genomic landscape of glioblastoma. Cell (2013) 11.73
Trait-associated SNPs are more likely to be eQTLs: annotation to enhance discovery from GWAS. PLoS Genet (2010) 10.75
The incidence of co-morbidities related to obesity and overweight: a systematic review and meta-analysis. BMC Public Health (2009) 9.79
Structure of dengue virus: implications for flavivirus organization, maturation, and fusion. Cell (2002) 9.13
Effect of PCI on quality of life in patients with stable coronary disease. N Engl J Med (2008) 7.75
HSV-1 ICP34.5 confers neurovirulence by targeting the Beclin 1 autophagy protein. Cell Host Microbe (2007) 7.34
Consuming fructose-sweetened, not glucose-sweetened, beverages increases visceral adiposity and lipids and decreases insulin sensitivity in overweight/obese humans. J Clin Invest (2009) 7.09
Probabilistic Boolean Networks: a rule-based uncertainty model for gene regulatory networks. Bioinformatics (2002) 6.90
Association of BRCA1 and BRCA2 mutations with survival, chemotherapy sensitivity, and gene mutator phenotype in patients with ovarian cancer. JAMA (2011) 6.81
Pten regulates neuronal arborization and social interaction in mice. Neuron (2006) 6.11
SCAN: SNP and copy number annotation. Bioinformatics (2009) 5.96
Comprehensive, Integrative Genomic Analysis of Diffuse Lower-Grade Gliomas. N Engl J Med (2015) 5.71
The four-herb Chinese medicine PHY906 reduces chemotherapy-induced gastrointestinal toxicity. Sci Transl Med (2010) 4.78
Sequence and analysis of rice chromosome 4. Nature (2002) 4.39
A genome-wide approach to identify genetic variants that contribute to etoposide-induced cytotoxicity. Proc Natl Acad Sci U S A (2007) 4.35
Concern Calmodulin kinase II and arrhythmias in a mouse model of cardiac hypertrophy. Circulation (2002) 4.16
Watching a protein as it functions with 150-ps time-resolved x-ray crystallography. Science (2003) 4.12
Casq2 deletion causes sarcoplasmic reticulum volume increase, premature Ca2+ release, and catecholaminergic polymorphic ventricular tachycardia. J Clin Invest (2006) 4.06
Stargazin modulates AMPA receptor gating and trafficking by distinct domains. Nature (2005) 3.88
Epigenetic-mediated dysfunction of the bone morphogenetic protein pathway inhibits differentiation of glioblastoma-initiating cells. Cancer Cell (2008) 3.87
Structure of the immature dengue virus at low pH primes proteolytic maturation. Science (2008) 3.86
Variation in virulence among clades of Escherichia coli O157:H7 associated with disease outbreaks. Proc Natl Acad Sci U S A (2008) 3.69
Imaging of amyloid beta in Alzheimer's disease with 18F-BAY94-9172, a novel PET tracer: proof of mechanism. Lancet Neurol (2008) 3.67
Conformational changes of the flavivirus E glycoprotein. Structure (2004) 3.66
Shell-isolated nanoparticle-enhanced Raman spectroscopy. Nature (2010) 3.64
A missense mutation in KIT kinase domain 1 correlates with imatinib resistance in gastrointestinal stromal tumors. Cancer Res (2004) 3.63
Structures of immature flavivirus particles. EMBO J (2003) 3.62
Genetic architecture of transcript-level variation in humans. Am J Hum Genet (2008) 3.36
Isolation and characterization of a bat SARS-like coronavirus that uses the ACE2 receptor. Nature (2013) 3.27
Relation of hospital volume to colostomy rates and survival for patients with rectal cancer. J Natl Cancer Inst (2003) 3.21
Identification of transcribed sequences in Arabidopsis thaliana by using high-resolution genome tiling arrays. Proc Natl Acad Sci U S A (2005) 3.21
Genome-wide association study identifies susceptibility loci for polycystic ovary syndrome on chromosome 2p16.3, 2p21 and 9q33.3. Nat Genet (2010) 3.02
Molecular basis of binding between novel human coronavirus MERS-CoV and its receptor CD26. Nature (2013) 3.00
Defining the sequence-recognition profile of DNA-binding molecules. Proc Natl Acad Sci U S A (2006) 2.97
Precise segmental renal artery clamping under the guidance of dual-source computed tomography angiography during laparoscopic partial nephrectomy. Eur Urol (2012) 2.95
High expression of macrophage colony-stimulating factor in peritumoral liver tissue is associated with poor survival after curative resection of hepatocellular carcinoma. J Clin Oncol (2008) 2.92
Pharmacological inhibition of mTORC1 suppresses anatomical, cellular, and behavioral abnormalities in neural-specific Pten knock-out mice. J Neurosci (2009) 2.90
Endobronchial ultrasound-guided transbronchial needle aspiration for staging of lung cancer: a systematic review and meta-analysis. Eur J Cancer (2009) 2.85
Alterations in genes of the EGFR signaling pathway and their relationship to EGFR tyrosine kinase inhibitor sensitivity in lung cancer cell lines. PLoS One (2009) 2.79
Dynamics of proteins in crystals: comparison of experiment with simple models. Biophys J (2002) 2.71
GTPase activation of elongation factor EF-Tu by the ribosome during decoding. EMBO J (2009) 2.71
Nitrogen fixation island and rhizosphere competence traits in the genome of root-associated Pseudomonas stutzeri A1501. Proc Natl Acad Sci U S A (2008) 2.70
Mitochondrial respiration defects in cancer cells cause activation of Akt survival pathway through a redox-mediated mechanism. J Cell Biol (2006) 2.68
Quantized anomalous Hall effect in magnetic topological insulators. Science (2010) 2.67
The mechanical behaviors of polytetrafluorethylene/Al/W energetic composites. J Phys Condens Matter (2009) 2.64
Blocking Scn10a channels in heart reduces late sodium current and is antiarrhythmic. Circ Res (2012) 2.61
Faster STORM using compressed sensing. Nat Methods (2012) 2.61
Trends in prevalence, awareness, management, and control of hypertension among United States adults, 1999 to 2010. J Am Coll Cardiol (2012) 2.57
CCAT2, a novel noncoding RNA mapping to 8q24, underlies metastatic progression and chromosomal instability in colon cancer. Genome Res (2013) 2.57
Circulating plasma MiR-141 is a novel biomarker for metastatic colon cancer and predicts poor prognosis. PLoS One (2011) 2.57
Preclinical properties of 18F-AV-45: a PET agent for Abeta plaques in the brain. J Nucl Med (2009) 2.51
Structural variation in two human genomes mapped at single-nucleotide resolution by whole genome de novo assembly. Nat Biotechnol (2011) 2.45
Systematic review and meta-analysis of circulatory disease from exposure to low-level ionizing radiation and estimates of potential population mortality risks. Environ Health Perspect (2012) 2.42
Highly accurate two-gene classifier for differentiating gastrointestinal stromal tumors and leiomyosarcomas. Proc Natl Acad Sci U S A (2007) 2.38
IL-22BP is regulated by the inflammasome and modulates tumorigenesis in the intestine. Nature (2012) 2.36
Integrated analyses identify a master microRNA regulatory network for the mesenchymal subtype in serous ovarian cancer. Cancer Cell (2013) 2.34
Structures and receptor binding of hemagglutinins from human-infecting H7N9 influenza viruses. Science (2013) 2.34
The SCF/Slimb ubiquitin ligase limits centrosome amplification through degradation of SAK/PLK4. Curr Biol (2008) 2.33
[(18)F]T807, a novel tau positron emission tomography imaging agent for Alzheimer's disease. Alzheimers Dement (2013) 2.31
Clinical characteristics of 26 human cases of highly pathogenic avian influenza A (H5N1) virus infection in China. PLoS One (2008) 2.28
In silico microdissection of microarray data from heterogeneous cell populations. BMC Bioinformatics (2005) 2.26
Transjugular intrahepatic portosystemic shunt for Budd-Chiari syndrome: techniques, indications and results on 51 Chinese patients from a single centre. Liver Int (2013) 2.22
Project management system for structural and functional proteomics: Sesame. J Struct Funct Genomics (2003) 2.19
Enhanced fluorescence emission from quantum dots on a photonic crystal surface. Nat Nanotechnol (2007) 2.18
Downregulation of miR-21 inhibits EGFR pathway and suppresses the growth of human glioblastoma cells independent of PTEN status. Lab Invest (2010) 2.17
Ensemble refinement of protein crystal structures: validation and application. Structure (2007) 2.16
Differential requirement for conserved tryptophans in human immunodeficiency virus type 1 Vif for the selective suppression of APOBEC3G and APOBEC3F. J Virol (2006) 2.16
Glycogen synthase kinase-3 inhibition induces glioma cell death through c-MYC, nuclear factor-kappaB, and glucose regulation. Cancer Res (2008) 2.16
HAb18G/CD147 promotes activation of hepatic stellate cells and is a target for antibody therapy of liver fibrosis. J Hepatol (2012) 2.15
Leptin: a potential novel antidepressant. Proc Natl Acad Sci U S A (2006) 2.15
Protein structural variation in computational models and crystallographic data. Structure (2007) 2.13
Polymorphisms in microRNA targets: a gold mine for molecular epidemiology. Carcinogenesis (2008) 2.12
Monitoring cystic fibrosis lung disease by computed tomography. Radiation risk in perspective. Am J Respir Crit Care Med (2014) 2.11
The Fas-FADD death domain complex structure unravels signalling by receptor clustering. Nature (2008) 2.11
Genome-scale analysis of DNA methylation in lung adenocarcinoma and integration with mRNA expression. Genome Res (2012) 2.10
Binary analysis and optimization-based normalization of gene expression data. Bioinformatics (2002) 2.10
CD4(+)CD25(+)FoxP3(+) regulatory T cells suppress Mycobacterium tuberculosis immunity in patients with active disease. Clin Immunol (2007) 2.08
Drosophila NOMPC is a mechanotransduction channel subunit for gentle-touch sensation. Nature (2012) 2.07
Combination of melphalan and dexamethasone for patients with newly diagnosed POEMS syndrome. Blood (2011) 2.06
MiR-375 frequently downregulated in gastric cancer inhibits cell proliferation by targeting JAK2. Cell Res (2010) 2.04
Functional proteomics of Arabidopsis thaliana guard cells uncovers new stomatal signaling pathways. Plant Cell (2008) 2.04
Clinical, pathological, and molecular variables predictive of malignant peripheral nerve sheath tumor outcome. Ann Surg (2009) 2.04
Protocols for production of selenomethionine-labeled proteins in 2-L polyethylene terephthalate bottles using auto-induction medium. Protein Expr Purif (2005) 2.02
Genome-wide association study identifies eight new risk loci for polycystic ovary syndrome. Nat Genet (2012) 2.02
Analysis of the activation status of Akt, NFkappaB, and Stat3 in human diffuse gliomas. Lab Invest (2004) 2.02
Elevated expression of PCGEM1, a prostate-specific gene with cell growth-promoting function, is associated with high-risk prostate cancer patients. Oncogene (2004) 2.02
In vivo prevention of transplant arteriosclerosis by ex vivo-expanded human regulatory T cells. Nat Med (2010) 2.01
Inverse relationship between macular pigment optical density and axial length in Chinese subjects with myopia. Graefes Arch Clin Exp Ophthalmol (2012) 1.99
The 2009 pandemic H1N1 neuraminidase N1 lacks the 150-cavity in its active site. Nat Struct Mol Biol (2010) 1.98
Structural basis for the recognition of histone H4 by the histone-chaperone RbAp46. Structure (2008) 1.98
Gene perturbation and intervention in probabilistic Boolean networks. Bioinformatics (2002) 1.98
New molecular insights into osteosarcoma targeted therapy. Curr Opin Oncol (2013) 1.97
Pharmacogenomic discovery using cell-based models. Pharmacol Rev (2009) 1.96
Insulin-like growth factor binding protein 2 enhances glioblastoma invasion by activating invasion-enhancing genes. Cancer Res (2003) 1.96
Antituberculosis activity of the molecular libraries screening center network library. Tuberculosis (Edinb) (2009) 1.94
Oncogene mutations, copy number gains and mutant allele specific imbalance (MASI) frequently occur together in tumor cells. PLoS One (2009) 1.94