Published in J Biol Chem on April 04, 2005
Mff is an essential factor for mitochondrial recruitment of Drp1 during mitochondrial fission in mammalian cells. J Cell Biol (2010) 3.91
Dnm1 forms spirals that are structurally tailored to fit mitochondria. J Cell Biol (2005) 3.75
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Direct binding of the dynamin-like GTPase, Dnm1, to mitochondrial dynamics protein Fis1 is negatively regulated by the Fis1 N-terminal arm. J Biol Chem (2007) 1.28
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A designed point mutant in Fis1 disrupts dimerization and mitochondrial fission. J Mol Biol (2012) 0.78
The 1.75 Å resolution structure of fission protein Fis1 from Saccharomyces cerevisiae reveals elusive interactions of the autoinhibitory domain. Acta Crystallogr Sect F Struct Biol Cryst Commun (2011) 0.78
Refinement of protein structure against non-redundant carbonyl 13C NMR relaxation. J Biomol NMR (2007) 0.77
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Roles of the mammalian mitochondrial fission and fusion mediators Fis1, Drp1, and Opa1 in apoptosis. Mol Biol Cell (2004) 5.94
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Spatial and temporal association of Bax with mitochondrial fission sites, Drp1, and Mfn2 during apoptosis. J Cell Biol (2002) 5.01
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Nitric oxide-induced mitochondrial fission is regulated by dynamin-related GTPases in neurons. EMBO J (2006) 4.43
Mff is an essential factor for mitochondrial recruitment of Drp1 during mitochondrial fission in mammalian cells. J Cell Biol (2010) 3.91
The mitochondrial E3 ubiquitin ligase MARCH5 is required for Drp1 dependent mitochondrial division. J Cell Biol (2007) 3.83
Mitochondrial membrane potential regulates PINK1 import and proteolytic destabilization by PARL. J Cell Biol (2010) 3.68
p62/SQSTM1 is required for Parkin-induced mitochondrial clustering but not mitophagy; VDAC1 is dispensable for both. Autophagy (2010) 3.68
Quantitation of mitochondrial dynamics by photolabeling of individual organelles shows that mitochondrial fusion is blocked during the Bax activation phase of apoptosis. J Cell Biol (2004) 3.55
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Drp-1-dependent division of the mitochondrial network blocks intraorganellar Ca2+ waves and protects against Ca2+-mediated apoptosis. Mol Cell (2004) 3.28
Bcl-x(L) retrotranslocates Bax from the mitochondria into the cytosol. Cell (2011) 3.23
PINK1 phosphorylates ubiquitin to activate Parkin E3 ubiquitin ligase activity. J Cell Biol (2014) 3.12
JNK-mediated BIM phosphorylation potentiates BAX-dependent apoptosis. Neuron (2003) 2.86
Mitofusin-1 protein is a generally expressed mediator of mitochondrial fusion in mammalian cells. J Cell Sci (2003) 2.68
OPA1 mutations associated with dominant optic atrophy impair oxidative phosphorylation and mitochondrial fusion. Brain (2008) 2.57
Role of PINK1 binding to the TOM complex and alternate intracellular membranes in recruitment and activation of the E3 ligase Parkin. Dev Cell (2012) 2.52
The soluble form of Bax regulates mitochondrial fusion via MFN2 homotypic complexes. Mol Cell (2011) 2.43
Loss of Bif-1 suppresses Bax/Bak conformational change and mitochondrial apoptosis. Mol Cell Biol (2005) 2.31
Endophilin B1 is required for the maintenance of mitochondrial morphology. J Cell Biol (2004) 2.28
Anti-apoptotic MCL-1 localizes to the mitochondrial matrix and couples mitochondrial fusion to respiration. Nat Cell Biol (2012) 2.25
Mitochondrial fission and fusion mediators, hFis1 and OPA1, modulate cellular senescence. J Biol Chem (2007) 2.22
Mitochondrial release of AIF and EndoG requires caspase activation downstream of Bax/Bak-mediated permeabilization. EMBO J (2003) 2.16
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Parkin overexpression selects against a deleterious mtDNA mutation in heteroplasmic cybrid cells. Proc Natl Acad Sci U S A (2010) 2.10
PINK1 drives Parkin self-association and HECT-like E3 activity upstream of mitochondrial binding. J Cell Biol (2013) 2.04
Control of mitochondrial permeability by Bcl-2 family members. Biochim Biophys Acta (2004) 2.00
Structural basis for recognition of centromere histone variant CenH3 by the chaperone Scm3. Nature (2011) 1.99
A chemical inhibitor of DRP1 uncouples mitochondrial fission and apoptosis. Mol Cell (2008) 1.94
Role of mitochondrial remodeling in programmed cell death in Drosophila melanogaster. Dev Cell (2007) 1.91
Hsp90-Cdc37 chaperone complex regulates Ulk1- and Atg13-mediated mitophagy. Mol Cell (2011) 1.91
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Cytomegalovirus cell death suppressor vMIA blocks Bax- but not Bak-mediated apoptosis by binding and sequestering Bax at mitochondria. Proc Natl Acad Sci U S A (2004) 1.85
Parkin-induced mitophagy in the pathogenesis of Parkinson disease. Autophagy (2009) 1.82
Targeting mitochondrial dysfunction: role for PINK1 and Parkin in mitochondrial quality control. Antioxid Redox Signal (2011) 1.82
Bcl-x(L) sequesters its C-terminal membrane anchor in soluble, cytosolic homodimers. EMBO J (2004) 1.77
The solution structure of human mitochondria fission protein Fis1 reveals a novel TPR-like helix bundle. J Mol Biol (2003) 1.70
PINK1 is degraded through the N-end rule pathway. Autophagy (2013) 1.63
Polyubiquitin-sensor proteins reveal localization and linkage-type dependence of cellular ubiquitin signaling. Nat Methods (2012) 1.62
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Bid, but not Bax, regulates VDAC channels. J Biol Chem (2004) 1.57
Instability of the mitofusin Fzo1 regulates mitochondrial morphology during the mating response of the yeast Saccharomyces cerevisiae. J Biol Chem (2005) 1.54
Overall structure and sugar dynamics of a DNA dodecamer from homo- and heteronuclear dipolar couplings and 31P chemical shift anisotropy. J Biomol NMR (2003) 1.53
Parkin is a lipid-responsive regulator of fat uptake in mice and mutant human cells. J Clin Invest (2011) 1.52
Structural basis for redox regulation of Yap1 transcription factor localization. Nature (2004) 1.50
Loss of MARCH5 mitochondrial E3 ubiquitin ligase induces cellular senescence through dynamin-related protein 1 and mitofusin 1. J Cell Sci (2010) 1.47
The permeability transition pore signals apoptosis by directing Bax translocation and multimerization. FASEB J (2002) 1.46
Outer mitochondrial membrane protein degradation by the proteasome. Novartis Found Symp (2007) 1.36
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The accumulation of misfolded proteins in the mitochondrial matrix is sensed by PINK1 to induce PARK2/Parkin-mediated mitophagy of polarized mitochondria. Autophagy (2013) 1.31
Neurodegeneration as a consequence of failed mitochondrial maintenance. Acta Neuropathol (2011) 1.28
Entry into cells and selective degradation of tRNAs by a cytotoxic member of the RNase A family. J Biol Chem (2002) 1.27
Role of the ubiquitin conjugation system in the maintenance of mitochondrial homeostasis. Ann N Y Acad Sci (2008) 1.26
Solution NMR characterizations of oligomerization and dynamics of equine infectious anemia virus matrix protein and its interaction with PIP2. Biochemistry (2008) 1.24
Pseudomonas exotoxin A-mediated apoptosis is Bak dependent and preceded by the degradation of Mcl-1. Mol Cell Biol (2010) 1.23
Temperature dependence of domain motions of calmodulin probed by NMR relaxation at multiple fields. J Am Chem Soc (2003) 1.22
Specific non-native hydrophobic interactions in a hidden folding intermediate: implications for protein folding. Biochemistry (2003) 1.22
Solution structure of human saposin C: pH-dependent interaction with phospholipid vesicles. Biochemistry (2003) 1.17
Role of membrane association and Atg14-dependent phosphorylation in beclin-1-mediated autophagy. Mol Cell Biol (2013) 1.16
Completely automated, highly error-tolerant macromolecular structure determination from multidimensional nuclear overhauser enhancement spectra and chemical shift assignments. J Am Chem Soc (2004) 1.11
Temperature dependence of protein backbone motion from carbonyl 13C and amide 15N NMR relaxation. J Magn Reson (2005) 1.09
Cytomegalovirus proteins vMIA and m38.5 link mitochondrial morphogenesis to Bcl-2 family proteins. J Virol (2008) 1.09
IBRDC2, an IBR-type E3 ubiquitin ligase, is a regulatory factor for Bax and apoptosis activation. EMBO J (2010) 1.08
Structure, stability, and interaction of the fibrin(ogen) alphaC-domains. Biochemistry (2009) 1.07
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15N chemical shift anisotropy in protein structure refinement and comparison with NH residual dipolar couplings. J Magn Reson (2003) 1.06
A low pKa cysteine at the active site of mouse methionine sulfoxide reductase A. J Biol Chem (2012) 1.05
Identification of an ordered compact structure within the recombinant bovine fibrinogen alphaC-domain fragment by NMR. Biochemistry (2006) 1.04
A systematic search for endoplasmic reticulum (ER) membrane-associated RING finger proteins identifies Nixin/ZNRF4 as a regulator of calnexin stability and ER homeostasis. J Biol Chem (2011) 1.04
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Phosphoinositides direct equine infectious anemia virus gag trafficking and release. Traffic (2011) 1.03
Ligand-free open-closed transitions of periplasmic binding proteins: the case of glutamine-binding protein. Biochemistry (2010) 1.01
Solution structure of human saposin C in a detergent environment. J Mol Biol (2005) 1.01
Jak3-independent trafficking of the common gamma chain receptor subunit: chaperone function of Jaks revisited. Mol Cell Biol (2004) 1.01
Involvement of mitochondrial dynamics in the segregation of mitochondrial matrix proteins during stationary phase mitophagy. Nat Commun (2013) 1.01
Structural basis of focal adhesion localization of LIM-only adaptor PINCH by integrin-linked kinase. J Biol Chem (2008) 0.99
Molecular mechanisms for the subversion of MyD88 signaling by TcpC from virulent uropathogenic Escherichia coli. Proc Natl Acad Sci U S A (2013) 0.99
NMR solution structure, stability, and interaction of the recombinant bovine fibrinogen alphaC-domain fragment. Biochemistry (2007) 0.98
Coupling mitochondrial and cell division. Nat Cell Biol (2011) 0.98
Mutations in Fis1 disrupt orderly disposal of defective mitochondria. Mol Biol Cell (2013) 0.98
Water proton spin saturation affects measured protein backbone 15N spin relaxation rates. J Magn Reson (2011) 0.96
Mitochondrial fission and fusion. Essays Biochem (2010) 0.96
On the accurate measurement of amide one-bond 15N-1H couplings in proteins: effects of cross-correlated relaxation, selective pulses and dynamic frequency shifts. J Magn Reson (2006) 0.96
Extended model free approach to analyze correlation functions of multidomain proteins in the presence of motional coupling. J Am Chem Soc (2008) 0.95