Published in Biochemistry on December 23, 2003
Alpha-synuclein interacts with Glucocerebrosidase providing a molecular link between Parkinson and Gaucher diseases. J Biol Chem (2011) 1.42
Effects of pH and iminosugar pharmacological chaperones on lysosomal glycosidase structure and stability. Biochemistry (2009) 1.38
A short guided tour through functional and structural features of saposin-like proteins. Biochem J (2005) 1.35
Detection of ligand binding hot spots on protein surfaces via fragment-based methods: application to DJ-1 and glucocerebrosidase. J Comput Aided Mol Des (2009) 1.30
Crystal structures of saposins A and C. Protein Sci (2006) 1.17
Molecular imaging of membrane interfaces reveals mode of beta-glucosidase activation by saposin C. Proc Natl Acad Sci U S A (2007) 1.16
Point mutational analysis of the liganding site in human glycolipid transfer protein. Functionality of the complex. J Biol Chem (2005) 1.04
Insights into Krabbe disease from structures of galactocerebrosidase. Proc Natl Acad Sci U S A (2011) 1.03
The role of saposin C in Gaucher disease. Mol Genet Metab (2012) 1.02
The N370S (Asn370-->Ser) mutation affects the capacity of glucosylceramidase to interact with anionic phospholipid-containing membranes and saposin C. Biochem J (2005) 0.96
Membrane curvature sensing by the C-terminal domain of complexin. Nat Commun (2014) 0.95
Structure-function correlations of pulmonary surfactant protein SP-B and the saposin-like family of proteins. Eur Biophys J (2012) 0.89
A Guided Tour of the Structural Biology of Gaucher Disease: Acid-β-Glucosidase and Saposin C. Enzyme Res (2011) 0.88
NMR structure of a fungal virulence factor reveals structural homology with mammalian saposin B. Mol Microbiol (2009) 0.87
Saposins utilize two strategies for lipid transfer and CD1 antigen presentation. Proc Natl Acad Sci U S A (2012) 0.84
Investigating the interaction of saposin C with POPS and POPC phospholipids: a solid-state NMR spectroscopic study. Biophys J (2007) 0.80
SapC-DOPS nanovesicles as targeted therapy for lung cancer. Mol Cancer Ther (2015) 0.80
Saposin C protects glucocerebrosidase against α-synuclein inhibition. Biochemistry (2013) 0.80
Variation in human cancer cell external phosphatidylserine is regulated by flippase activity and intracellular calcium. Oncotarget (2015) 0.78
Imaging and Therapy of Pancreatic Cancer with Phosphatidylserine-Targeted Nanovesicles. Transl Oncol (2015) 0.77
Dissociation of glucocerebrosidase dimer in solution by its co-factor, saposin C. Biochem Biophys Res Commun (2015) 0.77
Crystallization and preliminary characterization of three different crystal forms of human saposin C heterologously expressed in Pichia pastoris. Acta Crystallogr Sect F Struct Biol Cryst Commun (2006) 0.77
NMR of molecules interacting with lipids in small unilamellar vesicles. Eur Biophys J (2007) 0.76
In silico insights into protein-protein interactions and folding dynamics of the saposin-like domain of Solanum tuberosum aspartic protease. PLoS One (2014) 0.76
Structure of human saposin A at lysosomal pH. Acta Crystallogr F Struct Biol Commun (2015) 0.75
Design of Surfactant Protein B Peptide Mimics Based on the Saposin Fold for Synthetic Lung Surfactants. Biomed Hub (2016) 0.75
J-Spectroscopy in the presence of residual dipolar couplings: determination of one-bond coupling constants and scalable resolution. J Biomol NMR (2007) 0.75
Advances on the Transfer of Lipids by Lipid Transfer Proteins. Trends Biochem Sci (2017) 0.75
The Xplor-NIH NMR molecular structure determination package. J Magn Reson (2003) 16.23
Distinct BH3 domains either sensitize or activate mitochondrial apoptosis, serving as prototype cancer therapeutics. Cancer Cell (2002) 11.09
BAX activation is initiated at a novel interaction site. Nature (2008) 6.07
A distinct pathway remodels mitochondrial cristae and mobilizes cytochrome c during apoptosis. Dev Cell (2002) 5.45
Bcl-x(L) retrotranslocates Bax from the mitochondria into the cytosol. Cell (2011) 3.23
Structural basis for recognition of centromere histone variant CenH3 by the chaperone Scm3. Nature (2011) 1.99
The solution structure of human mitochondria fission protein Fis1 reveals a novel TPR-like helix bundle. J Mol Biol (2003) 1.70
Residual dipolar couplings in NMR structure analysis. Annu Rev Biophys Biomol Struct (2004) 1.62
Overall structure and sugar dynamics of a DNA dodecamer from homo- and heteronuclear dipolar couplings and 31P chemical shift anisotropy. J Biomol NMR (2003) 1.53
Structural basis for redox regulation of Yap1 transcription factor localization. Nature (2004) 1.50
Novel structure of the N terminus in yeast Fis1 correlates with a specialized function in mitochondrial fission. J Biol Chem (2005) 1.27
Solution NMR characterizations of oligomerization and dynamics of equine infectious anemia virus matrix protein and its interaction with PIP2. Biochemistry (2008) 1.24
Temperature dependence of domain motions of calmodulin probed by NMR relaxation at multiple fields. J Am Chem Soc (2003) 1.22
Specific non-native hydrophobic interactions in a hidden folding intermediate: implications for protein folding. Biochemistry (2003) 1.22
GP369, an FGFR2-IIIb-specific antibody, exhibits potent antitumor activity against human cancers driven by activated FGFR2 signaling. Cancer Res (2010) 1.18
Completely automated, highly error-tolerant macromolecular structure determination from multidimensional nuclear overhauser enhancement spectra and chemical shift assignments. J Am Chem Soc (2004) 1.11
Temperature dependence of protein backbone motion from carbonyl 13C and amide 15N NMR relaxation. J Magn Reson (2005) 1.09
Structure, stability, and interaction of the fibrin(ogen) alphaC-domains. Biochemistry (2009) 1.07
15N chemical shift anisotropy in protein structure refinement and comparison with NH residual dipolar couplings. J Magn Reson (2003) 1.06
A low pKa cysteine at the active site of mouse methionine sulfoxide reductase A. J Biol Chem (2012) 1.05
Identification of an ordered compact structure within the recombinant bovine fibrinogen alphaC-domain fragment by NMR. Biochemistry (2006) 1.04
Phosphoinositides direct equine infectious anemia virus gag trafficking and release. Traffic (2011) 1.03
Ligand-free open-closed transitions of periplasmic binding proteins: the case of glutamine-binding protein. Biochemistry (2010) 1.01
Solution structure of human saposin C in a detergent environment. J Mol Biol (2005) 1.01
Synthesis, in vitro and in vivo activity of thiamine antagonist transketolase inhibitors. Bioorg Med Chem Lett (2007) 1.00
Structural basis of focal adhesion localization of LIM-only adaptor PINCH by integrin-linked kinase. J Biol Chem (2008) 0.99
Molecular mechanisms for the subversion of MyD88 signaling by TcpC from virulent uropathogenic Escherichia coli. Proc Natl Acad Sci U S A (2013) 0.99
NMR solution structure, stability, and interaction of the recombinant bovine fibrinogen alphaC-domain fragment. Biochemistry (2007) 0.98
Water proton spin saturation affects measured protein backbone 15N spin relaxation rates. J Magn Reson (2011) 0.96
On the accurate measurement of amide one-bond 15N-1H couplings in proteins: effects of cross-correlated relaxation, selective pulses and dynamic frequency shifts. J Magn Reson (2006) 0.96
Extended model free approach to analyze correlation functions of multidomain proteins in the presence of motional coupling. J Am Chem Soc (2008) 0.95
Determination of the solution-bound conformation of an amino acid binding protein by NMR paramagnetic relaxation enhancement: use of a single flexible paramagnetic probe with improved estimation of its sampling space. J Am Chem Soc (2009) 0.94
Structural mechanism of Bax inhibition by cytomegalovirus protein vMIA. Proc Natl Acad Sci U S A (2012) 0.94
Characterization of the N-terminal tail domain of histone H3 in condensed nucleosome arrays by hydrogen exchange and NMR. J Am Chem Soc (2009) 0.93
Molecular basis for barbed end uncapping by CARMIL homology domain 3 of mouse CARMIL-1. J Biol Chem (2010) 0.92
On the mechanism of αC polymer formation in fibrin. Biochemistry (2012) 0.92
Structural insights of tBid, the caspase-8-activated Bid, and its BH3 domain. J Biol Chem (2013) 0.91
Structural studies on the Ca2+-binding domain of human nucleobindin (calnuc). Biochemistry (2004) 0.90
Hydrogen bonding in high-resolution protein structures: a new method to assess NMR protein geometry. J Am Chem Soc (2002) 0.90
The use of residual dipolar coupling in studying proteins by NMR. Top Curr Chem (2012) 0.89
A practical implementation of cross-spectrum in protein backbone resonance assignment. J Magn Reson (2009) 0.87
Prodrug thiamine analogs as inhibitors of the enzyme transketolase. Bioorg Med Chem Lett (2007) 0.87
Characterization and solution structure of mouse myristoylated methionine sulfoxide reductase A. J Biol Chem (2012) 0.86
Structural basis for capping protein sequestration by myotrophin (V-1). J Biol Chem (2010) 0.86
Non-charged thiamine analogs as inhibitors of enzyme transketolase. Bioorg Med Chem Lett (2007) 0.86
Parameterization of solvent-protein interaction and its use on NMR protein structure determination. J Magn Reson (2012) 0.85
Interference between cross-correlated relaxation and the measurement of scalar and dipolar couplings by Quantitative J. J Biomol NMR (2006) 0.85
Residual dipolar couplings in protein structure determination. Methods Mol Biol (2004) 0.84
An ab initio study of amide proton shift tensor dependence on local protein structure. J Am Chem Soc (2002) 0.84
Determination of the residue-specific 15N CSA tensor principal components using multiple alignment media. J Biomol NMR (2006) 0.84
Estimation of interdomain flexibility of N-terminus of factor H using residual dipolar couplings. Biochemistry (2011) 0.83
Structural and dynamics studies of the D54A mutant of human T cell leukemia virus-1 capsid protein. J Biol Chem (2004) 0.83
Residue-specific 13C' CSA tensor principal components for ubiquitin: correlation between tensor components and hydrogen bonding. J Am Chem Soc (2007) 0.82
Top-down approach in protein RDC data analysis: de novo estimation of the alignment tensor. J Biomol NMR (2007) 0.81
Direct measurements of protein backbone 15N spin relaxation rates from peak line-width using a fully-relaxed Accordion 3D HNCO experiment. J Magn Reson (2008) 0.81
The maturational refolding of the β-hairpin motif of equine infectious anemia virus capsid protein extends its helix α1 at capsid assembly locus. J Biol Chem (2012) 0.81
Analysis of the isomer ratios of polymethylated-DOTA complexes and the implications on protein structural studies. Dalton Trans (2016) 0.81
Deuteration of Escherichia coli enzyme I(Ntr) alters its stability. Arch Biochem Biophys (2010) 0.80
Weak alignment of biomacromolecules in collagen gels: an alternative way to yield residual dipolar couplings for NMR measurements. J Am Chem Soc (2008) 0.80
Solution NMR studies of periplasmic binding proteins and their interaction partners. Biomol Concepts (2011) 0.79
Backbone (15)N relaxation analysis of the N-terminal domain of the HTLV-I capsid protein and comparison with the capsid protein of HIV-1. Protein Sci (2003) 0.78
Solution NMR structure of selenium-binding protein from Methanococcus vannielii. J Biol Chem (2008) 0.78
15N-1H scalar coupling perturbation: an additional probe for measuring structural changes due to ligand binding. J Am Chem Soc (2009) 0.77
Decoding the components of dynamics in three-domain proteins. J Comput Chem (2013) 0.76
Determining interdomain structure and dynamics of a retroviral capsid protein in the presence of oligomerization: implication for structural transition in capsid assembly. Biochemistry (2013) 0.75
Temperature dependence of molecular interactions involved in defining stability of glutamine binding protein and its complex with L-glutamine. Biochemistry (2012) 0.75
Exploiting image registration for automated resonance assignment in NMR. J Biomol NMR (2015) 0.75