Published in Annu Rev Biochem on January 01, 2006
Mammalian sirtuins: biological insights and disease relevance. Annu Rev Pathol (2010) 8.55
Sirtuins in mammals: insights into their biological function. Biochem J (2007) 7.60
Epigenetic protein families: a new frontier for drug discovery. Nat Rev Drug Discov (2012) 6.70
The NAD+-dependent deacetylase SIRT1 modulates CLOCK-mediated chromatin remodeling and circadian control. Cell (2008) 6.44
FOXO3A genotype is strongly associated with human longevity. Proc Natl Acad Sci U S A (2008) 5.71
Glucose restriction inhibits skeletal myoblast differentiation by activating SIRT1 through AMPK-mediated regulation of Nampt. Dev Cell (2008) 5.51
SRT1720, SRT2183, SRT1460, and resveratrol are not direct activators of SIRT1. J Biol Chem (2010) 5.43
Sirt5 is a NAD-dependent protein lysine demalonylase and desuccinylase. Science (2011) 4.16
Evidence for a common mechanism of SIRT1 regulation by allosteric activators. Science (2013) 3.40
The secret life of NAD+: an old metabolite controlling new metabolic signaling pathways. Endocr Rev (2009) 3.23
Lysine propionylation and butyrylation are novel post-translational modifications in histones. Mol Cell Proteomics (2007) 3.09
Influence of metabolism on epigenetics and disease. Cell (2013) 2.64
SIRT6 regulates TNF-α secretion through hydrolysis of long-chain fatty acyl lysine. Nature (2013) 2.52
SIRT1, an antiinflammatory and antiaging protein, is decreased in lungs of patients with chronic obstructive pulmonary disease. Am J Respir Crit Care Med (2008) 2.49
Disruption of the Ang II type 1 receptor promotes longevity in mice. J Clin Invest (2009) 2.49
The neuroprotective properties of calorie restriction, the ketogenic diet, and ketone bodies. Brain Res Rev (2008) 2.39
Histone deacetylase (HDAC) inhibitors in recent clinical trials for cancer therapy. Clin Epigenetics (2010) 2.26
Oxidative stress and aberrant signaling in aging and cognitive decline. Aging Cell (2007) 2.13
Structural insights into intermediate steps in the Sir2 deacetylation reaction. Structure (2008) 2.12
HDAC6 is a specific deacetylase of peroxiredoxins and is involved in redox regulation. Proc Natl Acad Sci U S A (2008) 2.10
Metabolism control by the circadian clock and vice versa. Nat Struct Mol Biol (2009) 1.99
Regulation of SIRT1 in cellular functions: role of polyphenols. Arch Biochem Biophys (2010) 1.91
Mechanisms and molecular probes of sirtuins. Chem Biol (2008) 1.90
HAMAP in 2015: updates to the protein family classification and annotation system. Nucleic Acids Res (2014) 1.88
Targeting sirtuin 1 to improve metabolism: all you need is NAD(+)? Pharmacol Rev (2011) 1.85
Age related changes in NAD+ metabolism oxidative stress and Sirt1 activity in wistar rats. PLoS One (2011) 1.81
SIRT1 activation by small molecules: kinetic and biophysical evidence for direct interaction of enzyme and activator. J Biol Chem (2010) 1.75
Enzymes in the NAD+ salvage pathway regulate SIRT1 activity at target gene promoters. J Biol Chem (2009) 1.70
NAMPT is essential for the G-CSF-induced myeloid differentiation via a NAD(+)-sirtuin-1-dependent pathway. Nat Med (2009) 1.66
Regulation of cartilage-specific gene expression in human chondrocytes by SirT1 and nicotinamide phosphoribosyltransferase. J Biol Chem (2008) 1.66
SIRT6 in DNA repair, metabolism and ageing. J Intern Med (2008) 1.61
Mitochondrial protein acylation and intermediary metabolism: regulation by sirtuins and implications for metabolic disease. J Biol Chem (2012) 1.58
NAD metabolism and sirtuins: metabolic regulation of protein deacetylation in stress and toxicity. AAPS J (2006) 1.57
SIRT1 is a redox-sensitive deacetylase that is post-translationally modified by oxidants and carbonyl stress. FASEB J (2010) 1.54
Protein lysine acylation and cysteine succination by intermediates of energy metabolism. ACS Chem Biol (2012) 1.49
Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription. Mol Cell Proteomics (2012) 1.49
Retracted The effect of marathon on mRNA expression of anti-apoptotic and pro-apoptotic proteins and sirtuins family in male recreational long-distance runners. BMC Physiol (2010) 1.47
Role of sirtuin histone deacetylase SIRT1 in prostate cancer. A target for prostate cancer management via its inhibition? J Biol Chem (2008) 1.46
Loss of a histone deacetylase dramatically alters the genomic distribution of Spo11p-catalyzed DNA breaks in Saccharomyces cerevisiae. Proc Natl Acad Sci U S A (2007) 1.46
Deacetylase-independent function of HDAC3 in transcription and metabolism requires nuclear receptor corepressor. Mol Cell (2013) 1.44
SIRT1-dependent regulation of chromatin and transcription: linking NAD(+) metabolism and signaling to the control of cellular functions. Biochim Biophys Acta (2009) 1.41
Mitochondrial protein acetylation regulates metabolism. Essays Biochem (2012) 1.40
Nutrient-dependent regulation of PGC-1alpha's acetylation state and metabolic function through the enzymatic activities of Sirt1/GCN5. Biochim Biophys Acta (2009) 1.39
Human immunodeficiency virus type 1 Tat protein inhibits the SIRT1 deacetylase and induces T cell hyperactivation. Cell Host Microbe (2008) 1.35
Plasmodium falciparum Sir2A preferentially hydrolyzes medium and long chain fatty acyl lysine. ACS Chem Biol (2011) 1.33
SirT1 enhances survival of human osteoarthritic chondrocytes by repressing protein tyrosine phosphatase 1B and activating the insulin-like growth factor receptor pathway. Arthritis Rheum (2010) 1.33
Small-molecule allosteric activators of sirtuins. Annu Rev Pharmacol Toxicol (2013) 1.31
The ketogenic diet in a pill: is this possible? Epilepsia (2008) 1.28
A molecular mechanism for direct sirtuin activation by resveratrol. PLoS One (2012) 1.26
The chronobiology, etiology and pathophysiology of obesity. Int J Obes (Lond) (2010) 1.22
High glucose induced alteration of SIRTs in endothelial cells causes rapid aging in a p300 and FOXO regulated pathway. PLoS One (2013) 1.20
Structure-based development of novel sirtuin inhibitors. Aging (Albany NY) (2011) 1.19
Ex-527 inhibits Sirtuins by exploiting their unique NAD+-dependent deacetylation mechanism. Proc Natl Acad Sci U S A (2013) 1.18
Three novel acetylation sites in the Foxp3 transcription factor regulate the suppressive activity of regulatory T cells. J Immunol (2012) 1.18
Cytoprotection by the modulation of mitochondrial electron transport chain: the emerging role of mitochondrial STAT3. Mitochondrion (2011) 1.17
Mitochondrial protein acetylation as a cell-intrinsic, evolutionary driver of fat storage: chemical and metabolic logic of acetyl-lysine modifications. Crit Rev Biochem Mol Biol (2013) 1.17
Redox regulation of SIRT1 in inflammation and cellular senescence. Free Radic Biol Med (2013) 1.17
Sirtuin chemical mechanisms. Biochim Biophys Acta (2010) 1.16
SIRT1 is a circadian deacetylase for core clock components. Cell (2008) 1.15
Protective effects and mechanisms of sirtuins in the nervous system. Prog Neurobiol (2011) 1.14
The activity of HDAC8 depends on local and distal sequences of its peptide substrates. Biochemistry (2008) 1.14
Highly dissociative and concerted mechanism for the nicotinamide cleavage reaction in Sir2Tm enzyme suggested by ab initio QM/MM molecular dynamics simulations. J Am Chem Soc (2008) 1.14
Sir2 deacetylases exhibit nucleophilic participation of acetyl-lysine in NAD+ cleavage. J Am Chem Soc (2007) 1.14
Identification of 'erasers' for lysine crotonylated histone marks using a chemical proteomics approach. Elife (2014) 1.13
NAD+ as a signaling molecule modulating metabolism. Cold Spring Harb Symp Quant Biol (2012) 1.12
A maternal high-fat diet modulates fetal SIRT1 histone and protein deacetylase activity in nonhuman primates. FASEB J (2012) 1.11
The SIRT2 deacetylase regulates autoacetylation of p300. Mol Cell (2008) 1.11
Diet-induced lethality due to deletion of the Hdac3 gene in heart and skeletal muscle. J Biol Chem (2011) 1.10
Resveratrol modulates interleukin-1β-induced phosphatidylinositol 3-kinase and nuclear factor κB signaling pathways in human tenocytes. J Biol Chem (2012) 1.10
Nicotinamide-induced mitophagy: event mediated by high NAD+/NADH ratio and SIRT1 protein activation. J Biol Chem (2012) 1.08
Effects of Kynurenine Pathway Metabolites on Intracellular NAD Synthesis and Cell Death in Human Primary Astrocytes and Neurons. Int J Tryptophan Res (2009) 1.07
Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription. Mol Cell Proteomics (2011) 1.07
Natural genetic variation in yeast longevity. Genome Res (2012) 1.07
Metabostemness: a new cancer hallmark. Front Oncol (2014) 1.05
Assimilation of endogenous nicotinamide riboside is essential for calorie restriction-mediated life span extension in Saccharomyces cerevisiae. J Biol Chem (2009) 1.04
Slx5 promotes transcriptional silencing and is required for robust growth in the absence of Sir2. Mol Cell Biol (2007) 1.04
Sirt1 activation by resveratrol is substrate sequence-selective. Aging (Albany NY) (2013) 1.04
Sirtuins, melatonin and circadian rhythms: building a bridge between aging and cancer. J Pineal Res (2010) 1.02
Regulation of yeast sirtuins by NAD(+) metabolism and calorie restriction. Biochim Biophys Acta (2009) 1.02
Plasmodium falciparum Sir2 is an NAD+-dependent deacetylase and an acetyllysine-dependent and acetyllysine-independent NAD+ glycohydrolase. Biochemistry (2008) 1.01
Structural and functional analysis of human SIRT1. J Mol Biol (2013) 1.01
Heterochromatin and the cohesion of sister chromatids. Chromosome Res (2009) 0.99
Acylation of Biomolecules in Prokaryotes: a Widespread Strategy for the Control of Biological Function and Metabolic Stress. Microbiol Mol Biol Rev (2015) 0.99
In search of antiaging modalities: evaluation of mTOR- and ROS/DNA damage-signaling by cytometry. Cytometry A (2014) 0.99
Characterization of nicotinamidases: steady state kinetic parameters, classwide inhibition by nicotinaldehydes, and catalytic mechanism. Biochemistry (2010) 0.98
SIRT1 expression is associated with the chemotherapy response and prognosis of patients with advanced NSCLC. PLoS One (2013) 0.98
In Bacillus subtilis, the sirtuin protein deacetylase, encoded by the srtN gene (formerly yhdZ), and functions encoded by the acuABC genes control the activity of acetyl coenzyme A synthetase. J Bacteriol (2009) 0.98
Bypassing Sir2 and O-acetyl-ADP-ribose in transcriptional silencing. Mol Cell (2008) 0.98
RNA-assisted catalysis in a protein enzyme: The 2'-hydroxyl of tRNA(Thr) A76 promotes aminoacylation by threonyl-tRNA synthetase. Proc Natl Acad Sci U S A (2008) 0.96
Sirt5 deacylation activities show differential sensitivities to nicotinamide inhibition. PLoS One (2012) 0.96
Resveratrol up-regulates SIRT1 and inhibits cellular oxidative stress in the diabetic milieu: mechanistic insights. J Nutr Biochem (2011) 0.95
Mechanistic studies on the effects of nicotinamide on megakaryocytic polyploidization and the roles of NAD+ levels and SIRT inhibition. Exp Hematol (2009) 0.93
The bicyclic intermediate structure provides insights into the desuccinylation mechanism of human sirtuin 5 (SIRT5). J Biol Chem (2012) 0.92
Reinventing heterochromatin in budding yeasts: Sir2 and the origin recognition complex take center stage. Eukaryot Cell (2011) 0.91
Minireview: NAD+, a circadian metabolite with an epigenetic twist. Endocrinology (2011) 0.91
Identification of a novel pathway that selectively modulates apoptosis of breast cancer cells. Cancer Res (2009) 0.91
Impact of soy isoflavones on the epigenome in cancer prevention. Nutrients (2014) 0.90
Thiosuccinyl peptides as Sirt5-specific inhibitors. J Am Chem Soc (2012) 0.90
Sirtuins: from metabolic regulation to brain aging. Front Aging Neurosci (2013) 0.90
Functional profiling of the Saccharomyces cerevisiae genome. Nature (2002) 36.10
SIRT4 inhibits glutamate dehydrogenase and opposes the effects of calorie restriction in pancreatic beta cells. Cell (2006) 6.79
Analysis of the human protein interactome and comparison with yeast, worm and fly interaction datasets. Nat Genet (2006) 6.74
A DNA integrity network in the yeast Saccharomyces cerevisiae. Cell (2006) 6.61
Transcriptional disruption by the L1 retrotransposon and implications for mammalian transcriptomes. Nature (2004) 5.15
Human l1 retrotransposition is associated with genetic instability in vivo. Cell (2002) 4.79
A robust toolkit for functional profiling of the yeast genome. Mol Cell (2004) 4.69
SIRT3, a human SIR2 homologue, is an NAD-dependent deacetylase localized to mitochondria. Proc Natl Acad Sci U S A (2002) 4.27
Nampt/PBEF/Visfatin regulates insulin secretion in beta cells as a systemic NAD biosynthetic enzyme. Cell Metab (2007) 4.16
DNA helicase gene interaction network defined using synthetic lethality analyzed by microarray. Nat Genet (2003) 4.14
Mms2-Ubc13 covalently bound to ubiquitin reveals the structural basis of linkage-specific polyubiquitin chain formation. Nat Struct Mol Biol (2006) 3.71
Mobile interspersed repeats are major structural variants in the human genome. Cell (2010) 3.60
Human L1 element target-primed reverse transcription in vitro. EMBO J (2002) 3.54
The sirtuins hst3 and Hst4p preserve genome integrity by controlling histone h3 lysine 56 deacetylation. Curr Biol (2006) 3.37
Total synthesis of a functional designer eukaryotic chromosome. Science (2014) 3.31
Nucleocytosolic acetyl-coenzyme a synthetase is required for histone acetylation and global transcription. Mol Cell (2006) 3.22
Mighty Piwis defend the germline against genome intruders. Cell (2007) 3.06
Protein acetylation microarray reveals that NuA4 controls key metabolic target regulating gluconeogenesis. Cell (2009) 2.99
Synthetic chromosome arms function in yeast and generate phenotypic diversity by design. Nature (2011) 2.81
Functional genomics of genes with small open reading frames (sORFs) in S. cerevisiae. Genome Res (2006) 2.81
Regulated nucleosome mobility and the histone code. Nat Struct Mol Biol (2004) 2.76
A core nucleosome surface crucial for transcriptional silencing. Nat Genet (2002) 2.67
A highly active synthetic mammalian retrotransposon. Nature (2004) 2.51
Toward a comprehensive temperature-sensitive mutant repository of the essential genes of Saccharomyces cerevisiae. Mol Cell (2008) 2.39
A conserved catalytic residue in the ubiquitin-conjugating enzyme family. EMBO J (2003) 2.37
Insights into the role of histone H3 and histone H4 core modifiable residues in Saccharomyces cerevisiae. Mol Cell Biol (2005) 2.33
Mechanism of sirtuin inhibition by nicotinamide: altering the NAD(+) cosubstrate specificity of a Sir2 enzyme. Mol Cell (2005) 2.31
Enzymatic transition states and dynamic motion in barrier crossing. Nat Chem Biol (2009) 2.30
LINE-1 retrotransposons: modulators of quantity and quality of mammalian gene expression? Bioessays (2005) 2.24
Transition state analysis for human and Plasmodium falciparum purine nucleoside phosphorylases. Biochemistry (2004) 2.24
Crystal structure and solution NMR studies of Lys48-linked tetraubiquitin at neutral pH. J Mol Biol (2006) 2.22
Molecular archeology of L1 insertions in the human genome. Genome Biol (2002) 2.14
Structural insights into intermediate steps in the Sir2 deacetylation reaction. Structure (2008) 2.12
Glucose and weight control in mice with a designed ghrelin O-acyltransferase inhibitor. Science (2010) 2.12
Acetylation of yeast AMPK controls intrinsic aging independently of caloric restriction. Cell (2011) 2.10
Orientation-dependent regulation of integrated HIV-1 expression by host gene transcriptional readthrough. Cell Host Microbe (2008) 2.08
Gene function prediction from congruent synthetic lethal interactions in yeast. Mol Syst Biol (2005) 2.04
Structure of Nampt/PBEF/visfatin, a mammalian NAD+ biosynthetic enzyme. Nat Struct Mol Biol (2006) 2.03
A comprehensive synthetic genetic interaction network governing yeast histone acetylation and deacetylation. Genes Dev (2008) 2.01
Atomic detail of chemical transformation at the transition state of an enzymatic reaction. Proc Natl Acad Sci U S A (2008) 2.01
Structure of a Sir2 enzyme bound to an acetylated p53 peptide. Mol Cell (2002) 2.00
Probing nucleosome function: a highly versatile library of synthetic histone H3 and H4 mutants. Cell (2008) 1.99
Transposon-mediated genome manipulation in vertebrates. Nat Methods (2009) 1.96
Lysine succinylation and lysine malonylation in histones. Mol Cell Proteomics (2012) 1.95
N-lysine propionylation controls the activity of propionyl-CoA synthetase. J Biol Chem (2007) 1.95
Genome-wide identification of Isw2 chromatin-remodeling targets by localization of a catalytically inactive mutant. Genes Dev (2005) 1.92
GeneDesign: rapid, automated design of multikilobase synthetic genes. Genome Res (2006) 1.87
Sir2 regulation by nicotinamide results from switching between base exchange and deacetylation chemistry. Biochemistry (2003) 1.83
Evidence for bidentate substrate binding as the basis for the K48 linkage specificity of otubain 1. J Mol Biol (2009) 1.82
Global synthetic-lethality analysis and yeast functional profiling. Trends Genet (2005) 1.82
Structure of HoxA9 and Pbx1 bound to DNA: Hox hexapeptide and DNA recognition anterior to posterior. Genes Dev (2003) 1.82
Human transposon tectonics. Cell (2012) 1.81
The structure and conformation of Lys63-linked tetraubiquitin. J Mol Biol (2009) 1.77
Femtomolar transition state analogue inhibitors of 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase from Escherichia coli. J Biol Chem (2005) 1.76
Genome-wide consequences of deleting any single gene. Mol Cell (2013) 1.76
Structural insights into the assembly and function of the SAGA deubiquitinating module. Science (2010) 1.74
Short-chain fatty acid activation by acyl-coenzyme A synthetases requires SIR2 protein function in Salmonella enterica and Saccharomyces cerevisiae. Genetics (2003) 1.73
Transition state structure of 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase from Escherichia coli and its similarity to transition state analogues. Biochemistry (2005) 1.73
Chemical activation of Sir2-dependent silencing by relief of nicotinamide inhibition. Mol Cell (2005) 1.71
Transcriptional interactions between yeast tRNA genes, flanking genes and Ty elements: a genomic point of view. Genome Res (2003) 1.71
The mechanism of OTUB1-mediated inhibition of ubiquitination. Nature (2012) 1.70
Insights into the sirtuin mechanism from ternary complexes containing NAD+ and acetylated peptide. Structure (2006) 1.66
Rapid identification of monospecific monoclonal antibodies using a human proteome microarray. Mol Cell Proteomics (2012) 1.65
Polyubiquitin-sensor proteins reveal localization and linkage-type dependence of cellular ubiquitin signaling. Nat Methods (2012) 1.62
Finding friends and enemies in an enemies-only network: a graph diffusion kernel for predicting novel genetic interactions and co-complex membership from yeast genetic interactions. Genome Res (2008) 1.61
Telomeric and rDNA silencing in Saccharomyces cerevisiae are dependent on a nuclear NAD(+) salvage pathway. Genetics (2002) 1.60
Gene-breaking: a new paradigm for human retrotransposon-mediated gene evolution. Genome Res (2005) 1.58
Microarray-based genetic screen defines SAW1, a gene required for Rad1/Rad10-dependent processing of recombination intermediates. Mol Cell (2008) 1.56
Ribocation transition state capture and rebound in human purine nucleoside phosphorylase. Chem Biol (2009) 1.55
Neighboring group participation in the transition state of human purine nucleoside phosphorylase. Biochemistry (2007) 1.53
A microarray-based genetic screen for yeast chronological aging factors. PLoS Genet (2010) 1.53
Efficient Tor signaling requires a functional class C Vps protein complex in Saccharomyces cerevisiae. Genetics (2007) 1.52
Active transposition in genomes. Annu Rev Genet (2012) 1.51
Active retrotransposition by a synthetic L1 element in mice. Proc Natl Acad Sci U S A (2006) 1.48
A transition state analogue of 5'-methylthioadenosine phosphorylase induces apoptosis in head and neck cancers. J Biol Chem (2007) 1.47
Achieving the ultimate physiological goal in transition state analogue inhibitors for purine nucleoside phosphorylase. J Biol Chem (2003) 1.46
Remote mutations and active site dynamics correlate with catalytic properties of purine nucleoside phosphorylase. Biophys J (2008) 1.46
Femtosecond dynamics coupled to chemical barrier crossing in a Born-Oppenheimer enzyme. Proc Natl Acad Sci U S A (2011) 1.46
Use of mixture models in a microarray-based screening procedure for detecting differentially represented yeast mutants. Stat Appl Genet Mol Biol (2003) 1.45
Teaching synthetic biology, bioinformatics and engineering to undergraduates: the interdisciplinary Build-a-Genome course. Genetics (2008) 1.41
RNF4-dependent hybrid SUMO-ubiquitin chains are signals for RAP80 and thereby mediate the recruitment of BRCA1 to sites of DNA damage. Sci Signal (2012) 1.40
How does the histone code work? Biochem Cell Biol (2005) 1.40
The structural basis of sirtuin substrate affinity. Biochemistry (2006) 1.40
Transition state analogs of 5'-methylthioadenosine nucleosidase disrupt quorum sensing. Nat Chem Biol (2009) 1.39
Structural basis for the mechanism and regulation of Sir2 enzymes. Mol Cell (2004) 1.37
Picomolar inhibitors as transition-state probes of 5'-methylthioadenosine nucleosidases. ACS Chem Biol (2007) 1.37
Picomolar transition state analogue inhibitors of human 5'-methylthioadenosine phosphorylase and X-ray structure with MT-immucillin-A. Biochemistry (2004) 1.35
Affinity proteomics reveals human host factors implicated in discrete stages of LINE-1 retrotransposition. Cell (2013) 1.34
Targeting a novel Plasmodium falciparum purine recycling pathway with specific immucillins. J Biol Chem (2004) 1.34
Reconstitution of papillomavirus E2-mediated plasmid maintenance in Saccharomyces cerevisiae by the Brd4 bromodomain protein. Proc Natl Acad Sci U S A (2005) 1.34
TFIIIB subunit Bdp1p is required for periodic integration of the Ty1 retrotransposon and targeting of Isw2p to S. cerevisiae tDNAs. Genes Dev (2005) 1.33
Promoting vibrations in human purine nucleoside phosphorylase. A molecular dynamics and hybrid quantum mechanical/molecular mechanical study. J Am Chem Soc (2004) 1.32
Extracellular Nampt promotes macrophage survival via a nonenzymatic interleukin-6/STAT3 signaling mechanism. J Biol Chem (2008) 1.29
Retracted Functional dissection of lysine deacetylases reveals that HDAC1 and p300 regulate AMPK. Nature (2012) 1.29
Third-generation immucillins: syntheses and bioactivities of acyclic immucillin inhibitors of human purine nucleoside phosphorylase. J Med Chem (2009) 1.29