PubRank

Koichi Furukawa

Author PubWeight™ 119.17‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Gene silencing in cancer by histone H3 lysine 27 trimethylation independent of promoter DNA methylation. Nat Genet 2008 5.08
2 RNA polymerase II is required for RNAi-dependent heterochromatin assembly. Science 2005 3.94
3 Complex formation of Plk1 and INCENP required for metaphase-anaphase transition. Nat Cell Biol 2005 2.41
4 Gangliosides GM1 and GM3 in the living cell membrane form clusters susceptible to cholesterol depletion and chilling. Mol Biol Cell 2007 2.38
5 Carbohydrate mimicry between human ganglioside GM1 and Campylobacter jejuni lipooligosaccharide causes Guillain-Barre syndrome. Proc Natl Acad Sci U S A 2004 2.16
6 Autophosphorylation of a newly identified site of Aurora-B is indispensable for cytokinesis. J Biol Chem 2004 1.97
7 Anti-GD1a antibodies activate complement and calpain to injure distal motor nodes of Ranvier in mice. Brain 2010 1.90
8 O-linked N-acetylglucosamine is present on the extracellular domain of notch receptors. J Biol Chem 2008 1.65
9 Silencing effect of CpG island hypermethylation and histone modifications on O6-methylguanine-DNA methyltransferase (MGMT) gene expression in human cancer. Oncogene 2003 1.47
10 Targeted disruption of Gb3/CD77 synthase gene resulted in the complete deletion of globo-series glycosphingolipids and loss of sensitivity to verotoxins. J Biol Chem 2006 1.44
11 O-linked-N-acetylglucosamine on extracellular protein domains mediates epithelial cell-matrix interactions. Nat Commun 2011 1.42
12 b-series Ganglioside deficiency exhibits no definite changes in the neurogenesis and the sensitivity to Fas-mediated apoptosis but impairs regeneration of the lesioned hypoglossal nerve. J Biol Chem 2001 1.38
13 Aurora-B associated protein phosphatases as negative regulators of kinase activation. Oncogene 2002 1.37
14 Gangliosides contribute to stability of paranodal junctions and ion channel clusters in myelinated nerve fibers. Glia 2007 1.36
15 Ganglioside GD3 expression on target cells can modulate NK cell cytotoxicity via siglec-7-dependent and -independent mechanisms. Eur J Immunol 2003 1.35
16 Gene therapy for mitochondrial disease by delivering restriction endonuclease SmaI into mitochondria. J Biomed Sci 2002 1.29
17 Direct association with inner centromere protein (INCENP) activates the novel chromosomal passenger protein, Aurora-C. J Biol Chem 2004 1.23
18 O-linked-N-acetylglucosamine modification of mammalian Notch receptors by an atypical O-GlcNAc transferase Eogt1. Biochem Biophys Res Commun 2012 1.21
19 Degradation of human Aurora-A protein kinase is mediated by hCdh1. FEBS Lett 2002 1.20
20 Analysis of the role of Aurora B on the chromosomal targeting of condensin I. Nucleic Acids Res 2007 1.14
21 Tolerance to self gangliosides is the major factor restricting the antibody response to lipopolysaccharide core oligosaccharides in Campylobacter jejuni strains associated with Guillain-Barré syndrome. Infect Immun 2002 1.13
22 Immunologic glycosphingolipidomics and NKT cell development in mouse thymus. J Proteome Res 2009 1.11
23 Ganglioside GD3 promotes cell growth and invasion through p130Cas and paxillin in malignant melanoma cells. Proc Natl Acad Sci U S A 2005 1.06
24 Complex gangliosides at the neuromuscular junction are membrane receptors for autoantibodies and botulinum neurotoxin but redundant for normal synaptic function. J Neurosci 2002 1.05
25 TRP channels and ASICs mediate mechanical hyperalgesia in models of inflammatory muscle pain and delayed onset muscle soreness. Pain 2008 1.04
26 Mechanisms for the apoptosis of small cell lung cancer cells induced by anti-GD2 monoclonal antibodies: roles of anoikis. J Biol Chem 2005 1.04
27 Overexpressed GM1 suppresses nerve growth factor (NGF) signals by modulating the intracellular localization of NGF receptors and membrane fluidity in PC12 cells. J Biol Chem 2004 1.03
28 Overexpression of GD1a ganglioside sensitizes motor nerve terminals to anti-GD1a antibody-mediated injury in a model of acute motor axonal neuropathy. J Neurosci 2005 1.02
29 Mitotic regulation of the stability of microtubule plus-end tracking protein EB3 by ubiquitin ligase SIAH-1 and Aurora mitotic kinases. J Biol Chem 2009 1.02
30 Cholera toxin activates dendritic cells through dependence on GM1-ganglioside which is mediated by NF-kappaB translocation. Eur J Immunol 2003 1.01
31 Loss of disialyl Lewis(a), the ligand for lymphocyte inhibitory receptor sialic acid-binding immunoglobulin-like lectin-7 (Siglec-7) associated with increased sialyl Lewis(a) expression on human colon cancers. Cancer Res 2004 1.01
32 The neuropathic potential of anti-GM1 autoantibodies is regulated by the local glycolipid environment in mice. J Clin Invest 2009 1.00
33 Overexpression of ganglioside GM1 results in the dispersion of platelet-derived growth factor receptor from glycolipid-enriched microdomains and in the suppression of cell growth signals. J Biol Chem 2002 0.99
34 Gangliosides are essential in the protection of inflammation and neurodegeneration via maintenance of lipid rafts: elucidation by a series of ganglioside-deficient mutant mice. J Neurochem 2011 0.98
35 Characterisation of the immunoglobulin variable region gene usage encoding the murine anti-ganglioside antibody repertoire. J Neuroimmunol 2005 0.98
36 Refractory skin injury in complex knock-out mice expressing only the GM3 ganglioside. J Biol Chem 2002 0.97
37 Gangliosides play pivotal roles in the regulation of complement systems and in the maintenance of integrity in nerve tissues. Proc Natl Acad Sci U S A 2009 0.97
38 Synthesis of disialyl Lewis a (Le(a)) structure in colon cancer cell lines by a sialyltransferase, ST6GalNAc VI, responsible for the synthesis of alpha-series gangliosides. J Biol Chem 2003 0.96
39 Ganglioside GD3 enhances adhesion signals and augments malignant properties of melanoma cells by recruiting integrins to glycolipid-enriched microdomains. J Biol Chem 2010 0.96
40 GTDC2 modifies O-mannosylated α-dystroglycan in the endoplasmic reticulum to generate N-acetyl glucosamine epitopes reactive with CTD110.6 antibody. Biochem Biophys Res Commun 2013 0.95
41 Innate murine B cells produce anti-disialosyl antibodies reactive with Campylobacter jejuni LPS and gangliosides that are polyreactive and encoded by a restricted set of unmutated V genes. J Neuroimmunol 2004 0.94
42 Focal adhesion kinase as well as p130Cas and paxillin is crucially involved in the enhanced malignant properties under expression of ganglioside GD3 in melanoma cells. Biochim Biophys Acta 2007 0.94
43 Murine glycosyltransferases responsible for the expression of globo-series glycolipids: cDNA structures, mRNA expression, and distribution of their products. Glycobiology 2005 0.93
44 Reduced motor and sensory functions and emotional response in GM3-only mice: emergence from early stage of life and exacerbation with aging. Behav Brain Res 2008 0.93
45 Clostridium perfringens alpha-toxin recognizes the GM1a-TrkA complex. J Biol Chem 2012 0.92
46 C9-R95X polymorphism in patients with neovascular age-related macular degeneration. Invest Ophthalmol Vis Sci 2012 0.92
47 Overexpression of caveolin-1 in a human melanoma cell line results in dispersion of ganglioside GD3 from lipid rafts and alteration of leading edges, leading to attenuation of malignant properties. Cancer Sci 2007 0.91
48 Gangliosides determine the amyloid pathology of Alzheimer's disease. Neuroreport 2009 0.91
49 Different response of the knockout mice lacking b-series gangliosides against botulinum and tetanus toxins. Biochim Biophys Acta 2005 0.90
50 Essential roles of gangliosides in the formation and maintenance of membrane microdomains in brain tissues. Neurochem Res 2012 0.89
51 The blood group P1 synthase gene is identical to the Gb3/CD77 synthase gene. A clue to the solution of the P1/P2/p puzzle. J Biol Chem 2003 0.89
52 Identification of a Drosophila gene encoding xylosylprotein beta4-galactosyltransferase that is essential for the synthesis of glycosaminoglycans and for morphogenesis. J Biol Chem 2002 0.89
53 Proteomic analysis of ganglioside-associated membrane molecules: substantial basis for molecular clustering. Proteomics 2012 0.88
54 A novel, promoter-based, target-specific assay identifies 2-deoxy-D-glucose as an inhibitor of globotriaosylceramide biosynthesis. FEBS J 2009 0.88
55 β4GalT6 is involved in the synthesis of lactosylceramide with less intensity than β4GalT5. Glycobiology 2013 0.87
56 Developmental stage-dependent expression of an alpha2,8-trisialic acid unit on glycoproteins in mouse brain. Glycobiology 2010 0.87
57 Functional activation of Src family kinase yes protein is essential for the enhanced malignant properties of human melanoma cells expressing ganglioside GD3. J Biol Chem 2011 0.87
58 Metastatic potential of mouse Lewis lung cancer cells is regulated via ganglioside GM1 by modulating the matrix metalloprotease-9 localization in lipid rafts. J Biol Chem 2006 0.87
59 O-GlcNAc modification of the extracellular domain of Notch receptors. Methods Enzymol 2010 0.86
60 Essential roles of integrin-mediated signaling for the enhancement of malignant properties of melanomas based on the expression of GD3. Biochem Biophys Res Commun 2008 0.86
61 Increased globotriaosylceramide levels in a transgenic mouse expressing human alpha1,4-galactosyltransferase and a mouse model for treating Fabry disease. J Biochem 2010 0.86
62 Molecular cloning and expression of human ST6GalNAc III: restricted tissue distribution and substrate specificity. J Biochem 2005 0.86
63 Positive feedback loop between PI3K-Akt-mTORC1 signaling and the lipogenic pathway boosts Akt signaling: induction of the lipogenic pathway by a melanoma antigen. Cancer Res 2011 0.86
64 GM1 / GD1b / GA1 synthase expression results in the reduced cancer phenotypes with modulation of composition and raft-localization of gangliosides in a melanoma cell line. Cancer Sci 2010 0.86
65 Role of estrogen receptor-related antigen in initiating the growth of human glioma cells. J Neurosurg 2004 0.86
66 An anti-GD2 monoclonal antibody enhances apoptotic effects of anti-cancer drugs against small cell lung cancer cells via JNK (c-Jun terminal kinase) activation. Jpn J Cancer Res 2002 0.85
67 Glycosphingolipids are not pivotal receptors for Subtilase cytotoxin in vivo: sensitivity analysis with glycosylation-defective mutant mice. Biochem Biophys Res Commun 2008 0.85
68 Enhancement of malignant properties of human osteosarcoma cells with disialyl gangliosides GD2/GD3. Cancer Sci 2012 0.85
69 Disruption of GM2/GD2 synthase gene resulted in overt expression of 9-O-acetyl GD3 irrespective of Tis21. J Neurochem 2008 0.84
70 pp-GalNAc-T13 induces high metastatic potential of murine Lewis lung cancer by generating trimeric Tn antigen. Biochem Biophys Res Commun 2012 0.84
71 Over-expression of GM1 enhances cell proliferation with epidermal growth factor without affecting the receptor localization in the microdomain in PC12 cells. Int J Oncol 2005 0.83
72 Neuromuscular synaptic transmission in aged ganglioside-deficient mice. Neurobiol Aging 2009 0.83
73 GD3 synthase gene knockout mice exhibit thermal hyperalgesia and mechanical allodynia but decreased response to formalin-induced prolonged noxious stimulation. Pain 2005 0.83
74 Neuronal expression of GalNAc transferase is sufficient to prevent the age-related neurodegenerative phenotype of complex ganglioside-deficient mice. J Neurosci 2014 0.82
75 Isolation and functional analysis of the melanoma specific promoter region of human GD3 synthase gene. Biochim Biophys Acta 2003 0.82
76 Dysfunction of muscarinic acetylcholine receptors as a substantial basis for progressive neurological deterioration in GM3-only mice. Behav Brain Res 2009 0.82
77 Membrane sialidase NEU3 is highly expressed in human melanoma cells promoting cell growth with minimal changes in the composition of gangliosides. Cancer Sci 2011 0.81
78 Plasma membrane rafts complete cholesterol synthesis by participating in retrograde movement of precursor sterols. J Biol Chem 2007 0.81
79 Suppression of lung metastasis of mouse Lewis lung cancer P29 with transfection of the ganglioside GM2/GD2 synthase gene. Int J Cancer 2003 0.81
80 Na(+)-independent Mg(2+) transport sensitive to 2-aminoethoxydiphenyl borate (2-APB) in vascular smooth muscle cells: involvement of TRPM-like channels. J Cell Mol Med 2008 0.81
81 Wisp2/CCN5 up-regulated in the central nervous system of GM3-only mice facilitates neurite formation in Neuro2a cells via integrin-Akt signaling. Biochem Biophys Res Commun 2011 0.80
82 Identification and expression of a sialyltransferase responsible for the synthesis of disialylgalactosylgloboside in normal and malignant kidney cells: downregulation of ST6GalNAc VI in renal cancers. Biochem J 2007 0.80
83 Expansion of natural killer cells in mice transgenic for IgM antibody to ganglioside GD2: demonstration of prolonged survival after challenge with syngeneic tumor cells. Int J Oncol 2003 0.80
84 Simultaneous combined balloon-occluded retrograde transvenous obliteration and partial splenic embolization for portosystemic shunts. J Vasc Interv Radiol 2012 0.80
85 Impaired hypoglossal nerve regeneration in mutant mice lacking complex gangliosides: down-regulation of neurotrophic factors and receptors as possible mechanisms. Glycobiology 2008 0.80
86 Induction of cellular immunity by anti-idiotypic antibodies mimicking GD2 ganglioside. Cancer Immunol Immunother 2003 0.80
87 Roles of complex gangliosides at the neuromuscular junction. Ann N Y Acad Sci 2003 0.79
88 Involvement of NGF in the rat model of persistent muscle pain associated with taut band. J Pain 2011 0.79
89 Differential enhancing effects of alpha2,8-sialyltransferase on the cell proliferation and mobility. Int J Oncol 2005 0.79
90 Stable transfection of GM1 synthase gene into GM1-deficient NG108-15 cells, CR-72 cells, rescues the responsiveness of Trk-neurotrophin receptor to its ligand, NGF. Neurochem Res 2002 0.78
91 Total ganglioside ablation at mouse motor nerve terminals alters neurotransmitter release level. Synapse 2010 0.78
92 Roles of complex gangliosides in the development of experimental autoimmune encephalomyelitis. Glycobiology 2008 0.78
93 Expression of the Gb3/CD77 synthase gene in megakaryoblastic leukemia cells: implication in the sensitivity to verotoxins. J Biol Chem 2002 0.78
94 Trimeric Tn antigen on syndecan 1 produced by ppGalNAc-T13 enhances cancer metastasis via a complex formation with integrin α5β1 and matrix metalloproteinase 9. J Biol Chem 2013 0.78
95 Morphological study of disordered myelination and the degeneration of nerve fibers in the spinal cord of mice lacking complex gangliosides. Arch Histol Cytol 2003 0.78
96 Impaired hippocampal long-term potentiation and failure of learning in β1,4-N-acetylgalactosaminyltransferase gene transgenic mice. Glycobiology 2011 0.78
97 [A case of gastric cancer with abdominal wall invasion treated by weekly low-dose paclitaxel therapy]. Gan To Kagaku Ryoho 2006 0.78
98 Efficient generation of useful monoclonal antibodies reactive with globotriaosylceramide using knockout mice lacking Gb3/CD77 synthase. Glycoconj J 2011 0.78
99 TLR4-MD-2 complex is negatively regulated by an endogenous ligand, globotetraosylceramide. Proc Natl Acad Sci U S A 2013 0.78
100 In vitro analysis of glial cell function in ganglioside-deficient mice. J Neurosci Res 2009 0.77
101 Binding of a sialic acid-recognizing lectin Siglec-9 modulates adhesion dynamics of cancer cells via calpain-mediated protein degradation. J Biol Chem 2013 0.77
102 Genetic mechanisms for the synthesis of fucosyl GM1 in small cell lung cancer cell lines. Glycobiology 2006 0.77
103 Deficits in cognitive function and hippocampal plasticity in GM2/GD2 synthase knockout mice. Hippocampus 2014 0.77
104 Ganglioside GD3 induces convergence and synergism of adhesion and hepatocyte growth factor/Met signals in melanomas. Cancer Sci 2013 0.76
105 Lewis y antigen is expressed in oral squamous cell carcinoma cell lines and tissues, but disappears in the invasive regions leading to the enhanced malignant properties irrespective of sialyl-Lewis x. Glycoconj J 2012 0.76
106 Expression and roles of a xenopus head-forming gene homologue in human cancer cell lines. Nagoya J Med Sci 2008 0.76
107 GM1 expression in H-ras-transformed NIH3T3 results in the suppression of cell proliferation inducing the partial transfer of activated H-ras from non-raft to raft fraction. Int J Oncol 2005 0.76
108 Cutting edge: Guillain-Barre syndrome-associated IgG responses to gangliosides are generated independently of CD1 function in mice. J Immunol 2008 0.76
109 Heart slice NMR. Am J Physiol Heart Circ Physiol 2006 0.76
110 [Glycobiology basics: glycolipids]. Tanpakushitsu Kakusan Koso 2003 0.75
111 Strong antibody reaction against glycosphingolipids injected in liposome-embedded forms in beta3GN-T5 knockout mice. Nagoya J Med Sci 2011 0.75
112 Impairment of hippocampal long-term potentiation and failure of learning in mice treated with d-threo-1-phenyl-2-decanoylamino-3-morpholino-1-propanol. Biomed Res 2012 0.75
113 The effects of age and ganglioside composition on the rate of motor nerve terminal regeneration following antibody-mediated injury in mice. Synapse 2013 0.75
114 Imipramine inhibition of TRPM-like plasmalemmal Mg2+ transport in vascular smooth muscle cells. J Cell Mol Med 2011 0.75
115 Lack of antibody response to Guillain-Barré syndrome-related gangliosides in mice and men after novel flu vaccination. J Neurol Neurosurg Psychiatry 2010 0.75
116 Expression of LY6D is induced at the surface of MCF10A cells by X-ray irradiation. FEBS J 2012 0.75
117 Down-regulation of caveolin-1 in mouse Lewis lung cancer P29 is a causal factor for the malignant properties in a high-metastatic subline. Oncol Rep 2006 0.75
118 BAFF aids generation of IgG anti-ganglioside antibodies in response to Campylobacter jejuni lipo-oligosaccharide. J Neuroimmunol 2009 0.75
119 Jejunal varices after choledochojejunostomy treated with laparotomic transcatheter variceal embolization. Nihon Shokakibyo Gakkai Zasshi 2016 0.75
120 [Molecular dynamics and regulatory mechanisms for signals of glycosphingolipids in membrane lipid rafts]. Seikagaku 2016 0.75
121 Incorporation, remodeling and re-expression of exogenous gangliosides in human cancer cell lines in vitro and in vivo. Nagoya J Med Sci 2004 0.75
122 [New perspectives on glycology for the progress of neurobiology]. Tanpakushitsu Kakusan Koso 2004 0.75