Published in J Infect Dis on November 14, 2003
Exploring the folate pathway in Plasmodium falciparum. Acta Trop (2005) 1.20
Analogs of natural aminoacyl-tRNA synthetase inhibitors clear malaria in vivo. Proc Natl Acad Sci U S A (2014) 0.91
Lactase persistence genotypes and malaria susceptibility in Fulani of Mali. Malar J (2011) 0.90
Plasmodium malaria and antimalarial antibodies in the first year of life. Parasitology (2016) 0.89
Malaria hotspots defined by clinical malaria, asymptomatic carriage, PCR and vector numbers in a low transmission area on the Kenyan Coast. Malar J (2016) 0.85
Plasmodium falciparum malaria in children aged 0-2 years: the role of foetal haemoglobin and maternal antibodies to two asexual malaria vaccine candidates (MSP3 and GLURP). PLoS One (2014) 0.83
The molecular basis of folate salvage in Plasmodium falciparum: characterization of two folate transporters. J Biol Chem (2011) 0.81
Drug treatment of malaria infections can reduce levels of protection transferred to offspring via maternal immunity. Proc Biol Sci (2012) 0.80
Dynamics and role of antibodies to Plasmodium falciparum merozoite antigens in children living in two settings with differing malaria transmission intensity. Vaccine (2015) 0.80
Experimental Immunization Based on Plasmodium Antigens Isolated by Antibody Affinity. J Immunol Res (2015) 0.75
High Dietary Folate in Mice Alters Immune Response and Reduces Survival after Malarial Infection. PLoS One (2015) 0.75
A nutrient mediates intraspecific competition between rodent malaria parasites in vivo. Proc Biol Sci (2017) 0.75
The biochemistry of sirtuins. Annu Rev Biochem (2006) 4.32
Bright and stable near-infrared fluorescent protein for in vivo imaging. Nat Biotechnol (2011) 4.14
Enzymatic transition states and dynamic motion in barrier crossing. Nat Chem Biol (2009) 2.30
Transition state analysis for human and Plasmodium falciparum purine nucleoside phosphorylases. Biochemistry (2004) 2.24
Structural insights into intermediate steps in the Sir2 deacetylation reaction. Structure (2008) 2.12
Atomic detail of chemical transformation at the transition state of an enzymatic reaction. Proc Natl Acad Sci U S A (2008) 2.01
Sir2 regulation by nicotinamide results from switching between base exchange and deacetylation chemistry. Biochemistry (2003) 1.83
Innate inhibition of adaptive immunity: Mycobacterium tuberculosis-induced IL-6 inhibits macrophage responses to IFN-gamma. J Immunol (2003) 1.78
Femtomolar transition state analogue inhibitors of 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase from Escherichia coli. J Biol Chem (2005) 1.76
Transition state structure of 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase from Escherichia coli and its similarity to transition state analogues. Biochemistry (2005) 1.73
Chemical activation of Sir2-dependent silencing by relief of nicotinamide inhibition. Mol Cell (2005) 1.71
A photoswitchable orange-to-far-red fluorescent protein, PSmOrange. Nat Methods (2011) 1.69
Epigenomic modifications predict active promoters and gene structure in Toxoplasma gondii. PLoS Pathog (2007) 1.69
Attenuated Plasmodium yoelii lacking purine nucleoside phosphorylase confer protective immunity. Nat Med (2008) 1.65
An analytical pipeline for genomic representations used for cytosine methylation studies. Bioinformatics (2008) 1.64
Post-translational modifications to Toxoplasma gondii alpha- and beta-tubulins include novel C-terminal methylation. J Proteome Res (2010) 1.64
Ribocation transition state capture and rebound in human purine nucleoside phosphorylase. Chem Biol (2009) 1.55
Neighboring group participation in the transition state of human purine nucleoside phosphorylase. Biochemistry (2007) 1.53
A transition state analogue of 5'-methylthioadenosine phosphorylase induces apoptosis in head and neck cancers. J Biol Chem (2007) 1.47
Achieving the ultimate physiological goal in transition state analogue inhibitors for purine nucleoside phosphorylase. J Biol Chem (2003) 1.46
Femtosecond dynamics coupled to chemical barrier crossing in a Born-Oppenheimer enzyme. Proc Natl Acad Sci U S A (2011) 1.46
Remote mutations and active site dynamics correlate with catalytic properties of purine nucleoside phosphorylase. Biophys J (2008) 1.46
Distinct mechanisms govern proteolytic shedding of a key invasion protein in apicomplexan pathogens. Mol Microbiol (2005) 1.45
Transition state analogs of 5'-methylthioadenosine nucleosidase disrupt quorum sensing. Nat Chem Biol (2009) 1.39
Picomolar inhibitors as transition-state probes of 5'-methylthioadenosine nucleosidases. ACS Chem Biol (2007) 1.37
Picomolar transition state analogue inhibitors of human 5'-methylthioadenosine phosphorylase and X-ray structure with MT-immucillin-A. Biochemistry (2004) 1.35
Targeting a novel Plasmodium falciparum purine recycling pathway with specific immucillins. J Biol Chem (2004) 1.34
Promoting vibrations in human purine nucleoside phosphorylase. A molecular dynamics and hybrid quantum mechanical/molecular mechanical study. J Am Chem Soc (2004) 1.32
Third-generation immucillins: syntheses and bioactivities of acyclic immucillin inhibitors of human purine nucleoside phosphorylase. J Med Chem (2009) 1.29
Energetic mapping of transition state analogue interactions with human and Plasmodium falciparum purine nucleoside phosphorylases. J Biol Chem (2005) 1.28
Noninvasive real-time monitoring of liver-stage development of bioluminescent Plasmodium parasites. J Infect Dis (2009) 1.28
Four generations of transition-state analogues for human purine nucleoside phosphorylase. Proc Natl Acad Sci U S A (2010) 1.28
Synthesis of second-generation transition state analogues of human purine nucleoside phosphorylase. J Med Chem (2003) 1.27
Altered enthalpy-entropy compensation in picomolar transition state analogues of human purine nucleoside phosphorylase. Biochemistry (2009) 1.26
Plasmodium falciparum purine nucleoside phosphorylase: crystal structures, immucillin inhibitors, and dual catalytic function. J Biol Chem (2004) 1.26
Structural rationale for the affinity of pico- and femtomolar transition state analogues of Escherichia coli 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase. J Biol Chem (2005) 1.26
Transition-state structure of human 5'-methylthioadenosine phosphorylase. J Am Chem Soc (2006) 1.25
Second generation transition state analogue inhibitors of human 5'-methylthioadenosine phosphorylase. J Med Chem (2005) 1.25
Transition state analogue inhibitors of purine nucleoside phosphorylase from Plasmodium falciparum. J Biol Chem (2001) 1.25
The Toxoplasma gondii rhoptry protein ROP4 is secreted into the parasitophorous vacuole and becomes phosphorylated in infected cells. Eukaryot Cell (2004) 1.25
Purine-less death in Plasmodium falciparum induced by immucillin-H, a transition state analogue of purine nucleoside phosphorylase. J Biol Chem (2001) 1.24
Transition State Structure for the Hydrolysis of NAD Catalyzed by Diphtheria Toxin. J Am Chem Soc (1997) 1.20
Detecting ricin: sensitive luminescent assay for ricin A-chain ribosome depurination kinetics. Anal Chem (2009) 1.19
TgSUB2 is a Toxoplasma gondii rhoptry organelle processing proteinase. Mol Microbiol (2003) 1.19
Synthesis of a transition state analogue inhibitor of purine nucleoside phosphorylase via the Mannich reaction. Org Lett (2003) 1.18
Mass-dependent bond vibrational dynamics influence catalysis by HIV-1 protease. J Am Chem Soc (2011) 1.18
Altered thermodynamics from remote mutations altering human toward bovine purine nucleoside phosphorylase. Biochemistry (2008) 1.18
Binding equilibrium isotope effects for glucose at the catalytic domain of human brain hexokinase. J Am Chem Soc (2003) 1.17
SIR2: the biochemical mechanism of NAD(+)-dependent protein deacetylation and ADP-ribosyl enzyme intermediates. Curr Med Chem (2004) 1.17
Transition state analogues in structures of ricin and saporin ribosome-inactivating proteins. Proc Natl Acad Sci U S A (2009) 1.15
Transition-state analysis of S. pneumoniae 5'-methylthioadenosine nucleosidase. J Am Chem Soc (2007) 1.15
Improved transfection and new selectable markers for the rodent malaria parasite Plasmodium yoelii. Mol Biochem Parasitol (2006) 1.14
Toxoplasma gondii sequesters centromeres to a specific nuclear region throughout the cell cycle. Proc Natl Acad Sci U S A (2011) 1.14
Insight into catalytically relevant correlated motions in human purine nucleoside phosphorylase. J Phys Chem A (2006) 1.14
Growth and metastases of human lung cancer are inhibited in mouse xenografts by a transition state analogue of 5'-methylthioadenosine phosphorylase. J Biol Chem (2010) 1.14
Remote mutations alter transition-state structure of human purine nucleoside phosphorylase. Biochemistry (2008) 1.13
Transition state analogue discrimination by related purine nucleoside phosphorylases. J Am Chem Soc (2006) 1.13
Transition states of Plasmodium falciparum and human orotate phosphoribosyltransferases. J Am Chem Soc (2009) 1.11
Plasmodium falciparum parasites are killed by a transition state analogue of purine nucleoside phosphorylase in a primate animal model. PLoS One (2011) 1.10
Computational analysis and experimental validation of gene predictions in Toxoplasma gondii. PLoS One (2008) 1.08
Conformational dynamics in human purine nucleoside phosphorylase with reactants and transition-state analogues. J Phys Chem B (2010) 1.07
Acyclic ribooxacarbenium ion mimics as transition state analogues of human and malarial purine nucleoside phosphorylases. J Am Chem Soc (2007) 1.06
Erythrocytic adenosine monophosphate as an alternative purine source in Plasmodium falciparum. J Biol Chem (2008) 1.06
Structure and inhibition of a quorum sensing target from Streptococcus pneumoniae. Biochemistry (2006) 1.06
Activating the phosphate nucleophile at the catalytic site of purine nucleoside phosphorylase: a vibrational spectroscopic study. J Am Chem Soc (2004) 1.04
Protein mass-modulated effects in the catalytic mechanism of dihydrofolate reductase: beyond promoting vibrations. J Am Chem Soc (2014) 1.04
Transition state structure for ADP-ribosylation of eukaryotic elongation factor 2 catalyzed by diphtheria toxin. Biochemistry (2004) 1.04
Exploring structure-activity relationships of transition state analogues of human purine nucleoside phosphorylase. J Med Chem (2003) 1.04
Toxoplasma gondii and Cryptosporidium parvum lack detectable DNA cytosine methylation. Eukaryot Cell (2008) 1.03
Identification and characterisation of a regulatory region in the Toxoplasma gondii hsp70 genomic locus. Int J Parasitol (2004) 1.03
Targeting the polyamine pathway with transition-state analogue inhibitors of 5'-methylthioadenosine phosphorylase. J Med Chem (2004) 1.03
A picomolar transition state analogue inhibitor of MTAN as a specific antibiotic for Helicobacter pylori. Biochemistry (2012) 1.02
Atomic dissection of the hydrogen bond network for transition-state analogue binding to purine nucleoside phosphorylase. Biochemistry (2002) 1.02
Synthesis of 5'-methylthio coformycins: specific inhibitors for malarial adenosine deaminase. J Am Chem Soc (2007) 1.02
Toxoplasma gondii protease TgSUB1 is required for cell surface processing of micronemal adhesive complexes and efficient adhesion of tachyzoites. Cell Microbiol (2010) 1.01
Plasmodium falciparum purine nucleoside phosphorylase is critical for viability of malaria parasites. J Biol Chem (2008) 1.01
Transition Path Sampling Study of the Reaction Catalyzed by Purine Nucleoside Phosphorylase. Z Phys Chem (N F) (2008) 1.01
The Toxoplasma nuclear factor TgAP2XI-4 controls bradyzoite gene expression and cyst formation. Mol Microbiol (2012) 1.01
Transport of purines and purine salvage pathway inhibitors by the Plasmodium falciparum equilibrative nucleoside transporter PfENT1. Mol Biochem Parasitol (2009) 1.01
Location, location, location: trafficking and function of secreted proteases of Toxoplasma and Plasmodium. Traffic (2004) 1.00
Proteolytic processing of the Cryptosporidium glycoprotein gp40/15 by human furin and by a parasite-derived furin-like protease activity. Infect Immun (2006) 1.00
Comprehensive proteomic analysis of membrane proteins in Toxoplasma gondii. Mol Cell Proteomics (2010) 1.00
Nucleophilic participation in the transition state for human thymidine phosphorylase. J Am Chem Soc (2004) 1.00
Transition states and inhibitors of the purine nucleoside phosphorylase family. Curr Top Med Chem (2005) 1.00
Loop-tryptophan human purine nucleoside phosphorylase reveals submillisecond protein dynamics. Biochemistry (2009) 0.99
Cyclic nucleotide kinases and tachyzoite-bradyzoite transition in Toxoplasma gondii. Int J Parasitol (2005) 0.99
Inhibition of ricin A-chain with pyrrolidine mimics of the oxacarbenium ion transition state. Biochemistry (2004) 0.98
Transition-state variation in human, bovine, and Plasmodium falciparum adenosine deaminases. J Am Chem Soc (2007) 0.98