Published in J Exp Med on December 01, 2003
Promiscuous gene expression in thymic epithelial cells is regulated at multiple levels. J Exp Med (2005) 4.06
Central tolerance to tissue-specific antigens mediated by direct and indirect antigen presentation. J Exp Med (2004) 3.30
Spontaneous autoimmunity prevented by thymic expression of a single self-antigen. J Exp Med (2006) 3.20
A look at autoimmunity and inflammation in the eye. J Clin Invest (2010) 2.30
Deaf1 isoforms control the expression of genes encoding peripheral tissue antigens in the pancreatic lymph nodes during type 1 diabetes. Nat Immunol (2009) 1.65
Endogenous IRBP can be dispensable for generation of natural CD4+CD25+ regulatory T cells that protect from IRBP-induced retinal autoimmunity. J Exp Med (2006) 1.34
Autoimmunity in the immune privileged eye: pathogenic and regulatory T cells. Immunol Res (2008) 1.34
Activation of invariant NKT cells ameliorates experimental ocular autoimmunity by a mechanism involving innate IFN-gamma production and dampening of the adaptive Th1 and Th17 responses. J Immunol (2008) 1.26
The living eye "disarms" uncommitted autoreactive T cells by converting them to Foxp3(+) regulatory cells following local antigen recognition. J Immunol (2012) 1.18
Inducible immune regulation following autoimmune disease in the immune-privileged eye. J Leukoc Biol (2005) 1.11
Understanding autoimmune uveitis through animal models. The Friedenwald Lecture. Invest Ophthalmol Vis Sci (2011) 1.11
Repertoire analysis and new pathogenic epitopes of IRBP in C57BL/6 (H-2b) and B10.RIII (H-2r) mice. Invest Ophthalmol Vis Sci (2008) 1.09
Hydrodynamic vaccination with DNA encoding an immunologically privileged retinal antigen protects from autoimmunity through induction of regulatory T cells. J Immunol (2007) 0.99
Thymic expression of peripheral tissue antigens in humans: a remarkable variability among individuals. Int Immunol (2005) 0.97
Expression of self-antigen in the thymus: a little goes a long way. J Exp Med (2003) 0.96
Parainflammation, chronic inflammation, and age-related macular degeneration. J Leukoc Biol (2015) 0.94
Lymphopenia-induced proliferation is a potent activator for CD4+ T cell-mediated autoimmune disease in the retina. J Immunol (2009) 0.89
Supplementation of CD4+CD25+ regulatory T cells suppresses experimental autoimmune uveoretinitis. Br J Ophthalmol (2006) 0.89
Peripheral induction of tolerance by retinal antigen expression. J Immunol (2009) 0.86
Regulation of CD8(+) T Cell Responses to Retinal Antigen by Local FoxP3(+) Regulatory T Cells. Front Immunol (2012) 0.84
Retinal antigen-specific regulatory T cells protect against spontaneous and induced autoimmunity and require local dendritic cells. J Neuroinflammation (2014) 0.78
Galectin-8 Ameliorates Murine Autoimmune Ocular Pathology and Promotes a Regulatory T Cell Response. PLoS One (2015) 0.78
Targeting the complement system for the management of retinal inflammatory and degenerative diseases. Eur J Pharmacol (2016) 0.78
Generation of Regulatory T Cells to Antigen Expressed in the Retina. Curr Immunol Rev (2015) 0.76
Increased frequency of anti-retina antibodies in asymptomatic patients with chronic t. gondii infection. Clinics (Sao Paulo) (2010) 0.76
A novel pathogenic RBP-3 peptide reveals epitope spreading in persistent experimental autoimmune uveoretinitis. Immunology (2015) 0.75
Projection of an immunological self shadow within the thymus by the aire protein. Science (2002) 12.15
Origin of regulatory T cells with known specificity for antigen. Nat Immunol (2002) 7.49
Promiscuous gene expression in medullary thymic epithelial cells mirrors the peripheral self. Nat Immunol (2001) 7.30
Cutting edge: CD4+CD25+ regulatory T cells suppress antigen-specific autoreactive immune responses and central nervous system inflammation during active experimental autoimmune encephalomyelitis. J Immunol (2002) 4.95
Control of T-cell activation by CD4+ CD25+ suppressor T cells. Immunol Rev (2001) 3.70
Shaping of the autoreactive T-cell repertoire by a splice variant of self protein expressed in thymic epithelial cells. Nat Med (2000) 2.94
A new model of autoimmune disease. Experimental autoimmune uveoretinitis induced in mice with two different retinal antigens. J Immunol (1988) 2.68
Cutting edge: depletion of CD4+CD25+ regulatory T cells is necessary, but not sufficient, for induction of organ-specific autoimmune disease. J Immunol (2002) 2.51
High frequency of autoreactive myelin proteolipid protein-specific T cells in the periphery of naive mice: mechanisms of selection of the self-reactive repertoire. J Exp Med (2000) 2.10
Differential tolerance is induced in T cells recognizing distinct epitopes of myelin basic protein. Immunity (1998) 1.97
Anterior chamber associated immune deviation (ACAID): regulation, biological relevance, and implications for therapy. Int Rev Immunol (2002) 1.71
Pathology of experimental autoimmune uveoretinitis in mice. J Autoimmun (1990) 1.71
Endogenous myelin basic protein inactivates the high avidity T cell repertoire. J Exp Med (1998) 1.70
Identification of a new epitope of human IRBP that induces autoimmune uveoretinitis in mice of the H-2b haplotype. Invest Ophthalmol Vis Sci (2000) 1.68
Thymic expression of autoantigens correlates with resistance to autoimmune disease. J Immunol (1997) 1.56
Array-based ELISAs for high-throughput analysis of human cytokines. Biotechniques (2001) 1.48
Promiscuous gene expression and central T-cell tolerance: more than meets the eye. Trends Immunol (2002) 1.46
Functional properties of interphotoreceptor retinoid-binding protein. Photochem Photobiol (1991) 1.44
The requirement for pertussis to induce EAU is strain-dependent: B10.RIII, but not B10.A mice, develop EAU and Th1 responses to IRBP without pertussis treatment. Invest Ophthalmol Vis Sci (1999) 1.42
Interphotoreceptor retinoid-binding protein (IRBP). Molecular biology and physiological role in the visual cycle of rhodopsin. Mol Neurobiol (1993) 1.41
Isolation and characterization of monkey interphotoreceptor retinoid-binding protein, a unique extracellular matrix component of the retina. Biochemistry (1985) 1.40
Early onset photoreceptor abnormalities induced by targeted disruption of the interphotoreceptor retinoid-binding protein gene. J Neurosci (1998) 1.40
Identification of a major pathogenic epitope in the human IRBP molecule recognized by mice of the H-2r haplotype. Invest Ophthalmol Vis Sci (1995) 1.37
Sampling of complementing self-antigen pools by thymic stromal cells maximizes the scope of central T cell tolerance. Eur J Immunol (2001) 1.32
Immune mechanisms in uveitis. Springer Semin Immunopathol (1999) 1.23
Retroviral gene therapy with an immunoglobulin-antigen fusion construct protects from experimental autoimmune uveitis. J Clin Invest (2000) 1.22
Regulation of the interaction between Th1 and Th2 T cell clones to provide help for antibody production in vivo. Eur J Immunol (1995) 1.10
The mouse as a model of experimental autoimmune uveoretinitis (EAU). Curr Eye Res (1990) 1.09
The eye's view of antigen presentation. Hum Immunol (2002) 1.05
Autoimmunity in the eye and its regulation. Curr Opin Immunol (1994) 1.05
Human interstitial retinoid binding protein. A potent uveitopathogenic agent for the induction of experimental autoimmune uveitis. J Immunol (1989) 1.00
Transgenic expression of an immunologically privileged retinal antigen extraocularly enhances self tolerance and abrogates susceptibility to autoimmune uveitis. Eur J Immunol (2000) 0.98
Structure-function relationships in interphotoreceptor retinoid-binding protein (IRBP). Mol Vis (1997) 0.94
Spontaneous induction of immunoregulation by an endogenous retinal antigen. Invest Ophthalmol Vis Sci (2002) 0.94
Suppression of experimental autoimmune uveitis in mice by induction of anterior chamber-associated immune deviation with interphotoreceptor retinoid-binding protein. J Immunol (1992) 0.94
Use of ACAID to suppress interphotoreceptor retinoid binding protein-induced experimental autoimmune uveitis. Curr Eye Res (1992) 0.91
Systemic expression of rat soluble retinal antigen induces resistance to experimental autoimmune uveoretinitis. J Immunol (1999) 0.91
Interphotoreceptor retinoid-binding protein (IRBP)-deficient C57BL/6 mice have enhanced immunological and immunopathogenic responses to IRBP and an altered recognition of IRBP epitopes. J Autoimmun (2003) 0.88
IRBP: preparation and characterization of site-specific monoclonal antibodies. Curr Eye Res (1990) 0.80
CD8+ T cell immunity against a tumor/self-antigen is augmented by CD4+ T helper cells and hindered by naturally occurring T regulatory cells. J Immunol (2005) 6.95
Tumor-specific Th17-polarized cells eradicate large established melanoma. Blood (2008) 6.81
Either a Th17 or a Th1 effector response can drive autoimmunity: conditions of disease induction affect dominant effector category. J Exp Med (2008) 5.25
The Rd8 mutation of the Crb1 gene is present in vendor lines of C57BL/6N mice and embryonic stem cells, and confounds ocular induced mutant phenotypes. Invest Ophthalmol Vis Sci (2012) 4.11
Seven new loci associated with age-related macular degeneration. Nat Genet (2013) 3.81
Rapamycin slows aging in mice. Aging Cell (2012) 3.76
Molecular pathology of age-related macular degeneration. Prog Retin Eye Res (2008) 3.35
Age-related macular degeneration. Lancet (2008) 3.34
Spontaneous autoimmunity prevented by thymic expression of a single self-antigen. J Exp Med (2006) 3.20
Cutting edge: NKT cells constitutively express IL-23 receptor and RORgammat and rapidly produce IL-17 upon receptor ligation in an IL-6-independent fashion. J Immunol (2008) 2.90
Th17 cells are long lived and retain a stem cell-like molecular signature. Immunity (2011) 2.64
Murine ccl2/cx3cr1 deficiency results in retinal lesions mimicking human age-related macular degeneration. Invest Ophthalmol Vis Sci (2007) 2.36
Conjunctival T-cell subpopulations in Sjögren's and non-Sjögren's patients with dry eye. Invest Ophthalmol Vis Sci (2002) 2.19
Genetic factors of age-related macular degeneration. Prog Retin Eye Res (2004) 2.17
X-linked retinoschisis: a clinical and molecular genetic review. Surv Ophthalmol (2004) 2.14
Th1 and Th17 cells: adversaries and collaborators. Ann N Y Acad Sci (2010) 2.08
Effective tumor treatment targeting a melanoma/melanocyte-associated antigen triggers severe ocular autoimmunity. Proc Natl Acad Sci U S A (2008) 2.07
Eosinophil-derived neurotoxin acts as an alarmin to activate the TLR2-MyD88 signal pathway in dendritic cells and enhances Th2 immune responses. J Exp Med (2008) 2.04
The involvement of sequence variation and expression of CX3CR1 in the pathogenesis of age-related macular degeneration. FASEB J (2004) 2.04
Vascular endothelial growth factor and diabetic retinopathy: role of oxidative stress. Curr Drug Targets (2005) 1.98
Serum inflammatory markers in diabetic retinopathy. Invest Ophthalmol Vis Sci (2005) 1.92
Innovations in 3D printing: a 3D overview from optics to organs. Br J Ophthalmol (2013) 1.83
Neuroprotective and blood-retinal barrier-preserving effects of cannabidiol in experimental diabetes. Am J Pathol (2006) 1.77
Cytotoxic T lymphocyte-associated antigen 4 blockade in patients with metastatic melanoma: a new cause of uveitis. J Immunother (2004) 1.77
Noncanonical autophagy promotes the visual cycle. Cell (2013) 1.74
Immunopathological aspects of age-related macular degeneration. Semin Immunopathol (2008) 1.63
Macrophage polarization in the maculae of age-related macular degeneration: a pilot study. Pathol Int (2011) 1.62
Peroxynitrite mediates retinal neurodegeneration by inhibiting nerve growth factor survival signaling in experimental and human diabetes. Diabetes (2008) 1.59
Calcitriol suppresses antiretinal autoimmunity through inhibitory effects on the Th17 effector response. J Immunol (2009) 1.57
The role of infectious agents in the etiology of ocular adnexal neoplasia. Surv Ophthalmol (2008) 1.57
Visual cycle: Dependence of retinol production and removal on photoproduct decay and cell morphology. J Gen Physiol (2006) 1.54
A double-masked, randomized study to investigate the safety and efficacy of daclizumab to treat the ocular complications related to Behçet's disease. Ocul Immunol Inflamm (2007) 1.53
Synergic effect of polymorphisms in ERCC6 5' flanking region and complement factor H on age-related macular degeneration predisposition. Proc Natl Acad Sci U S A (2006) 1.52
Essential role of the MyD88 pathway, but nonessential roles of TLRs 2, 4, and 9, in the adjuvant effect promoting Th1-mediated autoimmunity. J Immunol (2005) 1.50
Vitreous cytokine levels. Ophthalmology (2003) 1.48
Complement component C5a promotes expression of IL-22 and IL-17 from human T cells and its implication in age-related macular degeneration. J Transl Med (2011) 1.47
Rodent models of experimental autoimmune uveitis. Methods Mol Med (2004) 1.43
Resolution of autoimmune polyglandular syndrome-associated keratopathy with keratolimbal stem cell transplantation: case report and historical literature review. Cornea (2007) 1.42
Mouse models of MYH9-related disease: mutations in nonmuscle myosin II-A. Blood (2011) 1.41
Retinal ultrastructure of murine models of dry age-related macular degeneration (AMD). Prog Retin Eye Res (2010) 1.39
Pathological findings in eyes with the ganciclovir implant. Ophthalmology (2005) 1.38
Both Th1 and Th17 are immunopathogenic but differ in other key biological activities. J Immunol (2008) 1.36
Transforming growth factor-beta induces expression of vascular endothelial growth factor in human retinal pigment epithelial cells: involvement of mitogen-activated protein kinases. J Cell Physiol (2003) 1.35
Endogenous IRBP can be dispensable for generation of natural CD4+CD25+ regulatory T cells that protect from IRBP-induced retinal autoimmunity. J Exp Med (2006) 1.34
Choroideremia: new findings from ocular pathology and review of recent literature. Surv Ophthalmol (2009) 1.34
Inflammatory mediators in uveitis: differential induction of cytokines and chemokines in Th1- versus Th2-mediated ocular inflammation. J Immunol (2002) 1.33
A humanized model of experimental autoimmune uveitis in HLA class II transgenic mice. J Clin Invest (2003) 1.32
Retinal microglial activation and inflammation induced by amadori-glycated albumin in a rat model of diabetes. Diabetes (2011) 1.31
Biopsy techniques and yields in diagnosing primary intraocular lymphoma. Int Ophthalmol (2007) 1.31
Neuroprotective effect of (-)Delta9-tetrahydrocannabinol and cannabidiol in N-methyl-D-aspartate-induced retinal neurotoxicity: involvement of peroxynitrite. Am J Pathol (2003) 1.30
Aging is not a disease: distinguishing age-related macular degeneration from aging. Prog Retin Eye Res (2013) 1.29
Physiological and microfluorometric studies of reduction and clearance of retinal in bleached rod photoreceptors. J Gen Physiol (2004) 1.29
Hypomethylation of the IL17RC promoter associates with age-related macular degeneration. Cell Rep (2012) 1.28
Dual signaling by innate and adaptive immune receptors is required for TLR7-induced B-cell-mediated autoimmunity. Proc Natl Acad Sci U S A (2012) 1.28
Encapsulated cell-based intraocular delivery of ciliary neurotrophic factor in normal rabbit: dose-dependent effects on ERG and retinal histology. Invest Ophthalmol Vis Sci (2004) 1.27
Activation of invariant NKT cells ameliorates experimental ocular autoimmunity by a mechanism involving innate IFN-gamma production and dampening of the adaptive Th1 and Th17 responses. J Immunol (2008) 1.26
Waldenström's macroglobulinemia-associated retinopathy. Ophthalmology (2004) 1.26
Sympathetic ophthalmia: to the twenty-first century and beyond. J Ophthalmic Inflamm Infect (2013) 1.25
Ophthalmic manifestations, cytology, immunohistochemistry, and molecular analysis of intraocular metastatic T-cell lymphoma: report of a case and review of the literature. Surv Ophthalmol (2008) 1.24
Ophthalmic manifestations and histopathology of xeroderma pigmentosum: two clinicopathological cases and a review of the literature. Surv Ophthalmol (2011) 1.23
Dual effect of CD4+CD25+ regulatory T cells in neurodegeneration: a dialogue with microglia. Proc Natl Acad Sci U S A (2004) 1.22
Immunological protein expression profile in Ccl2/Cx3cr1 deficient mice with lesions similar to age-related macular degeneration. Exp Eye Res (2008) 1.19
Cytokines in autoimmune uveitis. J Interferon Cytokine Res (2011) 1.19
The living eye "disarms" uncommitted autoreactive T cells by converting them to Foxp3(+) regulatory cells following local antigen recognition. J Immunol (2012) 1.18
The LOC387715 polymorphism and age-related macular degeneration: replication in three case-control samples. Invest Ophthalmol Vis Sci (2007) 1.17
Genetic markers and biomarkers for age-related macular degeneration. Expert Rev Ophthalmol (2007) 1.15
Increased IL-15 production is associated with higher susceptibility of memory CD4 T cells to simian immunodeficiency virus during acute infection. J Immunol (2009) 1.14
Susceptibility to retinal light damage in transgenic rats with rhodopsin mutations. Invest Ophthalmol Vis Sci (2003) 1.14
Primary intraocular lymphoma. Arch Pathol Lab Med (2009) 1.13
Histopathology and regression of retinal hard exudates in diabetic retinopathy after reduction of elevated serum lipid levels. Ophthalmology (2003) 1.11
Interleukin 18 coexpression during respiratory syncytial virus infection results in enhanced disease mediated by natural killer cells. J Virol (2010) 1.09
Repertoire analysis and new pathogenic epitopes of IRBP in C57BL/6 (H-2b) and B10.RIII (H-2r) mice. Invest Ophthalmol Vis Sci (2008) 1.09
Induction of ocular inflammation by T-helper lymphocytes type 2. Invest Ophthalmol Vis Sci (2002) 1.09