PubRank

John Blenis

Author PubWeight™ 219.92‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 Molecular mechanisms of mTOR-mediated translational control. Nat Rev Mol Cell Biol 2009 13.89
2 Identification of the tuberous sclerosis complex-2 tumor suppressor gene product tuberin as a target of the phosphoinositide 3-kinase/akt pathway. Mol Cell 2002 11.65
3 ERK and p38 MAPK-activated protein kinases: a family of protein kinases with diverse biological functions. Microbiol Mol Biol Rev 2004 9.54
4 Mammalian cell size is controlled by mTOR and its downstream targets S6K1 and 4EBP1/eIF4E. Genes Dev 2002 8.31
5 Tuberous sclerosis complex gene products, Tuberin and Hamartin, control mTOR signaling by acting as a GTPase-activating protein complex toward Rheb. Curr Biol 2003 8.25
6 Target of rapamycin (TOR): an integrator of nutrient and growth factor signals and coordinator of cell growth and cell cycle progression. Oncogene 2004 7.92
7 Rapamycin differentially inhibits S6Ks and 4E-BP1 to mediate cell-type-specific repression of mRNA translation. Proc Natl Acad Sci U S A 2008 6.84
8 mTOR and S6K1 mediate assembly of the translation preinitiation complex through dynamic protein interchange and ordered phosphorylation events. Cell 2005 6.71
9 Molecular interpretation of ERK signal duration by immediate early gene products. Nat Cell Biol 2002 6.05
10 Phosphoproteomic analysis identifies Grb10 as an mTORC1 substrate that negatively regulates insulin signaling. Science 2011 5.73
11 mTOR controls cell cycle progression through its cell growth effectors S6K1 and 4E-BP1/eukaryotic translation initiation factor 4E. Mol Cell Biol 2004 5.46
12 Tumor-promoting phorbol esters and activated Ras inactivate the tuberous sclerosis tumor suppressor complex via p90 ribosomal S6 kinase. Proc Natl Acad Sci U S A 2004 5.16
13 Tuberous sclerosis complex-1 and -2 gene products function together to inhibit mammalian target of rapamycin (mTOR)-mediated downstream signaling. Proc Natl Acad Sci U S A 2002 4.93
14 The RSK family of kinases: emerging roles in cellular signalling. Nat Rev Mol Cell Biol 2008 4.92
15 RAS/ERK signaling promotes site-specific ribosomal protein S6 phosphorylation via RSK and stimulates cap-dependent translation. J Biol Chem 2007 4.45
16 Cutting edge: different Toll-like receptor agonists instruct dendritic cells to induce distinct Th responses via differential modulation of extracellular signal-regulated kinase-mitogen-activated protein kinase and c-Fos. J Immunol 2003 4.31
17 Glucose addiction of TSC null cells is caused by failed mTORC1-dependent balancing of metabolic demand with supply. Mol Cell 2010 4.07
18 TOS motif-mediated raptor binding regulates 4E-BP1 multisite phosphorylation and function. Curr Biol 2003 4.01
19 MAPK signal specificity: the right place at the right time. Trends Biochem Sci 2006 3.96
20 The Ras-ERK and PI3K-mTOR pathways: cross-talk and compensation. Trends Biochem Sci 2011 3.89
21 Sensitized RNAi screen of human kinases and phosphatases identifies new regulators of apoptosis and chemoresistance. Nat Cell Biol 2005 3.89
22 Identification of a conserved motif required for mTOR signaling. Curr Biol 2002 3.78
23 The mTOR/PI3K and MAPK pathways converge on eIF4B to control its phosphorylation and activity. EMBO J 2006 3.57
24 SKAR links pre-mRNA splicing to mTOR/S6K1-mediated enhanced translation efficiency of spliced mRNAs. Cell 2008 3.43
25 ERK2 but not ERK1 induces epithelial-to-mesenchymal transformation via DEF motif-dependent signaling events. Mol Cell 2010 3.03
26 Identification of S6 kinase 1 as a novel mammalian target of rapamycin (mTOR)-phosphorylating kinase. J Biol Chem 2005 2.84
27 mTOR, translational control and human disease. Semin Cell Dev Biol 2004 2.77
28 The mTORC1 pathway stimulates glutamine metabolism and cell proliferation by repressing SIRT4. Cell 2013 2.70
29 Not all substrates are treated equally: implications for mTOR, rapamycin-resistance and cancer therapy. Cell Cycle 2009 2.45
30 A genome-wide siRNA screen reveals multiple mTORC1 independent signaling pathways regulating autophagy under normal nutritional conditions. Dev Cell 2010 2.40
31 Coordinate regulation of translation by the PI 3-kinase and mTOR pathways. Adv Cancer Res 2002 2.37
32 Phosphorylation of p90 ribosomal S6 kinase (RSK) regulates extracellular signal-regulated kinase docking and RSK activity. Mol Cell Biol 2003 2.32
33 A network of immediate early gene products propagates subtle differences in mitogen-activated protein kinase signal amplitude and duration. Mol Cell Biol 2004 2.30
34 Quantitative phosphorylation profiling of the ERK/p90 ribosomal S6 kinase-signaling cassette and its targets, the tuberous sclerosis tumor suppressors. Proc Natl Acad Sci U S A 2005 2.23
35 Inactivation of the tuberous sclerosis complex-1 and -2 gene products occurs by phosphoinositide 3-kinase/Akt-dependent and -independent phosphorylation of tuberin. J Biol Chem 2003 2.12
36 SIRT4 has tumor-suppressive activity and regulates the cellular metabolic response to DNA damage by inhibiting mitochondrial glutamine metabolism. Cancer Cell 2013 1.99
37 Glycogen synthase kinase (GSK)-3 promotes p70 ribosomal protein S6 kinase (p70S6K) activity and cell proliferation. Proc Natl Acad Sci U S A 2011 1.90
38 SKAR is a specific target of S6 kinase 1 in cell growth control. Curr Biol 2004 1.90
39 Ribosomal S6 kinase (RSK) regulates phosphorylation of filamin A on an important regulatory site. Mol Cell Biol 2004 1.81
40 PI3-kinase and TOR: PIKTORing cell growth. Semin Cell Dev Biol 2004 1.78
41 The RSK factors of activating the Ras/MAPK signaling cascade. Front Biosci 2008 1.75
42 Sin1 phosphorylation impairs mTORC2 complex integrity and inhibits downstream Akt signalling to suppress tumorigenesis. Nat Cell Biol 2013 1.73
43 Activation of PI3K/Akt and MAPK pathways regulates Myc-mediated transcription by phosphorylating and promoting the degradation of Mad1. Proc Natl Acad Sci U S A 2008 1.69
44 Metabolic stress controls mTORC1 lysosomal localization and dimerization by regulating the TTT-RUVBL1/2 complex. Mol Cell 2012 1.50
45 PI3K induced actin filament remodeling through Akt and p70S6K1: implication of essential role in cell migration. Am J Physiol Cell Physiol 2003 1.49
46 Metformin decreases glucose oxidation and increases the dependency of prostate cancer cells on reductive glutamine metabolism. Cancer Res 2013 1.49
47 Analysis of mTOR signaling by the small G-proteins, Rheb and RhebL1. FEBS Lett 2005 1.48
48 Spatially separate docking sites on ERK2 regulate distinct signaling events in vivo. Curr Biol 2005 1.46
49 Deletion of ribosomal S6 kinases does not attenuate pathological, physiological, or insulin-like growth factor 1 receptor-phosphoinositide 3-kinase-induced cardiac hypertrophy. Mol Cell Biol 2004 1.43
50 Graded mitogen-activated protein kinase activity precedes switch-like c-Fos induction in mammalian cells. Mol Cell Biol 2005 1.42
51 Nutrient regulation of the mTOR complex 1 signaling pathway. Mol Cells 2013 1.42
52 The tumor suppressor DAP kinase is a target of RSK-mediated survival signaling. Curr Biol 2005 1.38
53 Ran-binding protein 3 phosphorylation links the Ras and PI3-kinase pathways to nucleocytoplasmic transport. Mol Cell 2008 1.33
54 TORgeting oncogene addiction for cancer therapy. Cancer Cell 2006 1.30
55 ERK-MAPK drives lamellipodia protrusion by activating the WAVE2 regulatory complex. Mol Cell 2011 1.22
56 Distinct roles for mammalian target of rapamycin complexes in the fibroblast response to transforming growth factor-beta. Cancer Res 2009 1.20
57 Characterization of a conserved C-terminal motif (RSPRR) in ribosomal protein S6 kinase 1 required for its mammalian target of rapamycin-dependent regulation. J Biol Chem 2005 1.17
58 p90 ribosomal S6 kinase and p70 ribosomal S6 kinase link phosphorylation of the eukaryotic chaperonin containing TCP-1 to growth factor, insulin, and nutrient signaling. J Biol Chem 2009 1.16
59 PHLPPing it off: phosphatases get in the Akt. Mol Cell 2007 1.14
60 Characterizing the interaction of the mammalian eIF4E-related protein 4EHP with 4E-BP1. FEBS Lett 2004 1.12
61 Characterization of phosphatidylinositol 3-kinase-dependent phosphorylation of the hydrophobic motif site Thr(389) in p70 S6 kinase 1. J Biol Chem 2002 1.08
62 Cell signaling in protein synthesis ribosome biogenesis and translation initiation and elongation. Prog Mol Biol Transl Sci 2009 1.03
63 AKT facilitates EGFR trafficking and degradation by phosphorylating and activating PIKfyve. Sci Signal 2013 1.03
64 Inhibition of ERK-MAP kinase signaling by RSK during Drosophila development. EMBO J 2006 1.01
65 Estradiol and mTORC2 cooperate to enhance prostaglandin biosynthesis and tumorigenesis in TSC2-deficient LAM cells. J Exp Med 2014 0.97
66 Down-regulation of CMTM8 induces epithelial-to-mesenchymal transition-like changes via c-MET/extracellular signal-regulated kinase (ERK) signaling. J Biol Chem 2012 0.97
67 Mind the GAP: Wnt steps onto the mTORC1 train. Cell 2006 0.95
68 Integration of mTOR and estrogen-ERK2 signaling in lymphangioleiomyomatosis pathogenesis. Proc Natl Acad Sci U S A 2013 0.92
69 Rheb activation of mTOR and S6K1 signaling. Methods Enzymol 2006 0.90
70 Hippo-YAP and mTOR pathways collaborate to regulate organ size. Nat Cell Biol 2012 0.90
71 A specific mechanomodulatory role for p38 MAPK in embryonic joint articular surface cell MEK-ERK pathway regulation. J Biol Chem 2006 0.90
72 A high-throughput, cell-based screening method for siRNA and small molecule inhibitors of mTORC1 signaling using the In Cell Western technique. Assay Drug Dev Technol 2010 0.89
73 ERK2/Fra1/ZEB pathway induces epithelial-to-mesenchymal transition. Cell Cycle 2010 0.86
74 SHP-2 regulates cell growth by controlling the mTOR/S6 kinase 1 pathway. J Biol Chem 2007 0.83
75 Appetite for destruction: the inhibition of glycolysis as a therapy for tuberous sclerosis complex-related tumors. BMC Biol 2011 0.82
76 ERK-MAP Kinase signaling in the cytoplasm. Methods Mol Biol 2010 0.78
77 mTORC1 signaling aids in CADalyzing pyrimidine biosynthesis. Cell Metab 2013 0.78
78 ATM: Promoter of metabolic "cost" reduction and "savings" usage during hypoxia through mTORC1 regulation. Mol Cell 2010 0.77
79 TPCK inhibits AGC kinases by direct activation loop adduction at phenylalanine-directed cysteine residues. FEBS Lett 2012 0.75