Published in Am J Hum Genet on December 04, 2003
Inhibition of SHP2 ameliorates the pathogenesis of systemic lupus erythematosus. J Clin Invest (2016) 2.06
Unraveling the genetics of systemic lupus erythematosus. Springer Semin Immunopathol (2006) 1.64
Systemic lupus erythematosus susceptibility loci defined by genome scan meta-analysis. Hum Genet (2005) 1.44
The lupus family registry and repository. Rheumatology (Oxford) (2010) 1.21
Current status of lupus genetics. Arthritis Res Ther (2007) 1.14
Role of an intronic polymorphism in the PDCD1 gene with the risk of sporadic systemic lupus erythematosus and the occurrence of antiphospholipid antibodies. Hum Genet (2004) 1.00
P2 receptors and immunity. Microbes Infect (2012) 0.93
Meta-analysis of genome-wide linkage studies across autoimmune diseases. Eur J Hum Genet (2008) 0.92
Localization and replication of the systemic lupus erythematosus linkage signal at 4p16: interaction with 2p11, 12q24 and 19q13 in European Americans. Hum Genet (2006) 0.91
Identification and characterization of a novel variant of the human P2X(7) receptor resulting in gain of function. Purinergic Signal (2009) 0.90
The P2X7 receptor is a candidate product of murine and human lupus susceptibility loci: a hypothesis and comparison of murine allelic products. Arthritis Res Ther (2005) 0.89
Olf1/EBF associated zinc finger protein interfered with antinuclear antibody production in patients with systemic lupus erythematosus. Arthritis Res Ther (2010) 0.81
Genetic linkage of systemic lupus erythematosus to 13q32 in African American families with affected male members. Hum Genet (2005) 0.81
Comprehensive Assessment of the Association between FCGRs polymorphisms and the risk of systemic lupus erythematosus: Evidence from a Meta-Analysis. Sci Rep (2016) 0.75
Investigation into the association between P2RX7 gene polymorphisms and susceptibility to primary gout and hyperuricemia in a Chinese Han male population. Rheumatol Int (2017) 0.75
The 1982 revised criteria for the classification of systemic lupus erythematosus. Arthritis Rheum (1982) 67.54
Genetic dissection of complex traits: guidelines for interpreting and reporting linkage results. Nat Genet (1995) 49.77
Updating the American College of Rheumatology revised criteria for the classification of systemic lupus erythematosus. Arthritis Rheum (1997) 43.47
Parametric and nonparametric linkage analysis: a unified multipoint approach. Am J Hum Genet (1996) 39.80
Faster sequential genetic linkage computations. Am J Hum Genet (1993) 18.83
Allegro, a new computer program for multipoint linkage analysis. Nat Genet (2000) 14.00
Allele-sharing models: LOD scores and accurate linkage tests. Am J Hum Genet (1997) 13.93
The affected-pedigree-member method of linkage analysis. Am J Hum Genet (1988) 13.67
Estimates of the prevalence of arthritis and selected musculoskeletal disorders in the United States. Arthritis Rheum (1998) 12.36
The new genomics: global views of biology. Science (1996) 10.77
A class of tests for linkage using affected pedigree members. Biometrics (1994) 10.40
Effects of misspecifying genetic parameters in lod score analysis. Biometrics (1986) 6.36
Population genetics--making sense out of sequence. Nat Genet (1999) 5.28
A revised estimate of twin concordance in systemic lupus erythematosus. Arthritis Rheum (1992) 4.50
A regulatory polymorphism in PDCD1 is associated with susceptibility to systemic lupus erythematosus in humans. Nat Genet (2002) 4.03
Genome scan of human systemic lupus erythematosus: evidence for linkage on chromosome 1q in African-American pedigrees. Proc Natl Acad Sci U S A (1998) 3.35
The information contained in multiple sibling pairs. Genet Epidemiol (1984) 3.10
The genetics of complex autoimmune diseases: non-MHC susceptibility genes. Nat Immunol (2001) 2.87
Mapping of a gene for type 2 diabetes associated with an insulin secretion defect by a genome scan in Finnish families. Nat Genet (1996) 2.48
Lods, wrods, and mods: the interpretation of lod scores calculated under different models. Genet Epidemiol (1994) 2.44
Magnitude of type I error when single-locus linkage analysis is maximized over models: a simulation study. Am J Hum Genet (1997) 2.38
A genome-wide search for susceptibility genes in human systemic lupus erythematosus sib-pair families. Proc Natl Acad Sci U S A (1998) 2.31
Genomewide search for type 2 diabetes susceptibility genes in four American populations. Am J Hum Genet (2000) 2.19
Affected-sib-pair interval mapping and exclusion for complex genetic traits: sampling considerations. Genet Epidemiol (1996) 2.06
Distribution of the admixture test for the detection of linkage under heterogeneity. Genet Epidemiol (1993) 1.93
Visualizing human leukocyte antigen class II risk haplotypes in human systemic lupus erythematosus. Am J Hum Genet (2002) 1.93
Identifying complex disease genes: progress and paradigms. Nat Genet (1994) 1.84
Genome screening in human systemic lupus erythematosus: results from a second Minnesota cohort and combined analyses of 187 sib-pair families. Am J Hum Genet (2000) 1.72
Genetic linkage and association of Fcgamma receptor IIIA (CD16A) on chromosome 1q23 with human systemic lupus erythematosus. Arthritis Rheum (2002) 1.71
Optimal allele-sharing statistics for genetic mapping using affected relatives. Genet Epidemiol (1999) 1.54
Genome-wide screen for systemic lupus erythematosus susceptibility genes in multiplex families. Hum Mol Genet (1999) 1.50
Genome scan of human systemic lupus erythematosus by regression modeling: evidence of linkage and epistasis at 4p16-15.2. Am J Hum Genet (2000) 1.47
Relationship estimation by Markov-process models in a sib-pair linkage study. Am J Hum Genet (1999) 1.40
The relationship between the sibling recurrence-risk ratio and genotype relative risk. Am J Hum Genet (2000) 1.34
The genetics of human systemic lupus erythematosus. Trends Immunol (2003) 1.34
The genetics of systemic lupus erythematosus: putting the pieces together. Genes Immun (2002) 1.21
A major susceptibility locus for systemic lupus erythemathosus maps to chromosome 1q31. Am J Hum Genet (2002) 1.10
The effect of race on incidence and clinical course in systemic lupus erythematosus: The Hopkins Lupus Cohort. J Am Med Womens Assoc (1998) 1.05
Fine mapping and single nucleotide polymorphism association results of candidate genes for asthma and related phenotypes. Hum Mutat (2001) 1.03
Dense mapping of chromosome 12q13.12-q23.3 and linkage to asthma and atopy. J Allergy Clin Immunol (1999) 0.99
A genome-wide linkage analysis of orchard grass-sensitive childhood seasonal allergic rhinitis in Japanese families. Genes Immun (2002) 0.92
Abnormal splicing of hepatocyte nuclear factor 1 alpha in maturity-onset diabetes of the young. Diabetologia (2002) 0.89
Interferon-gamma gene microsatellite polymorphisms in patients with Graves' disease. Thyroid (1998) 0.81
SLEB3 in systemic lupus erythematosus (SLE) is strongly related to SLE families ascertained through neuropsychiatric manifestations. Hum Genet (2002) 0.78
The genetic etiology of systemic lupus erythematosus: a short dispatch from the combat zone. Genes Immun (2002) 0.77
[Genetics of the neuronal NO synthase (NOS1) in the etiology of bronchial asthma]. Pneumologie (2001) 0.76
Genome-wide association scan in women with systemic lupus erythematosus identifies susceptibility variants in ITGAM, PXK, KIAA1542 and other loci. Nat Genet (2008) 12.51
Development of autoantibodies before the clinical onset of systemic lupus erythematosus. N Engl J Med (2003) 10.82
A regulatory polymorphism in PDCD1 is associated with susceptibility to systemic lupus erythematosus in humans. Nat Genet (2002) 4.03
Changes in the pattern of DNA methylation associate with twin discordance in systemic lupus erythematosus. Genome Res (2009) 3.81
A nonsynonymous functional variant in integrin-alpha(M) (encoded by ITGAM) is associated with systemic lupus erythematosus. Nat Genet (2008) 3.71
A functional variant in FCRL3, encoding Fc receptor-like 3, is associated with rheumatoid arthritis and several autoimmunities. Nat Genet (2005) 3.15
The microRNA miR-23b suppresses IL-17-associated autoimmune inflammation by targeting TAB2, TAB3 and IKK-α. Nat Med (2012) 2.66
Association of the IRF5 risk haplotype with high serum interferon-alpha activity in systemic lupus erythematosus patients. Arthritis Rheum (2008) 2.62
Association of a functional variant downstream of TNFAIP3 with systemic lupus erythematosus. Nat Genet (2011) 2.54
Genetic susceptibility to SLE: new insights from fine mapping and genome-wide association studies. Nat Rev Genet (2009) 2.46
Identification of IRAK1 as a risk gene with critical role in the pathogenesis of systemic lupus erythematosus. Proc Natl Acad Sci U S A (2009) 2.31
Comparison of the American-European Consensus Group Sjogren's syndrome classification criteria to newly proposed American College of Rheumatology criteria in a large, carefully characterised sicca cohort. Ann Rheum Dis (2013) 2.21
Vitamin D deficiency is associated with an increased autoimmune response in healthy individuals and in patients with systemic lupus erythematosus. Ann Rheum Dis (2011) 2.06
Identification of IFRD1 as a modifier gene for cystic fibrosis lung disease. Nature (2009) 2.05
Common variants within MECP2 confer risk of systemic lupus erythematosus. PLoS One (2008) 1.98
Differential genetic associations for systemic lupus erythematosus based on anti-dsDNA autoantibody production. PLoS Genet (2011) 1.92
Variants at multiple loci implicated in both innate and adaptive immune responses are associated with Sjögren's syndrome. Nat Genet (2013) 1.79
Early events in lupus humoral autoimmunity suggest initiation through molecular mimicry. Nat Med (2004) 1.79
Network analysis of associations between serum interferon-α activity, autoantibodies, and clinical features in systemic lupus erythematosus. Arthritis Rheum (2011) 1.79
Association of a functional IRF7 variant with systemic lupus erythematosus. Arthritis Rheum (2011) 1.78
Genetic linkage and association of Fcgamma receptor IIIA (CD16A) on chromosome 1q23 with human systemic lupus erythematosus. Arthritis Rheum (2002) 1.71
Specific combinations of HLA-DR2 and DR3 class II haplotypes contribute graded risk for disease susceptibility and autoantibodies in human SLE. Eur J Hum Genet (2007) 1.66
Klinefelter's syndrome (47,XXY) in male systemic lupus erythematosus patients: support for the notion of a gene-dose effect from the X chromosome. Arthritis Rheum (2008) 1.64
Epstein-Barr virus and molecular mimicry in systemic lupus erythematosus. Autoimmunity (2006) 1.64
Sex-specific association of X-linked Toll-like receptor 7 (TLR7) with male systemic lupus erythematosus. Proc Natl Acad Sci U S A (2010) 1.63
A comprehensive analysis of shared loci between systemic lupus erythematosus (SLE) and sixteen autoimmune diseases reveals limited genetic overlap. PLoS Genet (2011) 1.62
End-stage renal disease in African Americans with lupus nephritis is associated with APOL1. Arthritis Rheumatol (2014) 1.62
High-density SNP screening of the major histocompatibility complex in systemic lupus erythematosus demonstrates strong evidence for independent susceptibility regions. PLoS Genet (2009) 1.61
Clinical criteria for systemic lupus erythematosus precede diagnosis, and associated autoantibodies are present before clinical symptoms. Arthritis Rheum (2007) 1.59
Risk alleles for systemic lupus erythematosus in a large case-control collection and associations with clinical subphenotypes. PLoS Genet (2011) 1.57
Association between systemic lupus erythematosus and Helicobacter pylori seronegativity. J Rheumatol (2004) 1.56
Identification of microRNA-31 as a novel regulator contributing to impaired interleukin-2 production in T cells from patients with systemic lupus erythematosus. Arthritis Rheum (2012) 1.54
Kallikrein genes are associated with lupus and glomerular basement membrane-specific antibody-induced nephritis in mice and humans. J Clin Invest (2009) 1.54
Identification of unique microRNA signature associated with lupus nephritis. PLoS One (2010) 1.53
Age- and sex-related patterns of serum interferon-alpha activity in lupus families. Arthritis Rheum (2008) 1.53
Association of genetic variants in complement factor H and factor H-related genes with systemic lupus erythematosus susceptibility. PLoS Genet (2011) 1.49
Evaluation of imputation-based association in and around the integrin-alpha-M (ITGAM) gene and replication of robust association between a non-synonymous functional variant within ITGAM and systemic lupus erythematosus (SLE). Hum Mol Genet (2009) 1.46
The mannose-binding lectin gene polymorphisms and systemic lupus erythematosus: two case-control studies and a meta-analysis. Arthritis Rheum (2005) 1.45
Variants within MECP2, a key transcription regulator, are associated with increased susceptibility to lupus and differential gene expression in patients with systemic lupus erythematosus. Arthritis Rheum (2009) 1.43
Clarithromycin in adult-onset still's disease: a potentially useful therapeutic. J Clin Rheumatol (2011) 1.43
Identification of a systemic lupus erythematosus susceptibility locus at 11p13 between PDHX and CD44 in a multiethnic study. Am J Hum Genet (2010) 1.43
Identification of IRF8, TMEM39A, and IKZF3-ZPBP2 as susceptibility loci for systemic lupus erythematosus in a large-scale multiracial replication study. Am J Hum Genet (2012) 1.41
Phenotypic associations of genetic susceptibility loci in systemic lupus erythematosus. Ann Rheum Dis (2011) 1.41
Genome-wide association scan of Dupuytren's disease. J Hand Surg Am (2010) 1.40
IRF5 haplotypes demonstrate diverse serological associations which predict serum interferon alpha activity and explain the majority of the genetic association with systemic lupus erythematosus. Ann Rheum Dis (2011) 1.38
Osteopontin and systemic lupus erythematosus association: a probable gene-gender interaction. PLoS One (2008) 1.31
The prevalence, onset, and clinical significance of antiphospholipid antibodies prior to diagnosis of systemic lupus erythematosus. Arthritis Rheum (2004) 1.31
Lupus-associated causal mutation in neutrophil cytosolic factor 2 (NCF2) brings unique insights to the structure and function of NADPH oxidase. Proc Natl Acad Sci U S A (2011) 1.30
Polymorphisms of complement receptor 1 and interleukin-10 genes and systemic lupus erythematosus: a meta-analysis. Hum Genet (2005) 1.27
Early disease onset is predicted by a higher genetic risk for lupus and is associated with a more severe phenotype in lupus patients. Ann Rheum Dis (2010) 1.26
Autoantibody prevalence and lupus characteristics in a unique African American population. Arthritis Rheum (2008) 1.25
Meta-analysis of TNF-alpha promoter -308 A/G polymorphism and SLE susceptibility. Eur J Hum Genet (2006) 1.25
A polymorphism within IL21R confers risk for systemic lupus erythematosus. Arthritis Rheum (2009) 1.23
Genome-wide association study of African and European Americans implicates multiple shared and ethnic specific loci in sarcoidosis susceptibility. PLoS One (2012) 1.23
The lupus family registry and repository. Rheumatology (Oxford) (2010) 1.21
Aberrant Epstein-Barr viral infection in systemic lupus erythematosus. Autoimmun Rev (2009) 1.20
Identification of novel genetic susceptibility loci in African American lupus patients in a candidate gene association study. Arthritis Rheum (2011) 1.19
Epstein-Barr virus and systemic lupus erythematosus. Curr Opin Rheumatol (2006) 1.19
Genetics of human systemic lupus erythematosus: the emerging picture. Curr Opin Immunol (2004) 1.19
Comparison of autoantibody specificities between traditional and bead-based assays in a large, diverse collection of patients with systemic lupus erythematosus and family members. Arthritis Rheum (2012) 1.19
An altered immune response to Epstein-Barr nuclear antigen 1 in pediatric systemic lupus erythematosus. Arthritis Rheum (2006) 1.17
Genetic variation in the CRP promoter: association with systemic lupus erythematosus. Hum Mol Genet (2008) 1.16
A genome-wide integrative genomic study localizes genetic factors influencing antibodies against Epstein-Barr virus nuclear antigen 1 (EBNA-1). PLoS Genet (2013) 1.15
Admixture mapping in lupus identifies multiple functional variants within IFIH1 associated with apoptosis, inflammation, and autoantibody production. PLoS Genet (2013) 1.14
Evaluation of the genetic association of the PTPN22 R620W polymorphism in familial and sporadic systemic lupus erythematosus. Arthritis Rheum (2006) 1.14
CTLA-4 polymorphisms and systemic lupus erythematosus (SLE): a meta-analysis. Hum Genet (2005) 1.14
Current status of lupus genetics. Arthritis Res Ther (2007) 1.14
Dual effect of the macrophage migration inhibitory factor gene on the development and severity of human systemic lupus erythematosus. Arthritis Rheum (2011) 1.13
Identification of candidate loci at 6p21 and 21q22 in a genome-wide association study of cardiac manifestations of neonatal lupus. Arthritis Rheum (2010) 1.13
Evaluation of genetic association between an ITGAM non-synonymous SNP (rs1143679) and multiple autoimmune diseases. Autoimmun Rev (2011) 1.12
The genetics of systemic lupus erythematosus and implications for targeted therapy. Ann Rheum Dis (2011) 1.11
Antinuclear autoantibodies in systemic lupus erythematosus. Curr Opin Rheumatol (2004) 1.11
High-density genotyping of STAT4 reveals multiple haplotypic associations with systemic lupus erythematosus in different racial groups. Arthritis Rheum (2009) 1.11
Lupus-like autoantibody development in rabbits and mice after immunization with EBNA-1 fragments. J Autoimmun (2008) 1.10
Autoimmunity and Klinefelter's syndrome: when men have two X chromosomes. J Autoimmun (2009) 1.10
ITGAM coding variant (rs1143679) influences the risk of renal disease, discoid rash and immunological manifestations in patients with systemic lupus erythematosus with European ancestry. Ann Rheum Dis (2009) 1.08
Genetic and physical interaction of the B-cell systemic lupus erythematosus-associated genes BANK1 and BLK. Ann Rheum Dis (2011) 1.07
Large-scale analysis of tumor necrosis factor α levels in systemic lupus erythematosus. Arthritis Rheum (2012) 1.07
The role of genetic variation near interferon-kappa in systemic lupus erythematosus. J Biomed Biotechnol (2010) 1.07
Fine mapping of Xq28: both MECP2 and IRAK1 contribute to risk for systemic lupus erythematosus in multiple ancestral groups. Ann Rheum Dis (2012) 1.07
Analysis of autosomal genes reveals gene-sex interactions and higher total genetic risk in men with systemic lupus erythematosus. Ann Rheum Dis (2011) 1.06
60 kD Ro and nRNP A frequently initiate human lupus autoimmunity. PLoS One (2010) 1.05
Whole-exome sequencing reveals overlap between macrophage activation syndrome in systemic juvenile idiopathic arthritis and familial hemophagocytic lymphohistiocytosis. Arthritis Rheumatol (2014) 1.04
Genetically determined Amerindian ancestry correlates with increased frequency of risk alleles for systemic lupus erythematosus. Arthritis Rheum (2010) 1.04
Autoimmune thyroid disease is associated with a diagnosis of secondary Sjögren's syndrome in familial systemic lupus. Ann Rheum Dis (2006) 1.04
Unraveling multiple MHC gene associations with systemic lupus erythematosus: model choice indicates a role for HLA alleles and non-HLA genes in Europeans. Am J Hum Genet (2012) 1.02
Select human anthrax protective antigen epitope-specific antibodies provide protection from lethal toxin challenge. J Infect Dis (2010) 1.01
Impact of genetic ancestry and sociodemographic status on the clinical expression of systemic lupus erythematosus in American Indian-European populations. Arthritis Rheum (2012) 1.01
Genes and Sjögren's syndrome. Rheum Dis Clin North Am (2008) 1.01
Genetic analyses of interferon pathway-related genes reveal multiple new loci associated with systemic lupus erythematosus. Arthritis Rheum (2011) 1.01
MicroRNA-3148 modulates allelic expression of toll-like receptor 7 variant associated with systemic lupus erythematosus. PLoS Genet (2013) 0.99
Anthrax vaccination induced anti-lethal factor IgG: fine specificity and neutralizing capacity. Vaccine (2011) 0.99
Evidence for gene-gene epistatic interactions among susceptibility loci for systemic lupus erythematosus. Arthritis Rheum (2012) 0.99
Fine-mapping and transethnic genotyping establish IL2/IL21 genetic association with lupus and localize this genetic effect to IL21. Arthritis Rheum (2011) 0.98
Genome-wide linkage screen for stature and body mass index in 3.032 families: evidence for sex- and population-specific genetic effects. Eur J Hum Genet (2008) 0.98
Ribosomal P autoantibodies are present before SLE onset and are directed against non-C-terminal peptides. J Mol Med (Berl) (2010) 0.97
Thrombocytopenia identifies a severe familial phenotype of systemic lupus erythematosus and reveals genetic linkages at 1q22 and 11p13. Blood (2002) 0.97
Variation in the ICAM1-ICAM4-ICAM5 locus is associated with systemic lupus erythematosus susceptibility in multiple ancestries. Ann Rheum Dis (2012) 0.96