Published in Mol Cancer Ther on June 01, 2005
Metronomic chemotherapy: new rationale for new directions. Nat Rev Clin Oncol (2010) 3.02
Taxol allosterically alters the dynamics of the tubulin dimer and increases the flexibility of microtubules. Biophys J (2008) 1.24
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The roles of beta-tubulin mutations and isotype expression in acquired drug resistance. Cancer Inform (2007) 0.98
A simplified synthesis of novel dictyostatin analogues with in vitro activity against epothilone B-resistant cells and antiangiogenic activity in zebrafish embryos. Mol Cancer Ther (2011) 0.88
Specific β-tubulin isotypes can functionally enhance or diminish epothilone B sensitivity in non-small cell lung cancer cells. PLoS One (2011) 0.87
Stabilizing versus destabilizing the microtubules: a double-edge sword for an effective cancer treatment option? Anal Cell Pathol (Amst) (2015) 0.86
Altered TUBB3 expression contributes to the epothilone response of mitotic cells. Br J Cancer (2013) 0.85
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Peloruside- and laulimalide-resistant human ovarian carcinoma cells have βI-tubulin mutations and altered expression of βII- and βIII-tubulin isotypes. Mol Cancer Ther (2011) 0.84
Understanding the basis of drug resistance of the mutants of αβ-tubulin dimer via molecular dynamics simulations. PLoS One (2012) 0.81
Characterization of a human βV-tubulin antibody and expression of this isotype in normal and malignant human tissue. Cytoskeleton (Hoboken) (2012) 0.79
Novel combretastatin A-4 derivative XN0502 induces cell cycle arrest and apoptosis in A549 cells. Invest New Drugs (2010) 0.76
Proteomics of cancer cell lines resistant to microtubule-stabilizing agents. Mol Cancer Ther (2013) 0.76
Profile of Susan Band Horwitz. Proc Natl Acad Sci U S A (2006) 0.75
Prevalence of chronic kidney disease in China: a cross-sectional survey. Lancet (2012) 10.53
Aneuploidy acts both oncogenically and as a tumor suppressor. Cancer Cell (2006) 6.37
An inhibitor of mutant IDH1 delays growth and promotes differentiation of glioma cells. Science (2013) 5.10
Plasma soluble urokinase receptor levels are increased but do not distinguish primary from secondary focal segmental glomerulosclerosis. Kidney Int (2013) 3.97
Skp2 inhibits FOXO1 in tumor suppression through ubiquitin-mediated degradation. Proc Natl Acad Sci U S A (2005) 3.16
Mechanisms of Taxol resistance related to microtubules. Oncogene (2003) 3.16
Mammalian target of rapamycin up-regulation of pyruvate kinase isoenzyme type M2 is critical for aerobic glycolysis and tumor growth. Proc Natl Acad Sci U S A (2011) 3.14
Long noncoding RNA high expression in hepatocellular carcinoma facilitates tumor growth through enhancer of zeste homolog 2 in humans. Hepatology (2011) 3.05
Human microRNA clusters: genomic organization and expression profile in leukemia cell lines. Biochem Biophys Res Commun (2006) 2.65
Repression of the long noncoding RNA-LET by histone deacetylase 3 contributes to hypoxia-mediated metastasis. Mol Cell (2013) 2.61
SIRT1 deacetylation and repression of p300 involves lysine residues 1020/1024 within the cell cycle regulatory domain 1. J Biol Chem (2005) 2.59
4,5-Diaryl-1H-pyrrole-2-carboxylates as combretastatin A-4/lamellarin T hybrids: synthesis and evaluation as anti-mitotic and cytotoxic agents. Bioorg Med Chem (2006) 2.47
Alterations in the common fragile site gene Parkin in ovarian and other cancers. Oncogene (2003) 2.44
The human serum proteome: display of nearly 3700 chromatographically separated protein spots on two-dimensional electrophoresis gels and identification of 325 distinct proteins. Proteomics (2003) 2.41
Chemical and toxicological investigations of a previously unknown poisonous European mushroom Tricholoma terreum. Chemistry (2014) 2.27
Prevalence and factors associated with CKD: a population study from Beijing. Am J Kidney Dis (2008) 2.09
Common genetic variants of the human uromodulin gene regulate transcription and predict plasma uric acid levels. Kidney Int (2013) 2.05
Lactate dehydrogenase B is critical for hyperactive mTOR-mediated tumorigenesis. Cancer Res (2011) 2.00
Dietary and lifestyle changes associated with high prevalence of hyperuricemia and gout in the Shandong coastal cities of Eastern China. J Rheumatol (2008) 2.00
Insights into the mechanism of microtubule stabilization by Taxol. Proc Natl Acad Sci U S A (2006) 1.96
Hormonal control of androgen receptor function through SIRT1. Mol Cell Biol (2006) 1.91
Location matters: site of conjugation modulates stability and pharmacokinetics of antibody drug conjugates. Chem Biol (2013) 1.82
Mammalian target of rapamycin regulates murine and human cell differentiation through STAT3/p63/Jagged/Notch cascade. J Clin Invest (2009) 1.80
Recent advances in tumor-targeting anticancer drug conjugates. Bioorg Med Chem (2005) 1.77
Octamer 4 small interfering RNA results in cancer stem cell-like cell apoptosis. Cancer Res (2008) 1.76
MicroRNA-29a and microRNA-142-3p are regulators of myeloid differentiation and acute myeloid leukemia. Blood (2012) 1.75
Arabidopsis homolog of the yeast TREX-2 mRNA export complex: components and anchoring nucleoporin. Plant J (2009) 1.73
Differential mitotic responses to microtubule-stabilizing and -destabilizing drugs. Cancer Res (2002) 1.71
Epigenetic activation of the MiR-200 family contributes to H19-mediated metastasis suppression in hepatocellular carcinoma. Carcinogenesis (2012) 1.65
Physiological and transcriptome analysis of iron and phosphorus interaction in rice seedlings. Plant Physiol (2009) 1.65
Post-translational modifications to Toxoplasma gondii alpha- and beta-tubulins include novel C-terminal methylation. J Proteome Res (2010) 1.64
Relation between hypomethylation of long interspersed nucleotide elements and risk of neural tube defects. Am J Clin Nutr (2010) 1.63
Dynamical quorum sensing and synchronization in large populations of chemical oscillators. Science (2009) 1.60
Regulation of the cell cycle gene, BTG2, by miR-21 in human laryngeal carcinoma. Cell Res (2009) 1.58
The interaction between mitotic checkpoint proteins, CENP-E and BubR1, is diminished in epothilone B-resistant A549 cells. Cell Cycle (2010) 1.57
Functionalized single-walled carbon nanotubes as rationally designed vehicles for tumor-targeted drug delivery. J Am Chem Soc (2008) 1.56
Estrogen-related receptors stimulate pyruvate dehydrogenase kinase isoform 4 gene expression. J Biol Chem (2006) 1.56
DNA methylation downregulated mir-10b acts as a tumor suppressor in gastric cancer. Gastric Cancer (2014) 1.56
Elevated levels of microtubule destabilizing factors in a Taxol-resistant/dependent A549 cell line with an alpha-tubulin mutation. Cancer Res (2003) 1.55
Targeting protein translation in human non small cell lung cancer via combined MEK and mammalian target of rapamycin suppression. Cancer Res (2007) 1.55
Apatinib (YN968D1) reverses multidrug resistance by inhibiting the efflux function of multiple ATP-binding cassette transporters. Cancer Res (2010) 1.55
Implication of genetic variants near SLC30A8, HHEX, CDKAL1, CDKN2A/B, IGF2BP2, FTO, TCF2, KCNQ1, and WFS1 in type 2 diabetes in a Chinese population. BMC Med Genet (2010) 1.54
Initial neutrophil lymphocyte ratio is superior to platelet lymphocyte ratio as an adverse prognostic and predictive factor in metastatic colorectal cancer. Med Oncol (2013) 1.52
PVD following plasmin but not hyaluronidase: implications for combination pharmacologic vitreolysis therapy. Retina (2005) 1.52
Peptide YY3-36 and glucagon-like peptide-17-36 inhibit food intake additively. Endocrinology (2005) 1.49
Soybean NAC transcription factors promote abiotic stress tolerance and lateral root formation in transgenic plants. Plant J (2011) 1.48
Exploiting MEK inhibitor-mediated activation of ERα for therapeutic intervention in ER-positive ovarian carcinoma. PLoS One (2013) 1.48
Overprescribing in China, driven by financial incentives, results in very high use of antibiotics, injections, and corticosteroids. Health Aff (Millwood) (2012) 1.48
Sphingosine kinase type 1 induces G12/13-mediated stress fiber formation, yet promotes growth and survival independent of G protein-coupled receptors. J Biol Chem (2003) 1.47
Heat shock protein 70 silencing enhances apoptosis inducing factor-mediated cell death in hepatocellular carcinoma HepG2 cells. Cancer Biol Ther (2009) 1.44
Jasmonate regulates the inducer of cbf expression-C-repeat binding factor/DRE binding factor1 cascade and freezing tolerance in Arabidopsis. Plant Cell (2013) 1.43
Chlorotonil A, a macrolide with a unique gem-dichloro-1,3-dione functionality from Sorangium cellulosum, So ce1525. Angew Chem Int Ed Engl (2008) 1.43
Comparison of the activities of the truncated halichondrin B analog NSC 707389 (E7389) with those of the parent compound and a proposed binding site on tubulin. Mol Pharmacol (2006) 1.42
Fluorescent chemosensors based on spiroring-opening of xanthenes and related derivatives. Chem Rev (2011) 1.40
Long noncoding RNAs associated with liver regeneration 1 accelerates hepatocyte proliferation during liver regeneration by activating Wnt/β-catenin signaling. Hepatology (2013) 1.40
Does obesity attenuate the effect of metabolic syndrome on chronic kidney disease in patients with coronary artery disease? Report from China heart survey. Circ J (2010) 1.40
Capsule structural heterogeneity and antigenic variation in Cryptococcus neoformans. Eukaryot Cell (2007) 1.39
Tumor-infiltrating γδ T lymphocytes predict clinical outcome in human breast cancer. J Immunol (2012) 1.38
QDMR: a quantitative method for identification of differentially methylated regions by entropy. Nucleic Acids Res (2011) 1.37
Gene expression and mitotic exit induced by microtubule-stabilizing drugs. Cancer Res (2003) 1.36
Identification and expansion of cancer stem cells in tumor tissues and peripheral blood derived from gastric adenocarcinoma patients. Cell Res (2011) 1.36
Protection by tetrahydroxystilbene glucoside against cerebral ischemia: involvement of JNK, SIRT1, and NF-kappaB pathways and inhibition of intracellular ROS/RNS generation. Free Radic Biol Med (2009) 1.34
Mutation in nicotianamine aminotransferase stimulated the Fe(II) acquisition system and led to iron accumulation in rice. Plant Physiol (2007) 1.34
Analysis of inpatient bed allocation equity and utilization in the city community health service center of China. J Huazhong Univ Sci Technolog Med Sci (2010) 1.34
Community-based screening for chronic kidney disease among populations older than 40 years in Beijing. Nephrol Dial Transplant (2007) 1.32
miR-17-5p Promotes migration of human hepatocellular carcinoma cells through the p38 mitogen-activated protein kinase-heat shock protein 27 pathway. Hepatology (2010) 1.31
Targeting FtsZ for antituberculosis drug discovery: noncytotoxic taxanes as novel antituberculosis agents. J Med Chem (2006) 1.30
Novel trisubstituted benzimidazoles, targeting Mtb FtsZ, as a new class of antitubercular agents. J Med Chem (2010) 1.29
Biodiesel production with immobilized lipase: A review. Biotechnol Adv (2010) 1.28
HHMD: the human histone modification database. Nucleic Acids Res (2009) 1.27
Phase I clinical and pharmacokinetic study of BMS-247550, a novel derivative of epothilone B, in solid tumors. Clin Cancer Res (2004) 1.27
Plexin-B1 is a target of miR-214 in cervical cancer and promotes the growth and invasion of HeLa cells. Int J Biochem Cell Biol (2011) 1.27
Arabidopsis transcription factor WRKY8 functions antagonistically with its interacting partner VQ9 to modulate salinity stress tolerance. Plant J (2013) 1.26
Hollow porous SiO2 nanocubes towards high-performance anodes for lithium-ion batteries. Sci Rep (2013) 1.26
A novel receptor function for the heat shock protein Grp78: silencing of Grp78 gene expression attenuates alpha2M*-induced signalling. Cell Signal (2004) 1.26
Disruption of palladin results in neural tube closure defects in mice. Mol Cell Neurosci (2005) 1.26
High tumor-infiltrating macrophage density predicts poor prognosis in patients with primary hepatocellular carcinoma after resection. Hum Pathol (2008) 1.26
Overcoming multidrug resistance in taxane chemotherapy. Clin Chem Lab Med (2002) 1.25
Utility of mycobacterial interspersed repetitive unit typing for differentiating Mycobacterium tuberculosis isolates in Wuhan, China. J Med Microbiol (2007) 1.25
Changes in soil properties after establishment of Artemisia halodendron and Caragana microphylla on shifting sand dunes in semiarid Horqin Sandy Land, northern China. Environ Manage (2005) 1.24
Septin roles in tumorigenesis. Biol Chem (2011) 1.24
Sensitization of ABCG2-overexpressing cells to conventional chemotherapeutic agent by sunitinib was associated with inhibiting the function of ABCG2. Cancer Lett (2009) 1.24
Use of the tubulin bound paclitaxel conformation for structure-based rational drug design. Chem Biol (2005) 1.24
Induction of oxidative and nitrosative damage leads to cerebrovascular inflammation in an animal model of mild traumatic brain injury induced by primary blast. Free Radic Biol Med (2013) 1.23
Analysis of tubulin isotypes and mutations from taxol-resistant cells by combined isoelectrofocusing and mass spectrometry. Biochemistry (2003) 1.22
DiseaseMeth: a human disease methylation database. Nucleic Acids Res (2011) 1.22
Low concentrations of taxol cause mitotic delay followed by premature dissociation of p55CDC from Mad2 and BubR1 and abrogation of the spindle checkpoint, leading to aneuploidy. Cell Cycle (2005) 1.22
Association of telomere length with authentic pluripotency of ES/iPS cells. Cell Res (2011) 1.22
Bioproducts from Aureobasidium pullulans, a biotechnologically important yeast. Appl Microbiol Biotechnol (2009) 1.22
Characterization of healing following atherosclerotic carotid plaque rupture in acutely symptomatic patients: an exploratory study using in vivo cardiovascular magnetic resonance. J Cardiovasc Magn Reson (2011) 1.22