Published in N Engl J Med on December 04, 2003
Functionally significant insulin-like growth factor I receptor mutations in centenarians. Proc Natl Acad Sci U S A (2008) 5.14
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The role of liver-derived insulin-like growth factor-I. Endocr Rev (2009) 1.87
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Expanding the mind: insulin-like growth factor I and brain development. Endocrinology (2008) 1.39
Growth hormone and insulin-like growth factor-I in the transition from normal mammary development to preneoplastic mammary lesions. Endocr Rev (2008) 1.38
Insulin-like growth factor-binding protein-1 (IGFBP-1) mediates hypoxia-induced embryonic growth and developmental retardation. Proc Natl Acad Sci U S A (2005) 1.34
Pigs and humans with cystic fibrosis have reduced insulin-like growth factor 1 (IGF1) levels at birth. Proc Natl Acad Sci U S A (2010) 1.12
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Inhibition of the insulin-like growth factor-1 receptor (IGF1R) tyrosine kinase as a novel cancer therapy approach. J Med Chem (2009) 1.10
Mapping a new spontaneous preterm birth susceptibility gene, IGF1R, using linkage, haplotype sharing, and association analysis. PLoS Genet (2011) 1.09
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Insulin-like growth factors and the basis of growth. N Engl J Med (2003) 1.07
Molecular genetics of human growth hormone, insulin-like growth factors and their pathways in common disease. Hum Genet (2007) 1.06
Insulin and the IGF system in the human placenta of normal and diabetic pregnancies. J Anat (2009) 1.03
Zebrafish IGF genes: gene duplication, conservation and divergence, and novel roles in midline and notochord development. PLoS One (2009) 1.02
Large-scale pooled next-generation sequencing of 1077 genes to identify genetic causes of short stature. J Clin Endocrinol Metab (2013) 1.01
Insulin-like growth factor-I and bone: lessons from mice and men. Pediatr Nephrol (2008) 1.01
Angiogenic factors in preeclampsia and related disorders. Cold Spring Harb Perspect Med (2012) 0.99
Neurodevelopmental effects of insulin-like growth factor signaling. Front Neuroendocrinol (2012) 0.98
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A novel common variant in DCST2 is associated with length in early life and height in adulthood. Hum Mol Genet (2014) 0.98
Regulation of immature cartilage growth by IGF-I, TGF-beta1, BMP-7, and PDGF-AB: role of metabolic balance between fixed charge and collagen network. Biomech Model Mechanobiol (2007) 0.97
Common genetic variation in eight genes of the GH/IGF1 axis does not contribute to adult height variation. Hum Genet (2007) 0.94
Paternally expressed, imprinted insulin-like growth factor-2 in chorionic villi correlates significantly with birth weight. PLoS One (2014) 0.93
IGF1R variants associated with isolated single suture craniosynostosis. Am J Med Genet A (2011) 0.92
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25-hydroxyvitamin D, insulin-like growth factor-I, and bone mineral accrual during growth. J Clin Endocrinol Metab (2010) 0.90
Evolutionary genetics and implications of small size and twinning in callitrichine primates. Proc Natl Acad Sci U S A (2013) 0.90
The cullin7 E3 ubiquitin ligase: a novel player in growth control. Cell Cycle (2008) 0.90
Genetic evaluation of short stature. J Clin Endocrinol Metab (2014) 0.90
Association of polymorphisms and haplotypes in the insulin-like growth factor 1 receptor (IGF1R) gene with the risk of breast cancer in Korean women. PLoS One (2014) 0.89
Molecular physiology, pathology, and regulation of the growth hormone/insulin-like growth factor-I system. Pediatr Nephrol (2004) 0.89
Growth and body composition in very young SGA children. Pediatr Nephrol (2010) 0.89
Lin28 promotes the proliferative capacity of neural progenitor cells in brain development. Development (2015) 0.87
ABCG2pos lung mesenchymal stem cells are a novel pericyte subpopulation that contributes to fibrotic remodeling. Am J Physiol Cell Physiol (2014) 0.87
Insulin-like growth factor receptor 1b is required for zebrafish primordial germ cell migration and survival. Dev Biol (2007) 0.86
Growth hormone, insulin-like growth factor-1 and the aging brain. Exp Gerontol (2014) 0.86
Insulin sensitivity in children born small for gestational age (SGA). Rev Diabet Stud (2004) 0.86
Insulin-like growth factors in embryonic and fetal growth and skeletal development (Review). Mol Med Rep (2014) 0.85
Mutations in pregnancy-associated plasma protein A2 cause short stature due to low IGF-I availability. EMBO Mol Med (2016) 0.85
Causes of short stature identified in children presenting at a tertiary care hospital in Multan Pakistan. Pak J Med Sci (2013) 0.85
The insulin-like growth factor system in bone: basic and clinical implications. Endocrinol Metab Clin North Am (2012) 0.85
Gene regulation by growth hormone. Pediatr Nephrol (2009) 0.84
Nutritionally-induced catch-up growth. Nutrients (2015) 0.83
Recent research on the growth plate: Recent insights into the regulation of the growth plate. J Mol Endocrinol (2014) 0.82
miR-141 contributes to fetal growth restriction by regulating PLAG1 expression. PLoS One (2013) 0.82
Genetic factors associated with small for gestational age birth and the use of human growth hormone in treating the disorder. Int J Pediatr Endocrinol (2012) 0.79
Intragenic deletions of the IGF1 receptor gene in five individuals with psychiatric phenotypes and developmental delay. Eur J Hum Genet (2013) 0.79
Lack of association between insulin-like growth factor I receptor G(+3174)A polymorphism and retinopathy of prematurity. Graefes Arch Clin Exp Ophthalmol (2005) 0.78
Hypoxia impairs primordial germ cell migration in zebrafish (Danio rerio) embryos. PLoS One (2011) 0.77
SNP array screening of cryptic genomic imbalances in 450 Japanese subjects with intellectual disability and multiple congenital anomalies previously negative for large rearrangements. J Hum Genet (2016) 0.77
Towards identification of molecular mechanisms of short stature. Int J Pediatr Endocrinol (2013) 0.77
Expanding the clinical spectrum of chromosome 15q26 terminal deletions associated with IGF-1 resistance. Eur J Pediatr (2016) 0.77
Genetic Defects in the Growth Hormone-IGF-I Axis Causing Growth Hormone Insensitivity and Impaired Linear Growth. Front Endocrinol (Lausanne) (2011) 0.76
Effects of prenatal ethanol exposure on postnatal growth and the insulin-like growth factor axis. Horm Res Paediatr (2010) 0.76
Potential for sexual conflict assessed via testosterone-mediated transcriptional changes in liver and muscle of a songbird. J Exp Biol (2013) 0.76
Impact of placental insufficiency on fetal skeletal muscle growth. Mol Cell Endocrinol (2016) 0.75
The genome of the largest bony fish, ocean sunfish (Mola mola), provides insights into its fast growth rate. Gigascience (2016) 0.75
Clinical and functional characterization of a patient carrying a compound heterozygous pericentrin mutation and a heterozygous IGF1 receptor mutation. PLoS One (2012) 0.75
Association between polymorphisms in genes related to common adult diseases and fetal growth. Clin Med Pediatr (2009) 0.75
Insulin-like Growth Factor 1 Signaling Axis Meets p53 Genome Protection Pathways. Front Oncol (2016) 0.75
IGF-I receptor mutations and intrauterine and postnatal growth retardation. N Engl J Med (2004) 0.75
Domain-dependent effects of insulin and IGF-1 receptors on signalling and gene expression. Nat Commun (2017) 0.75
Bioinformatic analysis of benzo-α-pyrene-induced damage to the human placental insulin-like growth factor-1 gene. Reprod Sci (2013) 0.75
Involvement of Igf1r in Bronchiolar Epithelial Regeneration: Role during Repair Kinetics after Selective Club Cell Ablation. PLoS One (2016) 0.75
Abnormal Paraventricular Nucleus of Hypothalamus and Growth Retardation Associated with Loss of Nuclear Receptor Gene COUP-TFII. Sci Rep (2017) 0.75
Bone Status in a Patient with Insulin-Like Growth Factor-1 Receptor Deletion Syndrome: Bone Quality and Structure Evaluation Using Dual-Energy X-Ray Absorptiometry, Peripheral Quantitative Computed Tomography, and Quantitative Ultrasonography. Front Endocrinol (Lausanne) (2017) 0.75
One level up: abnormal proteolytic regulation of IGF activity plays a role in human pathophysiology. EMBO Mol Med (2017) 0.75
Variation in FTO contributes to childhood obesity and severe adult obesity. Nat Genet (2007) 13.62
Genome-wide association study for early-onset and morbid adult obesity identifies three new risk loci in European populations. Nat Genet (2009) 6.39
Large-scale association analyses identify new loci influencing glycemic traits and provide insight into the underlying biological pathways. Nat Genet (2012) 4.73
Nampt/PBEF/Visfatin regulates insulin secretion in beta cells as a systemic NAD biosynthetic enzyme. Cell Metab (2007) 4.16
Dysfunction of lipid sensor GPR120 leads to obesity in both mouse and human. Nature (2012) 3.41
CEP152 is a genome maintenance protein disrupted in Seckel syndrome. Nat Genet (2010) 3.25
Common nonsynonymous variants in PCSK1 confer risk of obesity. Nat Genet (2008) 3.24
Two new Loci for body-weight regulation identified in a joint analysis of genome-wide association studies for early-onset extreme obesity in French and german study groups. PLoS Genet (2010) 3.21
The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. Genome Res (2003) 2.91
International Small for Gestational Age Advisory Board consensus development conference statement: management of short children born small for gestational age, April 24-October 1, 2001. Pediatrics (2003) 2.83
Nampt: linking NAD biology, metabolism and cancer. Trends Endocrinol Metab (2008) 2.47
Age-specific stabilization in obesity prevalence in German children: a cross-sectional study from 1999 to 2008. Int J Pediatr Obes (2010) 2.47
Early optical polarization of a gamma-ray burst afterglow. Science (2007) 2.37
Alterations in height, weight, and body mass index of newborns, children, and young adults in eastern Germany after German reunification. J Pediatr (2003) 2.14
Insulin sensitivity among obese children and adolescents, according to degree of weight loss. Pediatrics (2004) 2.10
Total and high-molecular weight adiponectin in relation to metabolic variables at baseline and in response to an exercise treatment program: comparative evaluation of three assays. Diabetes Care (2007) 2.04
Serum levels of the adipokine progranulin depend on renal function. Diabetes Care (2012) 2.03
GAD65 antigen therapy in recently diagnosed type 1 diabetes mellitus. N Engl J Med (2012) 2.01
Serum vaspin concentrations in human obesity and type 2 diabetes. Diabetes (2007) 1.96
Gender differences of adiponectin levels develop during the progression of puberty and are related to serum androgen levels. J Clin Endocrinol Metab (2004) 1.92
New loci associated with birth weight identify genetic links between intrauterine growth and adult height and metabolism. Nat Genet (2012) 1.90
Adipocytokines: leptin--the classical, resistin--the controversical, adiponectin--the promising, and more to come. Best Pract Res Clin Endocrinol Metab (2005) 1.87
Serum levels of adipokine retinol-binding protein-4 in relation to renal function. Diabetes Care (2007) 1.85
Effect of a 4 week physical training program on plasma concentrations of inflammatory markers in patients with abnormal glucose tolerance. Eur J Endocrinol (2006) 1.76
ENPP1 variants and haplotypes predispose to early onset obesity and impaired glucose and insulin metabolism in German obese children. J Clin Endocrinol Metab (2006) 1.71
Obesity and type 2 diabetes: what can be unified and what needs to be individualized? J Clin Endocrinol Metab (2011) 1.63
Intima media thickness in childhood obesity: relations to inflammatory marker, glucose metabolism, and blood pressure. Metabolism (2006) 1.63
Effect of increased exercise in school children on physical fitness and endothelial progenitor cells: a prospective randomized trial. Circulation (2009) 1.61
Gender in childhood obesity: family environment, hormones, and genes. Gend Med (2009) 1.59
Technical evaluation of the first fully automated assay for the detection of TSH receptor autoantibodies. Clin Chim Acta (2008) 1.56
Impact of weight status on the onset and parameters of puberty: analysis of three representative cohorts from central Europe. J Pediatr Endocrinol Metab (2008) 1.56
Hyperglycemia enhances the cytokine production and oxidative responses to a low but not high dose of endotoxin in rats. Crit Care Med (2005) 1.55
Comparison of adrenal function tests in children--the glucagon stimulation test allows the simultaneous assessment of adrenal function and growth hormone response in children. J Pediatr Endocrinol Metab (2005) 1.55
Serum levels of fibroblast growth factor-21 are increased in chronic and acute renal dysfunction. Clin Endocrinol (Oxf) (2014) 1.49
Total and high-molecular-weight adiponectin in breast cancer: in vitro and in vivo studies. J Clin Endocrinol Metab (2006) 1.47
Serum insulin-like growth factor I reference values for an automated chemiluminescence immunoassay system: results from a multicenter study. Horm Res (2003) 1.47
Degree of external genital malformation at birth in children with a disorder of sex development and subsequent caregiver distress. J Urol (2012) 1.45
Inhibition of interleukin-6-activated janus kinases/signal transducers and activators of transcription but not mitogen-activated protein kinase signaling in liver of endotoxin-treated rats. Crit Care Med (2002) 1.45
Serum levels of the adipokine FGF21 depend on renal function. Diabetes Care (2008) 1.42
Assay-dependent variability of serum insulin levels during oral glucose tolerance test: influence on reference intervals for insulin and on cut-off values for insulin sensitivity indices. Clin Chem Lab Med (2008) 1.42
Elevated sex steroid hormones in great saphenous veins in men. J Vasc Surg (2010) 1.41
CACNA1C (Cav1.2) in the pathophysiology of psychiatric disease. Prog Neurobiol (2012) 1.40
Effect of terminated fetal circulation on maternal angiogenic factors in severe early preeclampsia. Hypertens Pregnancy (2012) 1.39
Changes in pediatric diabetes care throughout a 30-yr period at one institution for pediatric diabetology in Germany. Pediatr Diabetes (2002) 1.39
A prismatic case: A 31-year old man who did not miss his pituitary. Hormones (Athens) (2008) 1.38
TVs in the bedrooms of children: does it impact health and behavior? Prev Med (2010) 1.37
Recessive mutations in the INS gene result in neonatal diabetes through reduced insulin biosynthesis. Proc Natl Acad Sci U S A (2010) 1.36
Antiemetic medications in children with presumed infectious gastroenteritis--pharmacoepidemiology in Europe and Northern America. J Pediatr (2008) 1.35
Reducing LDL with PCSK9 Inhibitors--The Clinical Benefit of Lipid Drugs. N Engl J Med (2015) 1.34
Basal and feeding-evoked dopamine release in the rat nucleus accumbens is depressed by leptin. Eur J Pharmacol (2003) 1.32
Obesity and type 2 diabetes: what can be unified and what needs to be individualized? Diabetes Care (2011) 1.31
Mathematical model predicts a critical role for osteoclast autocrine regulation in the control of bone remodeling. Bone (2003) 1.29
The failure of R0. Comput Math Methods Med (2011) 1.26
Adipokine pattern in subjects with impaired fasting glucose and impaired glucose tolerance in comparison to normal glucose tolerance and diabetes. PLoS One (2010) 1.25
Mutations in the GIGYF2 (TNRC15) gene at the PARK11 locus in familial Parkinson disease. Am J Hum Genet (2008) 1.23
The adapter protein GRB10 is an endogenous negative regulator of insulin-like growth factor signaling. Endocrinology (2005) 1.22
Molecular and clinical spectrum of type I plasminogen deficiency: A series of 50 patients. Blood (2006) 1.20
Phenotypic differences in behavior, physiology and neurochemistry between rats selected for tameness and for defensive aggression towards humans. Horm Behav (2007) 1.19
Serum levels of the adipokine vaspin in relation to metabolic and renal parameters. J Clin Endocrinol Metab (2007) 1.19
Mechanical regulation of mitogen-activated protein kinase signaling in articular cartilage. J Biol Chem (2003) 1.19
Dysfunction of autonomic nervous system in childhood obesity: a cross-sectional study. PLoS One (2013) 1.18
Obesity-Related Differences between Women and Men in Brain Structure and Goal-Directed Behavior. Front Hum Neurosci (2011) 1.17
The cardiovascular safety of diabetes drugs--insights from the rosiglitazone experience. N Engl J Med (2013) 1.16
Genetic architecture of tameness in a rat model of animal domestication. Genetics (2009) 1.15
Pregnancy and birth cohort resources in europe: a large opportunity for aetiological child health research. Paediatr Perinat Epidemiol (2013) 1.15
The impact of media coverage on the transmission dynamics of human influenza. BMC Public Health (2011) 1.15
Effects of obesity on human sexual development. Nat Rev Endocrinol (2012) 1.13
HESX1 mutations are an uncommon cause of septooptic dysplasia and hypopituitarism. J Clin Endocrinol Metab (2006) 1.12
Therapeutic potential of SIRT1 and NAMPT-mediated NAD biosynthesis in type 2 diabetes. Front Biosci (Landmark Ed) (2009) 1.12
Adipose tissue expression and genetic variants of the bone morphogenetic protein receptor 1A gene (BMPR1A) are associated with human obesity. Diabetes (2009) 1.11
Validation of the phenylalanine/tyrosine ratio determined by tandem mass spectrometry: sensitive newborn screening for phenylketonuria. Clin Chem Lab Med (2002) 1.11
Molecular characteristics of serum visfatin and differential detection by immunoassays. J Clin Endocrinol Metab (2007) 1.11
Early detection of growth disorders with the CrescNet system at the Leipzig treatment center. Dtsch Arztebl Int (2011) 1.10
Creating larger and better connected protected areas enhances the persistence of big game species in the maputaland-pondoland-albany biodiversity hotspot. PLoS One (2013) 1.10
Body mass index, waist circumference, and waist-to-height ratio as predictors of cardiometabolic risk in childhood obesity depending on pubertal development. J Clin Endocrinol Metab (2013) 1.10
Two novel proteins that are linked to insulin-like growth factor (IGF-I) receptors by the Grb10 adapter and modulate IGF-I signaling. J Biol Chem (2003) 1.09
A novel 4EHP-GIGYF2 translational repressor complex is essential for mammalian development. Mol Cell Biol (2012) 1.09
Secular trends in body mass index in German children and adolescents: a cross-sectional data analysis via CrescNet between 1999 and 2006. Metabolism (2008) 1.08
Incidence of childhood diabetes in children aged less than 15 years and its clinical and metabolic characteristics at the time of diagnosis: data from the Childhood Diabetes Registry of Saxony, Germany. Horm Res Paediatr (2010) 1.08
Serum levels of adipocyte fatty acid-binding protein (AFABP) are increased in chronic haemodialysis (CD). Clin Endocrinol (Oxf) (2008) 1.07
Adiponectin expression in humans is dependent on differentiation of adipocytes and down-regulated by humoral serum components of high molecular weight. Biochem Biophys Res Commun (2005) 1.06
New predictors of the metabolic syndrome in children--role of adipocytokines. Pediatr Res (2007) 1.06
Associations between media consumption habits, physical activity, socioeconomic status, and glycemic control in children, adolescents, and young adults with type 1 diabetes. Diabetes Care (2011) 1.06