Published in Mol Cell Biol on January 01, 2004
ERK and p38 MAPK-activated protein kinases: a family of protein kinases with diverse biological functions. Microbiol Mol Biol Rev (2004) 9.54
Signalling ballet in space and time. Nat Rev Mol Cell Biol (2010) 3.32
ERK2 but not ERK1 induces epithelial-to-mesenchymal transformation via DEF motif-dependent signaling events. Mol Cell (2010) 3.03
Encoding and decoding cellular information through signaling dynamics. Cell (2013) 2.96
FSH signaling pathways in immature granulosa cells that regulate target gene expression: branching out from protein kinase A. Cell Signal (2006) 2.12
Ligand-specific c-Fos expression emerges from the spatiotemporal control of ErbB network dynamics. Cell (2010) 1.82
The ERK Cascade: Distinct Functions within Various Subcellular Organelles. Genes Cancer (2011) 1.74
Computational modelling of the receptor-tyrosine-kinase-activated MAPK pathway. Biochem J (2005) 1.70
Modeling supravalvular aortic stenosis syndrome with human induced pluripotent stem cells. Circulation (2012) 1.69
Substrate discrimination among mitogen-activated protein kinases through distinct docking sequence motifs. J Biol Chem (2008) 1.57
Down-regulation of c-Fos/c-Jun AP-1 dimer activity by sumoylation. Mol Cell Biol (2005) 1.55
Activated Kras, but not Hras or Nras, may initiate tumors of endodermal origin via stem cell expansion. Mol Cell Biol (2008) 1.53
Understanding the temporal codes of intra-cellular signals. Curr Opin Genet Dev (2010) 1.48
NFAT-induced histone acetylation relay switch promotes c-Myc-dependent growth in pancreatic cancer cells. Gastroenterology (2009) 1.47
Stimulus-coupled spatial restriction of extracellular signal-regulated kinase 1/2 activity contributes to the specificity of signal-response pathways. Mol Cell Biol (2004) 1.45
Graded mitogen-activated protein kinase activity precedes switch-like c-Fos induction in mammalian cells. Mol Cell Biol (2005) 1.42
Spatiotemporal regulation of ERK2 by dual specificity phosphatases. J Biol Chem (2008) 1.37
Untangling the signalling wires. Nat Cell Biol (2007) 1.25
Integrated analysis of breast cancer cell lines reveals unique signaling pathways. Genome Biol (2009) 1.25
Loss of c-Met disrupts gene expression program required for G2/M progression during liver regeneration in mice. PLoS One (2010) 1.17
Ubiquitin-independent proteasomal degradation of Fra-1 is antagonized by Erk1/2 pathway-mediated phosphorylation of a unique C-terminal destabilizer. Mol Cell Biol (2007) 1.16
Role of protein kinase D signaling in pancreatic cancer. Biochem Pharmacol (2010) 1.14
Growth factor pleiotropy is controlled by a receptor Tyr/Ser motif that acts as a binary switch. EMBO J (2006) 1.12
Computational approaches for modeling regulatory cellular networks. Trends Cell Biol (2004) 1.11
Mu- and kappa-opioids induce the differentiation of embryonic stem cells to neural progenitors. J Biol Chem (2006) 1.08
Four-dimensional dynamics of MAPK information processing systems. Wiley Interdiscip Rev Syst Biol Med (2010) 1.06
The progesterone receptor hinge region regulates the kinetics of transcriptional responses through acetylation, phosphorylation, and nuclear retention. Mol Endocrinol (2010) 1.01
Induced overexpression of protein kinase D1 stimulates mitogenic signaling in human pancreatic carcinoma PANC-1 cells. J Cell Physiol (2010) 1.01
Ligand-specific sequential regulation of transcription factors for differentiation of MCF-7 cells. BMC Genomics (2009) 1.00
Tumor-derived variants of Epstein-Barr virus latent membrane protein 1 induce sustained Erk activation and c-Fos. J Biol Chem (2008) 1.00
WRKY Transcription Factors Phosphorylated by MAPK Regulate a Plant Immune NADPH Oxidase in Nicotiana benthamiana. Plant Cell (2015) 0.97
Down-regulation of CMTM8 induces epithelial-to-mesenchymal transition-like changes via c-MET/extracellular signal-regulated kinase (ERK) signaling. J Biol Chem (2012) 0.97
Heterodimerization with different Jun proteins controls c-Fos intranuclear dynamics and distribution. J Biol Chem (2010) 0.96
Construction and validation of a Bovine Innate Immune Microarray. BMC Genomics (2005) 0.95
Integration of mTOR and estrogen-ERK2 signaling in lymphangioleiomyomatosis pathogenesis. Proc Natl Acad Sci U S A (2013) 0.92
Stimulus-induced uncoupling of extracellular signal-regulated kinase phosphorylation from nuclear localization is dependent on docking domain interactions. J Cell Sci (2010) 0.92
Towards a molecular understanding of the differential signals regulating alphabeta/gammadelta T lineage choice. Semin Immunol (2010) 0.91
RSK phosphorylates SOS1 creating 14-3-3-docking sites and negatively regulating MAPK activation. Biochem J (2012) 0.91
Analysis of mitogen-activated protein kinase activation and interactions with regulators and substrates. Methods (2006) 0.89
Complexity of receptor tyrosine kinase signal processing. Cold Spring Harb Perspect Biol (2013) 0.89
Mycobacterium tuberculosis 6-kDa early secreted antigenic target (ESAT-6) protein downregulates lipopolysaccharide induced c-myc expression by modulating the extracellular signal regulated kinases 1/2. BMC Immunol (2007) 0.89
Cigarette smoke-induced pulmonary inflammatory responses are mediated by EGR-1/GGPPS/MAPK signaling. Am J Pathol (2010) 0.89
Temporal decoding of MAP kinase and CREB phosphorylation by selective immediate early gene expression. PLoS One (2013) 0.89
Dual specificity phosphatases 10 and 16 are positive regulators of EGF-stimulated ERK activity: indirect regulation of ERK signals by JNK/p38 selective MAPK phosphatases. Cell Signal (2012) 0.87
Identification of pY19-caveolin-2 as a positive regulator of insulin-stimulated actin cytoskeleton-dependent mitogenesis. J Cell Mol Med (2009) 0.87
Receptor Level Mechanisms Are Required for Epidermal Growth Factor (EGF)-stimulated Extracellular Signal-regulated Kinase (ERK) Activity Pulses. J Biol Chem (2015) 0.86
Examining docking interactions on ERK2 with modular peptide substrates. Biochemistry (2011) 0.86
PKD1 mediates negative feedback of PI3K/Akt activation in response to G protein-coupled receptors. PLoS One (2013) 0.84
Scaffolding actions of membrane-associated progesterone receptors. Steroids (2008) 0.83
Molecular control of vascular development by the matricellular proteins CCN1 (Cyr61) and CCN2 (CTGF). Trends Dev Biol (2013) 0.83
ERK1 and ERK2 Map Kinases: Specific Roles or Functional Redundancy? Front Cell Dev Biol (2016) 0.82
FRA-1 as a driver of tumour heterogeneity: a nexus between oncogenes and embryonic signalling pathways in cancer. Oncogene (2014) 0.82
Retinoblastoma protein and MyoD function together to effect the repression of Fra-1 and in turn cyclin D1 during terminal cell cycle arrest associated with myogenesis. J Biol Chem (2014) 0.82
ERK-associated changes of AP-1 proteins during fear extinction. Mol Cell Neurosci (2011) 0.81
CCN1/Cyr61-PI3K/AKT signaling promotes retinal neovascularization in oxygen-induced retinopathy. Int J Mol Med (2015) 0.81
Effect of PTTG on endogenous gene expression in HEK 293 cells. BMC Genomics (2009) 0.81
Dynamic regulation of extracellular signal-regulated kinase (ERK) by protein phosphatase 2A regulatory subunit B56γ1 in nuclei induces cell migration. PLoS One (2013) 0.80
Mechanical strain induces involution-associated events in mammary epithelial cells. BMC Cell Biol (2009) 0.80
DEF pocket in p38α facilitates substrate selectivity and mediates autophosphorylation. J Biol Chem (2013) 0.79
Longevity is impacted by growth hormone action during early postnatal period. Elife (2017) 0.79
STAT3-mediated coincidence detection regulates noncanonical immediate early gene induction. J Biol Chem (2013) 0.79
GGPPS, a new EGR-1 target gene, reactivates ERK 1/2 signaling through increasing Ras prenylation. Am J Pathol (2011) 0.78
Activation of mitogen-activated protein kinase in descending pain modulatory system. J Signal Transduct (2010) 0.78
Promoter-level expression clustering identifies time development of transcriptional regulatory cascades initiated by ErbB receptors in breast cancer cells. Sci Rep (2015) 0.78
Tracking the embryonic stem cell transition from ground state pluripotency. Development (2017) 0.77
Signaling output: it's all about timing and feedbacks. Mol Syst Biol (2015) 0.77
Multi-Compartmentalisation in the MAPK Signalling Pathway Contributes to the Emergence of Oscillatory Behaviour and to Ultrasensitivity. PLoS One (2016) 0.77
Receptor cross-talk spatially restricts p-ERK during TLR4 stimulation of autoreactive B cells. J Immunol (2012) 0.77
Nerve growth factor-mediated inhibition of apoptosis post-caspase activation is due to removal of active caspase-3 in a lysosome-dependent manner. Cell Death Dis (2014) 0.77
MCPIP1 Regulates Fibroblast Migration in 3-D Collagen Matrices Downstream of MAP Kinases and NF-κB. J Invest Dermatol (2015) 0.77
Protein Kinase A-independent Ras Protein Activation Cooperates with Rap1 Protein to Mediate Activation of the Extracellular Signal-regulated Kinases (ERK) by cAMP. J Biol Chem (2016) 0.76
How MAP kinase modules function as robust, yet adaptable, circuits. Cell Cycle (2014) 0.76
Unique in vitro and in vivo thrombopoietic activities of ingenol 3,20 dibenzoate, a Ca(++)-independent protein kinase C isoform agonist. PLoS One (2012) 0.76
Extracellular matrix stiffness modulates VEGF calcium signaling in endothelial cells: individual cell and population analysis. Integr Biol (Camb) (2015) 0.76
Feedforward regulation of mRNA stability by prolonged extracellular signal-regulated kinase activity. FEBS J (2015) 0.76
Dichotomy of cellular inhibition by small-molecule inhibitors revealed by single-cell analysis. Nat Commun (2016) 0.75
Strategies for Overcoming Resistance in Tumours Harboring BRAF Mutations. Int J Mol Sci (2017) 0.75
A comparison of approximation techniques for variance-based sensitivity analysis of biochemical reaction systems. BMC Bioinformatics (2010) 0.75
Application of Gene Expression Trajectories Initiated from ErbB Receptor Activation Highlights the Dynamics of Divergent Promoter Usage. PLoS One (2015) 0.75
A model for how signal duration can determine distinct outcomes of gene transcription programs. PLoS One (2012) 0.75
Boolean Modeling Reveals the Necessity of Transcriptional Regulation for Bistability in PC12 Cell Differentiation. Front Genet (2016) 0.75
An immediate-late gene expression module decodes ERK signal duration. Mol Syst Biol (2017) 0.75
Endogenous, Regulatory Cysteine Sulfenylation of ERK Kinases in Response to Proliferative Signals. Free Radic Biol Med (2017) 0.75
β1-Integrin Deletion From the Lens Activates Cellular Stress Responses Leading to Apoptosis and Fibrosis. Invest Ophthalmol Vis Sci (2017) 0.75
Specificity of receptor tyrosine kinase signaling: transient versus sustained extracellular signal-regulated kinase activation. Cell (1995) 21.15
The role of Jun, Fos and the AP-1 complex in cell-proliferation and transformation. Biochim Biophys Acta (1991) 11.78
Multiple Ras-dependent phosphorylation pathways regulate Myc protein stability. Genes Dev (2000) 6.54
Molecular interpretation of ERK signal duration by immediate early gene products. Nat Cell Biol (2002) 6.05
A conserved docking motif in MAP kinases common to substrates, activators and regulators. Nat Cell Biol (2000) 5.46
Integration of MAP kinase signal transduction pathways at the serum response element. Science (1995) 5.45
Diverse signaling pathways activated by growth factor receptors induce broadly overlapping, rather than independent, sets of genes. Cell (1999) 4.97
Nerve growth factor and epidermal growth factor induce rapid transient changes in proto-oncogene transcription in PC12 cells. J Biol Chem (1985) 4.87
Rap1 mediates sustained MAP kinase activation induced by nerve growth factor. Nature (1998) 4.62
The novel ATM-related protein TRRAP is an essential cofactor for the c-Myc and E2F oncoproteins. Cell (1998) 4.52
Morphogen gradient interpretation. Nature (2001) 3.90
Multiple docking sites on substrate proteins form a modular system that mediates recognition by ERK MAP kinase. Genes Dev (1999) 3.79
c-Jun can recruit JNK to phosphorylate dimerization partners via specific docking interactions. Cell (1996) 3.54
Activation of the protein kinase ERK5/BMK1 by receptor tyrosine kinases. Identification and characterization of a signaling pathway to the nucleus. J Biol Chem (1999) 3.42
Deconstructing myc. Genes Dev (2001) 3.30
EGF triggers neuronal differentiation of PC12 cells that overexpress the EGF receptor. Curr Biol (1994) 3.06
Regulation of IL-4 expression by the transcription factor JunB during T helper cell differentiation. EMBO J (1999) 2.96
An ATPase/helicase complex is an essential cofactor for oncogenic transformation by c-Myc. Mol Cell (2000) 2.84
NMDA-mediated activation of the tyrosine phosphatase STEP regulates the duration of ERK signaling. Nat Neurosci (2003) 2.70
Identification and characterization of the Egr-1 gene product, a DNA-binding zinc finger protein induced by differentiation and growth signals. Mol Cell Biol (1990) 2.41
Ribosomal S6 kinase 1 (RSK1) activation requires signals dependent on and independent of the MAP kinase ERK. Curr Biol (1999) 2.29
Fra-1 induces morphological transformation and increases in vitro invasiveness and motility of epithelioid adenocarcinoma cells. Mol Cell Biol (1998) 2.22
Signaling life and death in the thymus: timing is everything. Science (2003) 2.20
ERK induces p35, a neuron-specific activator of Cdk5, through induction of Egr1. Nat Cell Biol (2001) 2.11
Differential regulation of c-Jun by ERK and JNK during PC12 cell differentiation. EMBO J (1998) 2.08
Fosl1 is a transcriptional target of c-Fos during osteoclast differentiation. Nat Genet (2000) 1.96
MAP kinase phosphatases. Genome Biol (2002) 1.88
Identification of Xenopus S6 protein kinase homologs (pp90rsk) in somatic cells: phosphorylation and activation during initiation of cell proliferation. Mol Cell Biol (1990) 1.87
Sustained MAP kinase activation is required for the expression of cyclin D1, p21Cip1 and a subset of AP-1 proteins in CCL39 cells. Oncogene (1999) 1.64
Crosstalk between cAMP-dependent kinase and MAP kinase through a protein tyrosine phosphatase. Nat Cell Biol (1999) 1.62
Fos family members induce cell cycle entry by activating cyclin D1. Mol Cell Biol (1998) 1.61
Phosphorylation of c-Fos at the C-terminus enhances its transforming activity. Oncogene (1996) 1.56
The Mos/MAP kinase pathway stabilizes c-Fos by phosphorylation and augments its transforming activity in NIH 3T3 cells. EMBO J (1995) 1.55
Conditional inhibition of the mitogen-activated protein kinase cascade by wortmannin. Dependence on signal strength. J Biol Chem (1997) 1.54
Nerve growth factor rapidly induces c-fos mRNA in PC12 rat pheochromocytoma cells. Proc Natl Acad Sci U S A (1986) 1.51
Role of endocytosis in the activation of the extracellular signal-regulated kinase cascade by sequestering and nonsequestering G protein-coupled receptors. Proc Natl Acad Sci U S A (2000) 1.50
Transcriptional activation of the fra-1 gene by AP-1 is mediated by regulatory sequences in the first intron. Mol Cell Biol (1995) 1.47
The induction of a neural-specific gene, SCG10, by nerve growth factor in PC12 cells is transcriptional, protein synthesis dependent, and glucocorticoid inhibitable. Dev Biol (1988) 1.29
Transactivation of Fra-1 and consequent activation of AP-1 occur extracellular signal-regulated kinase dependently. Mol Cell Biol (2002) 1.26
Morphogen gradients. A question of time or concentration? Trends Genet (2000) 1.06
Immediate-early gene induction by the stresses anisomycin and arsenite in human osteosarcoma cells involves MAPK cascade signaling to Elk-1, CREB and SRF. Oncogene (2003) 0.98
Structure and chromosomal assignment of the mouse fra-1 gene, and its exclusion as a candidate gene for oc (osteosclerosis). Oncogene (1997) 0.94
Fra-2-positive autoregulatory loop triggered by mitogen-activated protein kinase (MAPK) and Fra-2 phosphorylation sites by MAPK. Cell Growth Differ (1999) 0.94
Molecular mechanisms of mTOR-mediated translational control. Nat Rev Mol Cell Biol (2009) 13.89
Identification of the tuberous sclerosis complex-2 tumor suppressor gene product tuberin as a target of the phosphoinositide 3-kinase/akt pathway. Mol Cell (2002) 11.65
ERK and p38 MAPK-activated protein kinases: a family of protein kinases with diverse biological functions. Microbiol Mol Biol Rev (2004) 9.54
Mammalian cell size is controlled by mTOR and its downstream targets S6K1 and 4EBP1/eIF4E. Genes Dev (2002) 8.31
Tuberous sclerosis complex gene products, Tuberin and Hamartin, control mTOR signaling by acting as a GTPase-activating protein complex toward Rheb. Curr Biol (2003) 8.25
Target of rapamycin (TOR): an integrator of nutrient and growth factor signals and coordinator of cell growth and cell cycle progression. Oncogene (2004) 7.92
Bidirectional transport of amino acids regulates mTOR and autophagy. Cell (2009) 7.88
Activation of a metabolic gene regulatory network downstream of mTOR complex 1. Mol Cell (2010) 7.61
Rapamycin differentially inhibits S6Ks and 4E-BP1 to mediate cell-type-specific repression of mRNA translation. Proc Natl Acad Sci U S A (2008) 6.84
mTOR and S6K1 mediate assembly of the translation preinitiation complex through dynamic protein interchange and ordered phosphorylation events. Cell (2005) 6.71
Molecular interpretation of ERK signal duration by immediate early gene products. Nat Cell Biol (2002) 6.05
Phosphoproteomic analysis identifies Grb10 as an mTORC1 substrate that negatively regulates insulin signaling. Science (2011) 5.73
mTOR controls cell cycle progression through its cell growth effectors S6K1 and 4E-BP1/eukaryotic translation initiation factor 4E. Mol Cell Biol (2004) 5.46
Tumor-promoting phorbol esters and activated Ras inactivate the tuberous sclerosis tumor suppressor complex via p90 ribosomal S6 kinase. Proc Natl Acad Sci U S A (2004) 5.16
Tuberous sclerosis complex-1 and -2 gene products function together to inhibit mammalian target of rapamycin (mTOR)-mediated downstream signaling. Proc Natl Acad Sci U S A (2002) 4.93
The RSK family of kinases: emerging roles in cellular signalling. Nat Rev Mol Cell Biol (2008) 4.92
RAS/ERK signaling promotes site-specific ribosomal protein S6 phosphorylation via RSK and stimulates cap-dependent translation. J Biol Chem (2007) 4.45
Glucose addiction of TSC null cells is caused by failed mTORC1-dependent balancing of metabolic demand with supply. Mol Cell (2010) 4.07
TOS motif-mediated raptor binding regulates 4E-BP1 multisite phosphorylation and function. Curr Biol (2003) 4.01
MAPK signal specificity: the right place at the right time. Trends Biochem Sci (2006) 3.96
The Ras-ERK and PI3K-mTOR pathways: cross-talk and compensation. Trends Biochem Sci (2011) 3.89
Sensitized RNAi screen of human kinases and phosphatases identifies new regulators of apoptosis and chemoresistance. Nat Cell Biol (2005) 3.89
Identification of a conserved motif required for mTOR signaling. Curr Biol (2002) 3.78
The mTOR/PI3K and MAPK pathways converge on eIF4B to control its phosphorylation and activity. EMBO J (2006) 3.57
SKAR links pre-mRNA splicing to mTOR/S6K1-mediated enhanced translation efficiency of spliced mRNAs. Cell (2008) 3.43
ERK2 but not ERK1 induces epithelial-to-mesenchymal transformation via DEF motif-dependent signaling events. Mol Cell (2010) 3.03
Identification of S6 kinase 1 as a novel mammalian target of rapamycin (mTOR)-phosphorylating kinase. J Biol Chem (2005) 2.84
mTOR, translational control and human disease. Semin Cell Dev Biol (2004) 2.77
The mTORC1 pathway stimulates glutamine metabolism and cell proliferation by repressing SIRT4. Cell (2013) 2.70
Not all substrates are treated equally: implications for mTOR, rapamycin-resistance and cancer therapy. Cell Cycle (2009) 2.45
A genome-wide siRNA screen reveals multiple mTORC1 independent signaling pathways regulating autophagy under normal nutritional conditions. Dev Cell (2010) 2.40
Coordinate regulation of translation by the PI 3-kinase and mTOR pathways. Adv Cancer Res (2002) 2.37
Frequent somatic mutations in MAP3K5 and MAP3K9 in metastatic melanoma identified by exome sequencing. Nat Genet (2011) 2.36
Phosphorylation of p90 ribosomal S6 kinase (RSK) regulates extracellular signal-regulated kinase docking and RSK activity. Mol Cell Biol (2003) 2.32
Quantitative phosphorylation profiling of the ERK/p90 ribosomal S6 kinase-signaling cassette and its targets, the tuberous sclerosis tumor suppressors. Proc Natl Acad Sci U S A (2005) 2.23
Inactivation of the tuberous sclerosis complex-1 and -2 gene products occurs by phosphoinositide 3-kinase/Akt-dependent and -independent phosphorylation of tuberin. J Biol Chem (2003) 2.12
SIRT4 has tumor-suppressive activity and regulates the cellular metabolic response to DNA damage by inhibiting mitochondrial glutamine metabolism. Cancer Cell (2013) 1.99
Glycogen synthase kinase (GSK)-3 promotes p70 ribosomal protein S6 kinase (p70S6K) activity and cell proliferation. Proc Natl Acad Sci U S A (2011) 1.90
SKAR is a specific target of S6 kinase 1 in cell growth control. Curr Biol (2004) 1.90
Ribosomal S6 kinase (RSK) regulates phosphorylation of filamin A on an important regulatory site. Mol Cell Biol (2004) 1.81
PI3-kinase and TOR: PIKTORing cell growth. Semin Cell Dev Biol (2004) 1.78
The RSK factors of activating the Ras/MAPK signaling cascade. Front Biosci (2008) 1.75
Sin1 phosphorylation impairs mTORC2 complex integrity and inhibits downstream Akt signalling to suppress tumorigenesis. Nat Cell Biol (2013) 1.73
Activation of PI3K/Akt and MAPK pathways regulates Myc-mediated transcription by phosphorylating and promoting the degradation of Mad1. Proc Natl Acad Sci U S A (2008) 1.69
Identification of a lysosomal pathway that modulates glucocorticoid signaling and the inflammatory response. Sci Signal (2011) 1.58
Metabolic stress controls mTORC1 lysosomal localization and dimerization by regulating the TTT-RUVBL1/2 complex. Mol Cell (2012) 1.50
PI3K induced actin filament remodeling through Akt and p70S6K1: implication of essential role in cell migration. Am J Physiol Cell Physiol (2003) 1.49
Metformin decreases glucose oxidation and increases the dependency of prostate cancer cells on reductive glutamine metabolism. Cancer Res (2013) 1.49
Analysis of mTOR signaling by the small G-proteins, Rheb and RhebL1. FEBS Lett (2005) 1.48
Spatially separate docking sites on ERK2 regulate distinct signaling events in vivo. Curr Biol (2005) 1.46
Deletion of ribosomal S6 kinases does not attenuate pathological, physiological, or insulin-like growth factor 1 receptor-phosphoinositide 3-kinase-induced cardiac hypertrophy. Mol Cell Biol (2004) 1.43
Graded mitogen-activated protein kinase activity precedes switch-like c-Fos induction in mammalian cells. Mol Cell Biol (2005) 1.42
Nutrient regulation of the mTOR complex 1 signaling pathway. Mol Cells (2013) 1.42
The tumor suppressor DAP kinase is a target of RSK-mediated survival signaling. Curr Biol (2005) 1.38
Ran-binding protein 3 phosphorylation links the Ras and PI3-kinase pathways to nucleocytoplasmic transport. Mol Cell (2008) 1.33
TORgeting oncogene addiction for cancer therapy. Cancer Cell (2006) 1.30
ERK-MAPK drives lamellipodia protrusion by activating the WAVE2 regulatory complex. Mol Cell (2011) 1.22
Distinct roles for mammalian target of rapamycin complexes in the fibroblast response to transforming growth factor-beta. Cancer Res (2009) 1.20
Characterization of a conserved C-terminal motif (RSPRR) in ribosomal protein S6 kinase 1 required for its mammalian target of rapamycin-dependent regulation. J Biol Chem (2005) 1.17
p90 ribosomal S6 kinase and p70 ribosomal S6 kinase link phosphorylation of the eukaryotic chaperonin containing TCP-1 to growth factor, insulin, and nutrient signaling. J Biol Chem (2009) 1.16
PHLPPing it off: phosphatases get in the Akt. Mol Cell (2007) 1.14
Characterizing the interaction of the mammalian eIF4E-related protein 4EHP with 4E-BP1. FEBS Lett (2004) 1.12
Characterization of phosphatidylinositol 3-kinase-dependent phosphorylation of the hydrophobic motif site Thr(389) in p70 S6 kinase 1. J Biol Chem (2002) 1.08
Birt-Hogg-Dubé renal tumors are genetically distinct from other renal neoplasias and are associated with up-regulation of mitochondrial gene expression. BMC Med Genomics (2010) 1.06
Chromosomal amplification of leucine-rich repeat kinase-2 (LRRK2) is required for oncogenic MET signaling in papillary renal and thyroid carcinomas. Proc Natl Acad Sci U S A (2011) 1.05
Cell signaling in protein synthesis ribosome biogenesis and translation initiation and elongation. Prog Mol Biol Transl Sci (2009) 1.03
AKT facilitates EGFR trafficking and degradation by phosphorylating and activating PIKfyve. Sci Signal (2013) 1.03
Inhibition of ERK-MAP kinase signaling by RSK during Drosophila development. EMBO J (2006) 1.01
Morphological and behavioral impact of AAV2/5-mediated overexpression of human wildtype alpha-synuclein in the rat nigrostriatal system. PLoS One (2013) 0.99
Estradiol and mTORC2 cooperate to enhance prostaglandin biosynthesis and tumorigenesis in TSC2-deficient LAM cells. J Exp Med (2014) 0.97
Down-regulation of CMTM8 induces epithelial-to-mesenchymal transition-like changes via c-MET/extracellular signal-regulated kinase (ERK) signaling. J Biol Chem (2012) 0.97
Identification of PTPsigma as an autophagic phosphatase. J Cell Sci (2011) 0.95
Mind the GAP: Wnt steps onto the mTORC1 train. Cell (2006) 0.95
Integration of mTOR and estrogen-ERK2 signaling in lymphangioleiomyomatosis pathogenesis. Proc Natl Acad Sci U S A (2013) 0.92
Rheb activation of mTOR and S6K1 signaling. Methods Enzymol (2006) 0.90
Hippo-YAP and mTOR pathways collaborate to regulate organ size. Nat Cell Biol (2012) 0.90
A specific mechanomodulatory role for p38 MAPK in embryonic joint articular surface cell MEK-ERK pathway regulation. J Biol Chem (2006) 0.90
Transcriptional profiling of targets for combination therapy of lung carcinoma with paclitaxel and mitogen-activated protein/extracellular signal-regulated kinase kinase inhibitor. Cancer Res (2003) 0.90
A high-throughput, cell-based screening method for siRNA and small molecule inhibitors of mTORC1 signaling using the In Cell Western technique. Assay Drug Dev Technol (2010) 0.89
Kinase targets in renal-cell carcinomas: reassessing the old and discovering the new. Lancet Oncol (2010) 0.87
MK-STYX, a catalytically inactive phosphatase regulating mitochondrially dependent apoptosis. Mol Cell Biol (2011) 0.86
ERK2/Fra1/ZEB pathway induces epithelial-to-mesenchymal transition. Cell Cycle (2010) 0.86
Downregulation of the mitochondrial phosphatase PTPMT1 is sufficient to promote cancer cell death. PLoS One (2013) 0.84
SHP-2 regulates cell growth by controlling the mTOR/S6 kinase 1 pathway. J Biol Chem (2007) 0.83
Appetite for destruction: the inhibition of glycolysis as a therapy for tuberous sclerosis complex-related tumors. BMC Biol (2011) 0.82
Identification of small molecule inhibitors of PTPσ through an integrative virtual and biochemical approach. PLoS One (2012) 0.80
mTORC1 signaling aids in CADalyzing pyrimidine biosynthesis. Cell Metab (2013) 0.78
ERK-MAP Kinase signaling in the cytoplasm. Methods Mol Biol (2010) 0.78
ATM: Promoter of metabolic "cost" reduction and "savings" usage during hypoxia through mTORC1 regulation. Mol Cell (2010) 0.77
Mitochondrial phosphorylation in apoptosis: flipping the death switch. Antioxid Redox Signal (2012) 0.76
TPCK inhibits AGC kinases by direct activation loop adduction at phenylalanine-directed cysteine residues. FEBS Lett (2012) 0.75
Cytokine receptor-like factor 1 (CRLF1) protects against 6-hydroxydopamine toxicity independent of the gp130/JAK signaling pathway. PLoS One (2013) 0.75