Published in Proc Natl Acad Sci U S A on November 01, 2010
P(II) signal transduction proteins are ATPases whose activity is regulated by 2-oxoglutarate. Proc Natl Acad Sci U S A (2013) 0.95
Significant reduction in errors associated with nonbonded contacts in protein crystal structures: automated all-atom refinement with PrimeX. Acta Crystallogr D Biol Crystallogr (2012) 0.95
From cyanobacteria to plants: conservation of PII functions during plastid evolution. Planta (2012) 0.88
Structural basis and target-specific modulation of ADP sensing by the Synechococcus elongatus PII signaling protein. J Biol Chem (2014) 0.86
From PII signaling to metabolite sensing: a novel 2-oxoglutarate sensor that details PII-NAGK complex formation. PLoS One (2013) 0.83
Mechanism of disruption of the Amt-GlnK complex by P(II)-mediated sensing of 2-oxoglutarate. PLoS One (2011) 0.83
PipX, the coactivator of NtcA, is a global regulator in cyanobacteria. Proc Natl Acad Sci U S A (2014) 0.82
Crystal structure of the GlnZ-DraG complex reveals a different form of PII-target interaction. Proc Natl Acad Sci U S A (2011) 0.81
Energy Sensing versus 2-Oxoglutarate Dependent ATPase Switch in the Control of Synechococcus PII Interaction with Its Targets NAGK and PipX. PLoS One (2015) 0.78
Population shift of binding pocket size and dynamic correlation analysis shed new light on the anticooperative mechanism of PII protein. Proteins (2013) 0.78
The Emergence of 2-Oxoglutarate as a Master Regulator Metabolite. Microbiol Mol Biol Rev (2015) 0.78
The nitrogenase regulatory enzyme dinitrogenase reductase ADP-ribosyltransferase (DraT) is activated by direct interaction with the signal transduction protein GlnB. J Bacteriol (2012) 0.76
Interaction of the Nitrogen Regulatory Protein GlnB (PII) with Biotin Carboxyl Carrier Protein (BCCP) Controls Acetyl-CoA Levels in the Cyanobacterium Synechocystis sp. PCC 6803. Front Microbiol (2016) 0.75
Toward Multiscale Models of Cyanobacterial Growth: A Modular Approach. Front Bioeng Biotechnol (2016) 0.75
ATPase as a switch in P(II) signal transduction. Proc Natl Acad Sci U S A (2013) 0.75
Molecular basis for the distinct divalent cation requirement in the uridylylation of the signal transduction proteins GlnJ and GlnB from Rhodospirillum rubrum. BMC Microbiol (2012) 0.75
rre37 Overexpression alters gene expression related to the tricarboxylic acid cycle and pyruvate metabolism in Synechocystis sp. PCC 6803. ScientificWorldJournal (2014) 0.75
Expanding the Cyanobacterial Nitrogen Regulatory Network: The GntR-Like Regulator PlmA Interacts with the PII-PipX Complex. Front Microbiol (2016) 0.75
A PII-Like Protein Regulated by Bicarbonate: Structural and Biochemical Studies of the Carboxysome-Associated CPII Protein. J Mol Biol (2016) 0.75
Metabolic pathway engineering using the central signal processor PII. Microb Cell Fact (2015) 0.75
Coot: model-building tools for molecular graphics. Acta Crystallogr D Biol Crystallogr (2004) 227.01
Refinement of macromolecular structures by the maximum-likelihood method. Acta Crystallogr D Biol Crystallogr (1997) 137.43
XDS. Acta Crystallogr D Biol Crystallogr (2010) 67.46
Use of T7 RNA polymerase to direct expression of cloned genes. Methods Enzymol (1990) 61.47
Role of glnB and glnD gene products in regulation of the glnALG operon of Escherichia coli. J Bacteriol (1985) 4.19
PII signal transduction proteins: sensors of alpha-ketoglutarate that regulate nitrogen metabolism. Curr Opin Microbiol (2005) 2.25
Nitrogen regulation in bacteria and archaea. Annu Rev Microbiol (2007) 2.10
The crystal structure of the Escherichia coli AmtB-GlnK complex reveals how GlnK regulates the ammonia channel. Proc Natl Acad Sci U S A (2007) 1.98
The Synechococcus elongatus P signal transduction protein controls arginine synthesis by complex formation with N-acetyl-L-glutamate kinase. Mol Microbiol (2004) 1.97
Global carbon/nitrogen control by PII signal transduction in cyanobacteria: from signals to targets. FEMS Microbiol Rev (2004) 1.96
Inhibitory complex of the transmembrane ammonia channel, AmtB, and the cytosolic regulatory protein, GlnK, at 1.96 A. Proc Natl Acad Sci U S A (2006) 1.85
GlnK, a PII-homologue: structure reveals ATP binding site and indicates how the T-loops may be involved in molecular recognition. J Mol Biol (1998) 1.75
Structure/function analysis of the PII signal transduction protein of Escherichia coli: genetic separation of interactions with protein receptors. J Bacteriol (1997) 1.69
P(II) signal transducers: novel functional and structural insights. Trends Microbiol (2008) 1.63
Regulation of autophosphorylation of Escherichia coli nitrogen regulator II by the PII signal transduction protein. J Bacteriol (1999) 1.49
Escherichia coli PII signal transduction protein controlling nitrogen assimilation acts as a sensor of adenylate energy charge in vitro. Biochemistry (2007) 1.42
Interaction network in cyanobacterial nitrogen regulation: PipX, a protein that interacts in a 2-oxoglutarate dependent manner with PII and NtcA. Mol Microbiol (2006) 1.34
Structure of GlnK1 with bound effectors indicates regulatory mechanism for ammonia uptake. EMBO J (2007) 1.25
The crystal structure of the complex of PII and acetylglutamate kinase reveals how PII controls the storage of nitrogen as arginine. Proc Natl Acad Sci U S A (2007) 1.23
Phosphoprotein PII from cyanobacteria--analysis of functional conservation with the PII signal-transduction protein from Escherichia coli. Eur J Biochem (1997) 1.20
The structures of the PII proteins from the cyanobacteria Synechococcus sp. PCC 7942 and Synechocystis sp. PCC 6803. Acta Crystallogr D Biol Crystallogr (2003) 1.16
Structural basis for the regulation of NtcA-dependent transcription by proteins PipX and PII. Proc Natl Acad Sci U S A (2010) 1.15
Complex formation and catalytic activation by the PII signaling protein of N-acetyl-L-glutamate kinase from Synechococcus elongatus strain PCC 7942. J Biol Chem (2004) 1.14
A new P(II) protein structure identifies the 2-oxoglutarate binding site. J Mol Biol (2010) 1.14
The PII superfamily revised: a novel group and evolutionary insights. J Mol Evol (2009) 1.12
Interactions between the nitrogen signal transduction protein PII and N-acetyl glutamate kinase in organisms that perform oxygenic photosynthesis. J Bacteriol (2004) 1.11
Crystal structures of the signal transducing protein GlnK from Thermus thermophilus HB8. J Struct Biol (2005) 1.10
Molecular properties of the putative nitrogen sensor PII from Arabidopsis thaliana. Plant J (2003) 1.09
Chloroplast acetyl-CoA carboxylase activity is 2-oxoglutarate-regulated by interaction of PII with the biotin carboxyl carrier subunit. Proc Natl Acad Sci U S A (2009) 1.04
Structural basis for the regulation of N-acetylglutamate kinase by PII in Arabidopsis thaliana. J Biol Chem (2007) 1.01
Alpha-ketoglutarate controls the ability of the Escherichia coli PII signal transduction protein to regulate the activities of NRII (NrB but does not control the binding of PII to NRII. Biochemistry (2009) 0.93
A novel signal transduction protein P(II) variant from Synechococcus elongatus PCC 7942 indicates a two-step process for NAGK-P(II) complex formation. J Mol Biol (2010) 0.92
Cooperative binding of MgATP and MgADP in the trimeric P(II) protein GlnK2 from Archaeoglobus fulgidus. J Mol Biol (2010) 0.90
N-acetyl-L-glutamate kinase (NAGK) from oxygenic phototrophs: P(II) signal transduction across domains of life reveals novel insights in NAGK control. J Mol Biol (2009) 0.88
Structure of the human voltage-dependent anion channel. Proc Natl Acad Sci U S A (2008) 2.69
Substrate recognition by the AAA+ chaperone ClpB. Nat Struct Mol Biol (2004) 2.19
AAA+ proteins and substrate recognition, it all depends on their partner in crime. FEBS Lett (2002) 2.10
Structure and activity of the N-terminal substrate recognition domains in proteasomal ATPases. Mol Cell (2009) 2.05
The Synechococcus elongatus P signal transduction protein controls arginine synthesis by complex formation with N-acetyl-L-glutamate kinase. Mol Microbiol (2004) 1.97
Molecular details of Bax activation, oligomerization, and membrane insertion. J Biol Chem (2009) 1.60
Acclimation of unicellular cyanobacteria to macronutrient deficiency: emergence of a complex network of cellular responses. Microbiology (2005) 1.42
Regulatory links between carbon and nitrogen metabolism. Curr Opin Microbiol (2006) 1.40
Structural basis of outer membrane protein biogenesis in bacteria. J Biol Chem (2011) 1.38
Interaction network in cyanobacterial nitrogen regulation: PipX, a protein that interacts in a 2-oxoglutarate dependent manner with PII and NtcA. Mol Microbiol (2006) 1.34
The mechanisms of HAMP-mediated signaling in transmembrane receptors. Structure (2011) 1.30
The crystal structure of the complex of PII and acetylglutamate kinase reveals how PII controls the storage of nitrogen as arginine. Proc Natl Acad Sci U S A (2007) 1.23
Correct folding of the beta-barrel of the human membrane protein VDAC requires a lipid bilayer. J Mol Biol (2007) 1.21
Structure of the head of the Bartonella adhesin BadA. PLoS Pathog (2008) 1.17
The structures of the PII proteins from the cyanobacteria Synechococcus sp. PCC 7942 and Synechocystis sp. PCC 6803. Acta Crystallogr D Biol Crystallogr (2003) 1.16
Structural basis for the regulation of NtcA-dependent transcription by proteins PipX and PII. Proc Natl Acad Sci U S A (2010) 1.15
Complex formation and catalytic activation by the PII signaling protein of N-acetyl-L-glutamate kinase from Synechococcus elongatus strain PCC 7942. J Biol Chem (2004) 1.14
Structural analysis of the PP2C phosphatase tPphA from Thermosynechococcus elongatus: a flexible flap subdomain controls access to the catalytic site. J Mol Biol (2007) 1.14
The 3D structures of VDAC represent a native conformation. Trends Biochem Sci (2010) 1.13
Mechanism of regulation of receptor histidine kinases. Structure (2012) 1.13
Structural basis of N-end rule substrate recognition in Escherichia coli by the ClpAP adaptor protein ClpS. EMBO Rep (2009) 1.10
Purification of the YadA membrane anchor for secondary structure analysis and crystallization. Int J Biol Macromol (2006) 1.09
Omp85 from the thermophilic cyanobacterium Thermosynechococcus elongatus differs from proteobacterial Omp85 in structure and domain composition. J Biol Chem (2010) 1.07
A coiled-coil motif that sequesters ions to the hydrophobic core. Proc Natl Acad Sci U S A (2009) 1.07
High-level expression, refolding and probing the natural fold of the human voltage-dependent anion channel isoforms I and II. J Membr Biol (2007) 1.06
Metabolic and transcriptomic phenotyping of inorganic carbon acclimation in the Cyanobacterium Synechococcus elongatus PCC 7942. Plant Physiol (2011) 1.06
Signal transduction protein P(II) is required for NtcA-regulated gene expression during nitrogen deprivation in the cyanobacterium Synechococcus elongatus strain PCC 7942. J Bacteriol (2003) 1.04
Interaction of the membrane-bound GlnK-AmtB complex with the master regulator of nitrogen metabolism TnrA in Bacillus subtilis. J Biol Chem (2006) 1.03
Structure of a halophilic nucleoside diphosphate kinase from Halobacterium salinarum. FEBS Lett (2005) 1.02
The novel protein phosphatase PphA from Synechocystis PCC 6803 controls dephosphorylation of the signalling protein PII. Mol Microbiol (2002) 1.02
The Tim21 binding domain connects the preprotein translocases of both mitochondrial membranes. EMBO Rep (2006) 1.00
The morphogene AmiC2 is pivotal for multicellular development in the cyanobacterium Nostoc punctiforme. Mol Microbiol (2011) 1.00
PII-regulated arginine synthesis controls accumulation of cyanophycin in Synechocystis sp. strain PCC 6803. J Bacteriol (2006) 1.00
A new expression system for protein crystallization using trimeric coiled-coil adaptors. Protein Eng Des Sel (2007) 0.98
Transcript profiling reveals new insights into the acclimation of the mesophilic fresh-water cyanobacterium Synechococcus elongatus PCC 7942 to iron starvation. Plant Physiol (2008) 0.98
Requirement of the nitrogen starvation-induced protein Sll0783 for polyhydroxybutyrate accumulation in Synechocystis sp. strain PCC 6803. Appl Environ Microbiol (2010) 0.97
Ammonia triggers photodamage of photosystem II in the cyanobacterium Synechocystis sp. strain PCC 6803. Plant Physiol (2008) 0.97
Carbon-source-dependent nitrogen regulation in Escherichia coli is mediated through glutamine-dependent GlnB signalling. Microbiology (2003) 0.95
Conformational changes and protein stability of the pro-apoptotic protein Bax. J Bioenerg Biomembr (2009) 0.95
Conserved residues in the N-domain of the AAA+ chaperone ClpA regulate substrate recognition and unfolding. FEBS J (2008) 0.93
Role of the Synechococcus PCC 7942 nitrogen regulator protein PipX in NtcA-controlled processes. Microbiology (2007) 0.93
Identification of proteins targeted by the thioredoxin superfamily in Plasmodium falciparum. PLoS Pathog (2009) 0.93
Dodecins: a family of lumichrome binding proteins. J Mol Biol (2006) 0.92
A third metal is required for catalytic activity of the signal-transducing protein phosphatase M tPphA. J Biol Chem (2011) 0.92
Transcription factor TnrA inhibits the biosynthetic activity of glutamine synthetase in Bacillus subtilis. FEBS Lett (2013) 0.92
The structure of RseB: a sensor in periplasmic stress response of E. coli. J Mol Biol (2007) 0.92
A novel signal transduction protein P(II) variant from Synechococcus elongatus PCC 7942 indicates a two-step process for NAGK-P(II) complex formation. J Mol Biol (2010) 0.92
Unique mechanistic features of post-translational regulation of glutamine synthetase activity in Methanosarcina mazei strain Gö1 in response to nitrogen availability. Mol Microbiol (2005) 0.92
A transition from strong right-handed to canonical left-handed supercoiling in a conserved coiled-coil segment of trimeric autotransporter adhesins. J Struct Biol (2010) 0.91
Prokaryotic multicellularity: a nanopore array for bacterial cell communication. FASEB J (2013) 0.91
Protein phosphatase PphA from Synechocystis sp. PCC 6803: the physiological framework of PII-P dephosphorylation. Microbiology (2005) 0.91
Crystal structure and functional mechanism of a human antimicrobial membrane channel. Proc Natl Acad Sci U S A (2013) 0.91
Crystallization and preliminary X-ray data collection of the Escherichia coli lipoproteins BamC, BamD and BamE. Acta Crystallogr Sect F Struct Biol Cryst Commun (2010) 0.90
High resolution crystal structures and molecular dynamics studies reveal substrate binding in the porin Omp32. J Biol Chem (2006) 0.90
Crystal structure of SpoVT, the final modulator of gene expression during spore development in Bacillus subtilis. J Mol Biol (2008) 0.90
Cell-type specific modification of PII is involved in the regulation of nitrogen metabolism in the cyanobacterium Anabaena PCC 7120. FEBS Lett (2004) 0.90
The crystal structure of the dimeric colicin M immunity protein displays a 3D domain swap. J Struct Biol (2012) 0.89
A beta alpha-barrel built by the combination of fragments from different folds. Proc Natl Acad Sci U S A (2008) 0.89
N-acetyl-L-glutamate kinase (NAGK) from oxygenic phototrophs: P(II) signal transduction across domains of life reveals novel insights in NAGK control. J Mol Biol (2009) 0.88
Inactivation of the general transcription factor TnrA in Bacillus subtilis by proteolysis. Microbiology (2008) 0.88
Expression, crystallization and preliminary X-ray crystallographic studies of the outer membrane protein OmpW from Escherichia coli. Acta Crystallogr Sect F Struct Biol Cryst Commun (2006) 0.88
Structure and function of colicin S4, a colicin with a duplicated receptor-binding domain. J Biol Chem (2008) 0.88
Activation of colicin M by the FkpA prolyl cis-trans isomerase/chaperone. J Biol Chem (2010) 0.88
From cyanobacteria to plants: conservation of PII functions during plastid evolution. Planta (2012) 0.88
A CTP-dependent archaeal riboflavin kinase forms a bridge in the evolution of cradle-loop barrels. Structure (2007) 0.87
Signal-transduction protein P(II) from Synechococcus elongatus PCC 7942 senses low adenylate energy charge in vitro. Biochem J (2011) 0.87
Interaction of the general transcription factor TnrA with the PII-like protein GlnK and glutamine synthetase in Bacillus subtilis. FEBS J (2011) 0.87
Structural basis and target-specific modulation of ADP sensing by the Synechococcus elongatus PII signaling protein. J Biol Chem (2014) 0.86
An engineered PII protein variant that senses a novel ligand: atomic resolution structure of the complex with citrate. Acta Crystallogr D Biol Crystallogr (2012) 0.86
Exploiting tertiary structure through local folds for crystallographic phasing. Nat Methods (2013) 0.86
Interaction specificity between the chaperone and proteolytic components of the cyanobacterial Clp protease. Biochem J (2012) 0.85
Structural and mechanistic studies of pesticin, a bacterial homolog of phage lysozymes. J Biol Chem (2012) 0.85
Dodecin sequesters FAD in closed conformation from the aqueous solution. J Mol Biol (2006) 0.85
Role of calcium in acclimation of the cyanobacterium Synechococcus elongatus PCC 7942 to nitrogen starvation. Microbiology (2009) 0.85
Analysis of a non-canonical NtcA-dependent promoter in Synechococcus elongatus and its regulation by NtcA and PII. Arch Microbiol (2005) 0.84
Cell wall amidase AmiC1 is required for cellular communication and heterocyst development in the cyanobacterium Anabaena PCC 7120 but not for filament integrity. J Bacteriol (2012) 0.84
Alanine dehydrogenase activity is required for adequate progression of phycobilisome degradation during nitrogen starvation in Synechococcus elongatus PCC 7942. J Bacteriol (2006) 0.84
Structure of the atypical bacteriocin pectocin M2 implies a novel mechanism of protein uptake. Mol Microbiol (2014) 0.84
Structure and mechanism of iron translocation by a Dps protein from Microbacterium arborescens. J Biol Chem (2011) 0.83
Crystallization and preliminary X-ray crystallographic studies of human voltage-dependent anion channel isoform I (HVDAC1). Acta Crystallogr Sect F Struct Biol Cryst Commun (2008) 0.83
Effects of spontaneous mutations in PipX functions and regulatory complexes on the cyanobacterium Synechococcus elongatus strain PCC 7942. Microbiology (2010) 0.82
The crystal structure of the L1 intermediate of halorhodopsin at 1.9 angstroms resolution. Photochem Photobiol (2007) 0.82
Signal transduction protein PII phosphatase PphA is required for light-dependent control of nitrate utilization in synechocystis sp. strain PCC 6803. J Bacteriol (2005) 0.82
Determinants for substrate specificity of the bacterial PP2C protein phosphatase tPphA from Thermosynechococcus elongatus. FEBS J (2012) 0.82
Expression, crystallization and crystallographic analysis of DegS, a stress sensor of the bacterial periplasm. Acta Crystallogr D Biol Crystallogr (2004) 0.81
Characterization of the insertase BamA in three different membrane mimetics by solution NMR spectroscopy. J Biomol NMR (2015) 0.81
The bacterial signal transduction protein GlnB regulates the committed step in fatty acid biosynthesis by acting as a dissociable regulatory subunit of acetyl-CoA carboxylase. Mol Microbiol (2015) 0.80
Ammonium tolerance in the cyanobacterium Synechocystis sp. strain PCC 6803 and the role of the psbA multigene family. Plant Cell Environ (2013) 0.80
Novel ATP-driven pathway of glycolipid export involving TolC protein. J Biol Chem (2011) 0.79
Functional refolding and characterization of two Tom40 isoforms from human mitochondria. J Membr Biol (2011) 0.79
Population shift of binding pocket size and dynamic correlation analysis shed new light on the anticooperative mechanism of PII protein. Proteins (2013) 0.78
PII signal transduction protein in Chlamydomonas reinhardtii: localization and expression pattern. Protist (2012) 0.77
DevT (Alr4674), resembling a Ser/Thr protein phosphatase, is essential for heterocyst function in the cyanobacterium Anabaena sp. PCC 7120. Microbiology (2010) 0.77
Dermcidin: what is its antibiotic potential? Future Microbiol (2013) 0.76
The Role of Arg13 in Protein Phosphatase M tPphA from Thermosynechococcus elongatus. Enzyme Res (2012) 0.75
Expression, purification and crystallization of the Cmi immunity protein from Escherichia coli. Acta Crystallogr Sect F Struct Biol Cryst Commun (2011) 0.75