Published in Cancer Res on November 15, 2003
Mitochondrial survivin inhibits apoptosis and promotes tumorigenesis. J Clin Invest (2004) 2.59
Chromosomal instability determines taxane response. Proc Natl Acad Sci U S A (2009) 2.12
Apoptosis regulation in tetraploid cancer cells. EMBO J (2006) 1.89
Tumor and host factors that may limit efficacy of chemotherapy in non-small cell and small cell lung cancer. Crit Rev Oncol Hematol (2010) 1.82
The ability to survive mitosis in the presence of microtubule poisons differs significantly between human nontransformed (RPE-1) and cancer (U2OS, HeLa) cells. Cell Motil Cytoskeleton (2009) 1.32
Science review: searching for gene candidates in acute lung injury. Crit Care (2004) 1.27
Novel actions of next-generation taxanes benefit advanced stages of prostate cancer. Clin Cancer Res (2015) 1.13
Vorinostat increases carboplatin and paclitaxel activity in non-small-cell lung cancer cells. Int J Cancer (2010) 1.13
Targeting microtubules by natural agents for cancer therapy. Mol Cancer Ther (2014) 1.08
Gene expression profiling revealed novel mechanism of action of Taxotere and Furtulon in prostate cancer cells. BMC Cancer (2005) 1.04
Oncolytic herpes simplex virus vectors and taxanes synergize to promote killing of prostate cancer cells. Cancer Gene Ther (2009) 1.01
Sustained spindle-assembly checkpoint response requires de novo transcription and translation of cyclin B1. PLoS One (2010) 1.00
Up-regulation of cell cycle arrest protein BTG2 correlates with increased overall survival in breast cancer, as detected by immunohistochemistry using tissue microarray. BMC Cancer (2010) 0.94
Battle of the eternal rivals: restoring functional p53 and inhibiting Polo-like kinase 1 as cancer therapy. Oncotarget (2013) 0.86
B cell translocation gene 2 enhances susceptibility of HeLa cells to doxorubicin-induced oxidative damage. J Biol Chem (2008) 0.86
Comparison of cell death-inducing effect of novel taxane SB-T-1216 and paclitaxel in breast cancer cells. Anticancer Res (2009) 0.85
Impact of α-targeted radiation therapy on gene expression in a pre-clinical model for disseminated peritoneal disease when combined with paclitaxel. PLoS One (2014) 0.81
Unliganded progesterone receptors attenuate taxane-induced breast cancer cell death by modulating the spindle assembly checkpoint. Breast Cancer Res Treat (2011) 0.81
Colchitaxel, a coupled compound made from microtubule inhibitors colchicine and paclitaxel. Beilstein J Org Chem (2006) 0.81
N-(4-Hydroxyphenyl) retinamide potentiated paclitaxel for cell cycle arrest and apoptosis in glioblastoma C6 and RG2 cells. Brain Res (2009) 0.80
Dynamics of tumor hypoxia in response to patupilone and ionizing radiation. PLoS One (2012) 0.79
Epothilone B enhances surface EpCAM expression in ovarian cancer Hey cells. Gynecol Oncol (2010) 0.79
Mitotic slippage in non-cancer cells induced by a microtubule disruptor, disorazole C1. BMC Chem Biol (2010) 0.78
Comparative proteomic analysis of cysteine oxidation in colorectal cancer patients. Mol Cells (2013) 0.78
Connecting the speckles: Splicing kinases and their role in tumorigenesis and treatment response. Nucleus (2015) 0.78
Molecular mode of action and role of TP53 in the sensitivity to the novel epothilone sagopilone (ZK-EPO) in A549 non-small cell lung cancer cells. PLoS One (2011) 0.77
Evaluation of activity and combination strategies with the microtubule-targeting drug sagopilone in breast cancer cell lines. Front Oncol (2011) 0.77
Paclitaxel effects on the proteome of HL-60 promyelocytic leukemic cells: comparison to peloruside A. Invest New Drugs (2010) 0.76
Gene expression of peripheral blood cells reveals pathways downstream of glucocorticoid receptor antagonism and nab-paclitaxel treatment. Pharmacogenet Genomics (2014) 0.75
Inverse relationship between Alzheimer's disease and cancer, and other factors contributing to Alzheimer's disease: a systematic review. BMC Neurol (2016) 0.75
Survivin-specific small interfering RNAs enhance sensitivity of glioma U-87MG cells to paclitaxel by promoting apoptosis. Neural Regen Res (2012) 0.75
Peloruside A, a microtubule-stabilizing agent, induces aneuploidy in ovarian cancer cells. Invest New Drugs (2016) 0.75
Macrophages promote the invasion of breast carcinoma cells via a colony-stimulating factor-1/epidermal growth factor paracrine loop. Cancer Res (2005) 4.33
Mechanisms of Taxol resistance related to microtubules. Oncogene (2003) 3.16
EGF-induced PIP2 hydrolysis releases and activates cofilin locally in carcinoma cells. J Cell Biol (2007) 2.48
Myosin X is a downstream effector of PI(3)K during phagocytosis. Nat Cell Biol (2002) 2.04
Insights into the mechanism of microtubule stabilization by Taxol. Proc Natl Acad Sci U S A (2006) 1.96
Differential mitotic responses to microtubule-stabilizing and -destabilizing drugs. Cancer Res (2002) 1.71
Cyclin D1 governs adhesion and motility of macrophages. Mol Biol Cell (2003) 1.71
Structural and functional analysis of the costimulatory receptor programmed death-1. Immunity (2004) 1.70
Directional cell migration and chemotaxis in wound healing response to PDGF-AA are coordinated by the primary cilium in fibroblasts. Cell Physiol Biochem (2010) 1.63
The interaction between mitotic checkpoint proteins, CENP-E and BubR1, is diminished in epothilone B-resistant A549 cells. Cell Cycle (2010) 1.57
Elevated levels of microtubule destabilizing factors in a Taxol-resistant/dependent A549 cell line with an alpha-tubulin mutation. Cancer Res (2003) 1.55
Targeting protein translation in human non small cell lung cancer via combined MEK and mammalian target of rapamycin suppression. Cancer Res (2007) 1.55
Suppressing T cell motility induced by anti-CTLA-4 monotherapy improves antitumor effects. J Clin Invest (2012) 1.55
PD-1 promotes immune exhaustion by inducing antiviral T cell motility paralysis. J Exp Med (2013) 1.48
Exploiting MEK inhibitor-mediated activation of ERα for therapeutic intervention in ER-positive ovarian carcinoma. PLoS One (2013) 1.48
The growth arrest-specific gene product Gas6 promotes the survival of human oligodendrocytes via a phosphatidylinositol 3-kinase-dependent pathway. J Neurosci (2003) 1.36
Proteasome inhibitor (MG-132) treatment of mdx mice rescues the expression and membrane localization of dystrophin and dystrophin-associated proteins. Am J Pathol (2003) 1.33
Phase I clinical and pharmacokinetic study of BMS-247550, a novel derivative of epothilone B, in solid tumors. Clin Cancer Res (2004) 1.27
Enhancement of the therapeutic efficacy of taxol by the mitogen-activated protein kinase kinase inhibitor CI-1040 in nude mice bearing human heterotransplants. Cancer Res (2005) 1.22
Analysis of tubulin isotypes and mutations from taxol-resistant cells by combined isoelectrofocusing and mass spectrometry. Biochemistry (2003) 1.22
Low concentrations of taxol cause mitotic delay followed by premature dissociation of p55CDC from Mad2 and BubR1 and abrogation of the spindle checkpoint, leading to aneuploidy. Cell Cycle (2005) 1.22
The microtubule stabilizing agent discodermolide is a potent inducer of accelerated cell senescence. Cell Cycle (2005) 1.19
Synergistic suppression of microtubule dynamics by discodermolide and paclitaxel in non-small cell lung carcinoma cells. Cancer Res (2004) 1.13
Validation of the pharmacodynamics of BMS-247550, an analogue of epothilone B, during a phase I clinical study. Clin Cancer Res (2002) 1.10
Tubulin proteomics: towards breaking the code. Anal Biochem (2008) 1.10
Potentiation of taxol efficacy and by discodermolide in ovarian carcinoma xenograft-bearing mice. Clin Cancer Res (2006) 1.09
Cdc42 is required for EGF-stimulated protrusion and motility in MTLn3 carcinoma cells. J Cell Sci (2007) 1.07
Estrogen and resveratrol regulate Rac and Cdc42 signaling to the actin cytoskeleton of metastatic breast cancer cells. Neoplasia (2007) 1.07
A highly epothilone B-resistant A549 cell line with mutations in tubulin that confer drug dependence. Mol Cancer Ther (2005) 1.07
Hallmarks of molecular action of microtubule stabilizing agents: effects of epothilone B, ixabepilone, peloruside A, and laulimalide on microtubule conformation. J Biol Chem (2011) 1.07
Insulin-like growth factor 2 expression modulates Taxol resistance and is a candidate biomarker for reduced disease-free survival in ovarian cancer. Clin Cancer Res (2010) 1.03
Novel molecules that interact with microtubules and have functional activity similar to Taxol. Drug Discov Today (2001) 0.99
Wild-type class I beta-tubulin sensitizes Taxol-resistant breast adenocarcinoma cells harboring a beta-tubulin mutation. Cancer Lett (2007) 0.96
T Lymphocyte Myosin IIA is Required for Maturation of the Immunological Synapse. Front Immunol (2012) 0.96
Real time visualization of protein kinase activity in living cells. J Biol Chem (2002) 0.95
A photoaffinity analogue of discodermolide specifically labels a peptide in beta-tubulin. Biochemistry (2006) 0.95
Distinct pose of discodermolide in taxol binding pocket drives a complementary mode of microtubule stabilization. Biochemistry (2009) 0.94
Caveolin-1 expression determines the route of neutrophil extravasation through skin microvasculature. Am J Pathol (2009) 0.94
Detection of human betaV-tubulin expression in epithelial cancer cell lines by tubulin proteomics. Biochemistry (2005) 0.93
Insights into 4E-BP1 and p53 mediated regulation of accelerated cell senescence. Oncotarget (2011) 0.91
Increased levels of a unique post-translationally modified betaIVb-tubulin isotype in liver cancer. Biochemistry (2008) 0.90
Growth and pigment production on D-tryptophan medium by Cryptococcus gattii, Cryptococcus neoformans, and Candida albicans. J Clin Microbiol (2007) 0.89
Direct analysis of tubulin expression in cancer cell lines by electrospray ionization mass spectrometry. Biochemistry (2003) 0.89
Transcellular migration of neutrophils is a quantitatively significant pathway across dermal microvascular endothelial cells. Exp Dermatol (2008) 0.87
Distinct mechanisms of taxol-induced serine phosphorylation of the 66-kDa Shc isoform in A549 and RAW 264.7 cells. Biochim Biophys Acta (2002) 0.87
Exploring the mechanisms of action of the novel microtubule inhibitor vinflunine. Semin Oncol (2008) 0.87
Resistance to discodermolide, a microtubule-stabilizing agent and senescence inducer, is 4E-BP1-dependent. Proc Natl Acad Sci U S A (2010) 0.86
Structural evidence for cooperative microtubule stabilization by Taxol and the endogenous dynamics regulator MAP4. ACS Chem Biol (2012) 0.85
Nature as a remarkable chemist: a personal story of the discovery and development of Taxol. Anticancer Drugs (2014) 0.84
Design, synthesis, and evaluation of carbamate-substituted analogues of (+)-discodermolide. Org Lett (2005) 0.83
Methods in tubulin proteomics. Methods Cell Biol (2010) 0.83
Stathmin/Op18 is a novel mediator of vinblastine activity. FEBS Lett (2008) 0.82
Tissue microarray analysis of hormonal signaling pathways in uterine carcinosarcoma. Am J Obstet Gynecol (2009) 0.82
Imaging of HIV-1 envelope-induced virological synapse and signaling on synthetic lipid bilayers. J Vis Exp (2012) 0.82
Design, synthesis, and biological evaluation of potent discodermolide fluorescent and photoaffinity molecular probes. Org Lett (2005) 0.82
Analysis of primary cilia in directional cell migration in fibroblasts. Methods Enzymol (2013) 0.81
High expression of class III β-tubulin predicts good response to neoadjuvant taxane and doxorubicin/cyclophosphamide-based chemotherapy in estrogen receptor-negative breast cancer. Clin Breast Cancer (2012) 0.81
Response to microtubule-interacting agents in primary epithelial ovarian cancer cells. Cancer Cell Int (2013) 0.81
Epothilone B enhances Class I HLA and HLA-A2 surface molecule expression in ovarian cancer cells. Gynecol Oncol (2011) 0.80
Design and synthesis of (+)-discodermolide-paclitaxel hybrids leading to enhanced biological activity. J Med Chem (2011) 0.79
Epothilone B enhances surface EpCAM expression in ovarian cancer Hey cells. Gynecol Oncol (2010) 0.79
Characterization of a human βV-tubulin antibody and expression of this isotype in normal and malignant human tissue. Cytoskeleton (Hoboken) (2012) 0.79
Eribulin disrupts EB1-microtubule plus-tip complex formation. Cell Cycle (2014) 0.78
Design, synthesis, and evaluation of analogues of (+)-14-normethyldiscodermolide. Org Lett (2005) 0.78
Genetic suppression of inflammation blocks the tumor-promoting effects of TGF-β in gastric tissue. Cancer Res (2014) 0.77
Proteomics of cancer cell lines resistant to microtubule-stabilizing agents. Mol Cancer Ther (2013) 0.76
Correction: Exploiting MEK Inhibitor-Mediated Activation of ERα for Therapeutic Intervention in ER-Positive Ovarian Carcinoma. PLoS One (2016) 0.75